From A'ruk Herbal Division Nicholas Piramal India Ltd. 1 A, B, & C Nirlon Complex, Off. Western Express Highway, Near NSE Complex, Goregaon (East), Mumbai 400063,!!! "!! #$!! % &'jdagaonkar@nicholaspiramal.co.in ()*** +'' 1
Contents 1 Leseffort Powder Laxative powder 3-6 2 Leseffort SF Powder Laxative (Sugar-free) powder 7-10 3 Khasceeze Syrup Cough syrup 11-13 4 Phyleclip Capsule Hepatoprotective capsule 14-16 5 Dimarrest Capsule Diabetes Management capsule 17-19 6 Shedlip Capsule Weight Management capsule 20-22 7 Contudol Capsule Anti arthritic capsule 23-25 8 Contudol Gel Anti arthritic gel 26-27 9 Intelimax Capsule Memory Booster capsule 28-30 10 Flaxilip Capsule Cholesterol Management capsule 31-33 11 Soyaklin Capsule Menopause Care capsule 34-36 12 Prementrid Capsule PMS Care capsule 37-39 2
PRODUCT INFORMATION INTRODUCTION: Constipation is a very common condition seen all over the world, across various age groups, especially in the elderly people. Although there are several reasons for this, fiber-free or fiber-deficient diet is one of the reasons for constipation. The condition could become chronic if timely and proper treatment is not taken. The best remedy for this would be either a fiber rich diet or a fiber supplement. COMPOSITION: Each 5g contains: Plantago ovata husk - 2.5 g Trigonella foenum graecum - 0.1 g Standardized for fiber content Excipients q.s. PHARMACOLOGY: Leseffort is a safe bulk forming laxative and is naturally endowed with intestinal demulcent property. It not only treats constipation, but also helps in preserving appetite and improving digestion. Plantago ovata husk (Isapgol) is a well-known bulk forming laxative. Its property of swelling by absorbing water turns it into a bulk that is not digestible and hence, is not absorbed by the intestine. This bulk of indigestible residue provides the mechanical stimuli for evacuation of the bowel. Trigonella foenum graecum provides bulk to the waste and decreases the colon transit time from 20-36 hrs to 2-6 hrs. It is a gentle and safe laxative that helps reduce the risk of colo-rectal cancer and other bowel disorders often associated with low-fiber diet. 3
MECHANISM OF ACTION: Psyllium contains up to 70% of soluble and 30% of insoluble fibers. Recent study report of USFDA state that regular intake of Psyllium husk effectively reduces constipation, cholesterol level, diabetes and can be used in colon cancer. When Psyllium husk is mixed with water or other liquids like fruit juice, it forms a gel-like gelatinous mass It moves down the digestive organ soaking up toxins and harmful residues, it flushes out toxins of the body through stools. The Soluble fibers content of Psyllium husk has ability to bind with bile acids - an important player in digestion of fats. This process lowers circulating blood cholesterol level, by excretion of those fats. USAGE: IN CONSTIPATION: Psyllium husk by virtue of its hydrophillic property absorbs moisture from the bowel and thus forms a bulk. This bulk in turn stretches the colonic wall, thus initiating the peristaltic movement of the colon and expulsion of feces. Psyllium contains gelforming fibers composed of micro-polysaccharides and cellulose. This plant starch is hydrophilic in nature; hence they add moisture and bulk to stool in colon. The gel like starch softens the feces making hardened stool easier to be eliminated without any kind of damage to the bowelwall. The mucilage forms a temporary gelatinous layer that protects intestinal walls from irritation caused by caustic material in the intestine, thus allowing the repair of adjoining tissues. IN DIARRHOEA: The mucilage contents forms bond with water and hence creates a surface of mucous membrane, forming a sticky mass, which are not easily distributed. Hence this avoids formation of watery outlet during diarrhea and dysentery. 4
IN CHOLESTEROL CONTROL: Psyllium has cellulose fiber, which is responsible for decreasing the absorption of cholesterol into the blood stream. It also gives the feeling of fullness without adding calories. IN DIABETES: The fiber content reduces the release of dietary sugar from the digestive tract into the blood stream, thus assisting in the stabilization of blood sugar level. IN COLON CANCER: Insoluble fiber content dilutes cancer-causing bile acids or moves feces out of the colon more quickly; hence it reduces contact-time of feces in digestive system reducing chances of producing carcinogens (cancer-causing substance). ETHNOBOTANICAL / TRADITIONAL USES: It has also been used in traditional herbal systems of India and China to treat diarrhea, hemorrhoids, bladder problems, diverticular diseases, urinary disorders, coronary heart diseases and high blood pressure. INDICATIONS: Habitual constipation Irregular bowel habits Constipation due to old age, pregnancy and post surgery. As a supportive therapy in anorectal disorders like hemorrhoids, fissures, fistula in ano and in cardiac patients. DOSAGE AND ADMINISTRATION: Adults: 1-2 heaped teaspoon (Approximate 5 10 gm) with warm water at bedtime. Children: 1/2-1 heaped teaspoon (Approximate 2.5 5 gm) with warm water at bedtime or as directed by the physician. CONTRAINDICATIONS: Not reported in the recommended dosage. 5
