1 F01 1977 13 dog 7.4 37.5 liver AST, a.ph. F01 1980 13 rat 3.5 16.2 adrenal, kidney weight; BUN F01 1980 104 rat 2.5 12.5 liver fatty infiltration, weight F01 1980 104 mouse 35.7 178.5 body weight F01 1984 104 dog 8 80 liver, kidney mortality; liver + kidney w.; anemia, ALAT, a.ph.,album., salivation F02 1983 13 rat 10 30 urinary bladder urothelial hyperplasia; cholest. F02 1984 13 mouse 4 12 liver vacuolation, rel. weight F02 1983 13 dog 0.9 4.5 urinary bladder, mucosal hyperplasia ALAT albumin F02 1984 52 rat 0.5 2.5 liver hypertrophy, weight F02 1987 52 dog 0.2 0.7 liver, thyroid hyperplasia in liver + thyroid F02 1992 78 mouse 3.4 13 urinary bladder mucosal hyperplasia F03 1953 52 dog 50 250 thyroid hyperplasia F03 1953 104 rat < 25 25 thyroid hyperplasia F04 1990 4 dog 100 500 vomiting; food intake F04 1991 4 rat < 844 844 blood, kidney, adrenal MCV, MCH, cholest., kidney + adrenal w., tubular dilatation + necrosis in kidney; body w. + food F04 1991 4 mouse 202 606 adrenal abs. + rel. weight; body w.+ food intake F04 1990 13 dog 6.0 80 vomiting, water consumpt. F04 1991 13 rat 5.4 54 liver, kidney hypertrophy; colored urine F04 1991 13 mouse 12 190 liver glycogen depletion F04 1992 52 dog 30 250 blood, gastrointestine WBC, clotting time, diarrhoea body w. + food + water intake F04 1993 80 mouse 20 210 urinary bladder mortality; urinary tract lesions, urogenital tract lesions; food F04 1993 104 rat 17 221 liver, thyroid hypertrophy, eosinoph. foci, weight; GGT, a.ph., hypertrophy and hyperplasia of thyroidal epithelia; follicular cell tumors; b.w. + food intake F05 1984 52 dog 3 15 liver hepatitis-like lesions, weight F05 1985 108 mouse 0.75 9.3 prostate, adrenal, weights; GGT, BUN kidney F05 1985 116 rat 3.9 7.7 liver, blood weight; leucocyt. F06 1982 52 dog 5 20 testes atrophy of semineferous tubules LDH F06 1983 104 rat 5 50 blood, heart LDH, eosinoph.; weight F07 1992 4 rat 50 150 forestomach, blood hyperkeratosis and proliferation of endothelium; leucocytes, prot. F07 1992 4 dog 4 24 ALAT, globul. album. F07 1992 13 rat 7 35 thyroid, gastrointestine TG, T4, hyperkeratosis of oesophagus, Ca2+, body w. F07 1992 13 dog 15 120 liver, kidney, blood, eye, skin ALAT, GLDH, a.ph., 0-demeth. PNOD, P450, liver weight, portal inflammat. ph and urinary vol, excret. of protein platel.+neutroph., alopecia, dermatitis, cataract, degenerat. of lens F07 1992 13 mouse 70 210 gastrointestine hyperkerat. of mucosa food int. crouching posture F07 1992 52 dog 15 75 skin, liver dermatitsis, bilateral cataracts, alopecia; ALAT, GLDH F07 1993 53 rat 5 5.5 body weight F08 1976 4 rat 7.9 23.7 thyroid hyperplasia; body w. + food F08 1976 4 mouse 100 333 liver weight; body w. F08 1978 4 dog < 3.3 3.3 water consumpt. appl., application design, with asterisks () application via capsule or stomach intubation,
