Learning at the Leaning tower

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Learning at the Leaning tower Pisa Colorectal Cancer 2017 director Alfredo Falcone SECTION OF ONCOLOGY With the patronage of RESIDENTIAL COURSE Pisa, 30 th November-1 st december 2017 7,7 CME POINTS

Aims The goal is to provide an adjourn and discuss on the current scientific evidence concerning standard and new therapeutic strategies in colorectal cancer with a special attention to biological knowledge of treatments and translational research. Lectures and presentations of National and International experts will give large prospects in systemic and locoregional approaches of early and advanced phases. Addressed to Physicians specialized in anatomical pathology, gastroenterology, oncology, pharmacology, radiology, radiotherapy and surgeons involved with epidemiological, diagnostic, histopathological, biomolecular and instrumental management and treatment of patients affected by colorectal cancer; biologists. CME Based on Italian regulations, Accademia Nazionale di Medicina (provider n. 31), will assign to the activity CME (31-199254): 7,7 CME points. The credit certification is subject to: professions/specializations should correspond to those which have been accredited for CME; 90% attendance to the meeting; Completion of the meeting evaluation form; Completion of the final questionnarie ( at least 75% of correct answers). We would like to remind that only 1/3 of the CME credits acquired during the years 2017-2019 can come from a sponsorship. It won t be possible give credits to physicians specialized in different fields.

Program THURSDAY, 30 th NOVEMBER 9.00 Participants registration 9.30 Introduction and welcome Alfredo Falcone and Authorities (Paolo Mancarella - University of Pisa, Carlo Tomassini - Azienda Ospedaliero-Universitaria Pisana, Gianni Amunni - Istituto Toscano Tumori) I SESSION From lab to clinic: the daily challenge of translational research in CRC Chairmen: Gabriella Fontanini, Carmine Pinto 10.00 Biomarkers in mcrc today: what s needed? Filippo Pietrantonio 10.15 Biomarkers in mcrc tomorrow: what s on the horizon? Andrea Sartore Bianchi 10.30 Liquid biopsies to optimize the treatment: are we ready? Alberto Bardelli 10.45 Pharmacogenomic hints to prevent toxicity: practical points Romano Danesi, Marzia Del Re 11.00 Discussion 11.30 Coffee break SCIENTIFIC SYMPOSIUM Meet the experts Future is now: translational research in mcrc Chairmen: Stefano Cascinu, Alfredo Falcone 12.00 LECTURE Targeted therapies: what can we expect in the next future? Rodrigo Dienstmann 12.40 Round Table and debate with Italian experts Shooter: Chiara Cremolini Experts: Antonio Avallone, Alberto Bardelli, Filippo De Braud, Francesco Di Costanzo, Salvatore Siena 13.20 Lunch 14.20 LECTURE Immunotherapy: ready for prime time in colorectal cancer? Johanna Bendell 15.00 Round Table and debate with Italian experts Shooter: Filippo Pietrantonio Experts: Giuseppe Aprile, Roberto Labianca, Sara Lonardi, Evaristo Maiello, Giuseppe Tonini 15.40 Coffee break

II SESSION Localized colon and rectal cancer: open questions Chairmen: Luca Morelli, Francesco Di Costanzo 16.15 How to improve the estimation of the risk of relapse? Helps from the lab Francesco Leone 17.00 Practical points for the experts Carlotta Antoniotti 17.30 Discussion 18.00 Adjourn 16.30 When is TME too much? Is there room for conservative approaches in rectal cancer? Matteo Franceschi 16.45 Adjuvant chemo following neoadjuvant chemoradiotherapy: when to go and when not to go? Carlo Aschele

FRIDAY, 1 st DECEMBER III SESSION Systemic treatment of mcrc Chairmen: Giordano D. Beretta, Stefano Cascinu 9.00 The upfront treatment of mcrc: my algorithm Alfredo Falcone 9.15 Primary tumour location: the methodologist s perspective Luca Boni 9.30 Primary tumour location: the oncologist s perspective Mario Scartozzi 9.45 Practical points for the experts Roberto Moretto 10.05 Discussion 10.25 Coffee break 11.00 Treatments after progression: how to choose? Giuseppe Aprile 11.15 The new landscape of later lines: to go or not to go? Sara Lonardi 11.30 Practical points for the experts Emiliano Tamburin 11.50 Discussion 12.10 LECTURE Presenter: Roberto Labianca Adjuvant treatment of colon cancer: past, present and future Julien Taieb 13.00 Lunch IV SESSION The cure as an objective: liver-limited and oligometastatic colorectal cancer Chairmen: Giacomo Allegrini, Gianluca Masi 14.00 Systemic arrows : the oncologist s contribution Lisa Salvatore 14.15 Surgical arrows : old and new surgical options Dario Ribero 14.30 Locoregional arrows : new options from interventional radiology Irene Bargellini 14.45 Locoregional arrows : the radiotherapist s perspective Francesco Pasqualetti 15.00 Practical points for the experts Federica Marmorino 15.30 Discussion 16.00 Adjourn and final questionnaire

