TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 1 STUDY GOALS AND OBJECTIVES 1 REASONS FOR DOING THIS STUDY 1 CONTRIBUTIONS TO THE STUDY AND INTENDED AUDIENCE 1 SCOPE AND FORMAT 1 METHODOLOGY AND INFORMATION SOURCES 1 ANALYST CREDENTIALS 2 RELATED BCC REPORTS 2 BCC ON-LINE SERVICES 2 DISCLAIMER 2 CHAPTER 2 SUMMARY 5 SUMMARY TABLE GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY PRODUCT CATEGORY, THROUGH 2016 ($ SUMMARY FIGURE GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY PRODUCT CATEGORY, 2009-2016 ($ MARKET DYNAMICS 6 DRIVERS 6 CGM Technology Is an Improvement over SMBG 6 CGM Can Detect the Hypo and Hyperglycemic Events Much More Efficiently 7 CGM Can be Used Across All Age Groups 7 BARRIERS FOR CGM ADOPTION 7 Critical FDA Approval for Accuracy Remains Elusive for CGMs 7 Administrative and Reimbursement Challenges 7 Clinician Adoption Challenges 8 Need for Patient Involvement and Education 8 OPPORTUNITY AND GAP ANALYSIS 8 Restricted Use 8 Cost 8 Noncompliance with CGM Use 9 Limited or No Reimbursement under Insurance Cover 9 5 5 CHAPTER 3 MARKET OVERVIEW 11 CONTINUOUS GLUCOSE MONITORS 11 CGM TERMINOLOGY - A DISCUSSION 12 CGM COMPONENTS AND TECHNOLOGIES 13 CONTINUOUS GLUCOSE MONITORS 13 NON/MINIMALLY INVASIVE 14 HG1-C 14 NEAR-INFRARED DETECTION 14 ULTRASOUND 14 DIELECTRIC SPECTROSCOPY 15 PROFESSIONAL CGM IN THE FUTURE 15 HYPOGLYCAEMIA IN DIABETES 15 FREQUENCY IN T1DM 16 FREQUENCY IN T2DM 16
TREATMENT 17 HYPOGLYCEMIA UNAWARENESS 17 CGM AND INSURANCE 18 MARKET EVOLUTION 19 CONTINUOUS GLUCOSE MONITORS ARE IN THE EVOLVING MODE 19 CONTINUOUS IMPROVEMENT IN THE WORKING OF CGMS WILL LEAD TO FASTER COMMERCIALIZATION HUGE MARKET POTENTIAL FOR CGM DEVICES 19 PREVALENCE AND INCIDENCE OF DIABETES AND HEALTHCARE SPENDING 19 THE ECONOMIC BURDEN OF DIABETES 20 CHALLENGES IN MEASURING INTERSTITIAL GLUCOSE LEVELS ACCURATELY 20 ACCURACY IS A CONCERN 21 SAFETY RISKS 21 APPREHENSION OF CLINICIANS AND PATIENTS 21 COMPETITIVE AND LONG-TERM ALTERNATIVES 21 FOREIGN BODY RESPONSE 21 IN VIVO GLUCOSE SENSING 22 FLUORESCENT GLUCOSE BIOSENSORS 22 MICRODIALYSIS 22 COMPARATIVE ANALYSIS BY GEOGRAPHY 22 TABLE 1 TOP TEN COUNTRIES WITH RESPECT TO DIABETIC POPULATION 23 TECHNOLOGICAL INNOVATIONS, PIPELINE AND PATENT ANALYSIS: 24 INNOVATIVE BREAKTHROUGHS 24 PIPELINE AND PATENT ANALYSIS 25 PATENT ANALYSIS 26 GlySens Sensor 26 First CGM-enabled, Waterproof Insulin Pump System Approved in Europe 26 Predictive Control-based System and Method for Control of Insulin Delivery in Diabetes