II Congreso Internacional de Investigación e Innovación en Enfermedades Neurodegenerativas (CIIIEN)

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II Congreso Internacional de Investigación e Innovación en Enfermedades Neurodegenerativas (CIIIEN) II International Congress on Research and Innovation in Neurodegenerative Diseases X Simposio Internacional: Avances en la enfermedad de Alzheimer X International Symposium: Advances in Alzheimer s disease 8º Foro Científico CIBERNED th 8 Ciberned Scientific Forum Barcelona, 22-23 Septiembre 2014 Barcelona, September 22-23, 2014

Lunes 22 de Septiembre Monday, September 22 08:00 h. Welcome and registration. 08:30-10:30 h. Scientific Session I: Stem cells in neurodegenerative diseases. Chairperson : Dr. Antonia Gutiérrez. CIBERNED, University of Málaga, Spain. 08:30 h. Adult neurogenesis in animal models of Parkinson s disease. Dr. Isabel Fariñas. CIBERNED, University of Valencia, Spain. 09:00 h. Stem cells in the carotid body; physiology and biomedical implications. Dr. José L. López-Barneo. CIBERNED, Virgen del Rocío University Hospital, University of Sevilla, Spain. 09:30 h. Stem cells in aging and disease. Dr. Pura Muñoz. CIBERNED, Pompeu Fabra University, ICREA, Barcelona, Spain. 10:00 h. Modeling Parkinson s disease through patient-specific induced pluripotent stem (ips) cells. Dr. Ángel Raya. Center of Regenerative Medicine in Barcelona, Spain. 2

Lunes 22 de Septiembre Monday, September 22 10:30-12:30 h. Scientific Session II: Novel biomarkers in neurodegenerative diseases. Chairperson: Dr. Alberto Lleó. CIBERNED, Santa Creu i Sant Pau Hospital, Barcelona, Spain. 10:30 h. Structural and functional cortical networks in early neurodegeneration Dr. José Luis Cantero. CIBERNED, Pablo de Olavide University, Sevilla, Spain. 11:00 h. Molecular Imaging in Dementia. Its role in clinical practice. Dr. Pascual Sánchez-Juan. CIBERNED, Marqués de Valdecilla Hospital, Santander, Spain. 11:30 h. REM sleep behaviour disorder as an early marker of Parkinson disease. Dr. Alejandro Iranzo. CIBERNED, Hospital Clinic of Barcelona, Spain. 12:00 h. Complex regulation of prion biomarkers expression in sporadic Creutzfeldt-Jakob Disease (scjd). Dr. Franc Llorens. CIBERNED, Bellvitge Institute of Biomedical Research, Barcelona, Spain. 3

Lunes 22 de Septiembre Monday, September 22 With the Presidency of Her Majesty The Queen Sofia 12:30-14:15 h. 12:30 h. OFFICIAL OPENING. 12:35 h. Keynote address. Dr. Antonio Andreu. Director of the Carlos III Institute of Health. 12:40 h. Opening Session. Chairperson: Dr. Jesús Ávila. CIBERNED-CIEN Foundation, Center of Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain. 12:45 h. Does innate immunity contribute to Alzheimer s disease pathogenesis?. Dr. Michael Heneka. German Centre for Neurodegenerative Disease, University of Bonn, Germany. 13:30 h. What is normal in normal aging? The borders between aging and Alzheimer s disease. Dr. Anders Martin Fjell. Research Group for Lifespan Changes in Brain and Cognition, University of Oslo, Norway. 4

Lunes 22 de Septiembre Monday, September 22 14:15 h. Lunch and poster session. 15:45-17:05 h. Scientific Session III: Preclinical changes in neurodegenerative diseases. Chairperson: Dr. José A. Obeso. CIBERNED, Center of Applied Medical Research, Univ. Navarra, Pamplona, Spain. 15:45 h. Update on the Genetics of Parkinson s disease. Dr. Vincenzo Bonifati. Genetics of Parkinson s disease, Erasmus MC, Rotterdam, The Netherlands. 16:35 h. The mitocondrial DNA hypothesis of Alzheimer s Disease. Dr. Ramón Trullas. CIBERNED, Institute of Biomedical Research IDIBAPS-CSIC, Barcelona, Spain. 17:05-19:00 h. Coffee and poster session. 17:30-19:00 h. COMITÉ DE DIRECCIÓN. 19:00-20:00 h. CLAUSTRO CIBERNED. Premio Investigador Joven. 5

Martes 23 de Septiembre Tuesday, September 23 08:00 h. MEETINGS OF COOPERATIVE PROJECTS. 08:30-10:30 h. Scientific Session IV: Novel mechanisms of neurodegeneration and neuroprotection. Chairperson: Dr. José Rodríguez. CIBERNED, Autonomous University of Barcelona, Spain. 08:30 h. Protection of neuronal death and axonal degeneration by FAIM-L. Dr. Bruna Barneda. CIBERNED, Vall d Hebron University Hospital, Barcelona, Spain. 09:00 h. BDNF and STEP: dancing partners in the regulation of synaptic plasticity. Dr. Ana Saavedra. CIBERNED, University of Barcelona, Spain. 09:30 h. Reelin rescues amyloid and Tau pathologies in Alzheimer s disease models. Dr. Lluis Pujadas. CIBERNED, University of Barcelona, Spain. 6 10:00 h. Huntington s disease as a tauopathy. Dr. José Javier Lucas. CIBERNED, Center of Molecular Biology Severo Ochoa, CSIC-UAM, Madrid, Spain.

