SYLLABUS ON HEMATOLOGY FOR THE 4-YEAR STUDENTS, MEDICINE- Total hours number 70 hours, including course 0 hours, seminars 0 hours. Aim of the subject of Hematology: The study of etiology, pathogenesis, clinical manifestations, laboratory and instrumental options of patient examination axed on diagnosis of the diseases of hematopoietic system, to get hold of general principles of treatment and prophylaxis of this pathology. Basic content of the course: A. Lectures: No Topic Hours 1. Anemias. Definition. Classification of anemias. Iron deficiency anemia.. Megaloblastic anemias. Vitamin B1 deficiency anemia. Folate deficiency anemia. 3. Aplastic anemias. Metaplastic anemias. Renal anemias. Anemias of chronic disorders. 4. Hereditary and acquired hemolytic anemias.. Neoplastic disorders of hematopoietic system. Etiology. Pathogenesis. Acute leukemias. 6. Chronic myeloid leukemia. Idiopathic myelofibrosis. Polycythemia vera. 7. Plasma cell dyscrasias. Multiple myeloma. Chronic lymphocytic leukemia. 8. Malignant lymphomas. Classification. Pathogenesis. Hodgkin s lymphoma. Non-Hodgkin s lymphomas. 9. Disorders of primary hemostasis. Immune thrombocytopenias. Hereditary hemorrhagic teleangiectasia 10. Disorders of secondary hemostasis (coagulation). Hemophilia. Von Willebrand s disease. B. Seminars: Nr. Topic Hours 1. Anemias. Definition. Classification of anemias. Iron Deficiency Anemia. Definition. Incidence. Prevalence. Etiology. Pathogenesis. Definitions of iron deficiency states. Clinical manifestations, general symptoms. Fatigue and incidence of epithelial lesions in iron deficiency. Evolution and diagnosis. Laboratory findings. Plan of investigations in patients
with iron deficiency anemia. Differential diagnosis. Treatment. Prevention of relapse of iron deficiency anemia. Dispensary system.. Megaloblastic Anemias. Vitamin B1 Deficiency Anemia (Addison-Biermer Disease). Definition. Incidence. Etiology. Pathogenesis. Clinical manifestations. Evolution and diagnosis. Laboratory findings. Plan of investigations in patients with pernicious anemia. Diagnosis and differential diagnosis. Treatment. Reticulocyte response to treatment with vitamin B 1. Prognosis. Dispensary system. Folate Deficiency Anemia. Definition. Incidence. Etiology. Pathogenesis. Clinical manifestations, general symptoms. Laboratory findings. Diagnosis and differential diagnosis. Treatment of folate deficiency anemia. Prevention of relapse of anemia. Prognosis. Dispensary system. 3. Aplastic Anemia. Definition. Incidence. Etiology. Pathogenesis. Clinical manifestations, general symptoms. Laboratory findings. Diagnosis and differential diagnosis. Treatment. Prognosis. Dispensary system. Metaplastic Anemia. Definition. Etiology. Pathogenesis. Diseases associated with metaplastic anemia. Renal Anemia. Definition. Etiology. Pathogenesis. Anemias of Chronic Disorders. Etiology. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnosis. Treatment. 4. Hemolytic Anemias: General considerations. Definition. Pathogenesis and classifications. Clinical and laboratory manifestations. Diagnostic approach to the patient. Diagnosis and differential diagnosis with bilirubinopathies (Gilbert s syndrome), biliary mecanical disease, biliary parenchima disease. Hereditary Hemolytic Disordes Affecting the Red Cell Membrane (Hereditary Spherocytosis, Hereditary Elliptocytosis, Hereditary Stomatocytosis, Hereditary Acanthocytosis). Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Treatment. Prevention of relapse of anemia. Prognosis. Dispensary system. Hereditary Hemolytic Disordes Affecting the Red Cell Enzymes. Glucose- 6-Phosphate Dehydrogenase deficiency and related deficiencies involving the Pentose Phosphate Pathway and Glutathione Metabolism, other enzyme deficiencies. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnostic approach. Differential diagnosis. Treatment. Prognosis. Dispensary system. Hereditary Hemolytic Disorders Affecting Hemoglobin Structure and Synthesis (Hemoglobinopathies). The Thalassemias and Related Disorders - quantitative disorders of hemoglobin synthesis. Hemoglobinopathies S and the sickling syndromes (qualitative disorders). Prevalence and geographic distribution. Genetic mechanisms and molecular pathology. Clinical and laboratory features. Diagnosis and differential diagnosis. Treatment. Prognosis. Dispensary system. Acquired Hemolytic Anemias. Classification. Autoimmune hemolytic anemias. Etiology. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Complications. Treatment. Prognosis. Dispensary system. Pure Red Cell Aplasia. Definition. Etiology. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Treatment. Prognosis. Dispensary system. Paroxysmal Nocturnal Hemoglobinuria (Marchiafava-Micheli anemia).