Using Glucose Sensing Eco Therapeutics Symphony tcgm System 26 Arkal Medical 26 U.S. CGM PATENTS BY SEGMENT 27 FIGURE 1 U.S. CGM PATENTS BY SEGMENT (%) 27 U.S. CGM PATENTS BY COMPANY 28 FIGURE 2 U.S. CGM PATENTS BY COMPANY (%) 28 OTHER DIABETES CARE DEVICES MARKET 28 Self-monitoring of Blood Glucose (SMBG) 29 TABLE 2 GLOBAL SMBG MARKET BY GEOGRAPHY, THROUGH 2016 ($ 29 Blood Glucose Meters 29 Diabetes Test Strips 30 Electrochemical Blood Glucose Test Strips (EBGTS) 30 MEDTRONIC HAS STARTED CONTINUOUS GLUCOSE MONITOR TRIALS 30 CLINICAL EXPERIENCE WITH AN INTEGRATED CONTINUOUS GLUCOSE SENSOR/INSULIN PUMP PLATFORM: A FEASIBILITY STUDY GE HEALTHYMAGINATION FUND INVESTS IN C8 MEDISENSORS, A DEVELOPER OF NONINVASIVE CONTINUOUS GLUCOSE MONITORS 19 26 30 31 CHAPTER 4 CONTINOUS GLUCOSE MONITORING SYSTEMS BY DEVICES 33
TABLE 3 GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY GEOGRAPHY, THROUGH 2016 ($ INSULIN PUMPS 33 TABLE 4 GLOBAL CGM INSULIN PUMP MARKET BY GEOGRAPHY, THROUGH 2016 ($ TRANSMITTER 34 RECEIVER 34 TABLE 5 GLOBAL CGM RECEIVER AND TRANSMITTER MARKET BY GEOGRAPHY, THROUGH 2016 ($ SENSORS 35 TABLE 6 GLOBAL CGM SENSORS MARKET BY GEOGRAPHY, THROUGH 2016 ($ 36 NONINVASIVE GLUCOSE SENSORS 36 Microdialysis 36 SUBCUTANEOUS SENSORS 37 THE OLD TECHNOLOGY - HOLTER TYPE RETROSPECTIVE SENSORS 37 THE NEW TECHNOLOGY - REAL-TIME SENSORS 38 33 34 35 CHAPTER 5 CONTINUOUS GLUCOSE MONITORING SYSTEM BY APPLICATION SEGMENT 40 TABLE 7 GLOBAL CGM MARKET BY APPLICATION SEGMENTS, THROUGH 2016 ($ 40 CGM IN PRIVATE PRACTICE 40 TEAM MEMBERS 40 DEDICATED ROOM 41 DEVICE SCHEDULE 41 KEEPING THE PATIENTS INFORMED 41 AVAILABILITY OF THE DEVICE 41 TRAINING OF PATIENTS IN THE USE OF CGM DEVICES 42 BILLING AND REIMBURSEMENTS 42 HOSPITALS 43 TABLE 8 GLOBAL CGM MARKET IN HOSPITALS, THROUGH 2016 ($ 43 DIAGNOSTICS/CLINICS 44 TABLE 9 GLOBAL CGM MARKET IN DIAGNOSTIC CENTERS, THROUGH 2016 ($ 44 HOME 45 TABLE 10 GLOBAL CGM MARKET IN HOME SETTING, THROUGH 2016 ($ 45 CHALLENGES AND NEXT STEPS FOR INCREASED USE OF CGM 45 SET UP REGULATORY REVIEW WITH PROPER EVIDENCE 45 WORK TOWARDS IMPROVING REIMBURSEMENT 45 SET STAGE FOR EFFICIENT, CLINICAL USE 45 LAY GROUNDWORK FOR PATIENT ACCEPTANCE 46 CHAPTER 6 CONTINUOUS GLUCOSE MONITORING SYSTEM BY DIABETIC TYPE 48 TABLE 11 GLOBAL CGM MARKET BY TYPES OF DIABETES, THROUGH 2016 ($ 48 DIABETES IS WIDELY CLASSIFIED AS TWO MAJOR TYPES 48 CLASSIFICATION OF TYPE 2 DIABETES 49 BLOOD GLUCOSE MONITORING 49 TYPE 1 DIABETES 49 TABLE 12 GLOBAL CGM MARKET FOR TYPE 1 DIABETES, THROUGH 2016 ($ 49 TYPE 2 DIABETES 50 TABLE 13 GLOBAL CGM MARKET FOR TYPE 2 DIABETES, THROUGH 2016 ($ 50