F08 1991 52 dog 2.6 32.5 blood anemia, reticulocytosis; b.w. F08 1979 94 mouse 15 45 body w. + food intake F08 1981 119 rat 3.1 12.4 muscle skeletar muscular atrophy F09 1969 13 rat 15 37 kidney, prostate urinary incontinence; enlargement and edema of prostate F09 1969 13 dog 50 100 body weight F09 1976 80 mouse 75 no effect F09 1972 104 dog 30 60 body weight F09 1974 104 rat 15 37 kidney urinary incontinence F10 1978 4 rat < 10 10 blood, liver T.G., glucose, prot., Hb; rel. weight F10 1978 4 dog 5 10 ALAT, a.ph.; body w. F10 1979 13 rat 0.38 0.76 liver, ChE weight plasma-che F10 1979 13 dog 5 10 ALAT, a.ph. F10 1990 52 dog 3.2 12.8 a.ph., ALAT F10 1982 104 rat 0.3 1.5 ChE, liver brain-che; liver w.; b.w. F10 1982 104 mouse 3 15 ChE RBC-ChE F11 1989 13 rat 105 420 body weight gain F11 1990 13 mouse 225 932 liver centrilob. enlargement F11 1991 13 dog 35 61 liver, kidney, blood rel. liver rel. kidney w.; albumin protein, MCV, platelets F11 1990 52 dog 17 87 liver weight F11 1989 91 mouse 355 3000 liver granulomatous inflamm. in liver weight; body weight F11 1989 104 rat 20 99 body weight + food intake F12 1975 13 rat 20 80 liver weight, prot.,album., Ca2+ K+ F12 1982 13 dog 10 40 a.ph. body w. gain + food F13 1985 13 mouse 3.4 18.3 liver, adrenal hypertrophy, weight; adrenal w.; globulins album./glob. F13 1986 13 rat 0.3 1.5 liver AST, a.ph. body w.+ food int. F13 1986 13 dog 0.7 3.5 liver, kidney AST, a.ph.; urine vol. + ph gravity, IgG, body w. + food F13 1985 80 mouse 3.5 14 liver, skin mortality; hyperplasia, adenoma + carcinoma, weight; acanthosis, hyperkeratosis b.w. F13 1985 104 rat 0.3 1.2 pituitary, liver mortality; pituitary adenoma; bile duct prolif.+ portal sclerosis F13 1986 104 dog 0.6 no effect F14 1975 13 rat 7 10 liver pnod, weight F14 1975 13 dog 20 no effect F14 1975 13 mouse 36 62 liver, blood weight bilirubin F14 1985 52 dog 1.25 12.5 blood activated partial thromblast.time F14 1978 104 rat 0.5 1.0 glucose F14 1978 104 mouse 17 60 body weight F15 1988 13 rat 2.5 25 blood, gastrointestine (forestomach), kidney anemia; ulceration, mucosal hyperplasia, inflammat., erosion BUN bilirub., album.; body w.+food F15 1989 13 dog 1.25 2.3 blood anemia, prot., album., body w. F15 1991 52 dog 0.84 2.5 liver, weight; cholest., protein F15 1992 97 mouse 2.25 22.5 eye, urinary bladder retinal atrophy; protein-like bodies in urinary bladder; b.w. + food F15 1991 104 rat 1.5 7.5 blood, lpancreas, kidney anemia; hematopoiesis in liver; acinar atrophy in pancreas, steatosis/fatty infiltration of pancreas; kidney w.; b.w. F16 1981 52 mouse 43 430 lung weight, protein F16 1983 52 dog 2.7 27 liver, thyroid cyt.p-450, liver + thyroid w. food intake appl., application design, with asterisks () application via capsule or stomach intubation, 2
