(Inscrito na Ordem dos Médicos com a Cédula Profissional n.º 34040/7337)

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Eduardo José Silva (Inscrito na Ordem dos Médicos com a Cédula Profissional n.º 34040/7337) Eduardo José Gil Duarte Silva, MD, PhD, FEBO Work Address Serviço de Oftalmologia, Hospital Santa Maria Centro Hospitalar Lisboa Norte e Centro Cirúrgico de Coimbra Email esilva2579@hotmail.com eduardo_silva@ccci.pt Websites Linkedin: Eduardo Silva ResearchGate: Eduardo D Silva Academic Qualifications Professional Activity 1990 Degree in Medicine, University of Coimbra, Portugal (Best Student) 1991-92 General Internship, Hospitals of the University of Coimbra (CHUC), Portugal 1993-97 Complementary Internship in Ophthalmology, CHUC (Classification 19,4 / 20) 1994 - Jun/Jul Trainee in the Department of Medical Genetics, Academisch Ziekenhuis Groningen, The Netherlands 1997-98/1999-00 Clinical Fellowship in Hereditary Eye Diseases: The Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore MD, USA. Director of Fellowship: Irene Maumenee, MD 1997-01 Fellowship for Research in Ocular Development and Molecular Biology, The Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore MD, USA. Research Advisor: Olof H. Sundin, PhD 1998-99 Clinical Fellowship in Pediatric Ophthalmology and Strabismus, The Wilmer Eye Institute, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Director of Fellowship: David L.Guyton, MD 2000-08 Coordinator of the Genetics Module. PhD Program, Faculty of Medicine, University of Valladolid, Spain 2000 Ago./ 2014 Sep. Assistant Graduate in Ophthalmology, Hospitals of the University of Coimbra. Portugal 2002 Jan. 2014 Sep. Responsible for the Center for

Excellence in Ocular Hereditary Diseases. Hospitals of the University of Coimbra 2003 Jun./ 2006 Jun. Consultant for Ocular Genetics and Pediatric Ophthalmology, Instituto OftalmoBiologia Aplicada (IOBA) 2006 Mar./ 2014 Feb. Responsible for the Sector of Pediatric Ophthalmology and Strabismus, Hospitals of the University of Coimbra 2011-17 Invited Professor Master's Program - Doctorate in Sight Sciences, Faculty of Medicine of Valencia, Spain Sept.2016 Present Date Private medical practice (Consultant): Pediatric Ophthalmology / Pediatric Neurophthalmology / Genetics, Instituto de Olhos Carioca, Rio de Janeiro, Brazil 2014 Dec. Present date Responsible for Strabismus Sector - Santa Maria Hospital, Lisbon North Hospital Center, Lisbon 2004 Oct. 2017 Mar. Assistant Professor of Ophthalmology, Faculty of Medicine, University of Coimbra 2004 Oct./2016 Jul. Ophthalmologist of the Central Nucleus of the Central Cerebral Palsy Association (APCC) 2012-17 Guest Professor of the Basic Course of Ophthalmology, UNIFESP, São Paulo, Brazil May 2015 FEBO (Fellow European Board of Ophthalmology), Paris 2001 Present Date Private medical practice: Pediatric Ophthalmology / Strabismus / Pediatric Neurophthalmology / Genetics, Coimbra Surgical Center, Coimbra. May 2016 Present Date Private medical practice: Pediatric Ophthalmology / Strabismus / Pediatric Neurophthalmology / Genetics, Hospital Lusíadas, Lisbon 2011 Jul. Present Date Chief Medical Advisor (CMA): Start up Genomics, Coimbra Genomics Additional Activities 2003 Sep. Speakers Bureau (improvement of presentation skills), Dublin 2004-05 Portuguese Representative in the Leadership Development Program PAAO, San Francisco, CA, USA 2004-08 Portuguese Representative in the Consortium of the European Union EVI-GENORET: Functional Genomics of the retina in health and disease. 2005-06 Instructor in the Leadership Development Program PAAO, San Francisco, CA, USA 2003-04 2009-10 Coordinator of the Portuguese Group of Pediatric Ophthalmology and Strabismus of the Portuguese Society of Ophthalmology 2007 Sep. Present Date President of the Scientific Council of