GESTATIONAL DIABETES 50 TABLE 14 GLOBAL CGM MARKET FOR GESTATIONAL DIABETES, THROUGH 2016 ($ OTHER TYPES OF DIABETES 51 TABLE 15 GLOBAL CGM MARKET FOR OTHER TYPES OF DIABETES, THROUGH 2016 ($ 51 51 CHAPTER 7 CONTINUOUS GLUCOSE MONITORING SYSTEMS BY AGE AND RACE 53 TABLE 16 GLOBAL CGM MARKET BY AGE, THROUGH 2016 ($ 53 CHALLENGES TO MEASURING IMPACT OF CGM 53 HYPOGLYCEMIA DETECTION 53 SATISFACTION AND LIFESTYLE COMPLIANCE 53 EFFECTIVE ANALYSIS OF CGM DATA 54 SIZE OF THE DEVICE IS AN ISSUE FOR PEDIATRIC PATIENTS 54 ALARM 54 AGE 54 CHILDREN AND TEENS 54 TABLE 17 GLOBAL CGM MARKET AMONG CHILDREN, THROUGH 2016 ($ 54 TABLE 18 GLOBAL CGM MARKET AMONG TEENS, THROUGH 2016 ($ 55 SIZE IS A DISADVANTAGE FOR SMALLER CHILDREN 56 EFFECTIVE TOOL FOR DIABETES MANAGEMENT AND BEHAVIOUR MODIFICATION 57 CGM MAY BECOME TO CUMBERSOME TO WEAR 57 GLUCOSE ALARMS 58 CGM PROVIDES DATA ON DIRECTION AND RATE OF CHANGE 58 INFORMED USE OF CGM DATA MAKES LIFE WITH DIABETES EASIER 58 YOUTH 58 TABLE 19 GLOBAL CGM MARKET AMONG YOUTH, THROUGH 2016 ($ 58 MIDDLE-AGED AND AGED PATIENTS 59 TABLE 20 GLOBAL CGM MARKET AMONG MIDDLE ELDERLY, THROUGH 2016 ($ 59 TABLE 21 GLOBAL CGM MARKET AMONG AGED, THROUGH 2016 ($ 60 RACE 60 TABLE 22 GLOBAL CGM MARKET BY RACE, THROUGH 2016 ($ 60 UNITED STATES 61 DIABETES IN AFRICAN AMERICANS 61 EUROPEANS 61 ASIANS 62 CHAPTER 8 COMPETITIVE LANDSCAPE 64 FIGURE 3 RECENT DEVELOPMENTS BY COMPANY, 2009-2012 (%) 64 FIGURE 4 RECENT DEVELOPMENTS BY STRATEGY, 2009-2012 (%) 65 TABLE 23 RECENT DEVELOPMENTS, 2009-2012 66 CHAPTER 9 GEOGRAPHIC ANALYSIS OF CONTINUOUS GLUCOSE MONITORING SYSTEMS MARKET UNITED STATES 73 FIGURE 5 DIABETES PREVALENCE IN THE UNITED STATES ( 73 TABLE 24 DIABETICS BY AGE 74 TABLE 25 ESTIMATES FOR DIABETES, 2020 (%/$ BILLIONS) 75 73
TABLE 26 THE U.S. CGM DEVICES MARKET, THROUGH 2016 ($ 75 TABLE 27 THE U.S. CGM APPLICATION MARKET, THROUGH 2016 ($ 76 FIGURE 6 TOTAL OVERWEIGHT AND OBESE POPULATION, 1994-2008 ( 76 EUROPE 77 FIGURE 7 DRIVERS AND RESTRAINTS - EUROPE CGM MARKET 78 TABLE 28 THE EUROPE CGM DEVICES MARKET, THROUGH 2016 ($ 78 TABLE 29 THE EUROPE CGM APPLICATIONS MARKET, THROUGH 2016 ($ 79 ASIA 79 DIABETES CARE DEVICES MARKET SHARE BY SEGMENTS 80 TABLE 30 ASIA CGM DEVICES MARKET, THROUGH 2016 ($ 81 TABLE 31 ASIA CGM APPLICATIONS MARKET, THROUGH 2016 ($ 82 FIGURE 8 DRIVERS AND RESTRAINTS ASIAN CGM MARKET 82 FIGURE 9 DRIVERS AND RESTRAINTS IN INDIA 83 ROW 84 