Pharmacy Consultant, PEI Drug Programs Date : September 8, 2009 Tel / Tél : (902) Fax / Téléc : (902)

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To / Destinataire : All Retail Pharmacists and Staff From / Expéditeur : Patrick Crawford Pharmacy Consultant, PEI Drug Programs Date : September 8, 2009 Tel / Tél : (902) 368-6711 Fax / Téléc : (902) 368-4905 Subject / Objet : Revised September 2009 Update to the Interchangeable / Maximum Allowable Cost List E-mail / Courriel : pjcrawford@gov.pe.ca The September 2009 update to the PEI Drug Programs Interchangeable / Maximum Allowable Cost (MAC) List has been published. Changes in interchangeability will come into effect on 21 September 2009 Changes in pricing related to the addition of new interchangeable/mac categories will come into effect on 05 October 2009. Adobe Acrobat (pdf) and Excel versions of the complete list can be downloaded from the Government website at: www.gov.pe.ca/sss/. All product availability and pricing has been confirmed with manufacturers prior to publication of this update. Please contact the Pharmacy Services Office at 368-4947 (Charlottetown) or 1-877-577-3737 (toll-free in PEI) if you are unable to access a copy of the list online. Please note that the Maximum Allowable Cost List also contains products that although not listed in the Drug Programs Formulary but may be available through the Special Authorization (Exceptional Drug Request) Process. Refer to the Formulary to determine coverage of products under specific drug programs. In addition, some of the Interchangeable / MAC Categories are only available through the Palliative Home Care Drug Pilot Project. NEW INTERCHANGEABLE / MAC CATEGORIES The following new categories have been added to the Maximum Allowable Cost List. CLINDAMYCIN PHOSPHATE 00582301 DALACIN T PFI 0.2373 02266938 TARO-CLINDAMYCIN TAR FELODIPINE 02057778 PLENDIL AZE N/A 2.5MG SUSTAINED RELEASE 02221985 RENEDIL AVN MIRTAZAPINE 02248542 REMERON RD SCH 0.2866 15MG ORALLY DISINTEGRATING 02279894 NOVO-MIRTAZAPINE OD NOP TABLET MIRTAZAPINE 02248543 REMERON RD SCH 0.5733 30MG ORALLY DISINTEGRATING 02279908 NOVO-MIRTAZAPINE OD NOP TABLET September 2009 MAC List Update - 1

MIRTAZAPINE 02248544 REMERON RD SCH 0.8600 45MG ORALLY DISINTEGRATING 02279916 NOVO-MIRTAZAPINE OD NOP TABLET RIVASTIGMINE 02242115 EXELON NVR 1.3680 1.5MG CAPSUEL 02306034 PMS-RIVASTIGMINE PMS 02324563 SANDOZ RIVASTIGMINE SDZ RIVASTIGMINE 02242116 EXELON NVR 1.3680 3MG CAPSUEL 02306042 PMS-RIVASTIGMINE PMS 02324571 SANDOZ RIVASTIGMINE SDZ RIVASTIGMINE 02242117 EXELON NVR 1.3680 4.5MG CAPSUEL 02306050 PMS-RIVASTIGMINE PMS 02324598 SANDOZ RIVASTIGMINE SDZ RIVASTIGMINE 02242118 EXELON NVR 1.3680 6MG CAPSUEL 02306069 PMS-RIVASTIGMINE PMS 02324601 SANDOZ RIVASTIGMINE SDZ PRODUCTS ADDED TO THE INTERCHANGEABLE / MAC LIST The following products have been added to existing interchangeable categories. BETALOC DURULES 200MG SUSTAINED RELEASE TABLET 00497827 GEN-OMEPRAZPLE 20MG CAPSULE 02329433 NOVO-DOCUSATE 100MG CAPSULE 02020084 PMS-OXYCODONE-ACET 5MG & 325MG TABLET 02245758 RAN-CITALOPRAM 20MG TABLET 02268000 RAN-CITALOPRAM 40MG TABLET 02268019 The following reimbursement prices have changed. CHANGES TO MAC PRICES The N/A notation appearing in some categories stands for not applicable and means that there is no MAC price set because the prices of the various brands in the category are the same or similar. Each brand within that category will be reimbursed as defined within the present pharmacy services agreement. BROMAZEPAM 02177153 APO-BROMAZEPAM APX N/A 1.5MG TABLET 02192705 GEN-BROMAZEPAM GPM CAPTOPRIL 00893595 APO-CAPTO APX N/A 12.5 MG TABLET 01913824 NU-CAPTO NXP 01942964 NOVO-CAPTORIL NOP 02163551 GEN-CAPTOPRIL GPM 02230203 PMS-CAPTOPRIL PMS September 2009 MAC List Update - 2