Etiology and pathogenesis. Specific features of hemolytic syndrome. Clinical Treatment. Course and Prognosis. Dispensary system.. Neoplastic Disorders of the Hematopoietic System. Definition. Classification. Site of Origin in the Stem Cell Hierarchy. Etiology. Pathogenesis. Epidemiology. Incidence. Acute Leukemias. Definition. Morbidity. Pathogenesis. Classification. Clinical manifestations. Course, complications and causes of death; survival. Clinical difference between morphocytochemical variants. Diagnosis and differential diagnosis. Treatment. Prognosis. Dispensary system. 6. Chronic Leukemias. Definition. Classification. Chronic Myeloid Leukemia. Definition. Morbidity. Pathogenesis. Classification of chronic myeloid leukemia. Presenting features. Laboratory studies. Diagnosis and differential diagnosis. Course, complications and causes of death. Treatment. Prognosis. Dispensary system. Idiopathic Myelofibrosis. Definition. Morbidity. Pathogenesis. Clinical manifestations. Classification. Laboratory findings. Diagnosis and differential diagnosis. Complications and causes of death. Treatment. Prognosis. Dispensary system. Polycythemia Vera. Definition. Morbidity. Pathogenesis. Clinical manifestations. Blood and laboratory findings. Diagnosis and differential diagnosis. Complications. Treatment. Prognosis. Dispensary system. 7. Chronic Lymphocytic Leukemia. Definition. Morbidity. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Complications and causes of death. Variants of chronic lymphocytic leukemia.treatment. Prognosis. Dispensary system. Plasma Cell Dyscrasias. General Considerations. Multiple Myeloma. Definition. Morbidity. Pathogenesis. Clinical Staging and prognosis. Treatment. Dispensary system. Waldenstrom Disease. Definition. Morbidity. Pathogenesis. Clinical Staging and prognosis. Treatment. Dispensary system. 8. Malignant Lymphomas. Definition. Classification. Hodgkin s Lymphoma. Morbidity. Etiology. Pathogenesis. Presenting features. Staging procedures. Diagnosis and differential diagnosis. Prognostic variability. Course of disease. Histological classification of Hodgkin s disiase. Clinical Staging for Hodgkin s disease (Ann Arbor Classification). Plan of investigations in patients with Hodgkin s Disease. Treatment. Prognosis. Dispensary system. Non-Hodgkin s Lymphomas. Morbidity. Etiology. Pathogenesis. Clinical manifestations Clinical staging. Diagnosis and differential diagnosis. Plan of investigations in patients with non-hodgkin s lymphomas. Histological classification. Treatment. Prognosis. Dispensary system. 9. Disorders of Hemostasis and Coagulation. Definition. Classification. Clinical manifestations. Diagnostic approach to the bleeding disorders. Clinical evaluation of the bleeding patients. Laboratory methods for the study of hemostasis and blood coagulation. Thrombocytopenic Purpura. Defin0ition. Morbidity. Etiology. Pathogenesis. Classification. Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Complications. Treatment. Prognosis. Hereditary Hemorrhagic Teleangiectasia (Rendu-Osler Disease).
Definition. Morbidity. Etiology. Pathogenesis. Clinical manifestations. Laboratory findings. Diagnosis and differential diagnosis. Treatment. Prognosis. 10. Hemophilia. Morbidity. Etiology. Principles of pathophysiology. Genetics. Incidence. Clinical manifestations. Course and prognosis. Laboratory diagnosis. Differential diagnosis. Treatment. Dental and surgery care. Prevention. Von Willebrand s Disease. Morbidity. Etiology. Pathogenesis. Clinical manifestations. Laboratory diagnosis. Differential diagnosis. Treatment. Prognosis. SUBJECT PLAN FOR THE STUDY ON HEMATOLOGY FOR THE 4-YEAR STUDENTS, MEDICINE- No. 1. Topic Anemias. Definition. Classification of anemias. Iron deficiency anemia. Number of hours lectures seminars. Vitamin B1 deficiency anemia. Folate deficiency anemia. 3. Aplastic anemias. Metaplastic anemias. Anemias of chronic disorders. Renal anemias. 4. Hereditary and acquired hemolytic anemias.. 6. 7. 8. Neoplastic disorders of hematopoietic system: classifications, etiology, epidemiology, pathogenesis. Acute leukemias. Chronic myeloid leukemia. Idiopathic myelofibrosis. Polycythemia Vera. Chronic lymphocytic leukemia. Multiple myeloma. Waldenstrom Disease. Malignant lymphomas: Hodgkin s Lymphoma, non-hodgkin s Lymphomas. 9. Disorders of primary hemostasis. 10. Disorders of secondary hemostasis (coagulation). Recommended compulsory literature: Summary: 0 0
1. Course of Lectures on Hematology and Military Therapy by Musteata Vasile, Corcimaru Ion. Chisinau 004. 177 p.. American Society of Hematology Self-Assessment Program by Williams M.E., Kahn M.J. Blackwell Publishing: 00. 41 p. 3. The Washington Manual. Hematology and Oncology Subspecialty Consult by Pillot Giancarlo, Chantler Marcia, Magiera Holly et al. Lippincott, Williams & Wilkins: 004. 79 p.