CP80 Version: V01. Acute Oncology Management Service Date approved: 8 th May 2015 Date ratified: 1 st June 2015 Review date: 1 st June 2017

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STANDARD OPERATING PROCEDURE (SOP) AND PATHWAY FOR THE MANAGEMENT OF PATIENTS WITH METASTATIC SPINAL CORD COMPRESSION (MSCC) WITHIN THE CHRISTIE (Refer to the Manchester Cancer Network MSCC Pathway flowchart) Procedure reference: Version: Document owner: Lena Richards, Network MSCC Coordinator Accountable committee: Acute Oncology Management Service Date approved: 8 th May 2015 Date ratified: 1 st June 2015 Review date: 1 st June 2017 Parent policy Manchester Cancer Network MSCC Pathway and Guidelines - www.christie.nhs.uk/mscc Other associated policies NICE MSCC Guidelines (2008) Target audience: All clinical staff - 1 -

STATEMENT OF INTENT PURPOSE OF SOP To provide patients who have a suspicion of, or confirmed MSCC with timely and excellent care according to the network and Christie MSCC pathway and guidelines. To ensure patients who present at the Christie or to the Christie with a suspicion of, or confirmed MSCC receive urgent clinical examination, investigations and treatment in line with the NICE guidelines (2008), the Manchester Cancer MSCC pathway and the Christie internal MSCC pathway. Early recognition of signs and symptoms, urgent diagnosis and treatment will optimise favourable outcomes, i.e. patient maintains quality of life and function and life expectancy is improved. SCOPE AUTHORISED PERSONNEL / TRAINING REQUIRED REFERENCES (if applicable) All Christie clinical staff All Christie clinical staff must be aware of the signs and symptoms of MSCC and be aware of the internal pathway and where to find this. Manchester Cancer MSCC webpage (including Network pathway and guidelines) www.christie.nhs.uk/mscc National Institute for Health and Care Excellence (2008) Metastatic Spinal Cord Compression: Diagnosis and management of patients at risk of or with metastatic spinal cord compression. Cardiff: National Collaborating Centre for Cancer, cg75. (Online). Available: http://publications.nice.org.uk/metastatic-spinal-cordcompression-cg75 (16/9/13). National Institute for Health and Care Excellence (2012) NICE Pathways - http://pathways.nice.org.uk/pathways/metastaticspinal-cordcompression - 2 -

1. Prior to any onset of MSCC All at risk patients (Primary cancer with new diagnosis of bone metastases) should be given the Patient Information leaflet: Spinal Cord Compression What you need to know by a clinician. The contents must be explained to the patient face to face. It is available within the Christie guidelines under Patient Information - www.christie.nhs.uk/mscc 2. Confirm diagnosis Patient in The Christie, Out Patients (OP) or In Patients (IP) with suspicion of MSCC: New severe nerve root pain (band like, unilateral or bilateral) New severe localised vertebral pain (especially thoracic) NB: Loss of power / mobility / sphincter problems = late signs of MSCC If patient is seen as an OP, place on stretcher and commence flat bed rest / log roll. If bed available, arrange admission via Patient Admissions Transfer (PAT) suite or direct to Oncology Assessment Unit (OAU), (liaise with Bed Manager on bleep 12593), request urgent Magnetic Resonance (MR) whole spine (see below) on same day or within 24 hours of clinical suspicion. If patient is seen as an OP and there is no bed available, transfer patient to their local A&E via 999 ambulance (transfer patient flat and log roll). Call Accident & Emergency (A&E) with information regarding suspicion of MSCC and inform the local Acute Oncology team of patient s transfer. If patient already an IP, arrange urgent clinical assessment by the treating team and if appropriate request urgent MR scan of the whole spine to be done within 24 hours (see below). If patient has had a recent Computerised tomography (CT) staging scan at The Christie for suspicion of bone metastases and this shows incidental finding of cord compression or high risk of cord compression, arrange urgent admission for MR whole spine to Christie if bed available, if no bed, send to local hospital. If patient is at home with signs of MSCC, urgent ambulance and transfer to local A&E should take place. If treating consultant has specifically requested admission to The Christie, liaise with Bed Manager on bleep 12593 to ensure bed is available. Management Radiology: Referring clinician requests urgent MR scan via Christie Web Portal (CWP), see Patient Menu, under Referrals Request imaging. The request form should state suspected MSCC with a description of presenting signs and symptoms. This should be followed by a telephone call to the Pat Seed Department to make radiology aware. Standard and agreed reporting timings: For a.m. sessions report available by 13:00, for p.m. sessions report available by 17:00. Where urgent information is required, reporting Radiologist can be contacted for verbal report prior to formal written report available. - 3 -