Martes 23 de Septiembre Tuesday, September 23 10:30 h. Coffee break and poster session. 11:00-12:40 h. Scientific Session V: Progress in Huntington s and ALS. Chairperson: Dr. José Javier Lucas. CIBERNED, Center of Molecular Biology, Severo Ochoa, CSIC-UAM, Madrid, Spain. 11:00 h. Modeling and treatment approaches for Huntington s disease using stem cells. Dr. Leslie M. Thompson. University of California, Irvine, USA. 11:50 h. What causes ALS? Dr. Ammar Al-Chalabi. King s College London, Institute of Psychiatry, London, UK. 12:40-13:40 h. Scientific Session VI: Late-breaking news/poster highlights. Chairperson: Dr. Teresa Iglesias. CIBERNED, Institute of Biomedical Research CSIC-UAM, Madrid, Spain. 7

Martes 23 de Septiembre Tuesday, September 23 13:40 h. Lunch & poster session. 15:30-16:30 h. Scientific Session VII: Novel genetics factors in neurodegenerative diseases. Chairperson: Dr. María Jesús Bullido. CIBERNED, Autonomous University, Madrid, Spain. 15:30 h. New protein aggregate cardioskeletal myopathy associated with combined MuRF1 and MuRF3 mutations. Dr. Montserrat Olivé. CIBERNED, Bellvitge Institute of Biomedical Research, Barcelona, Spain. 16:00 h. The primary pathogenic role of muscle stem cells in a new type of muscular dystrophy. Dr. Carmen Paradas. CIBERNED, University of Sevilla, Spain. 16:30 h. Coffee break. 8

Martes 23 de Septiembre Tuesday, September 23 17:00-18:00 h. Scientific Session VIIi: Other institutions. Chairperson: Dr. Ramón Trullas. CIBERNED, Institute of Biomedical Research IDIBAPS-CSIC, Barcelona, Spain. 17:00 h. Genome-wide analysis of Alzheimer s disease (AD): A huge international effort to uncover genetic factors linked to AD etiology. Dr. Agustín Ruiz & DEGESCO. ACE Foundation. 17:20 h. Analysis of the genetic influence in brain structure and function: the ALFA (Alzheimer and Families project). Dr. Juan D. Gispert. Barcelonabeta Brain Research Centre. Pasqual Maragall Foundation. 17:40 h. The Vallecas Project for early detection of Alzheimer s disease (CIEN Foundation and Queen Sofia Foundation). Dr. Miguel Medina. CIBERNED-CIEN Foundation, Madrid, Spain. 9

Martes 23 de Septiembre Tuesday, September 23 18:30 20:45 FORO SOCIAL 18:30-20:00 h. ALZHEIMER S DISEASE. (Dr. Alberto Lleó, Patient Organizations, Round Table). 20:00-20:45 h. HUNTINGTON S DISEASE. (Dr. Mª Asunción Pastor, Patient Organizations). Parkinson s disease. (Dr. Eduardo Tolosa, Patient Organizations). 20:45 END of meeting. 10

Información Information SECRETARÍA / Secretariat: Fundación CIEN y CIBERNED: Almudena Flores. Soledad Valero. C/ Valderrebollo, 5 28031 Madrid. gerencia@fundacioncien.es / gerencia@ciberned.es Tel. 91 385 22 00 Fax: 91 385 21 18 www.fundacioncien.es / www.ciberned.es SECRETARÍA TÉCNICA Y ORGANIZACIÓN DEL CONGRESO: Congress Secretariat: VIAJES OASIS S.A. C/ Sor Ángela de la Cruz, 8-1º A 28020 Madrid jmicieces@viajesoasis.com Tel. 91 555 11 19 Fax: 91 555 35 81 www.viajesoasis.com SEDE / Venue: HOTEL BARCELÓ SANTS Plaça dels Països Catalans, s/n 08014 Barcelona. Tel. 93 503 53 00 11

Notas Notes 12

Notas Notes 13

COVER PICTURE: Neuronal staining of Tau (white) and nuclei (blue) in CA1 hippocampal region of mouse brain (A. Gamir, C. López-Menéndez and T. Iglesias).

www.fundacioncien.es www.ciberned.es #ciiien