Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c. VARIANT II TURBO Link. Fully-Automated HbA 1c Testing

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Bio-Rad Laboratories HEMOGLOBIN Testing Bio-Rad A1c VARIANT II TURBO Link Fully-Automated HbA 1c Testing

Bio-Rad Laboratories HEMOGLOBIN Testing VARIANT II TURBO Link Efficient streamlined process Powerful integrated system Automated saves time and resources You work hard every day to provide accurate, reliable results in the most efficient way possible. That commitment inspired us to develop the VARIANT II TURBO Link an advanced, fully-automated testing system designed to streamline operations while ensuring quality results. The VARIANT II TURBO Link integrates our proven HbA 1c assay performance with the Sysmex* HST-N fully-automated hematology system to handle over 90% of whole blood EDTA samples while delivering maximum flexibility and accuracy. The result is a consolidated offering that lets you be the difference for your patients and your lab.

Bio-Rad VARIANT II TURBO Link HbA 1c CDM 4.1 Software Patient Report V2_A1c_Link Patient Data Sample ID: A001899564 Patient ID: Name: Physician: Sex: DOB: Comments: A1c Concentration: 8.8%* Analysis Comments: %A1c 20.0 17.5 15.0 12.5 10.0 7.5 5.0 2.5 0.0 0.10 0.18 0.35 A1c 0.47 Analysis Data Analysis Performed: 12/28/2006 01:18:55 Injection Number: 1601 Run Number: 80 Rack ID: 000111Bio-Rad VARIANT II TURBO Link HbA 1c Tube Number: 9 CDM 4.1 Software Report Generated: 03/06/2007 11:58:38 Operator ID: Patient Data Sample ID: M02 Patient ID: Name: Physician: Sex: DOB: Comments: Analysis Data Analysis Performed: 06/28/2007 09:57:22 Injection Number: 2082 Peak Name Calibrated Area % Area % Retention Time (min) Peak Area Run Number: 39 A1a 0.2 0.104 4513 Rack ID: 009170 A1b 2.3 0.183 56243 Tube Number: 7 LA1c 0.6 0.351 14607 Report Generated: 10/25/2007 10:00:12 A1c 8.8* 0.472 86761 Operator ID: A0 54.7 0.825 1334917 S-Window 38.6 0.910 942699 *Values outside of expected range Peak Name Total Area: 2439739 Calibrated Area % Area % Retention Time (min) Peak Area 0.83 0.91 0.0 0.25 0.50 0.75 1.00 1.25 1.50 Time (min.) A1a 0.4 0.104 9055 A1b 1.7 0.191 37575 F 1.3 0.242 28267 LA1c 0.4 0.342 8661 CHb 2.7 0.390 60182 A1c 3.2* 0.537 15579 P3 3.5 0.745 79664 A0 48.7 0.818 1092831 Variant Window 40.7 0.867 912471 *Values outside of expected range Total Area: 2244284 A1c Concentration: 3.2%* Analysis Comments: 20.0 %A1c 17.5 15.0 12.5 10.0 7.5 5.0 2.5 0.0 0.10 0.24 0.19 0.34 0.39 0.54 A1c 0.75 0.82 0.87 Patient Report V2_A1c_Link A1C accuracy in the presence of heterozygous hemoglobins S or C 0.0 0.25 0.50 0.75 1.00 1.25 1.50 Time (min.) A1C accuracy in the presence of carbamylated hemoglobin (CHb) and labile A1C (LA 1c ) Experience superior HbA 1c quality and accuracy Ion-Exchange methodology detects potential interferences Anchored to the IFCC reference method NSGP certified and traceable to the Diabetes Control and Complications Trial (DCCT) quality results

Turn greater efficiency into greater patient care With the VARIANT II TURBO Link, we re combining Bio-Rad s decades of leadership in HbA 1c with Sysmex s proven expertise in automation to improve your laboratory s workflow. The result is a fully-automated solution that helps you be the difference with timely, accurate results. Streamlined Operations On-demand testing 24/7 Automated lavender top tube management Workflow optimization Reduced sample handling errors and delays Save Time and Labor Sample ID decision logic on HST-N automation line Specimen retrieval and archiving using a sorter Standardized automated sample data decisions using MOLIS WAM Automated reflex and repeat testing using MOLIS WAM Every patient deserves quality results. You deserve operational efficiency.

More than just an HbA 1c Result Bio-Rad A1c provides clinically significant information by detecting common hemoglobin variants potentially interfering substances Fully-automated solution with Sysmex HST-N CBC Slide Smear/Prep HbA 1c Sorter Information Systems

HEMOGLOBIN TESTING VARIANT II TURBO Link Unparalleled Support Bio-Rad s world class service and support team is backed by our decades-long leadership in the field of HbA 1c testing. The VARIANT II TURBO Link represents our continued commitment to helping you be the difference for the patients who count on you. Powerful testing, simplified Combining Performance and Efficiency VARIANT II TURBO Link adds greater efficiency to the combination of benefits you ve come to expect from our VARIANT II family, including precision, accuracy and real-time result delivery. Ordering Information Available through: Sysmex America, Inc. One Nelson C. White Parkway Mundelein, IL 60060 1-866-7-SYSMEX (1-866-779-7639) * Sysmex is a registered trademark of Sysmex Corporation. Bio-Rad A1c Be the difference Bio-Rad Laboratories For further information, please contact the Bio-Rad office nearest you or visit our website at www.bio-rad.com/diagnostics Clinical Diagnostics Group Website www.bio-rad.com/diagnostics U.S. 1-800-2BIO-RAD Australia 61-2-9914-2800 Austria 43-1-877-8901 Belgium 32-9-385-5511 Brazil 5521-3237-9400 Canada 1-514-334-4372 China 86-21-64260808 Czech Republic 420-241-430-532 Denmark +45-4452-1000 Finland 358-9-804-22-00 France 33-1-47-95-60-00 Germany +49-(0)89-318-840 Greece 30-210-7774396 Hong Kong 852-2789-3300 Hungary 36-1-455-8800 India 91-124-4029300 Israel 972-3-9636050 Italy +39-02-216091 Japan 81-3-6361-7070 Korea 82-2-3473-4460 Mexico +52(55)5488-7670 The Netherlands +31-318-540666 New Zealand 64-9-415-2280 Norway 47-23-38-41-30 Poland 48-22-3319999 Portugal 351-21-472-7700 Russia 7-495-721-14-04 Singapore 65-6415-3188 South Africa 27-11-442-85-08 Spain 34-91-590-5200 Sweden 46-8-555-127-00 Switzerland 41-61-717-95-55 Thailand 662-651-8311 United Kingdom +44-(0)20-8328-2000 06/08 DG08-196 A-254