TABLE 32 ROW CGM DEVICES MARKET, THROUGH 2016 ($ 85 TABLE 33 ROW CGM APPLICATIONS MARKET, THROUGH 2016 ($ 85 FIGURE 10 DRIVERS AND RESTRAINTS ROW CGM MARKET 85 CHAPTER 10 COMPANY PROFILES 88 77 ELEKTRONIKA KFT 88 TABLE 34 PRODUCT PORTFOLIO 88 ABBOTT LABORATORIES 89 TABLE 35 PRODUCT PORTFOLIO 89 TABLE 36 RECENT DEVELOPMENTS, 2010-2012 90 TABLE 37 FINIANCIAL ($ 91 ACON LABORATORIES 91 TABLE 38 PRODUCT PORTFOLIO 91 TABLE 39 RECENT DEVELOPMENTS 92 AGAMATRIX 93 TABLE 40 PRODUCT PORTFOLIO 93 TABLE 41 RECENT DEVELOPMENTS 94 ALL MEDICUS CO. LTD. 95 TABLE 42 PRODUCT PORTFOLIO 95 TABLE 43 RECENT DEVELOPMENTS, 2006-2012 96 ANIMAS 96 TABLE 44 PRODUCT PORTFOLIO 96 TABLE 45 RECENT DEVELOPMENTS, 2006-2012 97 ARKRAY USA 97 TABLE 46 PRODUCT PORTFOLIO 98 TABLE 47 RECENT DEVELOPMENTS 99 BAYER DIABETES CARE 99 TABLE 48 PRODUCT PORTFOLIO 100 TABLE 49 RECENT DEVELOPMENTS 101 TABLE 50 FINANCIAL ($ 101 BIOSIGN TECHNOLOGIES INC. 101 TABLE 51 RECENT DEVELOPMENTS, 2006-2012 102 C8 MEDISENSORS INC. 102
TABLE 52 PRODUCT PORTFOLIO 102 TABLE 53 RECENT DEVELOPMENTS 103 CALISTO MEDICAL INC. 103 TABLE 54 PRODUCT PORTFOLIO 103 TABLE 55 RECENT DEVELOPMENTS, 2005-2012 104 CASCADE METRIX 104 TABLE 56 PRODUCT PORTFOLIO 104 TABLE 57 RECENT DEVELOPMENTS, 2006-2012 105 DEXCOM LTS 105 TABLE 58 PRODUCT PORTFOLIO 105 TABLE 59 RECENT DEVELOPMENTS 106 TABLE 60 FINANCIAL ($ 106 ECHO THERAPEUTICS 107 TABLE 61 PRODUCT PORTFOLIO 107 TABLE 62 RECENT DEVELOPMENTS, 2006-2012 107 FREEDOM MEDITECH 108 TABLE 63 PRODUCT PORTFOLIO 108 TABLE 64 RECENT DEVELOPMENTS, 2006-2012 108 GLUMETRICS INC. 109 TABLE 65 PRODUCT PORTFOLIO 109 TABLE 66 RECENT DEVELOPMENTS, 2006-2012 109 GLYSENS INCORPORATED 109 TABLE 67 PRODUCT PORTFOLIO 110 GROVE INSTRUMENTS INC. 110 TABLE 68 PRODUCT PORTFOLIO 111 TABLE 69 RECENT DEVELOPMENTS, 2011 111 INLIGHT SOLUTIONS 111 TABLE 70 PRODUCT PORTFOLIO 112 INSULET CORP. 112 TABLE 71 PRODUCT PORTFOLIO 112 TABLE 72 RECENT DEVELOPMENTS, 2006-2012 113 TABLE 73 FINANCIAL, 2010-2006 ($ 113 INTEGRITY APPLICATIONS INC. 113 TABLE 74 PRODUCT PORTFOLIO 114 TABLE 75 RECENT DEVELOPMENTS 114 LIFESCAN (A JOHNSON & JOHNSON GROUP COMPANY) 114 TABLE 76 PRODUCT PORTFOLIO 114 MEDTRONIC 115 TABLE 77 PRODUCT PORTFOLIO 116 TABLE 78 RECENT DEVELOPMENTS, 2010 AND 2011 116 TABLE 79 FINANCIAL, 2007-2011 ($ 117 MENARINI 117 TABLE 80 PRODUCT PORTFOLIO 117 TABLE 81 RECENT DEVELOPMENTS, 2010 AND 2011 121 MENDOR 121 TABLE 82 PRODUCT PORTFOLIO 121 TABLE 83 RECENT DEVELOPMENTS 121
