Controversies and Advances in the Treatment of Cardiovascular Disease The Fifteenth in the Series November 19 & 20, 2015 Montage Beverly Hills Wednesday, November 18, 2015 6:00 8:00 PM Welcome Reception & Registration Montage Beverly Hills, Marquesa Foyer Oral Abstract Presentation Session Chairs: Wen Cheng, MD, Hasan Jilaihawi, MD Thursday, November 19, 2015 7:00 7:45 AM Registration, Continental Breakfast, and Visit Exhibits 7:45 7:50 AM Welcome Address Program Directors: Raj Makkar, MD, FACC, P.K. Shah, MD, MACC, Timothy D. Henry, MD, FACC, Alfredo Trento, MD, FACC, Saibal Kar, MD, FACC, John G. Harold, MD, MACC, Jon A. Kobashigawa, MD, FACC, Gregory P. Fontana, MD, FACC and Norman Lepor, MD, FACC 7:50 8:00 AM ACC Welcome Address John G. Harold, MD, MACC 8:00 10:10 AM Session I: Atherosclerosis and Dyslipidemia Chair: P.K. Shah, MD, MACC 8:00 8:30 AM Keynote Lecture: Global Epidemic of Cardiovascular Disease Valentin Fuster, MD, PhD, MACC 8:30 8:50 AM Familial Hypercholesterolemia: Magnitude of the Problem Paul N. Hopkins, MD, MSPH 8:50 9:10 AM Beyond Statins: Is the Excitement and Focus on PCSK9 Inhibitors Warranted? P.K. Shah, MD, MACC
9:10 9:30 AM Are Triglycerides a Legitimate Therapeutic Target or Is It a Passing Fad? Michael H. Davidson, MD, FACC 9:30 9:50 AM Targeting Inflammation in Atherosclerosis: Will that Finish the Job? Paul M. Ridker, MD, MPH, FACC 9:50 10:10 AM Roundtable Discussion Michael H. Davidson, MD, FACC, Valentin Fuster, MD, PhD, MACC, Paul N. Hopkins, MD,MSPH, Paul M. Ridker, MD, MPH, FACC, P.K. Shah, MD, MACC 10:10 10:30 AM Break & Visit Exhibits 10:30 AM 12:30 PM Session II: Hypertension Chair: Ronald G. Victor, MD, FACC How Much Should We Lower Systolic Blood Pressure: to Below 140 or 120 mmhg? Two NIH-funded Trials with the Same Design Give us Two Different Answers! 10:40 10:50 AM 140 is right! Norman M. Kaplan, MD 10:50 11:00 AM 120 is right! Suzanne Oparil, MD, FACC 10:50 11:00 AM Roundtable Discussion Ronald G. Victor, MD, FACC, Florian Rader, MD, MSc, FACC How Often does Aldosterone Cause Hypertension? 11:00 11:10 AM 20% of Our Patients Suzanne Oparil, MD, FACC 11:10 11:20 AM 1% of Our Patients Norman M. Kaplan, MD 11:20 11:30 AM Roundtable Discussion Ronald G. Victor, MD, FACC, Florian Rader, MD, MSc, FACC
Carotid Baroreceptor Pacing has Received European CE Approval for the Treatment of Resistant Hypertension and of Heart Failure: Should it also Receive FDA Approval for These Indications? 11:30 11:40 AM Baroreceptor Pacing for Resistant Hypertension Ronald G. Victor, MD, FACC 11:40 11:50 AM Baroreceptor Pacing for Hypertensive Heart Disease and Heart Failure Florian Rader, MD, MSc, FACC 11:50 12:10 PM Roundtable Discussion Norman M. Kaplan, MD, Suzanne Oparil, MD, FACC Florian Rader, MD, MSc, FACC, Ronald G. Victor, MD, FACC 12:10 12:30 PM Keynote Lecture Medical Innovation to Improve Global Human Health Michael Mack, MD, FACC 12:30 1:30 PM Lunch 1:30 2:00 PM Keynote Lecture: Stem Cell Treatment for Distolic Heart Failure Eduardo Marbán, MD, PhD, FACC 2:00 3:20 PM Session III: ACC Perspective Chairs: John G. Harold, MD, MACC, Ralph Brindis, MD, MACC Doctors Versus Boards: The Debate Over New Certification Rules 2:00 2:10 PM Doctors do Not Like the New Rules Paul S. Teirstein, MD, FACC 2:20 2:40 PM Doctors Need to Stay Sharp Richard Baron, MD 2:20 2:30 PM Roundtable Discussion Richard Baron, MD, Ralph Brindis, MD, MACC, John G. Harold, MD, MACC, Paul S. Teirstein, MD, FACC 2:30 2:45 PM How Will We Justify Expensive Medical Devices in Current Medical Era? David J. Cohen, MD, MSc