SIDE EFFECTS: Not reported in the recommended dosage. PRESENTATION: HDPE container of 100 g STORAGE: Store in a cool dry place, with the lid lightly short. Use dry spoon while administering. 6
PRODUCT INFORMATION INTRODUCTION: Constipation is a very common condition seen all over the world especially in the elderly people. Although there are several reasons for this, fiber free or less fiber diet is one of the reasons for constipation. The condition could be chronic if timely and proper treatment is not taken. The best remedy for this would be either a fiber rich diet or a fiber supplement. Diabetic patients who suffer from constipation need a fiber supplement that does not contain sugar. COMPOSITION: Each 5 g contains: Plantago ovata husk - 3.125 g Excipients - q.s PHARMACOLOGY: Leseffort - SF is a safe bulk forming laxative and is naturally endowed with intestinal demulcent property. It not only treats constipation, but also helps in preserving appetite and digestion. Plantago ovata husk (Isapgol) is a well-known bulk forming laxative. Its property of swelling up by absorbing water turns it into a bulk that is not digestible and is not absorbed by the intestine. This bulk of indigestible residue provides the mechanical stimuli for evacuation of the feces. The use of special excipients that make it effervescent also bestow on it mild carminative effect. Further, the absence of sugar in this formulation makes it especially interesting to diabetics as well as calorie conscious persons. 7
MECHANISM OF ACTION: Psyllium contains up to 70% of soluble and 30% of insoluble fibers. Recent study report of USFDA states that regular intake of Psyllium husk effectively reduces constipation, cholesterol level, diabetes and can be used in colon cancer. When Psyllium Husk is mixed with water or other liquids like juice, it forms a gel like gelatinous mass It moves down the digestive organ soaking up toxins and harmful residues, it flushes out toxins of the body through stools. Soluble fibers content of Psyllium husk has ability to bind with bile acids - an important player in digestion of fats found in our body from cholesterol. This process lowers circulating blood cholesterol level, by excretion of those facts. USAGE: IN CONSTIPATION: It increases the passage to the bowel content through formation of bond water. Psyllium contains gel-forming fibers composed of micro-polysaccharides and cellulose. This plant starch is hydrophilic in nature; hence they add moisture and bulk to stool in colon. The gel like starch softens the feces making hardened stool easier to eliminate without any kind of damage to bowel wall. The mucilage forms a temporary gelatinous layer that protects intestinal walls from irritation caused by caustic material in the intestine, thus allowing the repair of adjoining tissues. IN DIARRHOEA: The mucilage contents forms bond with water and hence creates a surface of mucous membrane, forming a sticky masses, which are not easily distributed. Hence this avoids watery outlet during diarrhoea and dysentery. IN CHOLESTEROL CONTROL: The content has cellulose fiber, which is responsible for decreasing the absorption of cholesterol into the blood stream. They also add the filling of fullness without adding calories. 8
IN DIABETES: The fiber content reduces the release of dietary sugar from the digestive tract into the blood stream, thus assisting in the stabilization of blood sugar level. IN COLON CANCER: Insoluble fiber content dilutes cancer-causing bile acids or moves feces out of the colon more quickly; hence it reduces contact-time of feces in digestive system reducing chances of producing carcinogens (cancer-causing substance). ETHNOBOTANICAL / TRADITIONAL USES: It has also been used in traditional herbal systems of India and China to treat diarrhea, hemorrhoids, bladder problems, diverticular diseases, urinary disorder, coronary heart diseases and high blood pressure. INDICATIONS: Habitual constipation Irregular bowel habits Constipation due to old age, pregnancy and post surgery. As a supportive therapy in anorectal disorders like hemorrhoids, fissures, fistula in ano and in cardiac patients. DOSAGE AND ADMINISTRATION: Adults: 1-2 heaped teaspoon (Approximate 5 10g) with warm water at bedtime. Children: 1/2-1 heaped teaspoon (Approximate 2.5 5g) with warm water at bedtime. Or as directed by the physician CONTRAINDICATIONS: Not reported in the recommended dosage. SIDE EFFECTS: Not reported in the recommended dosage. 9
PRESENTATION: HDPE Pack of 100g STORAGE: Store in a cool dry place with the lid lightly short. Use dry spoon while administering. 10
PRODUCT INFORMATION INTRODUCTION: Cough is the most common symptom of respiratory inflections allergic reactions etc. where it helps to throw out the excess mucus. It could also be due to environmental reasons such as pollution and is commonly seen in smokers. Cough could be of different types productive, dry, spasmodic etc. Meet cough syrups, particularly allopathic ones, contain ingredients, which cause drowsiness, irritability, and dryness in months etc., which affect the patients day-to-day functioning. Specially formulated Herbal cough syrups like Khasceeze offer a safe and side effect-free relief from cough. Khasceeze contains time-tested ingredients, which offer fast relief from different types of cough. The name Khasceeze is apply derived from a combination of the Indian word Khasi (meaning cough ) and the English word cease (meaning stop ) COMPOSITION: Each 5 ml contains: 1 Adhatoda vasica extract - 50 mg Standardized for Total alkaloids 1.5% 2 Ocimum sanctum extract - 40 mg Standardized for Tannins 4% 3 Solanum surattense extract - 10 mg Standardized for Total alkaloids 3 % 4 Hedychium spicatum extract - 10 mg Standardized for Glycoside 5 Piper longum extract - 10 mg Standardized for Piperine 0.5 % 6 Terminalia belerica extract - 60 mg Standardized for Tannins 20 % 7 Glycyrrhiza glabra extract - 20 mg 11