Out of hours - patients with suspected MSCC who require urgent MR scan should be discussed by referring consultant and consultant radiologist. If imaging confirms cord compression, the radiology department contact the referring clinician or treating team urgently (if not available, contact the on-call Specialist Trainee Registrar (ST) for Medical or Clinical Oncology. The MSCC Coordinator can also be contacted to assist with communication between clinicians: MSCC Coordinator: Contact on ext 6894 or bleep 12616 for advice and assistance. Advanced Nurse Practitioners: Contact on bleep 12002 to offer support to patient, provide information and ensure timely management. Steroids: Start Dexamethasone 16mg OD as initial loading dose with PPI cover, subsequent days 8mg BD. Flat bed rest / log roll: Immobilise patient (as per The Christie, Greater Manchester & Cheshire MSCC guidelines) Admission to the OAU: Admitting team: ST or ward doctor completes a thorough assessment with a full neurological examination. Nursing staff: MSCC forms to be completed every shift. Forms available on CWP under forms: Spinal cord compression care. Physiotherapy and Occupational Therapy: Patient to be referred on admission, fax 8151 (ext 3795). 4. Triaging and treatment No / Impending MSCC: If MR scan shows no or impending MSCC, inform treating team to ensure continued monitoring of signs and symptoms. If symptoms persist or worsen review patient urgently. If on-going problems with symptoms, refer to the Pain, Palliative Care Team and Symptom Control team via fax (referral form on intranet), for urgent referrals, bleep 12767. Confirmed MSCC: Contact the MSCC Coordinator in hours (ext 6894 or bleep 12616), or Clinical Oncology ST on-call out of hours to triage patient and decide treatment plan. The following information is required: Date and time of MR scan or results of scan if already reported History Full Neurological assessment Mobility immediately prior to and on admission Performance status Prognosis. Triage: the following 3 outcomes are possible: A. Clinical status and cancer prognosis require urgent surgical opinion B. Clinical status and cancer prognosis indicate immediate radiotherapy C. Clinical status and cancer prognosis indicate best supportive care only - 4 -

(NB: If surgery indicated, the MSCC Coordinator will contact the Spinal Team at Salford Royal Foundation Trust (SRFT) during working hours 9 5 Monday to Friday. If out of hours, the Clinical Oncology ST will contact the Spinal Team. If awaiting surgical opinion or transfer to SRFT patient should remain of flat bed rest / log roll and on 8 mg Dexamethasone + PPI unless spinal team advise otherwise. In some instances patient may be transferred to SRFT for assessment for suitability for surgery and if not suitable, will return to the Christie on the same day. If surgery not indicated and patient triaged to have radiotherapy, on-call Clinical Oncology team will arrange urgent treatment within 24 hours of confirmation of MSCC. If patient is not suitable for any treatment and is for best supportive care, ensure referral to Palliative Care team has been made. 5. Spinal stability and re-mobilisation Re-mobilisation: Once MR scan has been reported, and if confirmed or impending cord compression, decision regarding stability should take place at the earliest opportunity and is a joint decision by Clinical Oncology ST via bleep (call switch), Physiotherapist with advice from Radiology and refer to the Stability guidelines on the Christie MSCC webpage within the Guidelines - see http://www.christie.nhs.uk. NB This decision must be documented in the patient notes and on CWP. Spinal team should not routinely be contacted for advice, only if there is considerable doubt. If MR scan reported on a Friday, ensure graded sitting commences (by appropriately trained physiotherapist or nurse) to avoid unnecessary flat bed rest over the weekend. 6. Bracing with Cervical collars / Thoraco-lumbar supports If cervical collars are required for patients with suspicion of, or confirmed MSCC (patients with severe pain on movement and deteriorating neurology where pain is due to spinal instability) refer to the Physiotherapy Department from 8 am 4 pm (Mon-Fri) or the Advanced Nurse Practitioners (ANPs) on bleep 12002 from 4 pm 9.30 pm. Overnight and weekends (9.30 pm 8 am) referral should be made to the on-call physiotherapists via switchboard for initial fitting (stock of collars available 24/7). Braces (TLSOs) to be ordered from manufacturers as necessary (Mon Fri 8 am to 4 pm). Patients require these to be measured and ordered on a bespoke basis and therefore are to remain on flat bed rest / log rolled until appropriate brace can be fitted. For removal and re-positioning and care of collar/brace handover to nurse responsible for patient will be done by the physiotherapist following initial fitting of collar. The ANP may be contacted between 4 pm and 9.30 pm for any queries regarding re-positioning / care of collar / brace. - 5 -