director Scientific Secretary Speakers Alfredo Falcone Department of Oncology, Transplants, and New Technologies in Medicine University of Pisa Division of Medical Oncology University Hospital of Pisa (I) Chiara Cremolini Department of Oncology, Transplants and New Technologies in Medicine University of Pisa (I) Gianluca Masi Division of Medical Oncology University Hospital of Pisa (I) Giacomo Allegrini, Pisa (I) Carlotta Antoniotti, Pisa (I) Giuseppe Aprile, Vicenza (I) Carlo Aschele, La Spezia (I) Antonio Avallone, Naples (I) Alberto Bardelli, Candiolo TO (I) Irene Bargellini, Pisa (I) Johanna Bendell, Nashville (USA) Giordano D. Beretta, Bergamo (I) Luca Boni, Firenze Stefano Cascinu, Modena (I) Chiara Cremolini, Pisa (I) Romano Danesi, Pisa (I) Filippo De Braud, Milan (I) Marzia Del Re, Pisa (I) Francesco Di Costanzo, Florence (I) Rodrigo Dienstmann, Barcelona (S) Gabriella Fontanini, Pisa (I) Matteo Franceschi, Paisa- PI (I) Roberto Labianca, Bergamo (I) Francesco Leone, Candiolo TO (I) Sara Lonardi, Padua (I) Evaristo Maiello, Foggia (I) Federica Marmorino, Pisa (I) Gianluca Masi, Pisa (I) Luca Morelli, Pisa (I) Roberto Moretto, Pisa (I) Francesco Pasqualetti, Pisa (I) Filippo Pietrantonio, Milan (I) Carmine Pinto, Reggio Emilia (I) Dario Ribero, Milan (I) Lisa Salvatore, Pisa (I) Andrea Sartore Bianchi, Milan (I) Mario Scartozzi, Cagliari (I) Salvatore Siena, Milan (I) Julien Taieb, Paris (F) Emiliano Tamburini, Rimini (I) Giuseppe Tonini, Rome (I)

Registration FELLOWSHIPS The registration fee is 150,00 for physicians and 50,00 for resident physicians, tax free. Under the article 54 T.U.I.R and within the limits set out therein, the costs of participation in this activity are deductible in determing selfimployment income. To register, please send : Registration form duly filled out (even when sponsored by a pharmaceutical company); Privacy statment and consent to the use of personal data; Payment; For resident physicians, a Certificate of attendance signed by the School Director. To Accademia Nazionale di Medicina, Galleria Ugo Bassi 2, 40121 Bologna (fax + 39 051 0569162, email: info.bologna@accmed.org) within November 20 th 2017. Payment can be done by: nontransferable check addressed to Accademia Nazionale di Medicina, bank transfer addressed to: Accademia Nazionale di Medicina, Banco Popolare - IBAN: IT11M0503401405000000000966 - SWIFT(BIC) CODE: BAPPIT22 (please indicate Registration of Dr. at Course 17_RE_2487) credit card MasterCard, Visa, EuroCard (no AMEX cards). Otherwise it is possible to register online at www.accmed.org, without forgetting to send the wire transfer receipt or the credit card details by fax +39 051 0569162. Requests received without proof of payment and/or incomplete card won t be considered valid. The registration will be confirmed by the Secretariat by mail. CANCELLATION If the participants minimum number is not reached, Accademia Nazionale di Medicina will advise all participants by email and proceed with the total refund of the fee. In order to cancel please give advise with a written communication to Accademia Nazionale di Medicina within 10 days from the beginning. A 70% registration fee will be returned. Any cancellation after that deadline won t be reimbursed. Some fellowships will be awarded which will include registration, 1 night, 1 dinner and travel. Those interested should send the registration form together with a short Cv and a motivation letter within November 1 st. The Organizing Secretariat will confirm you the award of fellowship within November 15 th and it will proceed with the logistics. Official Language The official language of the Meeting is English. No simultaneous translation will be provided.

Meeting Venue Auditorium G. Toniolo Opera della Primaziale Pisana Piazza Arcivescovado, 1 Pisa How to reach the meeting venue: BY CAR: No matter which highway you're on (A1 from Rome, A11 from Florence, A12 from Genova), get off at the Pisa Nord exit then find your way to a parking lot-most of Pisa's historic center is now ZTL ("Zona Traffico Limitato" - only residents with permits are allowed to drive into it). There's a public parking lot just a block up from the western edge of the Campo dei Miracoli on Via Pietrasanta. BY TRAIN: From the train station, you can take one of these buses LAM ROSSA stop at via Cammeo/Piazza Manin N. 4 stop at Piazza Arcivescovado N. 21 night bus stop at Piazza Manin BY PLANE: From the airport, you can take: LAM ROSSA stop at via Cammeo/Piazza Manin N. 21 night bus stop at Piazza Manin Sponsored by ACCADEMIA NAZIONALE DI MEDICINA General Manager: Stefania Ledda Information and registration: www.accmed.org Ph. +39 051 0569163 Fax +39 051 0569162 info.bologna@accmed.org Organizing Partner Forum Service Via Martin Piaggio 17/6 16122 Genova Hotel booking Ph. +39 010 83794244 Fax +39 010 83794261 booking@forumservice.net With the unconditional contribution of GOLD SPONSOR BRONZE SPONSOR