Standardized for Glycyrrhizin 20 % 8 Clerodendrum serratum extract - 10 mg Standardized for Total alkaloids 1 % 9 Menthol (Natural Source) - 2.5 mg 10 Honey - 250 mg Flavoured syrup base - q.s. PHARMACOLOGY : Adhatoda vasica (Vasa) is a good expectorant. It liquefies the thick viscid mucus, which is then easily expectorated out. It possesses a slight but persistent bronchodilator action, which proves to be very helpful in chronic cough conditions, especially in cases of bronchial asthma. Ocimum sanctum (Tulsi) is also a proven anti-allergic which possesses action similar to disodium chromoglycate. It is also an adaptogen and an anti-microbial too. This improves the host defense mechanism. Solanum surrentes (Kantakari) is an antiseptic and anti-inflammatory, thus helps reduce inflammation in conditions like pharyngitis, laryngitis, bronchitis etc. Piper longum (Pippali) liquefies the thick cough. It is also a Rasayana, which builds up the immunity of respiratory system so as to reduce the recurrent infections of respiratory tract. Glycyrrhiza glabra (Yashtimadhu) is used extensively as a mild expectorant and anti-inflammatory agent. It is also used in throat infections Terminalia belerica (Baheda) and Hedychium spicatum (Shathi) show potent anti-inflammatory, bronchodilatory, expectorant and anti-spasmodic effect against bronchial spasm induced by histamine, 5-hydroxytryptamine. Clerodendron serratum have significant antinociceptive, anti-inflammatory and antipyretic activities in animal models. The results support the traditional claims as a remedy for pain, inflammation and fever. DOSAGE: Adults: 5 10 ml, 2-3 times a day Children: 2.5 5 ml, 2 3 times a day Or as directed by the physician 12
INDICATIONS: It is prescribed for symptomatic relief in: 1. The treatment of allergic and spasmodic cough 2. Sore throat 3. Dry cough, Smoker s cough 4. Mild infection such as laryngitis and lower respiratory tract infections due to infections (along with antibiotic) CONTRAINDICATIONS: Not reported in the recommended dosage. SIDE EFFECTS: Not reported in the recommended dosage. However, the uterotonic and abortifacient activity of Adhatoda vasica (Vasaka) in high dosage prevents its use in pregnancy or, advocates the same under medical supervision. PRESENTATION: Amber colored PET bottle of 100 ml 13
PRODUCT INFORMATION INTRODUCTION: The Liver plays a vital role in metabolism and has a number of functions in the body including glycogen storage, pharma protein synthesis, and drug detoxification Liver damages may be caused due to : Excess in take of fatty foods. Alcohol Certain drugs Microorganisms such as viruses, bacteria, amoebae etc. Many diseases of the liver are accompanied by jaundice (yellowing of skin, eyes) caused by increased levels of bilirubin in the body. Other symptoms of liver damage include: Loss of appetite or anorexia Jaundice Pain the abdominal region, nausea etc. DESCRIPTION: Ayurveda has a definite answer for the treatment of anorexia which modern science fails to offer. Various herbs have shown therapeutic properties, which would be useful in restoring normal liver functioning and promoting appetite. Considerable scientific work has been done on many herbs to prove their efficacy in anorexia and liver disorders. Phyleclip offers some of these well-documented herbs. Phyleclip offers comprehensive treatment that takes care of all the aspects needed for the treatment of anorexia. Phyleclip promotes appetite and corrects anorexia, corrects liver dysfunction and damage, reduces liver inflammation and enlargement, promotes normal bile secretion and flow, and regenerates liver parenchymal cells, which are lost due to any reason. Phyleclip thus offers complete treatment for anorexia and liver disorders. 14
COMPOSITION: Each capsule contains botanical extracts of: 1 Picrorrhiza kurroa extract - 125 mg Standardized for Bitters 5% 2 Eclipta alba extract - 50 mg Standardized for Wedelectone 1% 3 Phyllanthus niruri extract - 75 mg Standardized for Phyllanthin 1% 4 Tinospora cordifolia extract - 50 mg Standardized for Bitters 5% 5 Boerhaavia diffusa extract - 35 mg Standardized for Total alkaloid 1% 6 Bacopa monieri extract - 20 mg Standardized for Bacoside A & B 10% 7 Piper longum extract - 10 mg Standardized for 0.5% Piperene Excipients q.s. PHARMACOLOGY: Protective and therapeutic effects of Picrorrhiza kurroa have been shown against liver damage by many investigators in diverse models of liver injury in animals. The crude extract as well as the active principle has been shown to protect the liver from injury due to carbon tetrachloride, paracetamol, and alcohol. Marked bile promoting action has been shown in dogs. Anti-inflammatory action and reduction in mast cell degranulation have also been demonstrated. Eclipta alba protected guinea pigs against the mortality induced by CCl 4 liver damage. Reduction in serum transaminase observed. Histopathology of liver also showed a reduction in parenchymal damage. The hepatoprotective effect of Tinospora cordifolia extract was demonstrated in CCl 4 induced liver damage in rats. While acute damage was enhanced by prior exposure to the drug, it proved effective in the prevention of fibrosis, and in stimulating regeneration in hepatic tissue. Phyllanthus niruri-pretreated rats showed no signs of liver necrosis and no hepatic cellular degeneration was seen. This confirms its hepatoprotective effect. Bacopa monieri helps us give up bad habits and addictions 15
