UvA-DARE (Digital Academic Repository) Improvements in locoregional treatment of breast cancer Donker, Mila Link to publication Citation for published version (APA): Donker, M. (2014). Improvements in locoregional treatment of breast cancer General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 10 Jan 2018
IMPROVEMENTS IN LOCO - REGIO NAL TREATMENT OF BREAST CANCER Mila Donker
Improvements in locoregional treatment of breast cancer Mila Donker
The work in this thesis has been performed at the European Organisation for Research and Treatment of Cancer, Brussels, Belgium, and at the Netherlands Cancer Institute Antoni van Leeuwenhoek hospital, Amsterdam, the Netherlands. Unrestricted financial support for publication of this thesis was provided by GlaxoSmithKline, Pfizer, Astellas, Roche, Novartis, Bard, Agendia NV, and Sanofi. Printed by: Centurion Printing BV, Amsterdam Cover: Joseph Plateau Grafisch Ontwerpers, Amsterdam Layout: Joseph Plateau Grafisch Ontwerpers, Amsterdam ISBN/EAN: 978-90-9028560-3 2014 Mila Donker, Amsterdam, the Netherlands
IMPROVEMENTS IN LOCOREGIONAL TREATMENT OF BREAST CANCER ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D.C. van den Boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit op vrijdag 24 oktober 2014, te 13:00 uur door Mila Donker geboren te Zaanstad
Promotiecommissie Promotor: Co-promotor: Prof. dr. E.J.T. Rutgers Dr. M.J.T.F.D. Baas Vrancken Peeters Overige leden: Prof. dr. M.J. van de Vijver Prof. dr. P.M.M. Bossuyt Prof. dr. J.H.G. Klinkenbijl Prof. dr. S. Rodenhuis Prof. dr. H. Struikmans Dr. T. van Dalen Dr. N. Bijker Faculteit der Geneeskunde
Content Chapter 1 General introduction and outline of the thesis 7 Part I Local treatment of in-situ breast cancer Chapter 2 Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in situ: fifteen-year results of the European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 19 Part II Local treatment of the axilla in early breast cancer Chapter 3 Chapter 4 Comparison of the Sentinel Node Procedure between Patients with Multifocal and Unifocal Breast Cancer in the EORTC 10981-22023 AMAROS Trial: identification rate and nodal outcome Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer: results of the randomised controlled non-inferiority EORTC 10981-22023 AMAROS trial 41 55 Chapter 5 Axillary lymph node dissection versus axillary radiotherapy; a detailed analysis of morbidity. Results from the EORTC 10981-22023 AMAROS trial 79 Part IIi Locoregional treatment of the breast and the axilla after neoadjuvant systemic therapy Chapter 6 Chapter 7 Chapter 8 Surgical complications of skin sparing mastectomy and immediate prosthetic reconstruction after neoadjuvant chemotherapy for invasive breast cancer Radioguided Occult Lesion Localization (ROLL) in breastconserving surgery after neoadjuvant chemotherapy Guiding breast-conserving surgery in patients after neoadjuvant systemic therapy for breast cancer. A comparison of radioactive seed localization with the ROLL technique 95 107 121 Chapter 9 Marking Axillary lymph nodes with Radioactive Iodine seeds for axillary staging after neoadjuvant systemic treatment in breast cancer patients: the MARI-procedure 123 Chapter 10 Concluding remarks and future perspectives 145 Summary Samenvatting List of publications Dankwoord CV 156 159 162 164 167