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ORTHOPAEDICS FOR THE PRIMARY CARE PRACTITIONER & REHABILITATION THERAPIST JULY 20-22, 2018 CLEARWATER BEACH, FL

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The 6 th Asia Pacific Congress on Controversies in Gynecology, Infertility & Ultrasound November 20-22, 2014 Ho Chi Minh City (Saigon), Vietnam Support and Exhibition Invitation for the Industry Last Update: June 5, 2014 www.cogi.org/vietnam cogi@comtecmed.com

Welcome note After the success of the previous COGI Asia Pacific Congresses, we are delighted to invite you to take part in the 6 th Asia Pacific Congress on Controversies in Gynecology, Infertility & Ultrasound (COGI), which will take place in Ho Chi Minh City (Saigon), Vietnam, November 20-22, 2014. The 6 th Asia Pacific COGI Congress will provide a unique platform for world leaders and participants to conduct a vibrant discussion aimed at reaching consensus in the fields of gynecology, infertility & ultrasound. Debates, discussions and plenary lectures will facilitate this academic dialogue which will raise the most dynamic and challenging clinical and technological questions. The Congress will promote excellence in the fields of Gynecology, Infertility & Ultrasound and aims to bridge gaps between the expansion of information and its implementation in clinical practice. International and local experts will share and compare experiences in stimulating and interactive debates. Allowing ample time for speaker-audience discussion, the Congress aims at reaching up-to-date and agreed-upon answers to ongoing debates even when proof is lacking, through evidence-based medicine and expert opinion. The Congress will enable participants from all over the world to meet with outstanding world experts in various disciplines and to be updated on the most pressing issues facing clinicians today. Not only will this be an exciting scientific event, it will also be held in the equally exciting city of Vietnam. Vietnam is full of rich history, vast cultures and a rich blend of religious heritage. We look forward to welcoming you at this exciting scientific event and to the beautiful city of Vietnam! Sincerely, Nguyen Viet Tien Vice Ministry of Health Chairman of Vietnam Association of Gynecology, Obstetrics and Family Planning Zeev Shoham Congress Co-Chairperson

Aims of the Congress Congress Profile To promote excellence in the field of Gynecology, Infertility & Ultrasound by discussing, in a debate forum, evidence-based medicine and expert opinions on current controversial issues To bridge gaps between expansion of basic science and information, and their consolidation into clinical practice To promulgate ethics and standards of practice and treatment To reach consensus on certain controversial issues, through debates, round table discussions and plenary lectures To make it possible for the industry to meet with outstanding experts in the field, and to update international participants on pressing clinical and technological questions of the day The Program Controversial topics Debates and discussions on unresolved controversies Cohesive and integrative sessions World eminent speakers Audience/speaker discussions Continuing Medical Education (CME)-approved program 3

Preliminary List of Topics Menopause - Frail Bones: Old Concepts VS. New Strategies - Individual Fracture Risk Assessment: Global Variance - Are Calcium And Vitamin D Supplementation Still Needed? - The New Era Of Osteoporosis Therapies - What Really Bothers Menopausal Women? - Psychological Aspects - Neurocognitive Aspects - Sexual Aspects - Keep Physically Healthy (Diet And Lifestyle Perspectives) - Safety Of Postmenopausal Hormone Therapy Revisited - HRT And The Endometrium, The Breast, HRT And The Cardiovascular System - HRT And The Coagulation System Sperm - Is Male Infertility Genetic And Therefore Untreatable In Most Cases? - Sperm Test What Should Be Tested? - Should Caricocelectomy Be Done In The Era Of IVF/ICSI - What Should Be The Best Condition For IUI? - Who Really Would Benefit From IMSI, The Embryo Quality After The Procedure - Selecting The Right Sperm For ICSI - Do We Know Enough? The Debate About OHSS - Should This Be Treated Or Be Prevented? - When Will You Cancel A Cycle? - All Cycle Should Be Triggered With GnRH Agonist And Not By hcg - Angiogenesis In Reproduction - The Role Of OHSS - Minimal Stimulation And IVF Should Be The Treatment Of Choice. 10 Years Of Experience Collecting Data On IVF How This Should Be Interpreted? - Do Great Data Banks Help Us In Our Daily Work Or Will RCT And Meta Analysis Be Enough? Infertility - ART: The Role Of Improving Technologies - Do We Have A Prefer Way To Select The Best Embryo For Replacement? - Measuring Bio-markers - Using The Time-lapse Technology - Luteal Support - Is There A Place For New/old Formulation? - How Can We Choose Between The Various Preparations? - Should We Support The Luteal Phase With GnRH Agonist? - How Log The Support Needs To Be Given If Case Of Pregnancy? - Shall We Move To Oral Preparations? 4

