5th Pediatric Bone Health Symposium

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Presented by Department of Orthopaedic Surgery University of California, San Francisco School of Medicine 5th Pediatric Bone Health Symposium Hyatt Regency San Francisco 5 Embarcadero San Francisco, CA THURSDAY March 2, 2017 COURSE CO-CHAIRS Aenor J. Sawyer, MD, MS Director UCSF Skeletal Health Service Assistant Clinical Professor, Department Orthopaedic Surgery, UCSF Laura K. Bachrach, MD Professor of Pediatric Ellen B. Fung, PhD, RD, CCD Director Bone Density Clinic Associate Scientist UCSF Benioff Children's Hospital Oakland

5th Pediatric Bone Health Symposium The 5th Pediatric Bone Health Symposium will summarize recent findings on the following topics: Advances in knowledge about the acquisition of peak bone strength including the genetic and modifiable correlates of optimal bone health Guidelines for optimal interpretation of bone densitometry in children and teens Diagnostic criteria for pediatric osteoporosis underscoring the increased emphasis on fragility fractures Genetic determinants of primary osteoporosis (bone fragility) Prevalence, risk factors and treatment of secondary osteoporosis in chronic disease TARGET AUDIENCE The target audience includes general pediatricians as well as subspecialists in the areas of genetics, orthopedics, endocrinology, gastroenterology, rheumatology, neurology, nephrology, radiology and hematology/oncology who engage in clinical care and clinical research. The goals are to encourage optimization of bone health in all youth, increase awareness of risk factors for bone fragility and increase screening for fragility fractures including asymptomatic vertebral fractures. OBJECTIVES An attendee completing this course will be able to: Describe the contribution of genetics, diet, activity, and hormones to peak bone strength Identify children who are at greatest risk for bone fragility Articulate the value and limitations of bone density tests Discuss the current controversies surrounding the use of pharmacologic agents to treat osteoporosis in children and teens Hyatt Regency San Francisco San Francisco, California ACCREDITATION The University of California, San Francisco School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this live activity for a maximum of 7.25 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. March 2, 2017

5th Pediatric Bone Health Symposium Hyatt Regency San Francisco San Francisco, California 94111 Thursday, March 2, 2017 8:00 am Registration and Continental Breakfast 8:30 Welcome & Introduction Aenor Sawyer, Ellen Fung 8:40 Insights on Bone Acquisition & Importance Babette Zemel of Peak Bone Strength 9:30 The Window of Opportunity Updates on the Bonny Specker Influence of Exercise and Nutrition in Childhood 10:10 Break 10:30 Fragility Fractures & Chronic Illness in Pediatrics Leanne Ward 11:10 Cornerstones & Controversies: Perspectives Laura Bachrach from the Frontlines 11:30 Panel: Pediatric Bone Health at a Population Level: Are we gaining? Moderator: Laura Bachrach Panel: Leanne Ward, Bonny Specker, Babette Zemel 12:00 pm Lunch (provided) 12:30 Lunch Seminar: Bone Densiometry Kyla Kent in Growing Patients Practical Points 1:00 It is in the Genes: Diagnosis and Treatment of Frank Rauch Heritable Bone Fragility 1:40 Non-Imaging Diagnostics: Controversies Moderator: Leanne Ward Panel: Frank Rauch, Roger Long 2:10 Imaging: Updates on Current Methods Thomas Link 2:30 Future Directions in Bone Health Imaging: New Insights, Fewer Artifacts Moderator: Ellen Fung Panel: John Shepherd, Sharmila Majumdar 3:00 Break 3:15 Basic Science Breakthroughs: Part 1 Tamara Alliston 3:30 Basic Science Breakthroughs: Part 2 Ralph Marcucio 3:45 New Strategies for X-linked Hypophosphatemia Anthony Portale 4:00 Diabetes and Bone Moderator: Laura Bachrach Speakers: Roger Long, Hilary Seeley 4:30 Precision Medicine in Pediatric Bone Health: Are we gaining? Moderator: Aenor Sawyer Panel: Edward Hsiao, Frank Rauch, Farzana Perwad 5:00 pm Closing Remarks & Adjournment Aenor Sawyer, Ellen Fung Frank Rauch, MD Bonny L. Specker, PhD Leanne M. Ward MD, FAAP, FRCPC Babette S. Zemel, PhD

faculty COURSE DIRECTORS Aenor J. Sawyer, MD, MS Director UCSF Skeletal Health Service Assistant Clinical Professor, Department Orthopaedic Surgery, UCSF San Francisco, CA Laura K. Bachrach, MD Professor of Pediatrics Stanford, CA Ellen B. Fung, PhD, RD, CCD Director, Bone Density Clinic Associate Scientist UCSF Benioff Children s Hospital Oakland Oakland, CA COURSE FACULTY KEYNOTE FACULTY Frank Rauch, MD Professor of Pediatrics, McGill University Shriners Hospital for Children Montreal, Canada Bonny L. Specker, PhD Director and Chair of the Ethel Austin Martin (EAM) Program in Human Nutrition South Dakota State University Brookings, South Dakota Leanne M. Ward, MD, FAAP, FRCPC and Metabolism Department of Pediatrics Children s Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON Canada Babette S. Zemel, PhD Associate Program Director, CTRC Director, Bionutrition Core Laboratory, Research Professor of Pediatrics, University of Pennsylvania School of Medicine Adjunct Assistant Professor of Nursing, University of Pennsylvania School of Nursing LOCAL FACULTY Tamara Alliston, PhD Associate Professor Department of Orthopedic Surgery Edward Hsiao, MD, PhD Associate Professor, Department of Medicine Kyla Kent, MS, CBDT Technical Director SAMBA Center Thomas Link, MD, PhD Professor, Department of Radiology Roger Long, MD Associate Clinical Professor of Pediatrics Sharmila Majumdar, PhD Professor, Department of Radiology Ralph Marcucio, MD Professor Department of Orthopedic Surgery Farzana Perwad, MD Division of Pediatric Nephrology Anthony A. Portale, MD Professor in Residence, Pediatrics Chief, Division of Pediatric Nephrology Medical Director, Pediatric Renal Transplant Program; Program Director, Pediatric Nephrology; Fellowship Training Program Hilary Seeley, MD Department of Pediatrics John A. Shepherd, PhD, CCD Professor Radiology and Biomedical Imaging, UCSF; President International Society Clinical Densitometry; Director UCSF Body Composition, Exercise Physiology and Energy Metabolism Laboratory

