ISBT 128 Standard Terminology for Medical Products of Human Origin - Version Control Sheet Version 7.13 April 6, 2018 Section Change Rationale

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Version 7.13 April 6, 2018 1. 3.1.2 2. 4.1.1 3. 4.1.2 4. 4.1.3 5. 4.1.3 6. 4.1.3 Added New Class: MNC, CORD BLOOD Added New Classes: ARTERY ARTERY, AXILLARY-BRACHIAL ARTERY, CAROTID VEIN Added New Classes: TENDON, BICEPS WITH RADIUS TENDON, FLEXOR CARPI RADIALIS TENDON, PATELLAR WITH TIBIA AND MENISCI TENDON, PATELLAR, BISECTED WITH BONE BLOCK AND QUAD TENDON, TRICEPS WITH ULNA Added New Class: BONE, STAPES Added New Class: GLENOID WITH LABRUM Added New Classes: ACETABULUM WITH LABRUM BONE, CALCANEUS BONE, METATARSUS BONE, PHALANX, FINGER BONE, PHALANX, TOE BONE, TALUS WRIST Singapore Spain Spain Belgium Poland Spain Version 7.12 March 2, 2018 1. 10.2 10.2.1.2 Added New Attribute Group: Cryoprotectant Page 1 of 6

Version 7.12 March 2, 2018 2. 10.2.1.1 3. 10.2.1.2 4. 10.2.1.1 14.6 14.6.1.1 Added New Attribute Variable: Cryopreserved Added New Attribute Variables: None or not specified Glycerol Retired the following Attribute Variable: Frozen Version 7.11 February 1, 2018 1. 2.3.2.2.6 2. 2.3.2.2.11 3. 2.3.2.2.13 4. 14.1.3.2 Added new Attribute Variable: 800 milliliters Removed retired Attribute Variable: Solvent detergent-treated Added new Attribute Variables: Bacterial test day 5 Bacterial test day 6 Bacterial test day 7 Added Retired Attribute Variable: Solvent detergent-treated Australia Previously retired in ISBT 128 Code Database v4.34.0 Inadvertent omission. This attribute was added ISBT 128 Code Database v7.10.0 Previously retired in ISBT 128 Code Database v4.34.0 Page 2 of 6

1. 2.3.2.1 2. 3. 2.3.2.1 2.3.2.2.15 2.3.2.2.16 2.3.2.2 3.2.2.2 4. 3.2.2.1 Minor revisions to some of the Attribute Group names. Reordered the Antibody Specificity and Infection groups. Updated Attribute Group section headers to reflect appearance in ISBT 128 Product Description Minor revisions to some of the Attribute Group names. To provide exact consistency of the group names with To match the order of appearance in To provide exact consistency of the group names with To provide exact consistency of the group names with 5. 11.1 Updated definitions for the following Classes: EMBRYO OOCYTE TESTICULAR TISSUE 6. 11.2 Renamed Attribute Group and updated description: Collection/Recovery Method to Sperm Procurement Method To accommodate new Assisted terminology Page 3 of 6

7. 11.2 8. 11.2 9. 11.2.1.1 10. 11.2.1.1 11. 11.2.1.2 12. 11.2.1.2 13. 11.2.1.2 14. 11.2.1.3 Updated Attribute Group description: Type of Preservation Added New Attribute Groups: Oocyte Maturation Embryo Development Embryo Preservation Day Sperm Preparation Updated Attribute Variable Definition: Added New Attribute Variables: Cryopreserved by slow active freezing Cryopreserved by slow passive freezing Cryopreserved by vitrification Not cryopreserved Renamed Attribute Group: Collection/Recovery Method to Sperm Procurement Method Updated Attribute Variable Definitions: Ejaculated Added New Attribute Variables: Aspirated epididymal Aspirated testicular Biopsy testicular GV MI MII To accommodate new Assisted terminology To accommodate new Assisted terminology Page 4 of 6

15. 11.2.1.4 16. 11.2.1.5 17. 11.2.1.6 18. 14.6 19. 14.6.1 Blastocyst Cleavage stage Fertilized oocyte Morula Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Unwashed Washed Added New Retired Terminology section for obsolete Tissue terms. Added section for retired Attribute Groups: Donor-Intended Recipient Relationship Processing Status terminology were retired terminology were retired Page 5 of 6

20. 14.6.2.1 21. 14.6.2.2 22. 14.6.2.3 23. 14.6.2.4 Added section for Donor-Intended Recipient Relationship group. Retired the following Attribute Variables: Allogeneic Autologous Added section for Processing Status group. Retired the following Attribute Variables: Default: Not defined For further processing Added section for Type of Preservation Group. Retired the following Attribute Variable: Cryopreserved Added section for Sperm Procurement Group. Retired the following Attribute Variable: Extracted Page 6 of 6