F16 1981 104 rat 1.8 18 a.ph. F17 1970 13 rat 0.8 1 ChE RBC + plasma-che, ALAT F17 1973 13 dog 0.3 0.6 ChE RBC + plasma-che F17 1979 89 mouse 0.67 3.3 ChE RBC + plasma-che F17 1973/81 52 dog 0.4 1.0 ChE, kidney RBC + plasma-che, spec. gravity F17 1982 104 rat 0.1 1.0 ChE, kidney RBC + plasma-che, LDH, gravity F18 1979 13 dog < 50 50 gastrointestine infiltration with round cells, emesis, diarrhoea F18 1981 13 rat < 25 25 gastrointestine, skin lesions, hyperkerat. of tail skin body weight gain + food intake F18 1983 78 dog 10 40 emesis F18 1984 104 mouse 37.5 187.5 liver weight F18 1984 104 rat 100 no effect F19 1989 4 rat 26 85 liver GGT in liver + blood, weight F19 1990 4 dog < 16 16 liver, adrenal rel.liver + adrenal w. F19 1991 13 mouse 2 5 cholest., TG F19 1991 13 rat 8 21 liver GGT, cholest., hypertrophy, weight, fat deposition F19 1990 13 dog 2 7 kidney hypertrophy of prox. tubular cells F19 1992 52 dog 1.1 1.6 blood anemia, platelets F19 1992 78 mouse 0.9 35.8 liver hypertrophy, weight F19 1991 104 rat 2 8 blood platelets F20 1973 13 dog 20 60 a.ph. adrenal swelling and discolorat. of glandul. F20 1978 13 4 rat 15 (7.5) 50 (25) F20 1984 52 dog 25 150 liver, blood, bladder, adrenal F20 1993 (< 1992) F20 1992/92 (< 1992) 99 mouse 23 (180) 104 rat 7.5 (50) cells and fat droplets; body w. swollen livers,hepatic cord atrophy macrophages; a.ph., anemia; small granulomata in mucosa of urinary bladder; adrenal w. 115 liver, testes, hypertrophy; vacuolat. + hypertrophy gastrointestine of testicular interst. cells; hyperkeratosis of non-gland. 12.4 liver, testes,blood weight; interstitial testicul. cell hyperplasia, spermatozoa in epididymides; hemosiderin in spleen; vacuol. in adrenals F21 1966 13 rat 25 75 body weight gain F21 1968 13 dog 3.8 11.25 liver a.ph., AST; weight 3 F22 1994 13 rat 40 159 liver weight F22 1994 13 dog 159 814 gastrointestine vomiting, diarrhoea, body w. F22 1994 13 mouse 326 1326 liver weight F22 1994 52 dog 142 738 blood platelets body w. + food F22 1994 78 mouse 60 304 body w. + food intake F22 1994 104 rat 10 36 GGT ALAT body w. F23 1986 13 dog 11 33 CNS, thymus prostate a.ph., tremor, thymus + prostate weight F23 1987 13 rat 10 50 liver, heart, blood liver + heart w., anemia F23 1988 52 mouse 100 1000 liver, weight; a.ph., ALAT F23 1990 52 dog 14.7 58.8 liver, prostate a.ph.; liver weight, lipidosis; prostate weight F23 1991 102 rat 10 38 food intake F24 1974/93 13 rat 20 22 eye statiations of the lens (1993) (13) (15) (22) F24 1975 13 dog 12 40 blood thromocytes, Jolly bodies appl., application design, with asterisks () application via capsule or stomach intubation,
F24 1990 13 mouse 20 200 liver, testes, adrenal liver weight; focal hyperplasia in Leydig cells; lipogenic pigments in adrenal gland; TG, cholest., album. F24 1987 (1982) 52 (26) dog 2.5 (7) 5 adrenal, testes, prostate, blood hemosiderin; adrenal + testes w. prostate atrophy F24 1994 104 rat < 2.3 (28) 2.3 liver, adrenal, prostate, ovary, eye foci; lipidosis of adrenal cortex; interstit. fibrosis of prostate; lipidosis of ovarial interstit. cells; lenticular degeneration F25 1986 52 dog 10 50 liver, bile duct proliferat.; ALAT, a.ph gastrointestine salivation,vomiting, diarrhoea body w. F25 1987 80 mouse 9 36 liver, heart, testes weights F25 1988 104 