CIPROFLOXACIN 02155958 CIPRO BAY 1.4692 250MG TABLET 02161737 NOVO-CIPROFLOXACIN NOP 02229521 APO-CIPROFLOX APX 02245647 GEN-CIPROFLOXACIN GPM 02246825 RATIO-CIPROFLOXACIN RPH 02247339 CO CIPROFLOXACIN COB 02248437 PMS-CIPROFLOXACIN PMS 02248756 SANDOZ CIPROFLOXACIN SDZ 02266962 TARO-CIPROFLOXACIN TAR 02303728 RAN-CIPROFLOX RAN 02317427 MINT-CIPROFLOXACIN MNT NABUMETONE 02238639 APO-NABUMETONE APX N/A 500MG TABLET 02240867 NOVO-NABUMETONE NOP 02244563 GEN-NABUMETONE GPM PREDNISOLONE ACETATE 00301175 PRED-FORTE ALL 2.0370 1% OPH SUSPENSION 00700401 RATIO-PREDNISOLONE RPH 01916203 SANDOZ PREDNISOLONE SDZ 02023768 DIOPRED SDZ TICLOPIDINE HCL 02236848 NOVO-TICLOPIDINE NOP N/A 250MG TABLET 02237560 NU-TICLOPIDINE NXP 02237701 APO-TICLOPIDINE APX 02239744 GEN-TICLOPIDINE GPM 02243327 PMS-TICLOPIDINE PMS 02243587 SANDOZ TICLOPIDINE SDZ TIMOLOL MALEATE 00755826 APO-TIMOP APX N/A 0.25% OPH SOLUTION 00893773 GEN-TIMOLOL GPM 02083353 PMS-TIMOLOL PMS 02166712 SANDOZ TIMOLOL SDZ DELETED INTERCHANGEABLE / MAC CATEGORIES The following categories have been removed from the Maximum Allowable Cost List due to the discontinuation of one of the brands by the manufacturer. The discontinued products will not appear in the next publication of the Drug Programs Formulary, but will remain as benefits for the next twelve months. The remaining product within that category will be reimbursed as defined within the current Pharmacy Services Agreement. CHLORPROPAMIDE 00021350 NOVO-PROPAMIDE NOP (DISC) 250MG TABLET 00312711 APO-CHLORPROPAMIDE APX CIMETIDINE 00663727 NOVO-CIMETINE NOP (DISC) 800MG TABLET 00749494 APO-CIMETIDINE APX DEXAMETHASONE 00285471 DEXASONE VAL (DISC) 0.75MG TABLET 01964968 PMS-DEXAMETHASONE PMS 02240685 RATIO-DEXAMETHASONE RPH (DISC) DEXAMETHASONE 00739839 SANDOZ DEXAMETHASONE SDZ 0.1% OPH/OTIC 00785261 PMS-DEXAMETHASONE PMS (DISC) SOLUTION DIMENHYDRINATE 00013560 GRAVOL CDC (DISC) 10MG/ML I/V INJ SOL 00392731 DIMENHYDRINATE SDZ (5ML) September 2009 MAC List Update - 3

FLUNISOLIDE 00878790 RATIO-FULNISOLIDE RPH (DISC) 0.025% NASAL SPRAY 01927167 RHINARIS-F PMS (DISC) 02162687 RHINALAR IVX (DISC) 02239288 APO-FLUNISOLIDE APX HALOPERIDOL 00587702 APO-HALOPERIDOL APX (DISC) 2MG/ML ORAL SOLUTION 00759503 PMS-HALOPERIDOL PMS LABETALOL 02106272 TRANDATE SQP 100MG TABLET 02243538 APO-LABETALOL APX (DISC) LABETALOL 02106280 TRANDATE SQP 200MG TABLET 02243539 APO-LABETALOL APX (DISC) NAPROXEN 00522678 APO-NAPROXEN APX 125MG TABLET 00865621 NU-NAPROX NXP (DISC) NITROFURANTOIN 01997645 MACRODANTIN ALZ (DISC) 100MG CAPSULE 02231016 NOVO-FURANTOIN NOP (MACROCRYSTALS) PERGOLIDE 02123320 PERMAX DRX (DISC) 0.05MG TABLET 02266210 APO-PERGOLIDE APX (DISC) PERGOLIDE 02123339 PERMAX DRX (DISC) 0.25MG TABLET 02266229 APO-PERGOLIDE APX (DISC) PERGOLIDE 02123347 PERMAX DRX (DISC) 1MG TABLET 02266237 APO-PERGOLIDE APX (DISC) TRIAMCINOLONE ACETONIDE 01964054 ORACORT TAR 0.1% ORAL TOP OINTMENT 01999788 KENALOG-ORABASE WSD (DISC) DISCONTINUED PRODUCTS The following products have been removed from the Maximum Allowable Cost List. These products will not appear in the next publication of the Drug Programs Formulary, but will remain as benefits for the next twelve months. APO-KETOTIFEN 0.2MG/ML SYRUP 0221330 APO-SALVENT IPRAVENT 1.0MG & 0.2MG PER ML NEBULE 02266393 ENDANTADINE 100MG CAPSULE 02034468 LECTOPAM 1.5MG TABLET 00682314 LIN-BUSPIRONE 10MG TABLET 02176122 LIN-FOSINOPRIL 10MG TABLET 02242733 LIN-FOSINOPRIL 20MG TABLET 02242734 M.O.S. 5MG/ML SOLUTION 0062503 NOVO-BUPROPION SR 150MG SUSTAINED RELEASE TABLET 02260239 NOVO-DIFLUNISAL 500MG TABLET 02048507 NU-ALPRAZOLAM 0.25MG TABLET 01913239 NU-ALPRAZOLAM 0.5MG TABLET 01913247 September 2009 MAC List Update - 4