of all types. It aids in recovery from alcoholism or drug abuse. For this reason it is added to hepatoprotective formulation. Combined action of all the herbs cures anorexia by improving liver function. INDICATIONS: Anorexia and indigestion Liver damage due to alcohol, hepatotoxic drugs etc. General liver dysfunction Acute and chronic hepatitis Jaundice Fatty degeneration of liver Cirrhosis of liver CONTRAINDICATIONS: Not reported in the recommended dosage. SIDE EFFECTS: Not reported in the recommended dosage. DOSAGE & ADMINISTRATION: Two capsule two times a day, or as directed by the physician PRESENTATION: HDPE bottle of 60 capsules STORAGE: Store in a cool dry, away from direct sunlight 16
PRODUCT INFORMATION INTRODUCTION: Diabetes mellitus is one of the most common metabolic disorders affecting mankind. The number of diabetic patients in the world is increasing in an alarming proportion and is now considered as one of the major diseases responsible for number of deaths in the world. Diabetes is due to lack of insulin or its ineffectiveness in the body. There are two types of diabetes, one is Type I, which is also known as insulin dependant, and the other is Type II, which is non-insulin dependant. Another words Type I diabetes has to be treated by insulin which is given by injection where as Type II diabetes can be treated with other oral anti-diabetic drugs. Some of the common symptoms of diabetes Excessive thirst / hunger Weight loss Blurred vision Delayed wound-healing / recurrent infections Frequent urination Unexplained fatigue Dimarrest is thoughtfully designed product which can be used by both types of diabetics, having mild to moderate symptoms. It contains ingredients which have a beneficial effect on sugar metabolism, thereby controlling sugar levels. COMPOSITION: Each capsule contains: 1 Gymnema sylvestre extract - 150 mg Standardized for Gymnemic acid 50% 2 Tinospora cordifolia extract - 125 mg Standardized for Bitters 5% 17
3 Pterocarpus marsupium extract - 50 mg Standardized for Pterostillbene 4 Trigonella foenum-graecum extract - 50 mg Standardized for Total Saponins 10% Excipients q.s. PHARMACOLOGY: Gymnema sylvestre (MeshashrIngi) is reported to have anti diabetic, hypolipidaemic (lowering triglyceride, total cholesterol, LDL & VLDL) and anti-atherosclerotic property. Hypoglycemic effect is proved in animals as well as in human subjects. Recent scientific investigation on Gymnemic acid has upheld its effectiveness in both Type I and Type II diabetes. Gymnema sylvestre regenerates or revitalizes the insulinproducing beta cells of the pancreas and thereby it controls diabetes. Tinospora cordifolia (Guduchi) plant extract caused reduction in fasting blood sugars in rabbits and rats. The bitter fraction of the aqueous extract caused insignificant reduction in blood sugar levels, but significantly inhibited (48.4%) adrenaline-induced hyperglycemia. The hypoglycemic effect was marked and significant. Tinospora cordifolia extract caused reduction of blood sugar in alloxan-induced hyperglycemic rats and rabbits in the dose of 400 mg/kg body weight. Pterocarpus Marsupium (Vijaysara) has a long history of use in India as a treatment for diabetes. A potent flavonoid (Pterostilbene) in this tree has been shown to help regenerate beta cells in the pancreas as well. Researchers had studied the effects of this herb on 97 individuals with blood sugar problems and were amazed to find that it helped control blood sugar levels in 69% of them. Trigonella foenum graecum (Methi) has demonstrated significant anti-diabetic effects in experimental and clinical studies. An amino acid (4 hydroxyisoleucine) extracted from Fenugreek seed, exhibits an interesting glucose dependent insulin stimulating activity. Two studies in the European Journal of Clinical Nutrition reported that Fenugreek improves glucose tolerance in both Type I and Type II diabetes. Regular intake of fenugreek stimulates pancreatic function. In patients with relatively mild diabetes, fenugreek significantly reduced both fasting and post meal glucose levels and healthy subjects experienced no change in glucose levels. 18
INDICATIONS: Depending on the severity, Dimarrest may be used in both Type I and II Diabetes mellitus as a co therapy or as directed by the physician. DOSAGE & ADMINISTRATION: One capsule two times a day. Can be continued as long as required. CONTRAINDICATIONS: Not reported in recommended dosage SIDE EFFECTS: Not reported in recommended dosage PRESENTATION: HDPE pack of 60 capsules STORAGE: Store in a cool dry place. 19
