Pathology I PATH 400 Course Description Pathology I is introduces students to an understanding of the alterations in cells and tissues in response to harmful stimuli. These acquired skills of general pathology including inflammation, ischemia, infarction and necrosis will be applied to specific organ systems. Credit: 6.0 credits Repeatable: No Course Structure The study of Pathology is to recognize the structural alterations in cells and the effects of these changes on cell and tissue functions and ultimately the effects on patient s health. The main goal for the Pathology faculty is to guide students to develop sound knowledge base on general concepts of disease process i.e., cause, pathogenesis, gross and microscopic changes in the tissues from the particular disorder and finally laboratory diagnosis and prognosis. Pathology is broadly divided into General Pathology and Systemic Pathology. In General Pathology, during term 3 students learn about the reactions of cell and tissues to abnormal stimuli and inherited defects. Systemic Pathology, during term 4, helps the students to understand changes in the specialized organs and tissues in relation to disorders. The main theme is to develop a friendly learning environment of active discussion, independent thinking and self-learning with the hope of developing and producing the most competent diagnostic consultants that can work effectively both as leaders and team members. Objectives 1. To provide students with the opportunity for detailed study of various aspects of pathology 2. To provide a stimulating and challenging learning environment where teaching is informed and enhanced by research 3. To provide training in scientific principals and experience in the evaluation and practice of research 4. To bridge knowledge and skills learned in basic sciences with clinical medicine Schedule: Available through the online calendar. Lecture topic schedule Each lecture is well-planned and researched. It is designed to introduce the topic meaningfully. Didactic lectures are supplemented by resourceful power point presentation and lively interactive sessions. A review is held at the end of every chapter. Students are welcome to clarify doubts during the lecture sessions. Lectures are available in student s drive.
Event Topic Week 1 1 PATH_1_01 Orientation on Path_1 Course 2 PATH_1_02 Chapter 1 : Cellular Adaptations 3 PATH_1_03 Causes & Mechanisms - Cell Injury 4 PATH_1_04 Necrosis 5 PATH_1_05 Apoptosis 6 PATH_1_06 Subcellular Responses & Cell Aging Week2 7 PATH_1_07 Chapter 2 : Inflammation - Introduction 8 PATH_1_08 Vascular Events of Acute Inflammation 9 PATH_1_09 Cellular Events of Acute Inflammation 10 PATH_1_10 Chemical Mediators 11 PATH_1_11 Morphology of Acute inflammation 12 PATH_1_12 Ch: Inflammation & Systemic Effects of Inflammation Week 3 13 PATH_1_13 Chapter 3: Tissue Repair 14 PATH_1_14 Stem Cells 15 PATH_1_15 Growth Factors 16 PATH_1_16 Healing by Regeneration 17 PATH_1_17 Healing by Scar Formation 18 PATH_1_18 Week 4 19 PATH_1_19 Fibrosis Cutaneous Wound Healing & Factors Influencing Wound Healing 20 PATH_1_20 Review: Chapter 1-3 21 PATH_1_21 Quiz -1: Chapters 1-4 22 PATH_1_22 23 PATH_1_23 Haemostasis 24 PATH_1_24 Thrombosis Week 5 25 PATH_1_25 Embolism 26 PATH_1_26 Infarction 27 PATH_1_27 Shock Chapter- 4: Homodynamic Disorders, Edema, and Haemorrhage 29 PATH_1_29 Mid 1 Exam: Chapters 1-4 & Nutrition Week 6 30 PATH_1_30 Post Mid 1 Exam Review 31 PATH_1_31 Chapter- 5: Genetic Disorders - Mendelian Disorders 1 32 PATH_1_32 Mendelian Disorders 2 33 PATH_1_33 Lysosomal Storage Disorders 34 PATH_1_34 Disorders of Multifactorial inheritance 35 PATH_1_35 Single Gene Disorders Week 7 36 PATH_1_36 Karyotyping & Cytogenetic Disorders 37 PATH_1_37 Molecular Diagnosis 38 PATH_1_38 Chapter 6: Diseases of Immunity, Innate & Adaptive 39 PATH_1_39 Cytokines 40 PATH_1_40 HLA, Hypersensitivity Reactions
41 PATH_1_41 Auto-Immune Diseases 1 Week8 42 PATH_1_42 Auto-Immune Diseases 2 43 PATH_1_43 Immunologic Deficiency Syndromes 44 PATH_1_44 Amyloidosis 45 PATH_1_45 Review Chapters 5&6 46 PATH_1_46 Quiz 2: Chapters 5&6 47 PATH_1_47 Chapter 7: Neoplasia Week9 48 PATH_1_48 Nomenclature 49 PATH_1_49 Epidemiology 50 PATH_1_50 Benign & Malignant Tumors 51 PATH_1_51 Molecular Basis of Cancer 52 PATH_1_52 Oncogenes 53 PATH_1_53 Biology of Tumor Growth Week10 54 PATH_1_54 Invasion & Metastasis 55 PATH_1_55 Carcinogens 56 PATH_1_56 Diagnosis, Tumor, Immunity & Markers 58 PATH_1_58 Mid 2 Exam: Chapters 5-7 Week11 59 PATH_1_59 Post Mid 2 Exam Review 60 PATH_1_60 Chapter 8: Infectious Diseases 61 PATH_1_61 General Principles of Infectious Diseases 62 PATH_1_62 Microbial Pathogenesis 1 63 PATH_1_63 Microbial Pathogenesis 2 64 PATH_1_64 Viral Infections 65 PATH_1_65 