NILIMEDIX 122 TABLE 84 PRODUCT PORTFOLIO 123 TABLE 85 RECENT DEVELOPMENTS, 2006-2012 123 NIPRO DIAGNOSTICS INC. (NIPRO MEDICAL INDUSTRIES CO. LTD) 123 TABLE 86 PRODUCT PORTFOLIO 124 NOVABIOMEDICAL CORPORATION 125 TABLE 87 PRODUCT PORTFOLIO 125 TABLE 88 RECENT DEVELOPMENTS 125 NOVO NORDISK 126 TABLE 89 RECENT DEVELOPMENTS, 2006-2012 126 TABLE 90 FINANCIAL, 2008-2011 ($ 126 ORSENSE 127 TABLE 91 PRODUCT PORTFOLIO 127 TABLE 92 RECENT DEVELOPMENTS, 2006-2012 128 RELION 128 TABLE 93 PRODUCT PORTFOLIO 128 ROCHE 129 TABLE 94 PRODUCT PORTFOLIO 129 TABLE 95 RECENT DEVELOPMENTS, 2006-2012 131 TABLE 96 FINANCIAL ($ 131 SENSORS FOR MEDICINE AND SCIENCE INC. 131 TABLE 97 PRODUCT PORTFOLIO 132 TABLE 98 RECENT DEVELOPMENTS, 2006-2012 132 SENSYS MEDICAL INC. 132 TABLE 99 PRODUCT PORTFOLIO 132 SHANGHAI HUAZHE INTERNATIONALST 133 TABLE 100 PRODUCT PORTFOLIO 133 SMITHS MEDICAL 134 TABLE 101 PRODUCT PORTFOLIO 134 TABLE 102 RECENT DEVELOPMENTS, 2006-2012 135 TERUMO CORPORATION 135 CONTACT DETAILS 135 TABLE 103 RECENT DEVELOPMENTS, 2006-2012 136 TABLE 104 FINANCIAL, 2009-2011 ($ 136 US DIAGNOSTICS INC. 136 TABLE 105 PRODUCT PORTFOLIO 136 TABLE 106 RECENT DEVELOPMENTS, 2006-2012 138 VERALIGHT INC. 138 TABLE 107 PRODUCT PORTFOLIO 138 TABLE 108 RECENT DEVELOPMENTS, 2006-2012 139 YPSOMED AG 139 TABLE 109 PRODUCT PORTFOLIO 139 TABLE 110 RECENT DEVELOPMENTS, 2006-2012 140 TABLE 111 FINANCIAL, 2009-2011 ($ 141 CHAPTER 11 APPENDIX: MARKET ESTIMATES: CGM DEVICES MARKET AND DEMOGRAPHICS 143 TABLE 112 U.S. CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143
TABLE 113 EUROPE CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143 TABLE 114 ASIA CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143 TABLE 115 ROW CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 144 TABLE 116 GLOBAL CGM INSULIN PUMP MARKET BY RACE, THROUGH 2016 ($ 145 MARKET ESTIMATES: CGM APPLICATION MARKET AND DEMOGRAPHICS 145 TABLE 117 U.S. CGM HOMESETTING MARKET BY AGE, THROUGH 2016 ($ 145 TABLE 118 EUROPE CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 119 ASIA CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 120 ROW CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 121 GLOBAL CGM HOMESETTING MARKET BY RACE, THROUGH 2016 ($ 147 TABLE 122 U.S. CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 147 TABLE 123 EUROPE CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ TABLE 124 ASIA CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 148 TABLE 125 ROW CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 148 TABLE 126 GLOBAL CGM DIAGNOSTIC CENTER