rat 15 45 liver, thyroid hypertrophy, weight; follicular neoplasia; body w. F26 1983 13 rat 0.1 1.25 blood, liver, spleen, kidney RBC, reticul. liver, spleen + kidney w. F26 1985 13 dog 0.25 0.75 blood, gall bladder erythropoiesis in spleen,hematopoi. in bone marrow, hemosid. in Kupffer cells;thickening of mucosa F26 1988 52 dog 0.25 1.25 blood RBC, Heinz bodies; hemosiderosis in cortical renal tubules; erythropoiesis in bone marrow F26 1988 87 mouse 0.3 1.5 spleen, kidney weight; creatinine; b.w. F26 1988 104 rat 0.05 0.25 kidney, blood hemosiderosis in spleen, spleen + kidney w.; Heinz bodies,bilirub. F27 1977 13 dog 15 60 liver pnod, cyt.p450, cholest. body weight + food F27 1986 13 rat 8 40 liver enlargement, weight F27 1982 104 rat 7 28 liver, kidney AST, ALAT, GLDH, BUN, creatinine F27 1982 104 mouse 30 120 body weight F27 1984 104 dog 15 (> 2.5) 60 liver pnod; a.ph. F28 1974 13 rat 5 25 ALAT F28 1993 13 dog 3 5 blood, kidney RBC-parameters, ketonuria F28 1993 13 mouse 8.25 82.5 liver rel.weight, body weight 4 F29 1979 13 rat 5 10 liver AST, a.ph.; body w. F29 1979 13 dog 1 5 skin, thymus, prostate ALAT, a.ph.; inflamm. and conjunctivities prost. and thym.w. F29 1983/83 104 dog 1 1.6 adrenal ALAT, a.ph.; adrenal effects F29 1981 104 rat 5 25 body weight F29 1981 104 mouse 14.3 71 liver eosinophil. foci, weight body w. F30 1983 4 rat 30 90 kidney vacuolar swelling of tubular epithelial cells F30 1989 4 dog 32 65 cholest. F30 1991 52 dog 5 15.5 blood MCV; body weight F30 1991/69 104 rat 0.9 5 thyroid weight (1969) (< 5) (5) F30 1982 104 mouse 8 400 liver hypertrophy F31 1984/85 78 rat 5 15 liver, kidney weights; body w. F31 1977 78 mouse 40 no effect F31 1989/75 104 dog 2.5 5 liver ground glass of cytoplasm; b.w. F32 1977 13 dog 2 7.5 blood anemia, iron; bilirubin F32 1988 13 rat 4 20 kidney granular pigments in renal cortex appl., application design, with asterisks () application via capsule or stomach intubation,
F33 1986 13 rat 78.2 235 liver, testes,kidney cholest.,hypertrophy liver + testes w., urobilinogen body w F33 1986 13 dog 100 300 liver a.ph., weight, albumin, emesis body weight gain F33 1989 52 dog 50 250 liver, blood weight, brown pigment; a.ph. anemia; body w. + food F33 1989 106 rat 50 250 liver, thyroid weight, cholest.; thyroid neoplasia; acanthosis, b.w. F34 1989 13 dog 2.3 25 liver, blood cholest., ALAT, a.ph., weight; leucocyt., neutroph., platelets F34 1990 13 rat 10 50 liver, blood fatty vacuol., a.ph., weight Hb, body weight gain F34 1991 52 dog 2.5 25 kidney, adrenal, liver, blood cytoplasm. pigments in cortical tubul. epithel.; cortical fatty vacuol. in adrenals; liver w. a.ph., globuline, Hb, album. F34 1991 78 mouse 15 75 body w. + food intake F34 1992 104 rat 1 7.5 liver periacinar fatty vacuol. F35 1967 13 dog < 6.1 6.1 thyroid protein-bound iodine F35 1983 13 rat 1.5 3 kidney weight,glomerulonephr. ALAT F35 1970/66 104 dog 3 37.5 liver, kidney, bile duct prolif., pigmentation, gastrointestine