Mandatory training on management of braces to be attended by all registered nursing and radiotherapy staff, and other staff members who require this training. Further training /information will be accessible via the internet. All patients who are prescribed with a brace require routine follow up by clinical team to review the need for continued use of the brace. Brace prescription should include rationale for brace (spinal stability / pain control), duration of use (24 hours/day / for mobilising only). - 6 -

The Christie Internal Metastatic Spinal Cord Compression Pathway (See accompanying SOP and Pathway document for details) All at risk patients receive Patient Information leaflet: Spinal Cord Compression What You need to know Clinician reviews patient in The Christie (OP or IP) with suspicion of MSCC: New severe nerve root pain (band like, unilateral or bilateral) New severe localised vertebral pain (especially thoracic) NB - Loss of power / mobility / sphincter problems = late signs of MSCC Admitting team / ward doctor / ANP contact MSCC Co-ordinator with Information required: 1. Scan results or date and time of MR scan 2. History 3. Full Neurological assessment by team ST 4. Performance status 5. Mobility on admission 6. Prognosis If OP and due to be admitted contact ANPs on bp 12002 All patients referred to Physiotherapy and OT, fax 8151 (x 3795) Flat bed rest / log roll Start Dexamethasone and PPI Arrange admission via PAT suite or direct to OAU (liaise with Bed manager) Arrange urgent MR scan within 24 hours (admitting team / ANPs, OOH Consultant to Consultant request) Patient remains flat/log roll Yes No If no bed, send by ambulance to patients local A&E MRI scan confirms MSCC Patient managed by admitting team Urgent clinical triage takes place by the MSCC Co-ordinator and Clinical Oncology on-call ST / Consultant (in hours) and out of hours by direct contact with the Clinical Oncology on-call ST (via switch). MSCC Coordinator contact details: Ext 6894 or bleep 12616 Suitable for surgery: Await transfer to SRFT (patient remains on flat bed-rest / log roll and on 8 mg Dxm BD + PPI, unless spinal team advise otherwise) Suitable for XRT: Clinical Oncology on-call ST / Consultant to plan and treat within 24 hours (see Radiotherapy Pathway). Systemic treatment: Patient managed by responsible team Best Supportive Care: Ensure Palliative Care team contacted Stability and re-mobilisation: Once MR scan has been reported, stability decision to take place jointly without delay by Clinical Oncology ST on-call (via bleep), Physiotherapist and with advice from Radiology (refer to the Stability guidelines on the Christie MSCC webpage within the Guidelines ). Nursing management: MSCC forms to be completed by Nursing staff every shift. Nurses are competent to remove, replace and reposition Cervical collars and Spinal braces. Cervical collars or Spinal braces: (see Pathway document) For fitting of cervical collars contact Physiotherapy Department 8am-4pm (Mon-Fri) or ANPs on bleep 12002 4pm-9.30pm. Overnight/weekends 9.30pm-8am contact on-call physiotherapist via switch. Stock of collars available 24/7. For fitting of braces (TLSOs) contact Physiotherapy Department 8am-4pm (Mon-Fri). These are prescribed for patients with severe pain on movement, measured and ordered on a bespoke basis from manufacturers Mon- Fri 8am-4pm. Removal, re-positioning and care of collar / brace is the responsibility of the nurse looking after the patient. - 7 -

VERSION CONTROL SHEET Insert version number and any minor amendments in this section Version Date Author Status Comment 17/6/15 Lena Richards Created V02 29/2/16 Lena Richards Updated Medical Assessment Unit changed to Oncology Assessment Unit. - 8 -