CARDIOVASCULAR DISEASE UPDATE

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11TH ANNUAL CARDIOVASCULAR DISEASE UPDATE CONTINUING MEDICAL EDUCATION New case and imaging-based format! WEDNESDAY, OCTOBER 4, 2017 4:30 6 p.m. Registration and Reception Innovations in Health Care Exhibit from Cleveland Institute of Art 6 9:20 p.m. Dinner and CME Presentations Landerhaven 6111 Landerhaven Drive Mayfield Heights, Ohio 44124 PRESENTED BY: SPONSORED BY:

Physician Liaison Program Our team is dedicated to working with physicians and their staff to develop and maintain lasting relationships with University Hospitals. Connect physicians with our specialty services, including advanced medical and surgical care Facilitate personal meetings with University Hospitals specialists Arrange speakers for CME events, tumor boards, grand rounds and symposiums Bring CME to area practices through our Regional Rounds CME Program 216-286-9024 UHhospitals.org/PhysicianOutreach Download the University Hospitals Physician Directory App

OnDemand Grand Rounds and Continuing Medical Education Available online at UHDoctor.org/CVCME Free CME accessible anytime, anywhere Broad topic coverage in cardiovascular medicine and surgery Nationally and internationally renowned experts View annual Cardiovascular Disease Update and Vascular Disease Update courses These Activities have been approved for AMA PRA Category 1 Credit Presented by: Sponsored by:

11TH ANNUAL CARDIOVASCULAR DISEASE UPDATE CID 2611 REGISTRATION FORM TUITION AND FEES $50.00 Conference tuition includes all educational sessions, materials and dinner. Parking is free. WAYS TO REGISTER 1. Register online at http://case.edu/medicine/cme 2. Mail this registration with payment to: Registrar, CME Program 10524 Euclid Avenue Cleveland, Ohio 44106-6026 3. Fax this form with your credit card number to 216-844-8133 4. Call 216-983-1239 or 1-800-274-8263 with the information requested below and your credit card number Name Degree Social Security number (last 4 digits) Business phone Mailing address City State ZIP Email METHOD OF PAYMENT q Enclosed is my check payable to q Visa q MasterCard q Discover Card Card number Expiration date Security code on back Amount paid Authorized signature QUESTIONS? Contact the CME Program at 216-983-1239 or 1-800-274-8263. 2017 University Hospitals CME 625385

OVERVIEW Featuring specialists with University Hospitals Harrington Heart & Vascular Institute, this course takes a closer look at current topics in cardiovascular medicine and surgery, including new guidelines, clinical trials and the latest research findings and discoveries. Our experts examine the potential benefits and risks of these developments, and explore how they might impact patient care. 216-844-3800 UHhospitals.org/Heart LEARNING OBJECTIVES Review indications for common structural interventions and when to refer patients Define complications with transcatheter aortic valve replacement (TAVR) and follow-up care Review new therapies to lower risk in the diabetic patient with peripheral artery disease (PAD) Explain the impact and longevity of new therapies for critical limb ischemia (CLI) Describe advanced imaging options for evaluation of heart failure patients Discuss indications for mechanical therapies, including durability and efficacy, for heart failure WHO SHOULD ATTEND This conference is intended to update practicing internists, family medicine physicians, primary care physicians, cardiologists, cardiac surgeons, endocrinologists, podiatrists, vascular surgeons, physician assistants, nurse practitioners, nurses, residents and fellows on current topics in cardiovascular disease. ACCREDITATION STATEMENT is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. designates this live activity for a maximum of 3.0 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. POLICY DISCLOSURE The policy of CME Program requires that the Activity Director, planning committee members and all activity faculty (that is, anyone in a position to control the content of the education activity) disclose to the activity participants all relevant financial relationships with commercial interests. Disclosure will be made to activity participants prior to the commencement of the activity. Case Western Reserve University CME Program also requires that faculty make clinical recommendations based on the best available scientific evidence and that faculty identify any discussion of off-label or investigational use of pharmaceutical products or medical devices.

PROGRAM AGENDA 4:30 6 p.m. Registration and Reception 6 6:05 p.m. Welcome Innovations in Health Care: Cleveland Institute of Art 6:05 6:45 p.m. TRACK ONE: Restoring Structural Heart Function Moderator: Guilherme Attizzani, MD 6:05 6:15 p.m. Case Presentation Jun Li, MD 6:15 6:25 p.m. Recent Advances in Percutaneous Mitral Valve Intervention Ankur Kalra, MD 6:25 6:35 p.m. Left Atrial Appendage Occlusion: Who, When, How and Results Hiram Bezerra, MD, PhD 6:35 6:45 p.m. Audience Polling Question and Panel Discussion Panel: Yakov Elgudin, MD, PhD; Sri Krishna Madan Mohan, MD; Basar Sareyyupoglu, MD 6:45 7:50 p.m. TRACK TWO: Making a Difference for Patients with PAD Moderator: Mehdi Shishehbor, DO, PhD 6:45 6:55 p.m. Case Presentation Mehdi Shishehbor, DO, PhD 6:55 7:20 p.m. Evolving Challenges in Type 2 DM Management Guest Speaker: Michael Farkouh, MD 7:20 7:30 p.m. The ABCs of PAD and CLI in Type 2 DM Mehdi Shishehbor, DO, PhD 7:30 7:40 p.m. High-Risk Patient with Type 2 DM: New Evidence and Goals for Lipid Lowering Claire Sullivan, MD 7:40 7:50 p.m. Audience Polling Question and Panel Discussion Panel: Barry Effron, MD; Vikram Kashyap, MD; George Topalsky, MD 7:50 8:05 p.m. Break