pericholangitis, portal fibrosis; glomerulcytosis, degenerative changein epithel. cells of prox. tubulus; chronic gastritis F35 1987 104 mouse 1.6 4.5 forestomach squamous hyperplasia/hyperkerat. F35 1989 104 rat 1.8 3.8 stomach, fore-stomach, kidney, adrenal squamous hyperplasia, hyperkeratosis, erosion, ulcer; papilloma in forestomach; nephrosis, renal epithelial hyperplasia in prox. tubules kidney + adrenal w. F36 1971/71 (1972) 13 (26) rat 24 (6) 120 (30) blood anemia; hemosiderin deposition in liver, spleen, lung, kidney, heart F36 1971 13 dog 2.5 15 blood hemosiderin deposition in liver, spleen and bone marrow F36 1972 104 dog 2.5 25 blood hemosiderin in Kupffer cells and in bone marrow F36 1992 (1972) 104 (26) rat 9.6 (6) 96 (30) blood hemosiderin in spleen and Kupffer cells, Hb; body w. F36 1992 105 mouse 10 100 mortality; body w. F37 1990 13 rat 8.8 97 blood, liver, kidney thyroid anemia; hepatocell. lipofuscin chol., album., weight; glomerulonephritis, weight; follicular thyroid hyperplasia, weight F37 1991 (1991) 13 (13) dog < 50 (< 1.25) 50 (1.25) liver, thyroid ALAT, vacuolat. of cytoplasm; follic. cell hypertrophy in thyroid F37 1992 52 dog 8 40 liver, thyroid weight; hyperplasia of follicul. epithelium, weight; cholest., T4, BUN F37 1992 78 mouse 21.4 95 liver hypertrophy, adenomas F37 1992 104 rat 8.8 53 liver, thyroid, kidney, adrenal mortality; hypertrophy + lipofuscin; thyorid follicular cell hyperplasia, weight; nephro-pathy, weight, urinary protein; lipidosis of adrenal cortex; cholest., BUN, creatinine, TSH, T3, T4 F38 1977 13 dog 7.5 24 liver ALAT, a.ph., bile duct proliferat. F38 1980 13 mouse 22 77 liver hypertrophy, weight F39 1974 13 dog 620 no effect appl., application design, with asterisks () application via capsule or stomach intubation, 5
F39 1975 13 rat 25 50 liver,kidney weight; creatinine F40 1966 13 rat 0.5 1.25 thyroid, uterus thyroid + uterus w., leukopenia body weight gain + food intake F40 1967 17 dog 0.27 1.08 body weight + food intake F41 1989 13 rat 2.5 15 thyroid, kidney T3, kidney w. F41 1989 13 dog 3 15 kidney, thymus weight; a.ph.; thymus w. F41 1991 52 dog 1 5 kidney, liver blood urine, pigments, kidney + liver w., hepatocell. hypertrophy F41 1990 80 mouse 3 15 kidney chronic nephrosis of cortical tubules, weight F41 1991 104 rat 1 6 kidney neoplasia, proteinuria, urinary blood; GGT F42 1964 17 dog 11.3 34 liver ALAT, AST; bad condition (1.25) F42 1966 17 rat 50 150 liver, heart liver and heart weight F42 1968 104 rat 68 200 liver, kidney liver + kidney w.; body w. F42 1969 104 dog 22.6 68 adrenal, testes vacuol. + degenerative changes in cells of zona fascicul.; failure in spermatogenesis, Œweight Œbody w. + food intake F43 1971 4 dog < 20 20 liver weight F43 1972 4 rat 100 500 testes spermatogenesis F43 1985/78 13 rat 34 106 liver hepatomegaly F43 1973 13 dog 12.5 37 liver weight F43 1986 52 dog 6.4 16 cholest. F43 1976 80 mouse 34 550 liver foci, neoplastic