About the course. Disclosure policy. Accreditation. Target audience. Physicians. Registration fees. Inquiries

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The Lennox-Lombroso Pediatric Epilepsy Conference February 2-3, 2018 Hilton Boston Back Bay Boston, MA REGISTER NOW bostonchildrens.org/epilepsy2018 Early bird registration rates expire 11/30/17

About the course A History of Innovation & Quality Care has been at the forefront of pediatric epilepsy research and care since the founding of the first comprehensive pediatric epilepsy treatment unit in 1944 by Dr. William Lennox. In 1962, Dr. Cesare Lombroso succeeded Dr. Lennox as Chief of the Seizure Unit and EEG Laboratory at Boston Children s, a position he held until 1988. Both of these physicians believed that the best results in children with seizures are achieved in a center that simultaneously addresses the medical, psychosocial, behavioral and family issues that impact their lives. With this focus, the Seizure Unit at Boston Children s Hospital grew to be a preeminent center for both treatment and clinical investigation. State-of-the-art Education: The Lennox- Lombroso Pediatric Epilepsy Conference The inaugural Lennox-Lombroso Pediatric Epilepsy Conference extends Boston Children s tradition of excellence in continuing medical education to the field of childhood epilepsy diagnosis, management, and research. The course will cover a variety of topics including medical advances, discoveries and innovative technological approaches in epilepsy genetics, neurocritical care, computational neurophysiology, surgical procedures, and EEG ontogeny. In addition to presenting the latest advances and innovations in epilepsy research and care, the course will provide the practitioner with clear guides in terms of how to apply knowledge in all domains of pediatric epilepsy. Core faculty are from the Division of Epilepsy and Clinical Neurophysiology at and invited faculty have been selected to highlight and honor faculty alumni who continue to make great contributions to the field, including Keynote Speakers Gregory L. Holmes MD, successor to Dr. Lombroso and current Chair of Neuroscience at the University of Vermont; Mohamad Mikati MD, Chief of Pediatric Neurology at Duke University; and James J. Riviello, Jr. MD, Professor of Pediatric Neurology and Developmental Neuroscience at Baylor College of Medicine. Target audience This course is designed to meet the educational needs of physicians, clinicianscientists, physician assistants, nurses, nurse practitioners, psychologists, allied health professionals, residents and fellows who specialize or have an interest in: pediatric neurology pediatric epileptology epilepsy and clinical neurophysiology neuropsychology primary care * This course is also open to any patients and families that wish to attend. Registration fees Physician early bird fee* $500 Physician (regular rate) $550 Allied Health Professionals $300 Trainee $300 *Early bird ends 11/30/2017 Course directors»» Arnold J. Sansevere, MD Learning objectives Upon completion of this course, participants will be able to: recognize the effects of seizures and spikes on the developing brain identify high risk populations for seizures in the critical care unit and apply standardized EEG interpretation select patients for epilepsy surgery including the rationale for different forms of invasive monitoring and technical approaches identify the correct genetic test and translational opportunity for selected patients depending upon the clinical presentation Accreditation In support of improving patient care, Boston Children s Hospital is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Physicians designates this live activity for a maximum of 14.75 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in this activity. AAPA accepts AMA category 1 credit for the PRA from organizations accredited by ACCME. Nurses designates this activity for 14.75 contact hours for nurses. Nurses should claim only the credit commensurate with the extent of their participation in the activity. Refund policy To register by credit card, please visit bostonchildrens.org/epilepsy2018. To register by check, please contact the CME Department at: cmedepartment@childrens.harvard.edu to discuss payment. Please make checks payable to. Telephone or fax registration is not accepted. Registration with cash payment is not permitted. Upon receipt of your paid registration, an email confirmation from the Boston Children s office will be sent to you. Be sure to include an email address that you check frequently. Your email address is used for critical information, including registration confirmation, evaluation and certificate. Fifty-percent (50%) refunds will be issued for all cancellations received prior to the start of the course. Refund requests must be received by postal mail, email or telephone. No shows are subject to the full course fee, and no refunds will be issued once the conference has started. Disclosure policy adheres to all ACCME Essential Areas, Standards, and Policies. It is Boston Children s policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose all relevant financial relationships with commercial entities so that Boston Children s may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Additionally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations. Inquiries cmedepartment@childrens.harvard.edu or at 617-919-3108.