MARKET BY RACE, THROUGH 2016 ($ TABLE 127 U.S. CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 149 TABLE 128 EUROPE CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ TABLE 129 ASIA CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 150 TABLE 130 ROW CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 150 TABLE 131 GLOBAL CGM HOSPITAL SETTING MARKET BY RACE, THROUGH 2016 ($ U.S. PATENTS 151 TABLE 132 U.S. LIST OF CGM PATENTS MILLIONS 151 147 149 149 151
LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY PRODUCT CATEGORY, THROUGH 2016 ($ TABLE 1 TOP TEN COUNTRIES WITH RESPECT TO DIABETIC POPULATION 23 TABLE 2 GLOBAL SMBG MARKET BY GEOGRAPHY, THROUGH 2016 ($ 29 TABLE 3 GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY GEOGRAPHY, THROUGH 2016 ($ TABLE 4 GLOBAL CGM INSULIN PUMP MARKET BY GEOGRAPHY, THROUGH 2016 ($ TABLE 5 GLOBAL CGM RECEIVER AND TRANSMITTER MARKET BY GEOGRAPHY, THROUGH 2016 ($ TABLE 6 GLOBAL CGM SENSORS MARKET BY GEOGRAPHY, THROUGH 2016 ($ 36 TABLE 7 GLOBAL CGM MARKET BY APPLICATION SEGMENTS, THROUGH 2016 ($ 40 TABLE 8 GLOBAL CGM MARKET IN HOSPITALS, THROUGH 2016 ($ 43 TABLE 9 GLOBAL CGM MARKET IN DIAGNOSTIC CENTERS, THROUGH 2016 ($ 44 TABLE 10 GLOBAL CGM MARKET IN HOME SETTING, THROUGH 2016 ($ 45 TABLE 11 GLOBAL CGM MARKET BY TYPES OF DIABETES, THROUGH 2016 ($ 48 TABLE 12 GLOBAL CGM MARKET FOR TYPE 1 DIABETES, THROUGH 2016 ($ 49 TABLE 13 GLOBAL CGM MARKET FOR TYPE 2 DIABETES, THROUGH 2016 ($ 50 TABLE 14 GLOBAL CGM MARKET FOR GESTATIONAL DIABETES, THROUGH 2016 ($ 51 TABLE 15 GLOBAL CGM MARKET FOR OTHER TYPES OF DIABETES, THROUGH 2016 ($ TABLE 16 GLOBAL CGM MARKET BY AGE, THROUGH 2016 ($ 53 TABLE 17 GLOBAL CGM MARKET AMONG CHILDREN, THROUGH 2016 ($ 54 TABLE 18 GLOBAL CGM MARKET AMONG TEENS, THROUGH 2016 ($ 55 TABLE 19 GLOBAL CGM MARKET AMONG YOUTH, THROUGH 2016 ($ 58 TABLE 20 GLOBAL CGM MARKET AMONG MIDDLE ELDERLY, THROUGH 2016 ($ 59 TABLE 21 GLOBAL CGM MARKET AMONG AGED, THROUGH 2016 ($ 60 TABLE 22 GLOBAL CGM MARKET BY RACE, THROUGH 2016 ($ 60 TABLE 23 RECENT DEVELOPMENTS, 2009-2012 66 TABLE 24 DIABETICS BY AGE 74 TABLE 25 ESTIMATES FOR DIABETES, 2020 (%/$ BILLIONS) 75 TABLE 26 THE U.S. CGM DEVICES MARKET, THROUGH 2016 ($ 75 TABLE 27 THE U.S. CGM APPLICATION MARKET, THROUGH 2016 ($ 76 TABLE 28 THE EUROPE CGM DEVICES MARKET, THROUGH 2016 ($ 78 TABLE 29 THE EUROPE CGM APPLICATIONS MARKET, THROUGH 2016 ($ 79 TABLE 30 ASIA CGM DEVICES MARKET, THROUGH 2016 ($ 81 TABLE 31 ASIA CGM APPLICATIONS MARKET, THROUGH 2016 ($ 82 TABLE 32 ROW CGM DEVICES MARKET, THROUGH 2016 ($ 85 TABLE 33 ROW CGM APPLICATIONS MARKET, THROUGH 2016 ($ 85 TABLE 34 PRODUCT PORTFOLIO 88 TABLE 35 PRODUCT PORTFOLIO 89 TABLE 36 RECENT DEVELOPMENTS, 2010-2012 90 TABLE 37 FINIANCIAL ($ 91 TABLE 38 PRODUCT PORTFOLIO 91 TABLE 39 RECENT DEVELOPMENTS 92 TABLE 40 PRODUCT PORTFOLIO 93 TABLE 41 RECENT DEVELOPMENTS 94 5 33 34 35 51