nodules, hepatoblastoma, weight F43 1976 104 rat 15 480 blood Hb, HT; body w. F44 1993 52 dog 0.6 1.8 body weight F44 1994 104 rat 2.5 7.5 liver ALAT, AST F44 1995 104 mouse 5 12 liver weight; body w. F45 1982 13 dog 1 50 liver APND, weight F45 1986 13 rat 1 10 liver APND, fatty changes, prolif. of SER, weight F45 1986 52 dog 1 5 adrenal cortical vacuolation of zona fasciculata; a.ph. F45 1992 102 rat 1 10 liver, kidney fatty changes, clear cell foci, weight; urine ph F45 1985 104 mouse 1 5 liver, blood fatty changes; WBC F46 1988 52 dog 3.4 16 a.ph.; body weight F46 1989 78 mouse 4.7 46 liver hypertrophy, fatty changes, necrosis + bile stasis; ALAT, SDH; body w. F46 1989 104 rat 1 24 liver, blood hypertrophy; platelets, leucocyt body w. + food F47 1968 13 rat 2.5 5 body weight F47 1968 13 dog 26 no effect F47 1990 52 dog 1.6 4.7 liver, kidney hypertrophy; a.ph., ALAT, TG BUN F47 1991 78 mouse 5 20 body weight F47 1991 104 rat 1.5 3.8 a.ph. F48 1990/83 13 rat 3 6 liver, blood, weight, bilirubin, Hb gastrointestine leuco salivation, diarrhoea F48 1989 13 dog 2.5 7 liver, blood, prostate ALAT, a.ph., weight; RBC,Hb prostate weight F48 1994 13 mouse 6 25 liver weight F48 78 mouse 4.7 26 liver adenomas, fatty vacuol., weight F48 1993/83 104 rat 1.8 6.1 liver swollen livers; food intake F48 1983 104 dog 0.92 4.0 liver swollen livers, hypertrophy, a.ph appl., application design, with asterisks () application via capsule or stomach intubation, 6
F49 1974 13 dog 3.75 15 liver pnod F49 1976 13 rat 100 no effect (4) (3) (10) F49 1988 91 mouse < 7.5 7.5 liver hypertrophy F49 1991/76 (1976) 104 rat 15 (2.5) 25 (25) blood RBC, Hb; body w. F49 1978 104 dog 8.25 25 liver aminopyrine-n-dem., cyt.p-450 weight; a.ph. F50 1986 13 rat 10.8 43.2 adrenal, liver vacuolated adrenal cells in zona fascicul.; cyt. P450; body w. F50 1987 13 dog 8.3 41.5 liver pnod, a.ph.; body w. F50 1989 52 dog 2.95 4.4 adrenal hypertrophy of zona fascicul. cells F50 1988 91 mouse 3.0 9.0 liver periportal vacuolation F50 1988 104 rat 15 50 liver, blood pnod, pigments in Kupffer cells; hemosiderin in spleen; body w., food intake F51 1988 13 rat 1.3 5.2 liver hypertrophy, vacuolation F51 1988 13 dog 3.3 14 liver a.ph., weight, hypertrophy F51 1988 13 mouse 11.1 34 liver cell necrosis, hypertrophy AST F51 1990 52 dog 0.62 6.2 body weight F51 1991 78 mouse 1.3 26 liver hypertrophy + vacuol., weight F51 1990 105 rat 3 30 liver, thyroid hypertrophy and vacuolation, weight; cholest.; focal cystic hyperplasia in thyroid + follicular cell neoplasia, adenoma + carcinoma, weight; body w. F52 1983 52 dog 0.6 1.8 liver, blood karyomegaly, pigmentation, hematopoietic nodules F52 1993 (1971) 104 rat 2 (0.6) 7.5 adrenal, kidney weight; renal tubular cell hyperplasia; BUN, glucose cholest., TG; body w. F53 1967 13 rat 46 230 liver weight (230) F53 1968 13 dog 19 95 ALAT, a.ph.; album./glob. F53 1970 104 dog 13 65 liver, testes cirrhosis; cholest., a.ph., ALAT testicul. degeneration; anorexia