Schedule, Day 1: Friday, Feb. 2, 2018 7:30 8 a.m. Check in and Registration 8 8:30 a.m. Welcome and Historical Overview Presenter: Guests of Honor: Paul J. Lombroso, MD & Jane Lennox Herner 8:30 9:30 a.m. KEYNOTE Seizures, Spikes, and Brain Development Gregory L. Holmes, MD SYMPOSIUM: CRITICAL CARE IN EPILEPSY (9:30 11:45 a.m.) 9:30 10:15 a.m. KEYNOTE Critical Care and Epilepsy: Past, Present and Future James J. Riviello Jr., MD 10:15 10:45 a.m. Status Epilepticus Tobias Loddenkemper, MD 10:45 11 a.m. BREAK 11 11:30 a.m. ICU EEG Cases: Rules of the Road Arnold J. Sansevere, MD 11:30 11:45 a.m. PANEL Q&A 11:45 a.m. 12:15 p.m. Computational Neurophysiology Jurriaan M. Peters, MD, PhD 12:15 1:30 p.m. LUNCH SYMPOSIUM: SURGERY (1:30 5 p.m.) 1:30 2 p.m. Neurological Outcomes after Epilepsy Surgery The BCH Database Jeffrey Bolton, MD 2 2:30 p.m. Intracranial Monitoring: Pediatric Stereo EEG Scellig Stone, MD, PhD, FRCSC 2:30 3 p.m. Computer-based Techniques to Improve Epilepsy Surgery Joseph Madsen, MD 3 3:30 p.m. Electrocorticographic Applications Masanori Takeoka, MD 3:30 4 p.m. BREAK 4 5 p.m. Surgical Cases: The Best of... Epilepsy Fellows and Faculty 5 6 p.m. Creativity and the Brain... at the Piano 6 8 p.m. DINNER AND RECEPTION Schedule, Day 2: Saturday, Feb. 3, 2018 SYMPOSIUM: EPILEPSY GENETICS (8 11:15 a.m.) 8 8:45 a.m. KEYNOTE Emerging Treatments of Epileptic Encephalopathy Mohamad A. Mikati, MD 8:45 9:15 a.m. Case-based Testing in the New Genomic Era Christelle Achkar, MD 9:15 9:45 a.m. Case-based Epilepsy Genetics in the 21 st Century Heather Olson, MD, MS 9:45 10:15 a.m. Epilepsy Genetics: From Zebrafish to Clinic Annapurna Poduri, MD, MPH 10:15 10:45 a.m. BREAK 10:45 11:15 a.m. PANEL Q&A 11:15 a.m. noon Neuro-Modulation A New Era in Epilepsy Research and Treatment Alexander Rotenberg, MD, PhD Noon 1:15 p.m. LUNCH 1:15 1:45 p.m. Neonatal Seizures Ann M. Bergin, MB, ScM, MRCP SYMPOSIUM: INFANTILE SPASMS (1:45 p.m. 2:45 p.m.) 1:45 2:15 p.m. Clinical Chellamani Harini, MD 2:15 2:45 p.m. Experimental Christopher J. Yuskaitis, MD, PhD 2:45 3:15 p.m. BREAK 3:15 3:45 p.m. EEG: Clinical Cases Mark H. Libenson, MD 3:45 4:15 p.m. Spikes, Seizures and Cognition Katrina Boyer, PhD 4:15 4:45 p.m. Case Studies of Epilepsy, Cognition and Memory Clemente Vega, PsyD, ABPP-CN 4:45 5 p.m. Conclusions and Future Directions *Program changes/substitutions may be made without notice.