Preliminary List of Topics Cancer, Fertility And Pregnancy - How To Choose The Best Way To Handle With Pregnancy After Cured Gynecological Cancers - The Oncologic Perspective Of Fertility Preservation - Gyneco-oncology And Breast Cancer - Cryopreservation A Room For Improvement How To Treat Gynecological Cancer - When Is The Optimal Time To Become Pregnant For Women Cured Because Of Gynecological Cancer? - Who Should Manage Her Pregnancy (primary Ob/gyn, Or Clinical Obstetricians Or Gynecological Oncologist, Or All Them Together) - What Diagnostically Procedures And Supplementation She Should Be Suggested To Take Or To Avoid During Pregnancy. Fertility Preservation - Should Fertility Preservation Be Offered For Social Reasons? - The Possibility To Vitrify Egg, Embryo And Creating The Suitable Bank? - Breast Cancer, Chemotherapy And Fertility Preservation - Fresh And Frozen Ovary Transplant - Can We Transplant Ovarian Tissue From Cancer Patients? - Can We Tailor For The Best Stimulation Protocol? - Case Presentation And Expert Discussion - Stimulation Of Cancer Patients For Egg Retrieval Before Stating Treatment? - Diminished Ovarian Reserve In Breast Cancer Patients With BRACA 1 Positive PCOS Still An Unsolved Dilemma - The Rotterdam Consensus PCOS Criteria: Do We Really Need It? The Screening Test And The Responsibility Of The Expert? - Metformin Improved Ovarian Response To Stimulation And Should Be Used In All PCOD Patients - First Line Therapy For PCOS -- Should It Be Clomiphene Citrate Or Gonadotropin For Ovulation Induction? - What Should Be The Approach To Stimulation? - Should Ovarian Drilling Be Formed Before Any Treatment? - IVM Or IVF: Which Approach Should Come First? - COH For PCOS: Long Or Antagonist Should Be The Protocol Of Choice? Poor Ovarian Response - Can We Improve The Bioenergetics Of The Oocyte? - Improve Fertility Through Science: The Role Of Stem Cells - Is Through Assessment Of Ovarian Reserve Necessary? - Natural Vs. Stimulated Cycles? - How Do We Measure Ovarian Reserve? How Accurate Can Be The Results? 5

Preliminary List of Topics Endometriosis - What Is The Routine Investigation In Patients With Endometriosis? - The Dilemma Between Medical Vs. Surgical Treatment, How And When We Taking Decision On Surgical Treatment In Patients With Endometriosis? What Would Happen To The Ovarian Reserve? - What Is The Value Of The Diagram To Map The Locations Of Endometriosis On The Surgery? - Endometriosis-associated Ovarian Cancer: How Does It Happen? Should It Be Considered A Preneoplastic Lesions? - Pain Related Endometriosis: What Should Be The Approach? - Should We Consider Fertility Preservation In Women Wit Endometriosis? - Endometriosis And Sub-fertility: Surgery Obsolete?? ART Insufficiency: How To Improve It? - IVF Cycle As A Two-Step Procedure, One For Multifollicular Development And Embryo Formation (followed By Cryopreservation) And A Second Step Including Embryo Transfer - Should Embryo Transfer Be Always Performed Under Ultrasound Guidance? - Can Implantation Be Improved By Mechanical Injury Of The Endometrium? - Early Stage Embryo Vs. Blastocyst: What To Transfer? Pre-Implantation Genetic Diagnosis - Predicting Oocyte Competence By Polar Body Chromosome Analysis - Every Embryo Should Be Biopsied For acgh Or SnP And Every Oocyte Should Undergo Cumulus Cell Analysis - Should Proteomics, Metabolomics And Secretomics Become A Standard Procedure? - What Is The Less Detrimental Stage Of Biopsy? - From Polar Body To Blastocyst? What Is The Preferred Investigating Procedure? Advanced Paternal Age And Reproduction, The Role Of Egg Donation - Should Male s Age Be Limited In ART Treatments? - Freeze And Share Egg Banks: The Evolution Of Egg Sharing - The Option Of Freezing Eggs For Free By Donating A Proportion To An Egg Bank May Offer A Win-Win Situation. - Should Egg Banks Be Based On The Freeze And Share Policy Or On Paid/altruistic Egg Donors? - Science Fiction Becomes A Reality - Uterus Transplantation - Producing An Oocyte/sperm From A Somatic Cell, Or Stem Cell - Applications Of Nanotechnology In Cancer - How To Contract An Artificial Egg? What Are The Requirements For The Oocyte To Achieve It Mission? 6