NU-BROMAZEPAM 1.5MG TABLET 02171856 NU-BROMAZEPAM 3MG TABLET 02171864 NU-BROMAZEPAM 6MG TABLET 02171872 NU-KETOTIFEN 0.2MG/ML SYRUP 02218305 NU-SALBUTAMOL 1MG/ML NEBULE 02231783 NU-SALBUTAMOL 2MG/ML NEBULE 02231784 NU-TEMAZEPAM 15MG CAPSULE 02223570 NU-TEMAZEPAM 30MG CAPSULE 02223589 PMS-CIMETIDINE 300MG TABLET 02229718 PMS-CIMETIDINE 400MG TABLET 02229719 PMS-CIMETIDINE 600MG TABLET 02229720 PMS-FLAVOXATE 200MG TABLET 02245480 PMS-GENTAMICIN 0.3% OPHTHALMIC SOLUTION 00776521 PMS-PIROXICAM 10MG CAPSULE 00836249 PMS-PIROXICAM 20MG CAPSULE 00836230 PMS-TIAPROFENIC ACID 200MG TABLET 02230827 RATIO-ALPRAZOLAM 0.25MG TABLET 00677485 RATIO-ALPRAZOLAM 0.5MG TABLET 00677477 RATIO-DESIPRAMINE 25MG TABLET 01948784 RATIO-DESIPRAMINE 50MG TABLET 01948792 RATIO-MPA 2.5MG TABLET 02148552 RATIO-MPA 5MG TABLET 02148560 RATIO-MPA 10MG TABLET 02148579 RELAFEN 500MG TABLET 02083531 SANDOZ NABUMETONE 500MG TABLET 02242912 TICLID 250MG TABLET 02162776 TIMOPTIC 0.25% OPHTHALMIC SOLUTION 00451193 CHANGE IN MANUFACTURER DILAUDID 1MG/ML ORAL SOLUTION 00786535 PFR DILAUDID 1MG TABLET 00705438 PFR DILAUDID 2MG TABLET 00125083 PFR DILAUDID 4MG TABLET 00125121 PFR DILAUDID 8MG TABLET 00786543 PFR DILAUDID 2MG/ML INJECTION 00627100 PFR DILAUDID 10MG/ML INJECTION 02145928 PFR DILAUDID 20MG/ML INJECTION 02146118 PFR DILAUDID 50MG/ML INJECTION 02146126 PFR September 2009 MAC List Update - 5

IMPORTANT NOTICES CHANGES TO PDINS (PSEUDO DRUG IDENTIFICATION NUMBERS) In order to eliminate overlap with existing DINs, the PDINs for the following products have been changed: ACETYLSALICYLIC ACID 325MG TABLET (UNCOATED) 00999963 ASCORBIC ACID 500MG TABLET 00999970 CALCIUM CARBONATE 250MG TABLETS 00999910 USE OF PDINS (PSEUDO DRUG IDENTIFICATION NUMBERS) PDINs have been assigned to the following products since July 2006: 00999929 ACETAMINOPHEN 32MG/ML ELIXIR 00999719 ACETAMINOPHEN 80MG/ML DROPS 00999939 ACETAMINOPHEN 325MG TABLET 00999949 ACETAMINOPHEN 500MG TABLET 00999963 ACETYLSALICYCLIC ACID 325MG TABLET (UNCOATED) 00999970 ASCORBIC ACID 500MG TABLET 00999829 CALAMINE LOTION 00999910 CALCIUM CARBONATE 250MG TABLET 00999919 CALCIUM CARBONATE 500MG TABLET 00999899 FOLIC ACID 1MG TABLET 00999879 NIACIN 100MG TABLET 00999889 NIACIN 500MG TABLET 00999849 VITAMIN E 200UNIT CAPSULE 00999859 VITAMIN E 400UNIT CAPSULE 00999869 VITAMIN D 1000UNIT TABLET PDINs mus be used when submitting claims for any of these products and the regular DINs for products such a Apo- Calcium and Apo-Acetaminophen will not be accepted by the adjudication system. September 2009 MAC List Update - 6