Registries Versus Trial 2:45 2:55 PM Registries are Invaluable and Should Form the New Basis for Defining Patient Management Ralph Brindis, MD, MACC 2:55 3:05 PM Randomized Clinical Trials Remain the Gold Standard Sanjay Kaul, MD, FACC 3:05 3:20 PM Roundtable Discussion Ralph Brindis, MD, MACC, Sanjay Kaul, MD, FACC 3:20 4:20 PM Session IV: Chair: Evan Zahn, MD, FACC Congenital Heart Disease 3:20 3:35 PM Congenital Heart Disease No Longer Just a Pediatric Problem Jamil Aboulhosn, MD, FACC 3:35 3:50 PM My Adult Congenital Heart Disease Patient is Pregnant Help! Uri Elkayam, MD, FACC 3:50 4:05 PM Tetraology of Fallot in Adulthood: I Thought This was Fixed in Childhood Outlook, Outcome, and New Treatment Modalities Evan Zahn, MD, FACC 4:05 4:20 PM Roundtable Discussion 4:20 4:40 PM Break & Visit Exhibits 4:40 6:00 PM Session V: Controversies in Advanced Heart Disease Chairs: Jon A. Kobashigawa, MD, FACC, and Alfredo Trento, MD, FACC 4:40 5:00 PM New Pharmacologic Treatments in Heart Failure: Neprilysin Inhibitors, Ivabradine, and Beyond Michelle Kittleson, MD, PhD, FACC
Managing the INTERMACS 0/1 Patient: Bridge to Survival or Futility 5:00 5:10 PM Pro Futility Bradley T. Rosen, MD, MBA, FHM 5:20 5:30 PM Pro Survival Danny Ramzy, MD, PhD, FACC 5:20 5:30 PM Discussion Bradley T. Rosen, MD, MBA, FHM, and Danny Ramzy, MD, PhD, FACC Use of the Donation after Circulatory Death (DCD) Donor Heart: Is it Viable? 5:30 5:40 PM Pro Fardad Esmailian, MD, FACC 5:40 5:50 PM Con Jignesh Patel, MD, PhD, FACC 5:50 6:00 PM Discussion 6:00 PM Adjourn
Controversies and Advances in the Treatment of Cardiovascular Disease The Fifteenth in the Series November 19 & 20, 2015 Montage Beverly Hills Friday, November 20, 2015 7:00 7:45 AM Registration, Continental Breakfast, and Visit Exhibits 7:55 8:00 AM Welcome Address Program Directors: Raj Makkar, MD, FACC, P.K. Shah, MD, MACC, Timothy D. Henry, MD, FACC, Alfredo Trento, MD, FACC, Saibal Kar, MD, FACC, John G. Harold, MD, MACC, Jon A. Kobashigawa, MD, FACC, Gregory P. Fontana, MD, FACC Norman Lepor, MD, FACC 8:00 9:30 AM Session VI: Electrophysiology Honorary Chair: Sumeet Chugh, MD, FACC Chairs: Jeffrey S. Goodman, MD, FACC, Eli S. Gang, MD, FACC, Xunzhang Wang, MD, FACC Initial Approach to Treatment of Atrial Fibrillation 8:00 8:10 AM Catheter Ablation is First Line Therapy for Atrial Fibrillation Dhanunjaya Lakkireddy, MD, FACC 8:10 8:20 AM No Need to Reach for the Catheter Right Away, There are Other Approaches Walid Saliba, MD, FACC 8:20 8:30 AM Discussion Dhanunjaya Lakkireddy, MD, FACC, Walid Saliba, MD, FACC Stroke Prevention in Atrial Fibrillation 8:30 8:40 AM Oral Anticoagulation Works, Why Mess With It? Dhanunjaya Lakkireddy, MD, FACC 8:40 8:50 AM Use a Device, Lock the Atrial Appendage and Throw Away the Key Walid Saliba, MD, FACC 8:50 9:00 AM Discussion Dhanunjaya Lakkireddy, MD, FACC, Walid Saliba, MD, FACC
Athletes with Implantable Defibrillators 9:00 9:10 AM Say Yes to Sports, Find a Way to Help Them Play James P. Daubert, MD, FACC 9:10 9:20 AM Limit Their Activity, Sports is a Clear and Present Danger Charles D. Swerdlow, MD, FACC 9:20 9:30 AM Discussion James P. Daubert, MD, FACC, Charles D. Swerdlow, MD, FACC 9:30 10:00 AM Break & Visit Exhibits 10:00 10:30 AM Keynote Lecture: Overall Landscape in Structural Valve Interventions: Where are We Going? Martin B. Leon, MD, FACC 10:30 AM 12:00 PM Session VII: Recent Practice Changing Trials: Digging Into the Data Chairs: Sanjay Kaul, MD, FACC, and James S. Forrester, MD, FACC Impact of the TOTAL, IMPROVE-IT, PEGASUS, MATRIX, and PROMISE Trials 10:30 10:45 AM IMPROVE-IT Ori Ben-Yehuda, MD, FACC 10:45 11:00 AM TOTAL Gregg Stone, MD, FACC 11:00 11:15 AM PEGASUS Robert Harrington, MD, FACC 11:15 11:30 AM MATRIX Roxana Mehran, MD, FACC 11:30 11:45 AM PROMISE TBA 11:45 12:00 AM Roundtable Discussion Ori Ben-Yehuda, MD, FACC, Robert Harrington, MD, FACC, Roxana Mehran, MD, FACC, Gregg Stone, MD, FACC 12:00 1:00 PM Lunch 1:00 1:30 PM Keynote Lecture State of the Art: Interventional Treatment of Coronary Artery Disease Gregg Stone, MD, FACC