body w. +food intake F53 1981 104 mouse < 64 64 liver, thymus, brain carcinoma + adenoma, weight thymus + brain w. F53 1969 104 rat 125 no effect F54 1984 13 rat 0.5 2.5 liver weight, food intake F54 1984 13 dog 10 100 liver, eye bile duct hyperplasia, weight; retinal changes F54 1985 52 rat 0.5 5 liver, pancreas altered hepatocytes, weight; exocrine degranulat; cholest. F54 1985 52 dog 1 10 nose, bone marrow, liver, blood nasal dryness; myeloid/erythroid ratio in bone marrow; liver w. cholest., leucocyt. F54 1985 104 mouse 1 10 liver granulomatous hepatitis, weight F55 1985 13 rat 5 150 liver, kidney, cholest., hypertrophy, weight BUN, colored urine, regenerative tubular epithel. and granular casts F55 1987 13 dog 100 1000 gastrointestine dark and soft stool F55 1987 52 dog 100 1000 gastrointestine dark and soft stool F55 1989 104 rat 1.25 25 kidney, liver blue urine; liver weight F55 1989 105 mouse 20.4 214 kidney, liver, urinary bladder blue urine; centrilob. hypertrophy; epithelial hyperplasia F56 1992/1983 13 rat 20.4 211 liver, adrenal, blood weight; fatty degeneration of zona fasc. leucocyt.,. body weight gain appl., application design, with asterisks () application via capsule or stomach intubation, 7
F56 1993 13 dog 10 50 liver, gastrointestine weight; salivat., vomiting, fluid feces, body w. F56 1994/84 52 dog 3 15 liver weight, cholest. + triglyc. F56 1984 104 mouse 6.7 42 adrenal, liver adrenal +liver w., degenerat. and hypertrophy of hepatocytes F56 1995 104 rat 3.6 18.2 a.ph., ALAT F57 1991 13 rat < 3.2 3.2 thyroi cholest., phospholip.; hypertr. of thyroid follicle epithelia F57 1991 13 dog 45 210 body weight + food intake F57 1991 13 mouse 73 257 liver cell necrosis, depletion of glycogen F58 1985 13 mouse 18 167 liver, thyroid MFO; follicul. cell hyperplasia F58 1988 13 rat 7.4 15 thyroid T4, TSH F58 1988 13 dog 3 26 thyroid,blood, enlarged/dark thyroids; anemia; thymus cholest.,bilirub.; lymphoid deplet hematopoiesis in bone marrow F58 1988 52 dog 5 20 blood, testes, liver Hb, RBC, PCV, testes w. liver w. body w. + food F58 1992 78 mouse 14 144 body w. F58 1990/92 104 rat 4.8 16.8 thyroid increased height of follic. epithel. T4; body w. F59 1977 13 rat 365 1922 blood, kidney anemia; weight; hematopoiesis F59 1977 13 dog 270 1309 K+ in serum F59 1981 104 rat 400 1400 urinary bladder, urinary tract F59 1981 104 dog 250 750 testes degeneration calculi and mineralisation, epithelial hyperplasia and neo-plasia; hyperplasia and inflammat. in urinary tract F60 1976 13 rat 17 50 liver rel. liver w. body w. F60 1977 13 dog 2.5 10 blood Hb, PCV, WBC F60 1976 104 dog 10 58 blood RBC, PCV F60 1980 104 rat 10 30 blood, kidney anemia, BUN F61 1990 13 rat 0.8 8 liver hypertrophy F61 1990 13 dog 5 50 gastrointestine diarrhoea F61 1990 13 mouse 144 420 liver rel. weight, blue stain of pelvis 8 F61 1992 52 dog 3.3 33 Œbody w. F61 1993 78 mouse 112 360 liver, thymus, spleen, lymph node weight; enlarged thymus, spleen + lymph