Faculty GUESTS OF HONOR Paul Lombroso, MD Son of Cesare T. Lombroso, MD, PhD Elizabeth Mears and House Jameson Professor in the Child Study Center and Professor of Neuroscience and of Psychiatry; Director, Laboratory of Molecular Neurobiology; Biological and Biomedical Sciences, Yale University Jane Lennox Herner Granddaughter of William Gordon Lennox, MD COURSE DIRECTORS William G. Lennox Chair and Professor of Neurology, Harvard Medical School; Director of Epilepsy and Clinical Neurophysiology, Arnold J. Sansevere, MD SPEAKERS Christelle Achkar, MD Ann M. Bergin, MB, ScM, MRCP Assistant Professor of Neurology, Harvard Medical School; Vice President, Medical Staff Organization, Assistant in Neurology, Director, Multidisciplinary Ketogenic Diet Program, Jeffrey Bolton, MD Katrina Boyer, PhD Instructor in Psychology, Department of Psychiatry, Harvard Medical School; Neuropsychologist, Director, Neuropsychology of Epilepsy Program, Chellamani Harini, MD Assistant in Neurology, Epilepsy Program, Gregory L. Holmes, MD Keynote Speaker Chair, Department of Neurological Sciences, Professor of Neurological Sciences and Pediatrics, Larner College of Medicine, University of Vermont Mark H. Libenson, MD Assistant Professor of Neurology, Harvard Medical School; Senior Associate in Neurology; Director, EEG Laboratory; Medical Director, Electroneurodiagnostic (END) Technology Program, Tobias Loddenkemper, MD Associate Professor of Neurology, Harvard Medical School; Associate in Neurology, Electroneurodiagnostic (END) Technology Program; Director, Clinical Epilepsy Research Program, Boston Children s Hospital Program, Joseph Madsen, MD Associate Professor of Neurosurgery, Harvard Medical School; Associate in Neurosurgery, Director, Epilepsy Surgery Program, Mohamad A. Mikati, MD Keynote Speaker Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, Chief, Division of Pediatric Neurology, Director, Pediatric Epilepsy Program, Duke University School of Medicine Heather Olson, MD, MS Jurriaan M. Peters, MD, PhD Assistant Professor of Neurology, Harvard Medical School; Assistant in Neurology, Annapurna Poduri, MD, MPH Associate Professor of Neurology, Harvard Medical School; Director, Epilepsy Genetics Program, Associate in Neurology, Boston Children s Hospital James J. Riviello Jr., MD Keynote Speaker Professor, Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine; Associate Section Head for Epilepsy, Neurophysiology, and Neurocritical Care, Section of Neurology and Developmental Neuroscience, Texas Children s Hospital Alexander Rotenberg, MD, PhD Associate Professor of Neurology, Harvard Medical School; Associate in Neurology, Director, Neuromodulation Program, Scellig Stone, MD, PhD, FRCSC Assistant Professor of Neurology, Harvard Medical School; Associate in Neurosurgery; Director, Movement Disorders and Deep Brain Stimulation Program, Masanori Takeoka, MD Assistant Professor of Neurology, Harvard Medical School; Assistant in Neurology, Co-Director, Sturge-Weber Syndrome Clinic, Clemente Vega, PsyD, ABPP-CN IInstructor in Psychology, Department of Psychiatry, Harvard Medical School; Staff Neuropsychologist, Christopher J. Yuskaitis, MD, PhD

Continuing Medical Education Department 300 Longwood Avenue, LM 7, Boston, MA 02115 The Lennox-Lombroso Pediatric Epilepsy Conference February 2 3, 2018 Hilton Boston Back Bay REGISTER NOW bostonchildrens.org/epilepsy2018 Early bird registration rates expire 11/30/17