Columbia Pediatric Heart Valve Symposium: From Bench to Bedside

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NewYork-Presbyterian/Columbia University Medical Center Vivian and Seymour Milstein Family Heart Center New York City Columbia Pediatric Heart Valve Symposium: From Bench to Bedside Presented by the Columbia Pediatric Heart Valve Center Wednesday, May 30, 2018 Thursday, May 31, 2018 Course Directors Emile Bacha, MD, FACS David M. Kalfa, MD, PhD Alejandro J. Torres, MD Julie A. Vincent, MD, FACC, FSCAI, FAAP

Overall Goals Columbia Pediatric Heart Valve Symposium: From Bench to Bedside is the First Annual Cardiovascular Therapy Course focusing on medical and surgical management of congenital heart valve disease, hosted by NewYork-Presbyterian/ Columbia University Medical Center. This program represents a unique multidisciplinary collaboration between congenital and pediatric cardiac surgeons, pediatric cardiologists, pediatric interventional cardiologists and heart valve scientists, allowing for a truly comprehensive approach to the management of children and adults with congenital heart valve malformations. This one and a halfday course will further educate on the surgical and interventional management of patients with congenital heart valve malformations. Lectures will be given by internationally recognized experts who will review standard and emerging treatments for patients with congenital heart valve malformations, address the newest and most innovative therapies and review clinical, basic science and translational research programs, exploring edge-cutting and disruptive concepts to develop new valve devices. Such collaboration will ultimately improve care in children and adults with congenital heart valve malformations, thanks to a constant dialogue and works from bench to bed and back from bed to bench. Didactic sessions, case presentations and interactive discussions will engender learning and improvement in the management of patients with the full spectrum of congenital heart valve malformations. Learning Objectives Discuss advances and emerging innovative surgical procedures and techniques for repair and replacement of congenital heart valves Describe advances and emerging innovative transcatheter therapies for valve replacement in children and adults with congenital valve malformations Identify current options for non-invasive imaging of congenital heart valve malformations Explain the outcomes of the most recent trials of surgical and transcatheter valve procedures Define the most recent concepts and advances in heart valve tissue engineering, heart valve device development and heart valve biology and mechanobiology Target Audience This activity is designed for congenital and pediatric cardiac surgeons, pediatric cardiologists, pediatric interventional cardiologists, general pediatricians, intensivists, scientists and engineers interested in pediatric heart valve research and device development, RNs, NPs, PAs, and other medical professionals involved with the evaluation, diagnosis and/or management of patients with congenital heart disease.

Accreditation Statement In support of improving patient care, this activity has been planned and implemented by Columbia University Department of Surgery and Amedco. Amedco is jointly accredited by the American Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. Credit Designation Statement PHYSICIANS Amedco designates this live activity for a maximum of 10.25 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. PHYSICIAN ASSISTANTS AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credits TM from organizations accredited by ACCME or a recognized state medical society. PAs may receive a maximum of 10.25 AMA PRA Category 1 Credits TM for completing this activity. NURSE PRACTITIONERS The American Academy of Nurse Practitioners Certification Board (AANPCB) recognizes the Accreditation Council for Continuing Medical Education (ACCME) and the American Nurses Credentialing Center (ANCC) as approved accreditors and allow reciprocity for AANPCP continuing education credit. Satisfactory Completion Participants must complete an evaluation form to receive a certificate of completion. Your chosen sessions must be attended in their entirety. Partial credit of individual sessions is not available. If you are seeking continuing education credit for a specialty not listed above, it is your responsibility to contact your licensing/certification board to determine course eligibility for your licensing/ certification requirement. Support We expect support for this program through grants from medical device and pharmaceutical companies. Course Organizers Hearan Choo, MD Director of CME Columbia University Medical Center Department of Surgery, CME Office Jessica Mead Director of Special Events Columbia University Medical Center Department of Surgery, CME Office Phone: 212.304.7817 Email: jas2134@cumc.columbia.edu

