Collin County Community College BIOL 2401 : Anatomy/ Physiology PNS Peripheral Nervous System (PNS) PNS all neural structures outside the brain and spinal cord Includes sensory receptors, peripheral nerves, associated ganglia, and motor endings Provides links to and from the external environment 1
Peripheral Nervous System (PNS) Afferent Division of the Nervous System Receptors Sensory neurons Sensory pathways Efferent Division of the Nervous System Cerebral motor Nuclei Motor tracts Motor neurons Peripheral Nervous System (PNS) Immediate Involuntary Response Processing centers in the spinal cord or brain stem may direct an immediate reflex response even before sensations reach the cerebral cortex. Motor Pathway (involuntary) Sensory Pathway Arriving stimulus Depolarization of Receptor Action Potential Generation Propagation CNS Processing A stimulus produces a graded change in the membrane potential of a receptor cell. If the stimulus depolarizes the receptor cell to threshold, action potentials develop in the initial segment. Axons of sensory neurons carry information about the type of stimulus (touch, pressure, temperature) as action potentials to the CNS. Information processing occurs at every relay synapse. Sensory information may be distributed to multiple nuclei and centers in the spinal cord and brain. Voluntary Response The voluntary response, which is not immediate, can moderate, enhance, or supplement the relatively simple involuntary reflexive response. Motor Pathway (voluntary) Perception Only about 1 percent of arriving sensations are relayed to the primary sensory cortex. 2
PNS in the Nervous System Figure 13.1 Sensory Receptors Structures specialized to respond to stimuli Activation of sensory receptors results in depolarizations that trigger impulses to the CNS The realization of these stimuli, sensation and perception, occur in the brain Sensory Receptors can be specialized cells closely associated with peripheral endings of sensory neurons or specialized regions of sensory neurons. 3
Receptor Classification by Stimulus Type Mechanoreceptors respond to touch, pressure, vibration, stretch, and itch Thermoreceptors sensitive to changes in temperature Photoreceptors respond to light energy (e.g., retina) Chemoreceptors respond to chemicals (e.g., smell, taste, changes in blood chemistry) Nociceptors sensitive to pain-causing stimuli Receptor Class by Location: Exteroceptors Respond to stimuli arising outside the body Found near the body surface Sensitive to touch, pressure, pain, and temperature Include the special sense organs Receptor Class by Location: Interoceptors Respond to stimuli arising within the body Found in internal viscera and blood vessels Sensitive to chemical changes, stretch, and temperature changes 4
Receptor Classification by Structural Complexity Receptors are structurally classified as either simple or complex Most receptors are simple and include encapsulated and unencapsulated varieties Complex receptors are special sense organs Simple Receptors: Unencapsulated Free dendritic nerve endings Respond chiefly to temperature and pain Tonic receptors with small receptive fields (discussed later) Merkel (tactile) discs Fine touch and pressure receptors Extremely sensitive tonic receptors Have very small receptive fields Hair follicle receptors (root plexus) Monitor distortions and movements across the body surface wherever hairs are located Adapt rapidly, so are best at detecting initial contact and subsequent movements 5
Simple Receptors Hair root plexus Free nerve ending Merkel cell Nerve terminal (dendrite) Tactile disc Afferent nerve fiber Simple Receptors: Encapsulated Meissner s corpuscles (tactile corpuscles) Perceive sensations of fine touch, pressure, and low-frequency vibration Fairly large structures, usually in dermal papillae Adapt to stimulation within 1 second after contact Most abundant in the eyelids, lips, fingertips, nipples, and external genitalia Pacinian corpuscles (lamellated corpuscles) Deeper in dermis and sensitive to deep pressure; Fast-adapting receptors Most sensitive to pulsing or high-frequency vibrating stimuli Ruffini s corpuscles Located in the reticular (deep) dermis and sensitive to pressure and distortion of the skin Tonic receptors that show little if any adaptation 6
Tactile corpuscle Epidermis Capsule Dendrites Dermis Sensory nerve fiber Tactile corpuscle Tactile corpuscle LM 330 Dermis Dendritic process Acceesory cells (specialized fibroblasts) Concentric layers (lamellae) of collagen fibers separated by fluid Lamellated corpuscle Lamellated corpuscle (cross section) LM 125 7
Collagen fibers Sensory nerve fiber Capsule f Ruffini corpuscle Dendrites ProprioReceptors They monitor position of joints, tension in ligaments and tendons and state of muscular contraction Joint kinesthetic receptors Golgi tendon organs Muscle spindles BaroReceptors Monitor change in pressure Consist of free nerve endings that branch within elastic tissues of the walls of distensible organ (such as a blood vessel Respond immediately to a change in pressure, but adapt rapidly 8
Sensory Receptors The simple receptors provide us with information regarding Temperature Pain Touch Pressure General senses Vibration Proprioception The special senses have special within protective structures. They include smell, taste, vision, hearing, equilibrium Receptor Density Receptors vary in terms of abundance relative to each other. For example, there are far more pain receptors than temperature receptors in the body. Receptors also vary in terms of the concentration of their distribution over the surface of the body The fingertips having far more touch receptors than the skin of the back of the hand. The figure shows the distribution of temperature receptors in the skin by area. 9