Preliminary List of Topics Fibroids: Does This Chapter Need To Be Written? - The Role Of Pharmacological Treatment: Should This Come First? - Robotic Surgery For The Treatment Of Uterine Fibroids? - Robotic Surgery Vs. Simple Laparoscopy? Should Costs Be Considered As An Issue? - The Role Of Uterine Artery Embolization? Focused Ultrasound? - Hysterectomy Vs. Myomectomy In The Older Patient? Contraception - No Need To Stop The Pill. More Healthy With Better Compliance? - The Use Of Ulipersitol - The New Estrogen And Progesterone; Are They Better? Who Would Benefit From It? - How Do We Choose The Method For Emergency Contraception? - Do We Need A New Formulation For Oral Contraception? - How Can We Value Safety Vs. Risk Of Complications? - The Progesterone Only Contraception; Best Or Worse? - Should O.C. Be Prescribed Over The Counter? - The Non-oral Methods: What Role They Have? - Compliance In Contraception Use: Role Of Counseling, Awareness Of Culture/social Factors, Needs Of Different Patients Groups. - Safety Of Oral Contraception: Time To Look Again At The Evidence! - Restoring Testosterone Concentration And Libido During O.C. Treatment Robotic And Tele-surgery - Does Telesurgery (robotics) Add Value To Endoscopic Gynecological Procedures? The Debate Is Still On. - S-portal: Single Port Surgery Also In Gynecology - Adhesion Formation: Can Robotic Surgery Minimize It? Adolescence Gynecology - Should We Systematically Treat Adolescents With PCOS With Insulin Sensitizers? - Are Peripubertal Ovarian Cysts Always Functional? - Should We Wait Until 16-17 Years To Investigate Primary Amenorrhea? Endoscopy - Fertiloscopy Does It Contribute To Infertility Evaluation? - Hysteroscopy In Infertility, What Is The Contribution? - Can We Treat And Should We Treat Infertile Women With Adenomyosis? - Laparoscopy And Reproduction, Does It Matter Anymore? - Does Surgery For Endometriosis Has A Place In Failed IVF? 7

Preliminary List of Topics Ovarian Cancer - Pelvic Mass Risk Assessment: Who Should Operate? - Pelvic Mass In Pregnancy: Should You Operate Or Not? Cervical Cancer And Human Papilloma Virus (HPV) - Epidemiology Of Cervical Cancer And HPV - Prophylactic Value Of HPV Vaccine: Further Developments - HPV- DNA Typing Has No Role In The Routine Evaluation Of The Abnormal PAP Smear - Papanicolaou Smear (PAP) How Often? What Is The Best Technology? Guideline For Categorization: Should Colposcopy Be A Routine Part Of The Pelvic Examination? Endoscopic Surgery - Laparoscopy For Investigation And Management Of Infertility - Laparoscopic Hysterectomy Of Normal Size Uterus: Traditional Laparoscopy Vs. Robotic Vs. Single Port - Hysteroscopy Metroplasty In Primary Infertility - Hysteroscopy Polypectomy: Resectoscopy, Morcellator - Surgical Treatment Of Vaginal Vault Or Uterine Prolapse: Vaginal Vs. Laparoscopic - Laparoscopic Simulator Training In Residency: Not Necessary Vs. Obligatory - Laparoscopic Staging Of Endometrial Cancer: Traditional Laparoscopy Vs. Robotic Ultrasound - Screening of the fetus during pregnancy - Ultrasound vs. NIPT - Principle and pitfalls of ultrasound guidance for invasive procedures - The brain - The heart: early fetal cardiac evaluation - Detection of congenital heart disease: color Doppler, 3D and 4D - 3D vs. 4D Ultrasound: Gimmick or breakthrough - Case presentation: The thin fetus, the strange eye - Assessment of Gyne-oncology patients - The scan, genetic counseling and the outcome 8