PRODUCT INFORMATION INTRODUCTION: Obesity is a condition in which individual is significantly overweight. Excessive body fat is accumulated on the belly, buttocks, breasts and thighs. An individual is considered obese when weight is 20% (25% in women) or more over the maximum desirable for their height. In ayurveda, Charak Samhita describes eight different types of bodies that are disease-prone. Out of these, the obese body is described as Medoroga or the one afflicted with the most diseases and troubles. Extra fat puts a strain on the heart, kidneys, liver and on joints such as the hips, knees and ankles and thus, overweight people are susceptible to several diseases. Obesity is considered as a metabolic disorder in ayurveda. Shedlip capsules contain all the ingredients which have an effect on basal metabolism as well as it suppresses the appetite and improves the fat metabolism thereby controlling the body weight. COMPOSITION: Each capsule contains: 1 Garcinia cambogia extract 400 mg Standardized for HCA Ca. salt 50% 2 Commiphora mukul extract Standardized for Guggallsterone E & Z 2.5% - 100 mg 3 Aloe vera extract - 10 mg Standardized for Polysaccharide content 4 Piper nigrum extract Standardized for Piperine 95% - 10 mg Excipients q.s. 20
PHARMACOLOGY: Hydroxycitrate [HCA], a natural substance extracted from the rind of the fruit of Garcinia cambogia (Vrikshamla) is a potent, competitive inhibitor of citrate lyase, an enzyme that is crucial for regulating fat metabolism. The fat burning action of (-) HCA seems to reduce the free fatty acid levels in the blood. Thereby the fat metabolism gets corrected. As per Sushruta, Commiphora mukul (Guggulu) is very useful in the treatment of obesity. The research studies on Guggulu and its purified fractions validated by revealing hypocholesterolemic, hypolipidaemic and anti-atherosclerotic properties. Aloe vera (Kumari) is increasingly being recognized as one of the best agents to promote weight loss. Aloe vera stimulates the metabolic rate in liver cells helping to burn more energy. The activity of each cell rises and more heat is generated. The increasing amount of fuel required for this task is derived from fat and carbohydrate stores of the body. This has a direct effect on the body mass index. Aloe vera also has a high content of Collagen protein. Proteins are difficult to digest and the body spends more energy assimilating them into the system. It also has a laxative effect and improves the digestion. Piperine (Maricha) enhances the bioavailability of the drug. INDICATIONS: Management of obesity and related disorders Improves lipid profile DOSAGE AND ADMINISTRATION: Two capsule two times a day, before meals. The evening dose, preferable with luke warm water. Or as directed by the physician CONTRAINDICATIONS: Not reported in the recommended dosage SIDE EFFECTS: Not reported in the recommended dosage 21
PRESENTATION: HDPE bottle of 60 capsules STORAGE: Store in a cool dry place protected from light 22
PRODUCT INFORMATION INTRODUCTION: Osteoarthritis and other rheumatic disorders are increasingly common today. It affects not only the aging population but also the younger age groups due to physiological and psychological stresses of modern living. NSAIDs and other anti-inflammatory agents are useful but have the risk of side effects such as gastric ulcers and bleeding. That is the reason people are turning to gentle herbal preparations. This makes more sense considering that OA and RA and other articular disorders are chronic and call for long-term treatment. Contudol, a combination of 4 herbs Boswellia serrata, Curcuma longa, Moringa oleifera and Zingiber officinalis - is a natural herbal anti-arthritic. Contudol helps improve mobility and reduce pain in cases of arthritis and other musculo-skeletal disorders. COMPOSITION: Each capsule contains: 1 Boswellia serrata extract 200 mg Standardized for Boswellic acid 60% 2 Curcuma longa extract 100 mg Standardized for Curcuminoids 20% 3 Moringa oleifera extract 50 mg Standardized for Tannins 1% 4 Zingiber officinale extract 35 mg Standardized for Gingerol 5% Excipients q.s. 23
PHARMACOLOGY: Boswellia serrata (Salai guggul) has a marked anti-inflammatory and anti arthritic activity. Rheumatic disorders in many situations demand the same anti-inflammatory effect. Boswellia serrata in a dose range of 25-200 mg/kg orally displayed doserelated anti-inflammatory effect in variety of test models. In acute carrageenin tests it showed 27-46% inhibition of paw edema in rats and mice. In chronic test of formaldehyde-induced arthritis, it exhibited 45-67% anti-arthritic activity in a similar dose range. Curcuma longa (Haldi) Water extract showed significant antiinflammatory activity in acute edema. The alcoholic extract of Moringa oleifera (Shigru) root bark showed anti-inflammatory activity against formalin-induced rat paw edema, cotton pellet implantation and granuloma pouch in oral doses in albino rats. It also showed analgesic activity. Gingerol from Zingiber officinale (Sunthi) possesses anti-inflammatory, and analgesic properties. This formulation inhibits production of prostaglandins and leukotrienes that are responsible for pain and inflammation. An additional feature of Contudol is its disease modifying effect. This means that it slows down the progress of disease, stops further damage to the joint and peripheral structures to help the joint recover on its own. INDICATIONS: Suggested use for arthritis and other arthritic conditions, cervical and lumbar spondylosis, sciatica, sprains, frozen shoulder and other painful inflammatory conditions DOSAGE: Two capsule two times a day, or as directed by the physician CONTRAINDICATIONS: No specific contraindications except hypersensitivity and during pregnancy and lactation 24