Program Agenda Wednesday, May 30, 2018 6:00pm 7:00pm Cocktail Reception 7:00pm 9:00pm Dinner and Surgical & Transcatheter Case Presentations Thursday, May 31, 2018 7:00am 7:50am 7:50am 8:00am Registration, Breakfast & Vendor Exhibits Welcome & Introduction Emile Bacha, MD, FACS, MD & Julie A. Vincent, MD, FACC, FSCAI, FAAP Session 1: General Cardiology and Imaging Moderators: Rebecca T. Hahn, MD & Stéphanie Levasseur, MD, FRCPC 8:00am 8:15am 8:15am 8:30am 8:30am 8:45am 8:45am 8:55am 8:55am 9:10am 9:10am 9:20am 9:20am 9:45am 9:45am 10:00am 2D Echo Imaging Stéphanie Levasseur, MD, FRCPC 3D Echo Imaging Rebecca T. Hahn, MD MRI/CT Imaging Anjali Chelliah, MD 3D Virtual Reality and Printing: How it Impacts Diagnoses and Surgical Outcomes David M. Kalfa, MD, PhD Indications for Intervention Lindsay R. Freud, MD Anticoagulation after Valve Procedures Eva Cheung, MD Panel Discussion/Q&A: Rapid Fire Case Scenarios Moderators: Rebecca T. Hahn, MD & Stéphanie Levasseur, MD, FRCPC Panel: Stéphanie Levasseur, MD, FRCPC, Rebecca T. Hahn, MD, Anjali Chelliah, MD, David M. Kalfa, MD, PhD, Lindsay R. Freud, MD, Eva Cheung, MD Break & Vendor Exhibits

Session 2: Transcatheter Interventions for Congenital Heart Valves Moderators: Lee N. Benson, MD, FRCP(C), FACC, FSCAI & Julie A. Vincent, MD, FACC, FSCAI, FAAP 10:00am 10:15am 10:15am 10:30am 10:30am 10:50am 10:50am 11:05am 11:05am 11:20am 11:20am 11:30am 11:30am 12:00pm 12:00pm 12:20pm 12:20pm 1:00pm Fetal Valvuloplasty Matthew A. Crystal, MD Balloon Valvuloplasty Mariel E. Turner, MD, FAAP, FACC, FSCAI Historical Transcatheter Pulmonary Valve Implantation: Past and Future Lee N. Benson, MD, FRCP(C), FACC, FSCAI Available Transcatheter Pulmonary Valves Alejandro J. Torres, MD Transcatheter Valve Implantation and Endocarditis Ralf J. Holzer, MD, MSc, FACC, FSCAI Transcatheter Valve Implantation in the Tricuspid Valve Position Tamim M. Nazif, MD Keynote Transcatheter Lecture: Transcatheter Interventions for Native RVOT Lee N. Benson, MD, FRCP(C), FACC, FSCAI Panel Discussion/Q&A: Rapid Fire Case Scenarios Moderators: Lee N. Benson, MD, FRCP(C), FACC, FSCAI & Julie A. Vincent, MD, FACC, FSCAI, FAAP Panel: Matthew A. Crystal, MD, Mariel E. Turner, MD, FAAP, FACC, FSCAI, Lee N. Benson, MD, FRCP(C), FACC, FSCAI, Alejandro J. Torres, MD, Ralf J. Holzer, MD, MSc, FACC, FSCAI, Tamim M. Nazif, MD Lunch & Vendor Exhibits

1:00pm 1:15pm 1:15pm 1:30pm 1:30pm 1:40pm 1:40pm 1:50pm 1:50pm 2:10pm 2:10pm 2:30pm 2:30pm 2:45pm 2:45pm 3:00pm 3:00pm 3:15pm 3:15pm 3:30pm 3:30pm 3:45pm 3:45pm 4:10pm 4:10pm 4:30pm Session 3: Surgical Innovative Repair Techniques for Congenital Heart Valves Moderators: Paul J. Chai, MD & Richard G. Ohye, MD Innovative Repairs: Mitral Valve Repair David M. Kalfa, MD, PhD Innovative Repairs: Tricuspid Valve Repair and Ebstein Emile Bacha, MD, FACS I nnovative Repairs: Aortic Valve Repair Paul J. Chai, MD Innovative Repairs: Pulmonary Valve and Valve-sparing TOF Repair Damien J. LaPar, MD, MSc Keynote Surgical Lecture: Surgical Valve Repair on a Beating Heart: The Transatrial Approach Sitaram Emani, MD Panel Discussion/Q&A: Rapid Fire Case Scenarios Moderators: Paul J. Chai, MD & Richard G. Ohye, MD Panel: David M. Kalfa, MD, PhD, Emile Bacha, MD, FACS, Paul J. Chai, MD, Damien J. LaPar, MD, MSc, Sitaram Emani, MD Break & Vendor Exhibits Session 4: Surgical Innovative Replacement Techniques for Congenital Heart Valves Moderators: Paul J. Chai, MD & David M. Kalfa, MD, PhD Debate: Ross and Reinforced Ross or Ozaki? Emile Bacha, MD, FACS & Sitaram Emani, MD Tubular Valve Replacement in Tricuspid Position Richard G. Ohye, MD Surgical Implantation of Transcatheter Valves Sitaram Emani, MD Management of AV Valves in Single Ventricle Patients Richard G. Ohye, MD Panel Discussion/Q&A: Rapid Fire Case Scenarios Moderators: Paul J. Chai, MD & David M. Kalfa, MD, PhD Panel: Emile Bacha, MD, FACS, Sitaram Emani, MD, Richard G. Ohye, MD, David M. Kalfa, MD, PhD Break & Vendor Exhibits