TABLE HEADING TABLE 42 PRODUCT PORTFOLIO 95 TABLE 43 RECENT DEVELOPMENTS, 2006-2012 96 TABLE 44 PRODUCT PORTFOLIO 96 TABLE 45 RECENT DEVELOPMENTS, 2006-2012 97 TABLE 46 PRODUCT PORTFOLIO 98 TABLE 47 RECENT DEVELOPMENTS 99 TABLE 48 PRODUCT PORTFOLIO 100 TABLE 49 RECENT DEVELOPMENTS 101 TABLE 50 FINANCIAL ($ 101 TABLE 51 RECENT DEVELOPMENTS, 2006-2012 102 TABLE 52 PRODUCT PORTFOLIO 102 TABLE 53 RECENT DEVELOPMENTS 103 TABLE 54 PRODUCT PORTFOLIO 103 TABLE 55 RECENT DEVELOPMENTS, 2005-2012 104 TABLE 56 PRODUCT PORTFOLIO 104 TABLE 57 RECENT DEVELOPMENTS, 2006-2012 105 TABLE 58 PRODUCT PORTFOLIO 105 TABLE 59 RECENT DEVELOPMENTS 106 TABLE 60 FINANCIAL ($ 106 TABLE 61 PRODUCT PORTFOLIO 107 TABLE 62 RECENT DEVELOPMENTS, 2006-2012 107 TABLE 63 PRODUCT PORTFOLIO 108 TABLE 64 RECENT DEVELOPMENTS, 2006-2012 108 TABLE 65 PRODUCT PORTFOLIO 109 TABLE 66 RECENT DEVELOPMENTS, 2006-2012 109 TABLE 67 PRODUCT PORTFOLIO 110 TABLE 68 PRODUCT PORTFOLIO 111 TABLE 69 RECENT DEVELOPMENTS, 2011 111 TABLE 70 PRODUCT PORTFOLIO 112 TABLE 71 PRODUCT PORTFOLIO 112 TABLE 72 RECENT DEVELOPMENTS, 2006-2012 113 TABLE 73 FINANCIAL, 2010-2006 ($ 113 TABLE 74 PRODUCT PORTFOLIO 114 TABLE 75 RECENT DEVELOPMENTS 114 TABLE 76 PRODUCT PORTFOLIO 114 TABLE 77 PRODUCT PORTFOLIO 116 TABLE 78 RECENT DEVELOPMENTS, 2010 AND 2011 116 TABLE 79 FINANCIAL, 2007-2011 ($ 117 TABLE 80 PRODUCT PORTFOLIO 117 TABLE 81 RECENT DEVELOPMENTS, 2010 AND 2011 121 TABLE 82 PRODUCT PORTFOLIO 121 TABLE 83 RECENT DEVELOPMENTS 121 TABLE 84 PRODUCT PORTFOLIO 123 TABLE 85 RECENT DEVELOPMENTS, 2006-2012 123 TABLE 86 PRODUCT PORTFOLIO 124 TABLE 87 PRODUCT PORTFOLIO 125 TABLE 88 RECENT DEVELOPMENTS 125
TABLE HEADING TABLE 89 RECENT DEVELOPMENTS, 2006-2012 126 TABLE 90 FINANCIAL, 2008-2011 ($ 126 TABLE 91 PRODUCT PORTFOLIO 127 TABLE 92 RECENT DEVELOPMENTS, 2006-2012 128 TABLE 93 PRODUCT PORTFOLIO 128 TABLE 94 PRODUCT PORTFOLIO 129 TABLE 95 RECENT DEVELOPMENTS, 2006-2012 131 TABLE 96 FINANCIAL ($ 131 TABLE 97 PRODUCT PORTFOLIO 132 TABLE 98 RECENT DEVELOPMENTS, 2006-2012 132 TABLE 99 PRODUCT PORTFOLIO 132 TABLE 100 PRODUCT PORTFOLIO 133 TABLE 101 PRODUCT PORTFOLIO 134 TABLE 102 