SIDE EFFECTS: No side effects reported when used as directed PRESENTATION: HDPE pack of 60 capsules STORAGE: Store in a cool dry place protected from light 25
PRODUCT INFORMATION INTRODUCTION: Musculoskeletal injuries commonly occurs due to sports injuries and accidents. In such cases, a topical medication is useful for immediate relief from pain and inflammation. Also in other rheumatic conditions like osteoarthritis, rheumatoid arthritis, spondylosis, frozen shoulder, sciatica etc., topical application provides additional relief by supplementing the action of internal medication. Contudol gel provides supportive topical therapy in management of arthritic conditions. Contudol gel is a combination of 7 ingredients Methyl salicylate, camphor, Boswelia serrata oil, Eucalyptus oil, Cedrus deodara oil, menthol and Capcicum oleoresin and is indicated for topical use in rheumatoid arthritis and other arthritic conditions, spondylosis, sciatica, sprains, frozen shoulder and musculoskeletal injuries. COMPOSITION: Each 100g contains: 1 Methyl Salicylate 7.0 % 2 Cedrus deodara Oil 4.0 % 3 Boswellia serrata Oil 0.5 % 4 Eucalyptus Oil 4.0 % 5 Menthol 6.0 % 6 Camphor 3.0 % 7 Capsicum Oleoresin 0.1 % Gel base q.s PHARMACOLOGY: Contudol gel is the ideal combination for reducing pain, stiffness and inflammation. Boswellia serrata oil that is known anti-arthritic, anti-inflammatory and analgesic is presented for topical care. It works through a vascular phenomenon. Methyl 26
Salicylate, camphor, Eucalyptus oil, Cedrus deodara oil and Menthol are rubefacients and counter-irritants. These agents, when massaged gently on the affected area, improve the blood supply to that part. Because of which the particular area appears reddish in color and reduces the local pain. Capsicum Oleoresin contains capsacin that temporarily stimulates release of various neurotransmitters from these nerves, leading to their depletion. Without the neurotransmitters, pain signals can no longer be sent. Thereby it reduces the localized pain. INDICATIONS: Suggested in musculoskeletal pains, sprains, muscle strain, sciatica, fibrocytis, lumbago, and arthritis DOSAGE: Massage gently on the affected area. This treatment is repeated as and when necessary CONTRAINDICATIONS: No specific contraindications except hypersensitivity to ingredients SIDE EFFECTS: No side effects reported except minor irritation to skin in hyper sensitive personal. PRESENTATION: HDPE pack of 50 g STORAGE: Store in a cool dry place protected from light 27
PRODUCT INFORMATION INTRODUCTION: The modern world is very competitive. Man has not only to be physically fit to compete, but is expected to be as quick in the mind as in body. For man to succeed in life, he must perform well in school, college and at workplace. He is expected to remember vast amounts of data and concentrate on it fiercely. Ayurveda documents a number of herbs which are highly revered as mental stimulants - that kept the minds of the Rishis and their disciples sharp and active. Intelimax is a combination of 4 effective herbs: Bacopa monnieri (Brahmi), Convolvulous pluricaulis (Shankhpushpi), Winthania somnifera (Ashwagandha), and Nardostachys jatamansi that improves memory and enhances concentration and facilitates cognition and retention capacity. Intelimax reduces stress and performance anxiety. Intelimax is indicated for improving memory and concentration. All persons who need to concentrate on the knowledge and memorize it, can benefit from regular use of Intelimax. COMPOSITION: Each capsule contains: 1 Bacopa monieri extract 250 mg Standardized for Bacoside A & B 10% 2 Convolvulus pluricaulis extract 125 mg Standardized for Bitters 2% 3 Withania somnifera extract 50 mg Standardized for Withanoloide 3%, Total Alkaloid 1.5% 4 Nardostachys jatamansi extract 50 mg Standardized for Valepotriates 0.8% Excipients q.s 28
PHARMACOLOGY: Bacopa monieri (Brahmi) extract improves mental functions by a modulation of the cholinergic and GABAergic neurotransmission. By restoring the frontal cortical muscarinic and cholinergic receptor activities. Bacopa has also demonstrated a significant memory-promoting effect in animal models of Alzheimer's disease. Bacoside A and B were found to facilitate the capacity for mental retention in rats and were active in both positive and negative reinforcement experiments in and throughout the body's network of blood vessels that supply blood and oxygen to the organ systems. The ethanolic extract of the Convolvulus pluricaulis (Shankhpushpi) when administered to rats at different time intervals showed enhanced neuropeptide synthesis of the brain. It induces an increase in brain protein content, thus increasing memory acquisition efficiency. Withania somnifera (Ashwagandha) has been shown to inhibit the breakdown of Gamma Amino Butyric Acid (GABA) in the brain, and this is the primary inhibitory neurotransmitter in the brain. Drugs that increase the activity of GABA or increase its levels in the brain are used in the treatment of central nervous system disorders. Nardostachys jatamansi extract significantly improved learning and memory and also reversed the amnesia induced by diazepam in animal models. INDICATIONS: Loss of memory, age-related dementia, forgetfulness and mental fatigue DOSAGE: One capsule two times a day or as directed by physician CONTRAINDICATIONS: No specific contraindication except hypersensitivity and in pregnancy and lactation PRECAUTIONS: No specific precautions 29