Bacterial Infections 66 PATH_1_66 Fungal Infections Week12 67 PATH_1_67 Parasitic Infections 68 PATH_1_68 Chapter 9: Environment & Nutrition Pathology 69 PATH_1_69 Common Environment & Occupational Exposures 1 70 PATH_1_70 Common Environment & Occupational Exposures 2 71 PATH_1_71 Common Environment & Occupational Exposures 3 72 PATH_1_72 Common Environment & Occupational Exposures 4 73 PATH_1_73 Nutrition and Disease 1 Week13 74 PATH_1_74 Nutrition and Disease 2 75 PATH_1_75 Review: Chapters 8&9 76 PATH_1_76 Quiz 3: Chapters 8&9 77 PATH_1_77 Chapter 10: Pediatric Pathology 78 PATH_1_78 Congenital Anomalies 1 79 PATH_1_79 Congenital Anomalies 2 Week14 80 PATH_1_80 Perinatal Diseases 81 PATH_1_81 Neonatal Diseases
82 PATH_1_82 Pediatric Tumors 1 83 PATH_1_83 Pediatric Tumors 2 84 PATH_1_84 Grand Review 1 85 PATH_1_85 Grand Review 2 86 PATH_1_86 Grand Review 3 87 PATH_1_87 Grand Review 4 Lab Schedule Laboratory sessions will be in a PBL format for every chapter and will follow the lecture sessions on the same chapter. During each laboratory session students will go through a clinical vignette for a particular disorder. First, the students will analyze and demonstrate an understanding of the sequence of evolution of disease in the form of signs and symptoms. Then, they will determine the gross and microscopic changes of the disease to finally come up with a most probable diagnosis with other relevant differentials. In the end, students are challenged with the set of questions reinforcing the four basic concepts of every disease: cause, pathogenesis, gross and microscopic changes in the tissues and finally laboratory diagnosis and prognosis. These exercises further augments the entire learning process and helps a student to comprehend pathologic changes in disease states. Week2 88 PATH_1_88 Lab on Cell Adaptation and Cell Injury Week3 89 PATH_1_89 Lab on Inflammation Week4 90 PATH_1_90 Lab on Hemodynamic Disorders Week6 91 PATH_1_91 Lab on Immunological Disorders Week7 92 PATH_1_92 Lab on Neoplasia Week8 93 PATH_1_93 Lab on Hematopoietic System Textbooks and Reference Materials Robbins & Cotran Pathologic Basis of Disease, 9th Edition By Vinay Kumar, MBBS, MD, FRCPath, Abul K. Abbas, MBBS, Nelson Fausto, MD and Jon Aster, MD, Elsevier. ISBN: 978-0-8089-2450-0 Kaplan USMLE Step I lecture notes Publisher: Kaplan Medical (2016) ASIN: B002WW9JLK Robbins and Cotran: Review of Pathology, 4 th edition, 2015. ISBN: 987-1-4557-5155-6 Toronto Review Notes (March 1, 2010) Paperback: 1400 pages, ISBN-10: 1506200494 Evaluation Exams and Grading There will be three quizzes, two unified exams, and a final cumulative. There will be pre-exam review before each exam and post-exam reviews for both exams and Quizzes. There will be no post-exam review for final exam.
Material covered on the exams and individual exams may be weighted. *The exams are in multiple choice formats. Each question will be assigned approximately 80 seconds. Exams 1 and 2 will have approximately 50 questions each. The each quiz will be about 15-20 questions based on Gross and Microscopic pictures. The final exam will be cumulative one (10% of questions) and will have approximately 50 questions. These are approximate percentages of weight for the individual exam. All efforts will be made to give equal weight to each question. The # of questions is subject to change. Every attempt possible will be made to phrase exam questions clear and unambiguous. Exams will focus on but may not be limited to the material that has been covered in class. Note: All material covered by the reading assignments plus all of the additional material supplied during the course is testable. Exams will not be curved. Cumulative score will be curved to 80% (class average) at the end of the course. Performance grades from each exam will be directly communicated to the students on an individual and confidential basis after Academic Progress Committee meeting for Examinations 1 & 2. The grades for the quizzes will be posted with student secret numbers on the same day. Exam reviews will be held on the next working day after the exams. No personal review of the Quizzes and Unified exams, only class reviews of the concepts of the exam s questions. The final exam will be cumulative subject exam (10% of the exam s questions). *A failing grade ( zero ) will be assigned for a missed exam. The only acceptable exceptions are documented emergencies. A make-up exam for a failed students will be decided on individual cases by the School administration. Grade: Percent of Points Letter Grade 95-100% A(h) 90-94% A 85-89% B+ 80-84% B 75-79% C+ 70-74% C <70% F Faculty: Dr. Dragan Jovanovic djovanovic@trinityschoolofmedicine.org Office hours: 12-1 pm and 2-3 pm (weekdays) or by appointment