1:30 5:20 PM Session VIII: Interventional Cardiology: Structural Heart Disease/Coronary Artery Disease Should the Threshold to Treat Asymptomatic Aortic Stenosis Change in the TAVR Era? 1:30 1:40 PM Yes John Webb, MD 1:40 1:50 PM Medical Therapy is the Standard of Care for Asymptomatic Severe Aortic Stenosis Robert J. Siegel, MD, FACC 1:50 2:00 PM Roundtable Discussion Robert J. Siegel, MD, FACC, John Webb, MD TAVR for Moderate Aortic Stenosis 2:00 2:10 PM TAVR Should be Offered in Appropriately Selected Patients John Webb, MD 2:10 2:20 PM Let Us Not be Overenthusiastic TBA 2:50 3:00 PM Roundtable Discussion John Webb, MD TAVR is Ready for ALL-COMERS 2:30 2:40 PM Yes Martin B. Leon, MD, FACC 2:40 2:50 PM No TBA 2:50 3:00 PM Roundtable Discussion Martin B. Leon, MD, FACC Should the Thresholds Change for the Treatment of Asymptomatic Severe Mitral Regurgitation with Less Invasive Technologies? 3:00 3:10 PM MitralClip Therapy Should be Offered to Asymptomatic Patients with Severe Mitral Regurgitation TBA 3:10 3:20 PM Medical Therapy is the Standard of Care for Asymptomatic Patients with Severe Mitral Regurgitation Robert J. Siegel, MD, FACC 3:20 3:30 PM Roundtable Discussion Robert J. Siegel, MD, FACC
Repair or Replacement for Mitral Regurgitation? 3:30 3:40 PM Repair Always Ted Feldman, MD, FACC 3:40 3:50 PM Replacement Always Anson Cheung, MD 3:50 4:00 PM Roundtable Discussion Anson Cheung, MD, Ted Feldman, MD, FACC Duration of Antiplatelet Therapy after Drug Eluting Stents 4:00 4:10 PM The Case for Short-term DAPT in Most Patients Roxana Mehran, MD, FACC 4:10 4:20 PM Long-term DAPT should be Used Post-MI Ori Ben-Yehuda, MD, FACC 4:20 4:30 PM Until More Evidence is Available, 12 Months should be the Standard of Care Sanjay Kaul, MD, FACC 4:30 4:40 PM Roundtable Discussion Ori Ben-Yehuda, MD, FACC, Sanjay Kaul, MD, FACC, Roxana Mehran, MD, FACC Bioabsorbable Scaffolds or Metallic Stents? 4:40 4:50 PM Bioabsorbable Stents will be the Standard of Care Gregg Stone, MD, FACC 4:50 5:00 PM Metallic Stents will Continue to be the Standard of Care Ted Feldman, MD, FACC 5:00 5:10 PM Roundtable Discussion Ted Feldman, MD, FACC, Gregg Stone, MD, FACC 5:10 5:20 PM Should the Threshold to Treat Asymptomatic Aortic Stenosis Change in the TAVR Era? John Webb, MD 5:20 6:30 PM Session IX: STEMI Chairs: Timothy D. Henry, MD, FACC, Roxana Mehran, MD, FACC STEMI Controversies 5:20 5:30 PM EMS/ED (ED Bypass, EKG Transmission) Ivan C. Rokos, MD, FACC 5:30 5:40 PM Cath Lab/Procedural (Radial vs. Femoral, Antiplatelet, Antithrombin, Multivessel) Roxana Mehran, MD, FACC
5:40 6:00 PM High Risk Patients (Out of Hospital Cardiac Arrest, Advanced Cardiogenic Shock) David A. Cox, MD, FACC 6:00 6:10 PM Public Policy (Certificate of Need/Public Reporting) Ralph Brindis, MD, FACC 6:10 6:30 PM Roundtable Discussion Ralph Brindis, MD, FACC, David A. Cox, MD, FACC, William J. French, MD, FACC, Timothy D. Henry, MD, FACC, Morton J. Kern, MD, FACC, Roxana Mehran, MD, FACC, Ivan C. Rokos, MD, FACC, Gregg W. Stone, MD, FACC, Sam Torbati, MD 6:30 PM Adjourn