PRESENTATION: HDPE bottle of 30 capsules STORAGE: Store in a cool dry place, away from light 30
PRODUCT INFORMATION INTRODUCTION: Cholesterol, a fatty substance present normally in our body, is essential for normal functioning of the body. There are several types of fat of which high density lipoprotein (HDL), low density lipoprotein (LDL) and Triglycerides TG) are most important. HDL is known as good cholesterol and LDL as bad cholesterol. Excessive levels of this LDL accumulate on the walls of the arteries; reduce the blood flow, leading to diseases like heart attacks, atherosclerosis, ischemaemic heart diseases etc. There are many herbs which have been described in Indian system of medicine which help in reducing the blood levels of cholesterol. Shedlip is a perfectly blended formulation. It helps in managing the cholesterol levels in the body by naturally and safely improving cholesterol synthesis and thereby regulating lipid metabolism. It reduces LDL and increases the HDL level. COMPOSITION: Each soft gelatin capsule contains: 1 Dehydrated Allium sativum powder 200 mg Standardized for Allicin 1% 2 Commiphora mukul (Guggulu) extract 100 mg Standardized for Guggulsterone E & Z 2.5% 3 Linum usitatissimum oil 700 mg 4 Trigonella foenum-graecum extract 10 mg Standardized for 10 % Saponin content Excipients q.s PHARMACOLOGY: Allium sativum (Garlic) is having hypolipidemic, antiplatelet and pro-circulatory effect. Allium lowers total- and LDL-cholesterol and triglyceride concentrations without 31
affecting HDL-cholesterol concentrations. Garlic has a protective effect from atherogenic diets, both in human and animals. Commiphora mukul decreases LDL cholesterol and triglycerides by 15% to 20%. It inhibits liver cholesterol synthesis. At the same time it increases blood levels of HDL cholesterol. Linum usitatissimum (Flaxseed) contains a substance called alpha linolenic acid, which is metabolized to eicosopentanoic acid (EPA). These eicosanoids have anti-atherogenic properties. Trigonella foenum graecum is having hypocholesterolemic effect. MECHANISM OF ACTION: Allium sativum contains allicin that may act as a HMG-CoA reductase inhibitor to reduce serum cholesterol. Guggulsterone E & Z from Commiphora mukul is responsible for hypolipidemic effect. Alpha linolic acid from flax seeds is metabolized to eicosopentanoic acid (EPA) that has anti-atherogenic properties. INDICATIONS: Hyperlipidemia associated disorders Coronary artery diseases Cardiac disorders DOSAGE AND ADMINISTRATION: One capsule two times a day or as directed by physician CONTRAINDICATIONS: Not reported in the recommended dosage. SIDE EFFECTS: Not reported in the recommended dosage. 32
PRESENTATION: Sealed HDPE pack of 60 capsules STORAGE: Store in a cool dry place. Ensure that container lid is tightly closed. 33
PRODUCT INFORMATION INTRODUCTION: Many hormonal changes occur during menopause. Primarily as a result of decreases in estrogen, post-menopausal women are at higher risk of heart disease and osteoporosis. A number of unpleasant symptoms may also accompany menopause. Some, such as vaginal dryness, result from the lack of estrogen. Others, such as hot flushes (or flushes) and decreased libido are caused by more complex hormonal changes. Soyaklin is a combination of 5 effective ingredients: Glycine max (Soya isoflavones), Hypericum perforatum (St. John wort), Terminalia arjuna and Yasad Bhasma and is indicated for improving the menopausal symptoms COMPOSITION: Each capsule contains: 1 Glycine max extract 100 mg Standardized for Soya Isoflavone 40% 2 Hypericum perforatum extract 100 mg Standardized for Hyperforin 8% 3 Terminalia arjuna extract 100 mg Standardized for tannin content 15% 4 Yasad bhasma 15 mg Standardized for elemental Zinc Excipients q.s PHARMACOLOGY: Plant estrogens (called phytoestrogen ) are substances in plants that mimic the effects of human estrogens because the chemical structures are similar and capable of binding to estrogen receptors and forming the active estrogen-protein complex. In 34