RECENT DEVELOPMENTS, 2006-2012 135 TABLE 103 RECENT DEVELOPMENTS, 2006-2012 136 TABLE 104 FINANCIAL, 2009-2011 ($ 136 TABLE 105 PRODUCT PORTFOLIO 136 TABLE 106 RECENT DEVELOPMENTS, 2006-2012 138 TABLE 107 PRODUCT PORTFOLIO 138 TABLE 108 RECENT DEVELOPMENTS, 2006-2012 139 TABLE 109 PRODUCT PORTFOLIO 139 TABLE 110 RECENT DEVELOPMENTS, 2006-2012 140 TABLE 111 FINANCIAL, 2009-2011 ($ 141 TABLE 112 U.S. CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143 TABLE 113 EUROPE CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143 TABLE 114 ASIA CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 143 TABLE 115 ROW CGM INSULIN PUMP MARKET BY AGE, THROUGH 2016 ($ 144 TABLE 116 GLOBAL CGM INSULIN PUMP MARKET BY RACE, THROUGH 2016 ($ 145 TABLE 117 U.S. CGM HOMESETTING MARKET BY AGE, THROUGH 2016 ($ 145 TABLE 118 EUROPE CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 119 ASIA CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 120 ROW CGM HOMESETTING MARKET BY AGE, 2009-2016 ($ 146 TABLE 121 GLOBAL CGM HOMESETTING MARKET BY RACE, THROUGH 2016 ($ 147 TABLE 122 U.S. CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 147 TABLE 123 EUROPE CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ TABLE 124 ASIA CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 148 TABLE 125 ROW CGM DIAGNOSTIC CENTER MARKET BY AGE, THROUGH 2016 ($ 148 TABLE 126 GLOBAL CGM DIAGNOSTIC CENTER MARKET BY RACE, THROUGH 2016 ($ TABLE 127 U.S. CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 149 TABLE 128 EUROPE CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 149 TABLE 129 ASIA CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 150 TABLE 130 ROW CGM HOSPITAL SETTING MARKET BY AGE, THROUGH 2016 ($ 150 TABLE 131 GLOBAL CGM HOSPITAL SETTING MARKET BY RACE, THROUGH 2016 ($ TABLE 132 U.S. LIST OF CGM PATENTS MILLIONS 151 147 149 151
LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL CONTINUOUS GLUCOSE MONITORING SYSTEMS BY PRODUCT CATEGORY, 2009-2016 ($ FIGURE 1 U.S. CGM PATENTS BY SEGMENT (%) 27 FIGURE 2 U.S. CGM PATENTS BY COMPANY (%) 28 FIGURE 3 RECENT DEVELOPMENTS BY COMPANY, 2009-2012 (%) 64 FIGURE 4 RECENT DEVELOPMENTS BY STRATEGY, 2009-2012 (%) 65 FIGURE 5 DIABETES PREVALENCE IN THE UNITED STATES ( 73 FIGURE 6 TOTAL OVERWEIGHT AND OBESE POPULATION, 1994-2008 ( 76 FIGURE 7 DRIVERS AND RESTRAINTS - EUROPE CGM MARKET 78 FIGURE 8 DRIVERS AND RESTRAINTS ASIAN CGM MARKET 82 FIGURE 9 DRIVERS AND RESTRAINTS IN INDIA 83 FIGURE 10 DRIVERS AND RESTRAINTS ROW CGM MARKET 85 5