UvA-DARE (Digital Academic Repository) Clinical issues in the surgical treatment of colon cancer Amri, R. Link to publication Citation for published version (APA): Amri, R. (2015). Clinical issues in the surgical treatment of colon cancer General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 08 May 2018
Clinical Issues in the Surgical Treatment of Colon Cancer Ramzi Amri
Ph.D. dissertation of: Ramzi Amri, M.D. Postdoctoral Research Fellow Harvard Medical School & Massachusetts General Hospital Correspondence: Ramzi Amri, M.D. Massachusetts General Hospital Department of General and Gastrointestinal Surgery Wang Ambulatory Care Center, suite 460 15 Parkman Street 02114 Boston, MA E-mail: ramri@mgh.harvard.edu The work in this dissertation has been carried out under the joint auspices of Harvard Medical School and the University of Amsterdam. The studies presented in this dissertation were partially supported by unconditional grants from the Fulbright Foundation, the Dutch Cancer Society, the Dutch Digestive Foundation, the Royal Netherlands Academy of Arts and Sciences, Prins Bernhard Cultuurfonds, the Amsterdam University Funds, and the Harvard Catalyst Foundation. Cover and layout: Ramzi Amri Printed by: Ipskamp Drukkers ISBN: 978-94-625-9802-7 2015 Ramzi Amri No part of this dissertation may be reproduced, stored, or transmitted in any form or by any means without permission of the author or publishers of the included scientific papers.
CLINICAL ISSUES IN THE SURGICAL TREATMENT OF COLON CANCER ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. D.C. van den Boom ten overstaan van een door het college voor promoties ingestelde commissie, in het openbaar te verdedigen in de Aula der Universiteit op vrijdag 18 september 2015, te 11 uur door Ramzi Amri geboren te Hammamet, Tunesië
Promotiecommissie: Promotor: Prof. Dr. W.A. Bemelman Universiteit van Amsterdam Copromotor: Dr. D.L. Berger Harvard University Overige leden: Prof. Dr. E. Dekker Prof. Dr. J.F. Lange Prof. Dr. C.J.A. Punt Prof. Dr. M.J. van de Vijver Dr. P.J. Tanis Universiteit van Amsterdam Erasmus Universiteit Rotterdam Universiteit van Amsterdam Universiteit van Amsterdam Universiteit van Amsterdam Faculteit der Geneeskunde
Ζεῦ ἄλλοι τε θεοί, δότε δὴ καὶ τόνδε γενέσθαι παῖδ ἐµόν, ὡς καὶ ἐγώ περ, ἀριπρεπέα Τρώεσσιν, ὧδε βίην τ ἀγαθόν, καὶ Ἰλίου ἶφι ἀνάσσειν καί ποτέ τις εἴποι πατρός γ ὅδε πολλὸν ἀµείνων ἐκ πολέµου ἀνιόντα φέροι δ ἔναρα βροτόεντα κτείνας δήιον ἄνδρα, χαρείη δὲ φρένα µήτηρ. Homer, Iliad 6.476-481 To my mother.
Table of Contents Chapter 1 General introduction and outline of the dissertation 9! Part I: Baseline Presentation and Impact on Outcomes 19! Chapter 2 Impact of screening colonoscopy on outcomes in colon cancer surgery 21! JAMA Surgery. 2013;148(8):747-54.! Chapter 3 Colon cancer surgery following emergency presentation: effects on admission and stage-adjusted outcomes 35! American Journal of Surgery. 2015;209(2):246-53.! Chapter 4 Preoperative carcinoembryonic antigen as an outcome predictor in colon cancer 51! Journal of Surgical Oncology. 2013;108(1):14-18.! Chapter 5 Treatment delay in surgically treated colon cancer: does it affect outcomes? 65! Annals of Surgical Oncology. 2014;21(12):3909-16.! Part II: Patient and Population Factors 81! Chapter 6 Gender and ethnic disparities in colon cancer presentation and outcomes in a US universal health care setting 83! Journal of Surgical Oncology. 2014;109(7):645-51.! Chapter 7 The fate of unscreened women in colon cancer: impact on staging and prognosis 99! American Journal of Surgery. 2015;209(6):927-34.! Chapter 8 The conundrum of the young colon cancer patient 113! Surgery (accepted in revised form).! Chapter 9 Does active smoking induce hematogenous metastatic spread in colon cancer? 127! American Journal of Surgery. 2015; epub ahead of print.!
Part III: Surgical Safety and Complications 135! Chapter 10 The impact of adhesions on operations and postoperative recovery in colon cancer surgery 137! American Journal of Surgery. 2013;206(2):166-71.! Chapter 11 Renewed assessment of the stapled anastomosis with the increasing role of laparoscopic colectomy for colon cancer 149! Surgical Endoscopy. 2014; epub ahead of print.! Chapter 12 Obesity, outcomes and quality of care: body mass increases the risk of wound-related complications in colon cancer surgery 163! American Journal of Surgery. 2014;207(1):17-23.! Part IV: Surgical Pathology 177! Chapter 13 Association of radial margin positivity with colon cancer 179! JAMA Surgery. 2015; epub ahead of print.! Chapter 14 Correcting lymph node ratio for resection length does not improve its prognostic value in colon cancer 197! Submitted.! Chapter 15 Variations in metastasis site by primary location in colon cancer 211! Journal of Gastrointestinal Surgery. 2015;19(8):1522-7.! Chapter 16 Effects of high-grade disease on outcomes of surgically treated colon cancer 223! Submitted.! Appendices 235! Dissertation Summary 237! Nederlandse samenvatting voor niet-ingewijden 245! List of Publications and Author Contributions 253! PhD Portfolio 257! Acknowledgements 261! Curriculum Vitae 265!