Session 5: Translational Research in Congenital Heart Valves Moderator: Emile Bacha, MD, FACS 4:30pm 4:45pm 4:45pm 5:00pm 5:00pm 5:30pm 5:30pm 5:50pm 5:50pm 6:00pm Heart Valve Biology and Mechanobiology: Why Does a Biological Valve Degenerate? Giovanni Ferrari, PhD Advances in HV Tissue Engineering and the TEH-Tube Experience David M. Kalfa, MD, PhD What it Takes to Develop a New Valved Device for Children: Clinical, Engineering, Business and Regulatory Perspectives David M. Kalfa, MD, PhD, Richard L. Li, MS, Ron Katz, PhD, MBA & Andrea Nye, MBA, MPH Panel Discussion/Q&A: Rapid Fire Case Scenarios Moderator: Emile Bacha, MD, FACS Panel: Giovanni Ferrari, PhD, David M. Kalfa, MD, PhD, Sitaram Emani, MD, Richard L. Li, MS, Ron Katz, PhD, MBA, Andrea Nye, MBA, MPH Closing Remarks

NewYork-Presbyterian/Morgan Stanley Children s Hospital & Columbia University Vagelos College of Physicians and Surgeons Course Directors Emile Bacha, MD, FACS Roth Salzhauer Family Professor of Surgery Chief, Division of Cardiac, Thoracic, and Vascular Surgery NewYork-Presbyterian/ Columbia University Medical Center Director, Pediatric and Congenital Cardiac Surgery Combined Morgan Stanley Children s Hospital - Komansky Weill-Cornell Program David M. Kalfa, MD, PhD Assistant Professor of Surgery Section of Pediatric & Congenital Cardiac Surgery Director, Pediatric Heart Valve Center Assistant Director, Cardiothoracic Research Lab Alejandro J. Torres, MD Associate Professor of Pediatrics at CUMC Director, Pediatric Catheterization Laboratory NewYork-Presbyterian, Morgan Stanley Children s Hospital Julie A. Vincent, MD, FACC, FSCAI, FAAP Welton M Gersony Professor of Pediatric Cardiology Chief, Division of Pediatric Cardiology Columbia University Medical Center Alexandra and Steven Cohen Chief of Pediatric Cardiology NewYork-Presbyterian, Morgan Stanley Children s Hospital Guest Faculty Lee N. Benson, MD, FRCP(C), FACC, FSCAI Professor, Department of Paediatrics University of Toronto Section Head, Interventional Cardiology Director Cardiac Diagnostic and Interventional Unit The Hospital for Sick Children Sitaram Emani, MD Associate in Cardiac Surgery Director, Complex Biventricular Repair Program Boston Children s Hospital Ralf J. Holzer, MD, MSc, FACC, FSCAI Chief, Division of Pediatric Cardiology Weill Cornell Medicine Director, Pediatric Cardiac Catheterization NewYork-Presbyterian Komansky Children s Hospital Richard G. Ohye, MD Head of the Pediatric Cardiovascular Surgery Division Surgical Director of the Pediatric Heart Transplant Program Program Director, Congenital Cardiovascular Surgery Residencies C.S. Mott Children s Hospital NewYork-Presbyterian/Morgan Stanley Children s Hospital & Columbia University Vagelos College of Physicians and Surgeons Faculty Paul J. Chai, MD Assistant Professor of Surgery at CUMC Director, Pediatric Heart Transplantation and Mechanical Assist Device Services Director, Congenital Heart Surgery Services Weill Cornell Medical Center Anjali Chelliah, MD Assistant Professor of Pediatrics at CUMC Director, Congenital Cardiac MRI/CT Eva Cheung, MD Assistant Professor of Pediatrics at CUMC Medical Director, Pediatric ECMO Matthew A. Crystal, MD Pediatric Cardiology, Cardiac Catheterization Laboratory Associate Professor Columbia University Medical Center