Thermoreceptors As a population, thermoreceptor neurons show two general response profiles as a function of temperature: Some receptors are cold sensitive, others are warm sensitive. From Sensation to Perception Survival depends upon sensation and perception Sensation is the awareness of changes in the internal and external environment Perception is the conscious interpretation of those stimuli and of the external world from a pattern of different sensory nerve impulses via the sensory receptors. Some perceptions are indeed integrated compound sensations such as for example wetness ( touch, pressure and thermal input. there is no such thing as a wetreceptor ) 10
Organization of the Somatosensory System Input comes from exteroceptors, proprioceptors, and interoceptors The three main levels of neural integration in the somatosensory system are: Receptor level the sensor receptors Circuit level ascending pathways Perceptual level neuronal circuits in the cerebral cortex Processing at the Receptor Lever The receptor must have specificity for the stimulus energy ( temperature, touch, pressure, light, ) The receptor s receptive field must be stimulated Stimulus energy must be converted into a graded potential If the receptive field is in the same neuron that generates the action potential, we call it a generator potential. If the receptive field is in a separate cell, it is called a receptor potential. If summed up to reach threshold, hhis will then release neurotransmitters in order to excite the associated sensory neuron. 11
Receptive Field Receptive field 1 Receptive field 2 Processing at the Receptor Lever The steps in formation of a generator potential are not known for every receptor, but where it has been studied the start of the generator potential usually results from an increase in the permeability of the membrane of the receptor to all small ions Usually, the ion furthest from its electrochemical equilibrium and in greatest concentration, namely sodium, contributes the greatest current. ( and thus results in EPSP s) 12
Processing at the Receptor Lever Step1 : Stimulus) Step 2 : Generator Potential Step 3 : Action Potential N.T. release Step 1 : Stimulus Step 2 : Receptor Potential Step 3 : Action Potential Example : Muscle spindle Muscle spindles are composed of 3-10 intrafusal muscle fibers that lack myofilaments in their central regions, are noncontractile, and serve as receptive surfaces They inform the body of the muscle tone and length of a muscle. They become activated when stretched and send sensory impulses to the CNS. 13
Example : Muscle spindle The figure shows the graded responses of the muscle spindles when the muscle is stretched. The amplitude of the generator potentials increase with increasing stimulus strength. Different amounts of muscle stretch ( as shown by the heights in the lower trace) resulted in the graded series of generator potentials shown in the upper trace. Example : Pacinian Corpuscle Pacinian corpuscles are present in the skin, some mucous membranes etc. They are mechanoceptors, responding to pressure, or any kind of mechanical stimulus causing a deformation of the corpuscle. The Pacinian corpuscle has a single afferent nerve fiber. Its end is covered by a sensitive receptor membrane whose sodium channels will open when the membrane is deformed in any way. It is surrounded by several concentric capsules of connective tissue, with a viscous gel between them. 14
Example : Pacinian Corpuscle In the resting state, a crosssection through the corpuscle looks something like this Now, if the skin over the corpuscle is touched, it will be deformed and make a nuisance of itself: But the viscous gel between the capsules will move and allow the nerve ending to resume its normal shape: If the pressure is now released, the corpuscle as a whole will resume its original shape, but the nerve ending will be deformed in the process: The viscous gel will then flow back, and soon we are back at the beginning. Example : Pacinian Corpuscle The result is two generator potentials; one when pressure is applied and one when pressure is released. This system is thus very good for picking up vibrations. 15
Adaptation of Sensory Receptors To a certain extent, the duration of the generator potential depends upon the duration of the stimulus. However, some receptors have generator potentials that last only a short time, no matter how long the stimulus is maintained. We refer to a decrease in the amplitude of the generator potential or the frequency of discharge of the sensory fiber in the face of a persisting, constant stimulus as adaptation. Adaptation of Sensory Receptors Those that adapt slow or not at all are called tonic receptors. Receptors responding slowly include Merkel s discs, Ruffini s corpuscles, and interoceptors that respond to chemical levels in the blood Pain receptors and proprioceptors do not exhibit adaptation (why not?) 16
Stimulus Normal Increased Normal Frequency of action potentials a Time Tonic receptors are always active and generate action potentials at a frequency that reflects the background level of stimulation. When the stimulus increases or decreases, the rate of action potential generation changes accordingly. Adaptation of Sensory Receptors Some receptors are fast adapting. Those that adapt fast are called phasic receptors. Receptors responding to pressure, touch, and smell adapt quickly 17
