UvA-DARE (Digital Academic Repository) Surgery and medical therapy in Crohn s disease de Groof, E.J. Link to publication Citation for published version (APA): de Groof, E. J. (2017). Surgery and medical therapy in Crohn s disease: Improving treatment strategies General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 02 Jan 2018
Surgery and medical therapy in Crohn s disease improving treatment strategies Joline de Groof
Surgery and medical therapy in Crohn s disease improving treatment strategies Joline de Groof
Surgery and medical therapy in Crohn s disease, improving treatment strategies Thesis, University of Amsterdam, The Netherlands ISBN 978-94-6233-601-8 Cover design: Diving Duck Design Printed by: Gildeprint E.J. de Groof, Amsterdam, The Netherlands 2017 The LIR!C trial & PISA trial were financially supported by: The Netherlands Organization for Health Research and Development, Health Care Efficiency program (ZonMw grant number 170882201 and 837002002, respectively) The copyright of the published and accepted articles has been transferred to the respective publishers. No part of this thesis may be reproduced, stored or transmitted, in any form or by any means, without prior permission of the author. Financial support for the printing of this thesis was kindly provided by: Afdeling Chirurgie, Academisch Medisch Centrum, Afdeling Chirurgie en Wetenschapsfonds Tergooi, Nederlandse Vereniging voor Gastroenterologie, Nederlandse Vereniging voor Endoscopische Chirurgie, ABN AMRO, ChipSoft, Dr Falk Pharma B.V. en Abbvie.
Surgery and medical therapy in Crohn s disease improving treatment strategies ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. Ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit vrijdag op 2 juni 2017, te 9.00 uur door Elisabeth Joline de Groof geboren te Haarlem
PROMOTIECOMMISSIE Promotor Prof. Dr. W.A. Bemelman Prof. Dr. G.R.A.M. D Haens Co-promotores Dr. C.J. Buskens Dr. C.IJ. Ponsioen Overige leden Prof. Dr. G.R. van den Brink Prof. Dr. M.I. van Berge Henegouwen Prof. Dr. J. Stoker Prof. Dr. P. Fockens Prof. Dr. T. Rockall Dr. P.C.F. Stokkers Dr. J. Torkington Royal Surrey County Hospital OLVG West University Hospital of Wales Faculteit der Geneeskunde
TABLE OF CONTENTS General introduction 9 Aim and outline of the thesis 19 PART I Epidemiology 23 Chapter 1 Rising prevalence and burden of disease of inflammatory bowel 25 disease in a population-based cohort in The Netherlands PART II Ileocecal Crohn s disease 45 Chapter 2 Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn s disease: a randomised multicenter trial (LIR!C-trial) 47 Chapter 3 Abdominal abscess in Crohn s disease: multidisciplinary management 65 Chapter 4 The association between intensified medical treatment, time to surgery and ileocolic specimen length in Crohn s disease 79 Chapter 5 Single port laparoscopic ileocecal resection for Crohn s disease: a multicentre comparison with multi-port laparoscopy 93 Chapter 6 The role of single port surgery in Crohn s disease: a review of current evidence 105 Chapter 7 Is the conventional randomised controlled trial still the holy grail? Lessons learned from the LIRIC trial 121
PART III Perianal Crohn s disease 131 Chapter 8 Complex fistulas and advanced soft tissue techniques 133 Chapter 9 Treatment of perianal fistulas in Crohn s disease: a systematic review and meta-analysis comparing seton drainage and anti-tnf treatment 149 Chapter 10 Systematic review of evidence and consensus on perianal fistulas; an analysis of national and international guidelines 211 Chapter 11 Multimodal treatment of perianal fistulas in Crohn s disease: seton versus anti-tnf versus advancement plasty (PISA): study protocol of a randomised controlled trial 243 Chapter 12 The role of mesorectal macrophages in complications after rectal resection in inflammatory bowel disease 259 Chapter 13 Mesenteric tissue for the treatment of septic pelvic complications in the absence of greater omentum 273 Thesis summary, general discussion and future perspectives 281 Appendices Nederlandse samenvatting 291 List of publications 299 List of co-authors 305 PhD portfolio 315 Dankwoord 321 About the author 325