Giovanni Ferrari, PhD Associate Professor of Surgical Sciences Scientific Director, Cardiothoracic Surgery Research Director, Columbia Biobank for Translational Science (CBTS) Lindsay R. Freud, MD Assistant Professor of Pediatrics at CUMC Rebecca T. Hahn, MD Professor of Medicine at CUMC Director of Interventional Echocardiography Ron Katz, PhD, MBA Associate Director, Manhattanville Senior Technology Licensing Officer Damien J. LaPar, MD, MSc Assistant Professor of Surgery at CUMC Stéphanie Levasseur, MD, FRCPC Assistant Professor of Pediatrics at CUMC Director, Pediatric Non-Invasive Imaging Director, Fetal Cardiology Richard L. Li, MS PhD Candidate in Mechanical Engineering Tamim M. Nazif, MD Assistant Professor of Medicine Director of Research The Center for Interventional Vascular Therapy Director of Clinical Services The Columbia Heart Valve Center Andrea Nye, MBA, MPH Director of Biomedical Innovation Initiatives Mariel E. Turner, MD, FAAP, FACC, FSCAI Assistant Professor of Pediatrics at CUMC Meeting Location NewYork-Presbyterian/Columbia University Medical Center Vivian and Seymour Milstein Family Heart Center 173 Fort Washington Avenue, First Floor New York, NY 10032 Transportation Subway: Take the 1, A, C lines to 168th Street Washington Heights/Broadway Parking: Parking is available at the NewYork-Presbyterian/Columbia University Medical Center parking garage, located on the southwest corner of Fort Washington Avenue and West 165th Street. Parking fee is NOT included with registration. Valet parking is available at the entrance of the Milstein Hospital Building located at 177 Fort Washington Avenue. Hotels For a listing of local area hotels, visit www ColumbiaSurgeryCME.org and select Columbia Pediatric Heart Valve Symposium.

Registration Categories & Fees WEDNESDAY COCKTAIL AND CASE PRESENTATIONS 6pm 9pm $75 Registration is limited. Early registration is highly encouraged. THURSDAY REGISTRATION NYP Affiliates Non-NYP Affiliates $200 - MD, DO, PhD $250 - MD, DO, PhD $100 - RN, NP, PA $150 - RN, NP, PA Free - Resident & Fellows $50 - Resident & Fellows Free - Students Free - Students VERIFICATION REQUIRED. If you are fellow, resident, student, RN, NP or PA, you are required to submit with the registration form a letter written on official letterhead and signed by a department supervisor verifying status. Please send to Jessica Mead at jas2134@cumc.columbia.edu. Includes registration, course materials, CME certificate (if applicable) breakfast, breaks, lunch and dinner (if applicable). How to Register ONLINE: To make an online credit card payment please visit: www.columbiasurgerycme.org. For security purposes, credit card payments cannot be accepted in the mail or by phone. American Express, Discover, MasterCard and Visa only. BY MAIL: Complete the registration form and mail together with full payment to: Columbia University Medical Center Department of Surgery, CME Office Attention: Jessica Mead 400 Kelby Street, 9th Floor Fort Lee, NJ 07024 Enclose a check or money order made payable to: Columbia University Department of Surgery/CHD Valve Symposium. Checks must be in U.S. dollars drawn on a U.S. bank

Registration Please register me for the continuing medical education program entitled: Columbia Pediatric Heart Valve Symposium: From Bench to Bedside WEDNESDAY COCKTAIL AND CASE PRESENTATIONS 6pm 9pm m $75 Registration is limited. Early registration is highly encouraged. THURSDAY REGISTRATION NYP Affiliates m $200 - MD, DO, PhD m $100 - RN, NP, PA m Free - Resident & Fellows m Free - Students Non-NYP Affiliates m $250 - MD, DO, PhD m $150 - RN, NP, PA m $50 - Resident & Fellows m Free - Students Please print or type First Name M.I. Last Name Degree(s) Company/Institution Address City State Zip Daytime Phone Daytime Fax E-mail (required for confirmation purposes) Specialty Special Needs (specify accommodations needed) Attendee Signature Date PLEASE NOTE: Registration is limited and will be handled on a first-come, first-served basis. Telephone registrations and/or cancellations cannot be accepted. Refund of registration fee will be made if written notice of cancellation is received by May 16, 2018. Unfortunately, no refunds can be made thereafter.

Columbia University Medical Center Department of Surgery, CME Office 400 Kelby Street, 9th Floor Fort Lee, New Jersey 07024 Columbia Pediatric Heart Valve Symposium: From Bench to Bedside Presented by the Columbia Pediatric Heart Valve Center Wednesday, May 30, 2018 Thursday, May 31, 2018 Vivian and Seymour Milstein Family Heart Center New York City Register online: www.columbiasurgerycme.org A 10.25 CME Accredited Program