8:05 8:50 p.m. TRACK THREE: Managing Heart Failure and Preventing Sudden Cardiac Death Moderator: Guilherme Oliveira, MD 8:05 8:10 p.m. Case Presentation Michael Zacharias, DO 8:10 8:20 p.m. Advanced Imaging as a Diagnostic and Prognostic Tool in Heart Failure Sanjay Rajagopalan, MD 8:20 8:30 p.m. How to Evaluate Advanced Heart Failure Patients with Continuing Symptoms for Destination Therapies Chantal ElAmm, MD 8:30 8:40 p.m. Mechanical Assist Devices for the Heart Failure Patient with Limited Options Benjamin Medalion, MD 8:40 8:50 p.m. Audience Polling Question and Panel Discussion Panel: Rodolfo Benatti, MD; Judith Mackall, MD; Dina Sparano, MD; Arthur Ulatowski, DO 8:50 9:20 p.m. PLENARY SESSION Moderator: Soon Park, MD 8:50 9:10 p.m. State-of-the-Art Surgical Coronary Revascularization Joseph Sabik, MD 9:10 9:15 p.m. Discussion 9:15 9:20 p.m. Wrap-Up and Departure This program will be supported by grants from industry. A complete list of supporters will be provided in the syllabus materials distributed at the meeting. Acceptance of funding in support of this program does not constitute endorsement of any product or manufacturer.

ACTIVITY DIRECTOR: Sanjay Rajagopalan, MD Chief, Division of Cardiovascular Medicine, Co-Chair, Clinical Executive Committee, Herman K. Hellerstein, MD, Chair in Cardiovascular Research Director, Case Cardiovascular Research Institute Professor of Medicine, PLANNING COMMITTEE: Marco Costa, MD, PhD, MBA Chief Innovation Officer, University Hospitals President, UH Harrington Heart & Vascular Institute Angela and James Hambrick Master Clinician in Innovation Professor of Medicine, GUEST SPEAKER: Michael Farkouh, MD Professor and Vice-Chair, Research, Department of Medicine, University of Toronto Peter Munk Chair in Multinational Clinical Trials, Peter Munk Cardiac Centre Director, Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research SPEAKERS AND PANELISTS: Guilherme Attizzani, MD Co-Director, Valve & Structural Heart Disease Center, Co-Director, Cardiovascular Imaging Core Laboratory, John C. Haugh Valve Fellow Rodolfo Benatti, MD Clinical Hiram Bezerra, MD, PhD Co-Director, Cardiovascular CT and MRI Center, and Co-Director, Coronary Clinic, UH Harrington Heart & Vascular Institute Co-Director, Cardiovascular Imaging Core Laboratory, Associate Professor of Medicine, Barry Effron, MD Director, Evaluation & Prevention Center, Figgie Family Clinical Chair for Cardiovascular Excellence Associate Professor of Medicine, Chantal ElAmm, MD Yakov Elgudin, MD, PhD Co-Director, Aortic Center, and Co-Director, Coronary Clinic, Assistant Professor of Surgery, Ankur Kalra, MD Vikram Kashyap, MD Chief, Division of Vascular Surgery and Endovascular Therapy, Co-Chair, Clinical Executive Committee, and Co-Director, Vascular Center, Alan H. Markowitz, MD, Master Clinician for Cardiac and Vascular Surgery Professor of Surgery, Case Western Reserve University

Jun Li, MD Advanced Interventional Cardiology Fellow, Judith Mackall, MD Director, Center for Cardiovascular Genetics, Irving B. and Virginia Spitz Master Clinician in Cardiology Associate Professor of Medicine, Sri Krishna Madan Mohan, MD Chief Quality Officer, Benjamin Medalion, MD Director, Mechanical Circulatory Assistance, Clinical Associate Professor of Surgery, Guilherme Oliveira, MD Director, Advanced Heart Failure & Transplant Center, and Director, Cardio-Oncology Program, Lorraine and Bill Dodero Master Clinician in Heart Failure and Transplantation Clinical Associate Professor of Medicine, Soon Park, MD Co-Chair, Clinical Executive Committee, Chief, Division of Cardiac Surgery, Jay C. Akeney, MD, Chair in Cardiothoracic Surgery Professor of Surgery, Joseph Sabik, MD Chair, Department of Surgery, Surgeon-in-Chief, and Vice President, Surgical Operations, University Hospitals Professor of Surgery, Case Western Reserve University Basar Sareyyupoglu, MD Clinical Associate Professor of Surgery, Mehdi Shishehbor, DO, MPH, PhD Director, Interventional Cardiovascular Center, and Co-Director, Vascular Center, Dina Sparano, MD Associate Program Director, Electrophysiology, Clinical Claire Sullivan, MD Clinical George Topalsky, MD Vice President, Primary Care Institute, University Hospitals Clinical Instructor of Medicine, Arthur Ulatowski, DO Clinical Michael Zacharias, DO