Surveys and Anatomic Pathology Education Programs

Surveys and Anatomic Pathology Education Programs Performance Improvement Program in Surgical Pathology PIP-C 2017 Case Critiques and Educational Questions Review the slides and indicate the case diagnosis on the result form before reading this. 2016 College of American Pathologists. The College does not permit reproduction of any substantial portion of the material in this Report without its written authorization. The College hereby authorizes participants in the program to use the material in this Report solely for educational purposes within their own institutions. The College prohibits use of the material in the Report and any unauthorized use of the College s name or logo in connection with promotional efforts by marketers of laboratory equipment, reagents, materials, or services. Data from this program do not necessarily indicate the superiority or inferiority of instruments, reagents, or other materials used by participating laboratories. Use of these data to suggest such superiority or inferiority may be deceptive and misleading. The College will take all steps open to it under the law to prevent unauthorized reproduction of substantial portions of the material in this Report, deceptive use of any such material, and any unauthorized use of the College s name or logo in connection with promotional efforts by marketers of laboratory equipment, reagents, materials, or services.

2017 PIP/PIPW-C PARTICIPANT SUMMARY Program Update This report summarizes the diagnostic responses for set C of the 2017 Performance Improvement Program in Surgical Pathology (PIP & PIPW). A tabulation of the responses to the supplementary questions is not included since these are intended for educational purposes only. SURGICAL PATHOLOGY COMMITTEE Rochelle A. Simon, MD FCAP, Chair Aaron Auerbach, MD FCAP, Vice Chair Oyedele A. Adeyi, MBBS FCAP Vijayalakshmi Ananthanarayanan, MD FCAP Aleodor Alexandru Andea, MBA, MD FCAP Deborah Ann Belchis, MD FCAP Philip A. Branton, MD FCAP Rajan Dewar, MD, PhD FCAP H. Parry Dilworth, MD FCAP Leslie Dodd, MD FCAP Julie C. Fanburg-Smith, MD FCAP Marisa Rose Nucci, MD FCAP Nilsa C. Ramirez, MD FCAP Kirtee Raparia, MD FCAP Vijaya B. Reddy, MD, MBA FCAP Safia N. Salaria, MD FCAP J. Clint Stanfill, MD Nichole L. Steidler, MD FCAP Justin M. Wells, MD FCAP Danielle E. Westfall, MD FCAP

(1032) Acetaminophen hepatotoxicity Case # 2017-21 1032 Acetaminophen hepatotoxicity 6061 99.3 79 88.8 1022 Alcoholic steatohepatitis 21 0.3 5 5.6 3031 Amoxicillin-clavulanic acid (Augmentin) 6 0.1 0 0.0 hepatotoxicity 1763 Autoimmune hepatitis 4 0.1 2 2.2 1207 Herpes simplex hepatitis 4 0.1 0 0.0 1777 Wilson disease 6 0.1 3 3.3 001 Excellent 2989 53.4 002 1146 20.4 003 Satisfactory 1385 24.7 004 81 1.4 005 Unsatisfactory 5 0.1 (3032) Cardiac hemochromatosis Case # 2017-22 1985 Cardiac amyloidosis 64 1.1 1 1.1 3032 Cardiac hemochromatosis 5936 97.3 67 80.0 3033 Dilated cardiomyopathy 70 1.2 8 9.5 3034 Hypereosinophilic syndrome with 12 0.2 3 3.5 eosinophilic myocarditis 2543 Hypertrophic cardiomyopathy 12 0.2 5 5.9 3035 Post-rheumatic mitral and aortic valvular stenosis 0 0.0 0 0.0 001 Excellent 2765 50.0 002 1247 22.5 003 Satisfactory 1411 25.5 004 100 1.8 005 Unsatisfactory 9 0.2

(2268) Classical Hodgkin lymphoma, mixed cellularity subtype Case # 2017-23 3036 ALK(+) anaplastic large cell lymphoma 14 0.2 4 4.8 2268 Classical Hodgkin lymphoma, mixed 6045 99.1 69 82.1 cellularity subtype 2408 Hepatosplenic T-cell lymphoma 15 0.3 0 0.0 2476 Metastatic carcinoma 1 0.1 0 0.0 2531 Peripheral T-cell lymphoma, not otherwise 0 0.0 0 0.0 specified 3037 Splenic diffuse red pulp small B-cell 13 0.1 6 7.1 lymphoma 2844 T-cell/histiocyte-rich large B-cell lymphoma 10 0.2 5 6.0 001 Excellent 2517 45.9 002 1177 21.5 003 Satisfactory 1463 26.7 004 265 4.8 005 Unsatisfactory 62 1.1 (2389) Leiomyosarcoma Case # 2017-24 1901 Gastrointestinal stromal tumor 57 0.9 18 22.0 1646 Leiomyoma 122 2.0 5 6.1 2389 Leiomyosarcoma 5903 96.8 58 70.7 3038 Malignant peripheral nerve sheath tumor 12 0.2 1 1.2 1780 Schwannoma 1 0.1 0 0.0 001 Excellent 2835 51.8 002 1147 21.0 003 Satisfactory 1377 25.2 004 104 1.9 005 Unsatisfactory 13 0.2