LEVELS OF SUPPORT [ Level determined by the accumulation of items of value ] Platinum $ 45,000 and up Gold $ 30,000 45,000 Silver $ 15,000 30,000 Bronze $ 5,000 15,000 9

EDUCATIONAL SUPPORT OPPORTUNITIES CONTINUING MEDICAL EDUCATION (CME) APPROVED SESSION $ 18,000 Opportunity to support an existing session or to suggest a CME-approved session as part of the CME-approved scientific program. Session hall and basic audiovisual equipment 12 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) One full page color advertisement in the supporters booklet Brochure in the participants bags Company logo on regular announcements to congress database CONTINUING MEDICAL EDUCATION (CME) APPROVED PRESENTATION $ 8,000 Opportunity to support an existing presentation or to suggest a presentation as part of a CMEapproved session in the scientific program Session hall and basic audiovisual equipment One full page color advertisement in the supporters booklet Brochure in the participants bags PRIZES FOR OUTSTANDING ABSTRACTS Sole Support $ 4,000 Three prizes of $ 1,500, $ 1,000 and $ 500 will each be awarded to the authors of the three most outstanding abstracts/posters. Company representatives will be invited to attend the award ceremony 10

PROMOTIONAL SUPPORT OPPORTUNITIES INDUSTRIAL SYMPOSIUM (NON-CME APPROVED) Plenary Symposium $ 35,000 Parallel Symposium $ 30,000 Opportunity to hold a non-cme approved industrial symposium as part of the scientific program - the content and speakers are subject to approval from the Congress Chairpersons Symposium hall and basic audiovisual equipment 12 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) One full page color advertisement in the supporters booklet Brochure in the participants bags Company logo on regular announcements to congress database The expenses (travel, accommodation and registration) of the chairpersons and speakers of an industrial symposium are additional and the responsibility of the supporter. PRE-CONGRESS SATELLITE SYMPOSIUM (NON CME-APPROVED) $ 40,000 Opportunity to hold a non-cme-approved industrial pre-congress satellite symposium Symposium hall and basic audiovisual equipment 18 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) One full page color advertisement in the supporters booklet Brochure in the participants bags Optional webcast of Symposium at discounted rates Company logo on regular announcements to congress database The expenses (travel, accommodation and registration) of the chairpersons and speakers of an industrial pre-congress satellite symposium are additional and the responsibility of the supporter. YOUNG SCIENTISTS $ 5,000 Opportunity to support the registration of 15 young scientists below the age of 36, who will be selected by the Congress Chairpersons based on abstracts submitted and accepted Company profile in the sponsors booklet Names and contact details of selected scientists 11

PROMOTIONAL SUPPORT OPPORTUNITIES WELCOME RECEPTION Sole Support $ 10,000 Opportunity to support the welcome reception for all participants of the Congress Company logo on the official invitation to the welcome reception FACULTY DINNER Sole Support $ 10,000 Opportunity to support the official dinner for all invited speakers of the Congress Company logo on the official invitation to the faculty dinner SUPPORTERS BOOKLET Sole Support $ 6,000 The supporters booklet will include the profiles and advertisements of the Congress supporters. Two full page color advertisement in the supporters booklet (back cover and inside page) LUNCH Sole Support $ 6,000 (per lunch) Opportunity to support a buffet lunch to be served to all participants of the Congress Company logo on the official invitation Brochure in the participants bags INTERNET AREA Sole Support $ 5,000 The Internet Area will be outfitted with internet workstations for participants to stay updated between sessions Display logo as a screen background Opportunity to provide branded mouse pads 12