0569 University of California, San Francisco Office of CME UCSF Box 0742 San Francisco, CA 94143-0742 E Printed on Recycled Paper For more information or to register online visit our website at cme.ucsf.edu ou may also reach us by calling the Office of CME at (415) 476-4251 or emailing info@ocme.ucsf.edu. Cover photo courtesy of Daneen Akers 2017 Bone image: Claire Acevedo 2016 GENERAL INFORMATION Advanced registration will close (1) business day prior to start of course. Onsite registration fees will be applied after this date. HOW TO ENROLL Registration Fees are as follows Early Bird By 2/16/2017 $100 Physicians $100 Allied Health Professionals $50 Residents/Fellows Regular Fee After 2/16/2017 $150 Physicians $150 Allied Health Professionals $50 Residents/Fellows On Site Fee $150 Physicians $150 Allied Health Professionals $50 Residents/Fellows All meals included Printed Syllabus Included general info Payment can be made by Visa, MasterCard, American Express or check. Online: cme.ucsf.edu Mail: Complete course registration form and send with payment to: UCSF Office of Continuing Medical Education P.O. Box 45368 San Francisco, CA 94145-0368 Fax: Completed registration form with credit card number to: (415) 502-1795 Phone: To register by phone or to inquire about registration status, please call UCSF s CME Registration Office at (415) 476-5808. «On-Site Registration: We will accept on-site registration but credit cards will not be accepted. Enrollment at this course is limited, so early registration is recommended to ensure attendance. REFUND POLICY Cancellations received in writing before 2/16/2017, will be refunded, less a 25% administrative fee. No refunds will be made on cancellations received after that date. CONFERENCE LOCATION Enjoy San Francisco s renowned attractions such as the historic cable cars, shopping in Union Square, or visit San Francisco s culinary hub at the Ferry Building. Hyatt Regency San Francisco is just steps from Ferry Building and Embarcadero Shopping District. 5 Embarcadero Center, San Francisco, CA

cme.ucsf.edu 5th Pediatric Bone Health Symposium March 2, 2017 Hyatt Regency San Francisco San Francisco, CA 94111 Mail to : UCSF Office of CME P.O. Box 45368 San Francisco, CA 94145-0368 Fax: (415) 502-1795 Registration Information: (415) 476-5808 Course Information: (415) 476-4251 Course Listings: cme.ucsf.edu MMC17033 æ Dr. æ Ms. æ Mr. æ Mrs. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Email Address Label Code (see address label: example, A, B, C, D, etc.) Would you like to be on our priority email list? Yes No Date of birth to be used as OCME registrant number: / / X X Month Day Please indicate if you have any special needs: REGISTRATION FEES Early Bird By 2/16/2017 $100 Physicians $100 Allied Health Professionals $50 Residents/Fellows Regular Fee After 2/16/2017 $150 Physicians $150 Allied Health Professionals $50 Residents/Fellows Please confirm below so we may plan for the appropriate number of people: I will attend lunch (included in tuition) I will not attend Make checks payable to UC Regents Please charge my credit card: Visa MasterCard American Express for $ / Card # Expiration date Name on Card (Please Print) Authorized Signature Refund Policy: Cancellations received in writing before 2/16/2017 will be refunded, less 25% administrative fee. No refunds will be made on cancellations received after that date. Please check our website for up to date information on the course: ON-SITE REGISTRATION Time: 7:30 am Date: Thursday, March 2, 2017 Place: Hyatt Regency San Francisco 5 Embarcadero San Francisco, CA 94111 SSIAN HILL Leavenworth St able Car Line Hyde St Jones St NOB HILL SCO Leavenworth St Landmarks Taylor St Mason St Neighborhoods Points of Interest Parks Cable Car Lines GRACE CATHEDRAL MASONIC AUDITORIUM Jones St Taylor St Powell St Mason St Powell St BEACH Grant Av Stockton St Stockton St Kearny St Columbus Av Grant Av Pine St Bush St Post St Geary St Montgomery St Montgomery St TRANSAMERICA PYRAMID BLDG. CHINATOWN UNION SQUARE PORTSMOUTH SQUARE BANK OF AMERICA BLDG. FINANCIAL DISTRICT Kearny St CROCKER GALLERIA Vallejo St ont St Broadway Pacific St Jackson St Washington St Clay St Sansome St New Montgomery S Sacramento St California St Battery St 2nd St Davis St WALTON PARK GOLDEN GATE UNIV. MONTGOMERY ST. STATION 1st St Drumm St TRANSBAY TERMINAL BROADWAY PIER (Pedestrian) Hyatt Regency San Francisco Market St Fremont St JUSTIN HERMAN PLAZA Mission St Beale St RINCON CENTER Main St WORLD TRADE CTR. The Embarcadero EMBARCADERO STATION Spear St Howard St FERRY BUILDING Steuart St Folsom St