(3043) Malignant peripheral nerve sheath tumor, low-grade Case # 2017-25 3043 Malignant peripheral nerve sheath tumor, 5803 95.2 35 43.2 low-grade 3039 Mediastinal spindled mesothelioma 9 0.2 0 0.0 2504 Plexiform neurofibroma 193 3.2 40 49.3 1780 Schwannoma 71 1.2 2 2.5 1584 Spindle cell melanoma, subtle form 10 0.2 2 2.5 3040 Spindle cell pulmonary carcinoma 1 0.1 0 0.0 1117 Spindle cell thymoma 9 0.2 2 2.5 001 Excellent 2708 49.3 002 1234 22.5 003 Satisfactory 1435 26.1 004 102 1.9 005 Unsatisfactory 10 0.2 (2454) Diffuse large B-cell lymphoma Case # 2017-26 2453 Burkitt lymphoma 62 1.0 11 14.0 2454 Diffuse large B-cell lymphoma 6006 98.5 63 80.0 1934 Extranodal marginal zone/malt 26 0.4 5 6.0 lymphoma 1901 Gastrointestinal stromal tumor 0 0.0 0 0.0 2334 Mantle cell lymphoma 1 0.1 0 0.0 1674 Metastatic melanoma 0 0.0 0 0.0 001 Excellent 2960 54.0 002 1113 20.3 003 Satisfactory 1320 24.1 004 84 1.5 005 Unsatisfactory 6 0.1

(1649) Solitary fibrous tumor Case # 2017-27 2056 Angiosarcoma 162 2.7 26 35.0 2269 Embryonal sarcoma 35 0.6 4 5.2 1134 Metastatic gastrointestinal stromal tumor 47 0.8 4 5.2 2944 Metastatic leiomyosarcoma 7 0.1 1 1.3 1649 Solitary fibrous tumor 5846 95.8 40 53.3 001 Excellent 2651 48.2 002 1241 22.6 003 Satisfactory 1466 26.6 004 133 2.4 005 Unsatisfactory 13 0.2 (2446) Pheochromocytoma Case # 2017-28 1891 Adrenal cortical adenoma 2 0.1 2 2.6 2345 Adrenal cortical carcinoma 18 0.3 4 5.2 1992 Alveolar soft part sarcoma 5 0.1 1 1.3 1984 Chromophobe renal cell carcinoma 8 0.1 0 0.0 2352 Oncocytoma (adrenocortical) 4 0.1 0 0.0 1797 Papillary renal cell carcinoma 0 0.0 0 0.0 2446 Pheochromocytoma 6057 99.3 69 91.0 001 Excellent 2795 50.5 002 1192 21.6 003 Satisfactory 1434 25.9 004 103 1.9 005 Unsatisfactory 9 0.2

(1013) Rhabdomyosarcoma Case # 2017-29 2136 Desmoplastic small round cell tumor 310 5.1 35 46.7 1994 Embryonal carcinoma 89 1.5 14 18.6 2137 Ewing sarcoma/primitive neuroectodermal 60 1.0 2 2.7 tumor 2183 Lymphoma 3 0.1 0 0.0 1013 Rhabdomyosarcoma 5640 92.3 24 32.0 001 Excellent 2617 47.3 002 1285 23.2 003 Satisfactory 1479 26.7 004 131 2.4 005 Unsatisfactory 17 0.4 (2101) Sarcoidosis Case # 2017-30 3041 Allergic myocarditis 0 0.0 0 0.0 2397 Giant cell myocarditis 187 3.1 14 18.4 2399 Lymphocytic myocarditis 13 0.2 4 5.2 2101 Sarcoidosis 5872 96.4 51 67.2 3042 Tubercular myocarditis 18 0.3 7 9.2 001 Excellent 2737 49.4 002 1206 21.8 003 Satisfactory 1468 26.5 004 115 2.1 005 Unsatisfactory 10 0.2