PROMOTIONAL SUPPORT OPPORTUNITIES PARTICIPANTS BAGS Sole Support provided-in-kind + $ 6,000 Opportunity to provide branded bags for all participants of the Congress CONGRESS LANYARDS Sole Support provided-in-kind + $ 4,000 This opportunity is reserved for presidential circle, platinum and gold supporters, and will be available on a first-come, first-served basis. Opportunity to provide branded lanyards TRANSLATION $5,000 (per hall, per day) Simultaneous translation into any required language POSTER AREA $ 3,000 Abstracts selected by the Congress Chairpersons for poster presentation at the Congress NOTE PADS AND PENS Sole Support provided-in-kind + $ 3,000 Opportunity to provide branded note pads and pens to be distributed in the participants bags ADVERTISEMENT IN THE SUPPORTERS BOOKLET $ 2,000 Full page color advertisement in the supporters booklet (inside page) 13

PROMOTIONAL SUPPORT OPPORTUNITIES BROCHURE INSERT $ 1,500 Company brochure to be inserted into the participants bags COFFEE BREAK $ 2,000 (per coffee break) Opportunity to support, in part, a coffee break for all participants of the Congress TAILOR-MADE SUPPORT PACKAGES Support packages may be tailored to suit the company s budget and interests and in order to maximize visibility, and to best promote products and services. Please contact the Congress Organizer for further details on creating the appropriate package. EXHIBITION An exhibition will be held in conjunction with the Congress. The exhibition floor plan is designed to maximize exposure to the participants. All lunches and coffee breaks will be held in the exhibition area daily. Exhibition space will be available on a first-come, first-served basis, with priority given to Presidential Circle, Platinum and Gold Sponsors. Exhibition space will be available as follows: The cost for exhibition space rental is $ 400 per sq.m. Companies who will contribute minimum of $ 15,000 will be entitled to a special sponsors rate of $ 300 per sq.m. The minimum booth size is 2 x 3 sq.m. Please visit www.cogi.org/asia to view the exhibition floorplan. Exhibition space rental is priced according to size (per sq.m) and includes: Net stand area Company profile in Congress Program Book Two exhibitor registrations Exhibitors Manual General cleaning of public areas Venue security Stand equipment and additional services may be ordered by means of the forms in the Exhibitors Manual: Furniture, partition walls, carpets, telephone and data lines, electricity, stand cleaning, exhibitors insurance, logistics, among other services. 14

GENERAL INFORMATION LANGUAGE The official language of the Congress is English. CONGRESS ORGANIZER AND SPONSORSHIP / EXHIBITION CONTACT: 53, Rothschild Boulevard, PO Box 68 Tel Aviv, 61000, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 E-mail: danielle@comtecmed.com Website: www.cogi.org/asia Terms and Conditions: 1. Support items are allocated on a first-come, first-served basis 2. All support and exhibition prices quoted are in $ and are subject to VAT 3. All payments must be received before the beginning of the Congress. Should the company fail to make the payment prior to the commencement of the Congress, the Organizer saves the right to cancel the company s participation and benefits 4. Time slot allocation will be based on level of support and approval from the Organizing Committee 5. It is the responsibility of the supporters and exhibitors to comply with the regulations of the local authorities, EFPIA (European Federation of Pharmaceutical Industries & Associations) www.efpia.org and IFMPA (International Federation of Pharmaceutical Manufacturers & Associations) www.ifpma.org Code of Practice on the Promotion of Medicines. 6. The Congress Organizer reserves the right to accept or decline offers of support and application for exhibition space 7. The Congress Organizer reserves the right to amend the published floor plan should it be deemed necessary for the benefit of the exhibition and the Congress as a whole 8. Please note that the Congress Organizer must approve all exhibition stand designs 9. All benefits: (logo, profile, insert, advertisement and registration) that are mentioned as part of the Supporter /Exhibitor packages are to be provided as per Comtec specifications and deadlines to ensure maximum exposure at the Congress 10. Hermes & Merkur is the sole logistic supplier for the COGI Congress. All materials sent directly to the venue (not via our logistic agent AKA Hermes) will not be under COMTECMED s responsibility. We are not liable if the shipment does not arrive due to costumes clearness issues or any other delays that might occur. 15

The 6 th Asia Pacific Congress on Controversies in Gynecology, Infertility & Ultrasound www.cogi.org/vietnam cogi@comtecmed.com