nodes; food + water int. F61 1993 104 rat 37 113 liver, kidney, blood gastrointestine hepatocell. tumors, necrosis, atrophy, degeneration; nephro-pathy, cysts, urobilinogen; anemia; diarrhoea, body w. F62 13 rat 25 40 liver, thyroid hypertrophy; thyroid follicular cell (10) (40) hypertrophy; body weight + food F62 13 dog 35 75 gastrointestine emesis, saliv.; body w. + food F62 104 rat 10 40 blood, thyroid Hb, HT; thyroid w.; b.w. F62 104 dog 20 100 liver, kidney, adrenal liver, kidney, adrenal w. F62 104 mouse 10 110 heart, liver, kidney mortality; atrial thrombosis of myocard; liver + kidney w. body w. + food intake F63 1982 13 rat 10 50 body weight + food intake F63 1990 13 dog 80 no effect observed F64 1995/76 (1976) 13 (13) rat 20 (7.5) 25 (25) thymus, adrenal thymus w. adrenal w. F64 1974 (1986) 13 (52) dog 25 (12.5) 75 (62.5) appl., application design, with asterisks () application via capsule or stomach intubation, liver a.ph., PAS-react.; apathy, b.w. F64 1986 52 dog 12.5 62.5 kidney, liver alterations of cortical tubuli; a.ph., ALAT, GLDH, BUN, creatinine, glucose in urine; b.w.
F64 1982 104 rat 15 75 bone alterations F65 1979 13 rat 16.4 80 body weight gain F65 1979 13 dog 6.25 36 food intake F65 1991 13 mouse 2 50 liver hypertrophy, weight, cholest. 2 < 20 20 F65 1985 53 dog 6.25 no effect F65 1991 103 mouse 10 49 liver hypertrophy, weight F65 1982 109 rat 3.6 18 adrenal weight; glucose; body w. F66 1985 13 rat 1 4 piloerection body weight gain F66 1986 13 dog 0.7 3.5 liver, kidney a.ph., GGT, TG, album., hepatomegaly, weight; creatin. F66 1987 13 mouse 2.2 44 liver cell necrosis, eosinophilia, vacuol. F66 1988 52 dog 1 3.2 liver a.ph., cholest., bilirubin, albumin; hepatocytic pigment, intrahepatocytic bodies F66 1989 88 mouse 1.8 13.2 liver nodules + tumors, inflammation, single cell necrosis, hypertrophy body weight F66 1988 121 rat 1 2.2 liver GGT, cholest., protein, globul. TG; liver w. F67 1987 13 rat 5.22 19.7 liver hepatic MFO F67 1987 13 dog 0.34 7.88 liver hypertrophy F67 1987 52 dog 3.09 14.3 liver hypertrophy, weight; a.ph. F67 1987 104 rat 2.49 9.84 testes atrophy, weight F67 1987 104 mouse 2.7 13.5 liver MFO-activity F68 1984 13 rat 0.71 7.1 blood anemia, Na+, Cl- F68 1986 13 dog 200 1000 blood, liver, anemia, emesis, diarrhoea gastrointestinal a.ph., TG, weight F68 1988 52 dog 10 100 a.ph. F68 1988 104 rat 0.8 8 liver hepatocell. hypertrophy F69 1980/79 52 rat 2.1 2.5 liver, kidney vacuolation, weight, nitrosoanisole metabolism; creatinine F69 1980 52 dog < 10 10 liver, gastrointestine cholestasis; diarrhoea F69 1982 104 mouse 5.1 17 liver, blood hyperplasia,vacuol. ALAT,BUN 9 F70 1967 13 dog 2.5 10 spleen weight F70 1969 13 rat 1.25 2.5 sorbitol-dh (1980) 9 (0.75) (3) F70 1973 104 dog 25 75 liver a.ph., cholest., ALAT, GLDH, SDH; food intake F70 1974 104 rat 1.25 2.5 liver ALAT, AST F70 1980 104 mouse 120 appl., application design, with asterisks () application via capsule or stomach intubation,