the Retinopathy Association of Portugal (ARP) 2010 Sep. Present Date Co-chair of the TAG for WHO / ICO Task Force for ICD-11 - Pediatric Ophthalmology and Strabismus 2011-12 Member of the Central Commission of the Portuguese Society of Ophthalmology Representative of the SPO - Pan American Association of Ophthalmology (PAAO). Member of the Scientific Board of Orphanet Portugal. 2012 Member of the Board World Society of Pediatric Ophthalmology and Strabismus (WSPOS) 2012-17 Member European Board of Ophthalmology (EBO) - external examiner 2013-14 Vice-President of SPO (Biennium) 2013-16 Board Member of the Scientific and Research Committee of the World Society of Pediatric Ophthalmology and Strabismus (WSPOS) 2015 Mar. Present Date Member POWER (Pediatric Ophthalmology World Education Resource) Center Genetics Steering Group, American Academy of Ophthalmology (AAO) Research Activity Molecular Genetics of Hereditary Eye Diseases. Ocular Developmental Genetics (transcription factors). Principal Investigator: PIC / IC / 83155/2007; Title: Mechanisms of Neurosensory Inhibition associated with cognitive deficits in Neurofibromatosis type I: psychophysics, neurophysiology, and structural and functional neuroimaging. Project PTDC / SAL-NEU / 68483/2006; Title: Processing of visual information in retinocortical pathways, in normal and pathological aging, and in neurodevelopment models. ERARE Project 2009 (European Research Projects on Rare Diseases): Title: Comprehensive analysis of cone-rod degeneration associated with rhodopsin mutations (funded by FCT - Principal Investigator). Project erare4 / 0001/2012 -EUR-USH: European Young Investigators Network for Usher syndrome (funded by FCT - Principal Investigator). Project PTDC / DTP-EPI / 0929/2012 - Translational bigenomic investigation in Leber Optic Neuropathy (LHON). Genotype-phenotype correlation. Duration 01/04/13-31 / 03/2015. Investigator. (PI Manuela Grazina) Awards Pfizer Clinical Research Award 2005.

Quantitative phenotyping of Stargardt photoreceptor degeneration shows that mutation patterns in ABCR gene can induce distinct functional profiles even in apparently normal individuals (Honorable Mention). Pfizer Clinical Research Award 2006. Novel retinal mechanisms underlying genetically determined neural dysfunction in Williams Beuren syndrome. CGC Award Professor Doctor Amândio Tavares 2008. 2nd place: Genetic research applied to retinal degenerative diseases Member of the Editorial Board Vision Pan American Orphanet Journal of Rare Diseases (Pediatric Ophthalmology - chief Editor 2013-15) Ad hoc reviewer of Scientific Journals Molecular Vision Ophthalmic Genetics Australian and New Zealand Journal of Ophthalmology British Journal of Ophthalmology Investigative Ophthalmology and Visual Sciences Ophthalmologica Human Mutation Ophthalmology (SPO Magazine) Orphanet Journal of Rare Diseases Human Gene Therapy Vision PanAmerican Brazilian Archives of Ophthalmology Member of the Editorial Board Vision Pan American Orphanet Journal of Rare Diseases (Pediatric Ophthalmology - chief Editor 2013-15) Ad hoc reviewer of Scientific Journals Molecular Vision Ophthalmic Genetics Australian and New Zealand Journal of Ophthalmology British Journal of Ophthalmology Investigative Ophthalmology and Visual Sciences Ophthalmologica Human Mutation

Ophthalmology (SPO Magazine) Orphanet Journal of Rare Diseases Human Gene Therapy Vision PanAmerican Brazilian Archives of Ophthalmology International Reviewer of Projects and Scholarships Fight for Sight Foundation (UK) Foundation Fighting Blindness (UK) Fondation Voir et Entendre (France) Flanders Research Foundation (FWO) (Belgium) ORIA Advancing Eye Research in Australia (Australia) Scientific Societies Portuguese Society of Ophthalmology (SPO) American Academy of Ophthalmology (AAO) European Pediatric Ophthalmology Society (EPOS) ARVO World Society Pediatric Ophthalmology and Strabismus (WSPOS) American Association of Pediatric Ophthalmology and Strabismus (AAPOS) Portuguese Society of Human Genetics (SPGH) Others Languages Published Articles 92 Book Chapter s 20 Master s and PhD Thesis Advisor 31 PhD Thesis Reviewer and Jury 7 Languages Portuguese Native Language English Excellent writing and conversation level Proficiency in English British Council. French Excellent writing and conversation level Alliance Française Diplome d'études Supérieures Spanish Excellent writing and conversation level German Good writing level and conversation Italian Good writing level and conversation Dutch Basic level of writing and conversation