Peripheral Vascular Disease

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Peripheral artery disease (PAD) results from the buildup of plaque (atherosclerosis) in the arteries of the legs. For people with PAD, symptoms may be mild, requiring no treatment except modification of lifestyle (smoking cessation, diet modification, increased exercise, medications as indicated). In some people, the blockages may become more extensive with accompanying pain and disability that limits walking. In the most advanced cases, individuals may be at risk for loss of limbs unless circulation is improved. For these patients with severe PAD, attempts to improve blood flow in the leg are usually indicated. The goals of improving blood flow to the limbs are to reduce pain, improve functional ability and quality of life, and prevent amputation. Lower Extremity Percutaneous Interventional Procedures (N = 393) s team of vascular surgeons and interventional cardiologists performs a high volume of complex percutaneous peripheral vascular interventional procedures. 15 Angioplasty 196 Atherectomy Stenting 19 Thrombolysis Total 393 Lower Extremity Interventional Procedures, In-Hospital Overall Mortality (N = 393) 15 Lower Extremity Interventional Procedures, In-Hospital Mortality by Procedure (N = 393) 15 5 5 3 3 1 Mortality 1 Angioplasty % Atherectomy Stenting Thrombolysis Source: Data from the Vizient Clinical Data Base/Resource Manager used by permission of Vizient. All rights reserved. 6 Outcomes 15

Lower Extremity Surgery and 3-Day Mortality (N = 9) A total of 9 lower extremity surgical procedures were performed at in 15. Mortality rates were lower than expected. Lower Extremity Surgery Overall 3-Day Mortality 15 5 3 1 Mortality Source: Data from the Vizient Clinical Data Base/Resource Manager used by permission of Vizient. All rights reserved. Lower Extremity Surgery 3-Day Mortality by Procedure 15 8 6 % Bypass Thrombectomy/ Endarterectomy Embolectomy N = 8 7 1 Femoral Artery Occlusion The common femoral arteries, especially on the right, and the iliac arteries are severely diseased Inflow patency is restored with common femoral endarterectomy and iliac intervention Sydell and Arnold Miller Family Heart & Vascular Institute 61

Executive Health Screening Program 11 15 1 8 6 11 1 13 1 15 N = 18 569 99 736 697 The Executive Health Screening Program is designed to identify any potential peripheral vascular disorders that can affect a patient s health and well-being. The exam can identify problems such as carotid artery stenosis, which is a risk factor for stroke; peripheral artery disease, which can indicate an increased risk of heart attack and stroke and impair function and quality of life; and abdominal aortic aneurysm (AAA). A ruptured AAA is almost entirely preventable if it is identified and the patient is monitored; however, about 15, people die each year in the US due to ruptured AAAs. Noninvasive Vascular Lab Ultrasound Study and Distribution (N = 5,68) 15 The Noninvasive Vascular Laboratory provides service 7 days a week to diagnose arterial and venous disorders throughout the vascular tree and for follow-up after revascularization procedures, such as bypass grafts and stents. In 15, the staff performed 5,68 vascular lab ultrasound studies at s main campus and throughout the greater Cleveland region. All vascular lab technologists are certified registered vascular technologists, which exemplifies s commitment to quality patient care. % arterial duplex (N = 1,716) 51% arterial duplex (N = 919) 1% 1% venous duplex (N = 1,91) 1% 7% venous duplex (N = 51) 19% physiologic testing (N = 613) % physiologic testing (N = 95) s Main Campus (N = 31,65) Greater Cleveland Region (N = 18,618) 6 Outcomes 15

Fibromuscular Dysplasia Fibromuscular dysplasia (FMD) is a vascular condition in which there is abnormal cell growth in the walls of medium and large arteries. This can cause the arteries to become narrowed (stenosis) and can also lead to aneurysm and dissection. s FMD program is dedicated to caring for and educating patients with FMD. It conducts research to better understand the condition and treatment options. Fibromuscular Dysplasia, 11 15 6 11 1 13 1 15 N = 31 317 17 5 56 Thrombosis Center s Thrombosis Center was established in 9. It includes a multidisciplinary group of specialists in vascular medicine, vascular surgery, adult and pediatric care, hematology, interventional radiology, cardiology, cardiac surgery, and laboratory medicine. The group works together to provide the best possible treatment to patients with deep vein thrombosis, pulmonary embolism, and hypercoagulable states. Sydell and Arnold Miller Family Heart & Vascular Institute 63

Lower Extremity Wound Clinic 11 15 15 1 5 11 1 13 1 15 N = 1381 1397 179 17 1877 A total of 1877 patients received treatment in the Lower Extremity Wound Clinic at in 15. Iliac Stenting physicians performed 18 iliac stent procedures in 15. The use of stents to treat patients with iliac occlusive disease is associated with excellent outcomes that include restored blood flow and minimal complications. Iliac Stenting 11 15 15 1 5 11 1 13 1 15 N = 13 18 13 135 18 6 Outcomes 15

Iliac Stenting, In-Hospital Mortality Rate 1 15 6 1 15 N = 135 18 Source: Data from the Vizient Clinical Data Base/Resource Manager used by permission of Vizient. All rights reserved. Femoral Endarterectomy With Stenting, In-Hospital Mortality 1 15 In 15, performed 1 femoral endarterectomy procedures with stenting. This hybrid procedure is used in place of an aortic femoral bypass for patients with complex aortoiliac occlusive disease. Femoral Endarterectomy With Stenting for Treatment of Aortic Occlusion 6 Before % 1 15 N = 1 1 Source: Data from the Vizient Clinical Data Base/Resource Manager used by permission of Vizient. All rights reserved. After Sydell and Arnold Miller Family Heart & Vascular Institute 65

Angioplasty 1 15 15 1 1 13 1 15 15 1 1 13 1 15 5 5 Tibial Angioplasty Femoral-Popliteal Angioplasty N = 69 55 7 69 117 135 13 N = All Angioplasties 111 186 19 177 Lower extremity angioplasty offers a minimally invasive alternative to treat patients with severe claudication and limbthreatening ischemia. physicians performed 7 tibial and 13 femoral-popliteal angioplasty procedures in 15. Tibial Bypass 11 15 8 Vein Prosthetic 6 11 1 13 1 15 N = 66 71 78 7 8 Veins are the preferred conduit for treating patients with limb-threatening ischemia, but when unavailable, a prosthetic graft is used. Typically offered when endovascular options are not durable, vein bypasses are preferred for younger, lower-risk patients. 66 Outcomes 15