Figure 15-3b Tonic and Phasic Sensory Receptors. Increased Stimulus Normal Normal Frequency of action potentials b Time Phasic receptors are normally inactive, but become active for a short time in response to a change in the conditions they are monitoring. Skin receptors and adaptation RA = rapid adaptation SA = slow adaptation 18
Tonic and Phasic Receptors There is purpose to these differences. Tonic (slowly-adapting) receptors are important in situations where constant information about a stimulus is important ( they thus send information about ongoing stimulation) Example : internal blood pressure, muscle spindles, injuries (pain) Phasic (rapidly-adapting) receptors send information related to changing stimuli. They stop responding to a maintained stimulus, but when the stimulus is removed, they respond again Example : Hair follicles, pacinian corpuscles,.. Information Coding Any stimulus contains within it certain features that are of interest to the body. Stimuli have intensities or strengths locations or sites of application frequencies of application rates of application modalities Modality, broadly speaking, is a class of sensations that are referred to a single type of receptor. Vision, hearing, touch, smell, and taste are all modalities ( energy forms). Sensory receptors may be sensitive to different kind of energies. For example, putting pressure on the eye cause you to see light flashes, although the function of the eye receptors is to detect light. 19
Information Coding Doctrine of Specific Nerve Energies, as formulated by Johannus Müller, says that, although a sense organ may be sensitive to many forms of stimulus energy other than its real stimulus (called the adequate stimulus), the sensation evoked is always like that associated with the adequate stimulus, no matter what kind of energy was applied. For example : electrical stimulation of the optic nerve, does not result in an electric shock; the sensation evoked is one of seeing light. The doctrine of specific nerve energies implies that the modality or submodality of a sensation is determined not by the stimulus, but by what specific receptor or nerve fiber is stimulated. The doctrine also implies that the subjective qualities of a modality are determined, not in the receptors themselves, but in the central nervous system. (in this case for the optic nerve, it is determined by the visual cortex). Processing at the Circuit Level Chains of three (3) neurons conduct sensory impulses upward to the brain First-order neurons soma reside in dorsal root or cranial ganglia, and conduct impulses from the skin to the spinal cord or brain stem Second-order neurons soma reside in the dorsal horn of the spinal cord or medullary nuclei and transmit impulses to the thalamus or cerebellum Third-order neurons located in the thalamus and conduct impulses to the somatosensory cortex of the cerebrum 20
Processing at the Circuit Level Neuronal signals from skin and deeper structures are segregated in the spinal cord. For pain, temperature and the less discriminative aspects of touch, neurons in the dorsal horn have axons that cross in the spinal cord and ascend via the spinothalamic tract For discriminative touch and for conscious proprioception, the axons of primary sensory neurons ascend ipsilaterally ( do not cross over) in the dorsal funiculus (either gracile or cuneate fasciculus) and end in the gracile or cuneate nucleus. Fibers arising in these nuclei cross in the medulla and ascend in the medial lemniscus, which is near the midline in the medulla and shifts to a lateral location in the midbrain. The differences between the two main ascending somatosensory pathways are important functionally and clinically. Specific lesions within the spinal cord can thus results in specific loss of sensations in the body. Processing at the Circuit Level Discriminative touch, conscious proprioception Simple touch, temperature, pain 21
Processing at the Perceptual Level Both spinothalamic tract and the medial lemniscus terminate in the ventral posterior nucleus of the thalamus. The thalamus projects fibers to: The somatosensory cortex of postcentral gyrus Sensory association areas First one modality is sent, then those considering more than one The result is an internal, conscious image of the stimulus Main Aspects of Sensory Perception Perceptual detection detecting that a stimulus has occurred and requires summation Magnitude estimation how much of a stimulus is acting Spatial discrimination identifying the site or pattern of the stimulus Feature abstraction used to identify a substance that has specific texture or shape Quality discrimination the ability to identify submodalities of a sensation (e.g., sweet or sour tastes) Pattern recognition ability to recognize patterns in stimuli (e.g., melody, familiar face) 22
Structure of a Nerve Nerve cordlike organ of the PNS consisting of peripheral axons enclosed by connective tissue Connective tissue coverings include: Endoneurium loose connective tissue that surrounds axons Perineurium coarse connective tissue that bundles fibers into fascicles Epineurium tough fibrous sheath around a nerve Classification of Nerves Sensory and motor divisions Sensory (afferent) carry impulse to the CNS Motor (efferent) carry impulses from CNS Mixed sensory and motor fibers carry impulses to and from CNS; most common type of nerve 23
Peripheral Nerves Mixed nerves carry somatic and autonomic (visceral) impulses The four types of mixed nerves are: Somatic afferent and somatic efferent Visceral afferent and visceral efferent Peripheral nerves originate from the brain or spinal column 24