fact, phytoestrogens have been present in the human diet for thousands of years and are thought to be a source of estrogens that the human body needs to supplement the decreasing levels of estrogen naturally produced by a woman's body in midlife and beyond. Glycine max (Soya) contains Soya isoflavones that have an effect on phytoestrogens. These play an important role in steroid mechanism and synthesis, thus affecting the female hormone synthesis. Isoflavones have estrogen receptor agonism and antagonism activity. Thereby reducing the symptoms of menopause. Hyperforin from Hypericum perforatum (St. John s wort) extract exhibits significant antidepressant activity. Biochemical research demonstrates that hyperforin inhibits the reuptake of the neurotransmitters - norepinephrine, serotonin, and dopamine. All three of these compounds are naturally found in the brain and regulate moods and emotions. Numerous double-blind studies demonstrate that hyperforin-rich St. John wort extract is significantly superior to placebo and comparable to prescription antidepressants for the treatment of mild to moderate depression. In menopause it plays an important role in mood-elavation. Terminalia arjuna is a unique herb that helps maintain a healthy heart and reduces the effects of stress and nervousness. Arjuna promotes effective cardiac functioning and regulates blood pressure. Yasad bhasma is the natural source of Zinc and it helps strengthens the bone density, which is to reduced due to hormonal imbalance. Thus it prevents osteoporosis after menopause. INDICATIONS: Menopausal symptoms such as: Mood swings Hot flushes Anxiety Irritability Headache Depression 35
Other menopausal symptoms. DOSAGE: One capsule two times a day or as directed by physician CONTRAINDICATIONS: Not reported in recommended dosage PRECAUTIONS: No specific precautions PRESENTATION: HDPE pack of 60 capsules STORAGE: Store in a cool dry place. Protect from light. Keep out of reach from children 36
PRODUCT INFORMATION INTRODUCTION: Premenstrual syndrome (PMS) also known as premenstrual tension (PMT), is a mixture of physical and emotional symptoms that some women experience in the days, or sometimes weeks, leading up to their menstrual period. Symptoms of PMS can start up to two weeks before each period and usually stop when the period starts. PMS is more common in women over the age of 30 years and tends to stop with the menopause. PMS also stops in women who have an operation to remove both their ovaries. Prementrid contains four ingredients - Vitex agnus castus extract, Zingiber officinale (Ginger) extract, Trigonella foenum-graecum and iron from apple juice. Synergistic action of all ingredients takes care of physical and emotional symptoms of PMS. DESCRIPTION: Pre-Menstrual Syndrome (PMS) is a mixed expression of physical and psychological symptoms such as irritability, aggression, tension, anxiety, depression, fluid retention, breast tenderness, headache, feeling of bloating, spasmodic pains and heaviness of the body. Women are affected irrespective of socioeconomic status, race or cultural background and family clusters. The causes of the premenstrual syndrome have not been clearly elucidated but are attributed to hormone fluctuation, neurotransmitters and prostaglandins. A paradigm shift throughout the world (in the last 50 years) in the dietary habits, drugs used and the life style has made the treatment of PMS difficult, so the natural solution. COMPOSITION: Each capsule contains: 1 Vitex agnus castus extract 100 mg Standardized for Agnoside 6% 37
2 Zingiber officinale extract 50 mg Standardized for Gingerol 5% 3 Trigonella foenum-graecum extract 25 mg Standardized for 10% Saponin content 4 Iron from Apple juice 7.5 mg Standardized for Elemental Iron 5% Excipients q.s. PHARMACOLOGY: The fruits of Vitex agnus castus (Chaste tree) contain a mixture of iridoids and flavonoids, and some compounds similar in structure to the sex hormones have been isolated from the leaves and flowers. The effects of agnus castus have been described as similar to those of the corpus luteum. The mechanism of action may also be related to modulation of stress induced prolactin secretion via dopamine, without directly affecting luteinising hormone (LH) or follicle stimulating hormone (FSH). Binding to opioid receptors, endorphins, and neuroactive flavonoids may also have a role. The plant has been used traditionally to relieve the symptoms of the premenstrual syndrome. Hyperforin from St. John s wort exhibits significant anti-depressant activity. Biochemical research demonstrates that hyperforin inhibits the re-uptake of the neurotransmitters - norepinephrine, serotonin, and dopamine. All three of these compounds are naturally found in the brain and regulate mood and emotion. Numerous double-blind studies demonstrate that hyperforin-rich St. John s wort extracts are significantly superior to placebo and comparable to prescription antidepressants for the treatment of mild to moderate depression. In pre menstrual tension, it plays role in relieving CNS symptoms. Trigonella foenum graecum has ability to balance hormone levels aids in treating PMS. Insufficient amounts of dietary iron lead to excessive tiredness, decreased work and weak performance, decreased immune function among others. Iron from apple juice gets absorbed more easily in the body. Thereby it reduces fatigue during PMS. 38
INDICATIONS: Symptoms associated with Pre-Menstrual Syndrome such as - Anxiety Irritability Depression Fluid retention, breast tenderness, headache, feeling of bloating, spasmodic pains and heaviness of the body And other symptoms of Pre-Menstrual symptoms DOSAGE AND ADMINISTRATION: One capsule two times a day from 14 th day to 1 st day of menstruation SIDE EFFECTS: Not reported in recommended dosage CONTRAINDICATIONS: Not reported in recommended dosage PRESENTATION: Sealed HDPE pack of 30 capsules STORAGE: Store in a cool & dry place. 39