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CENTER FOR REPRODUCTIVE MEDCINE Glickman Urological and Kidney Institute and Ob/ Gyn and Women s Health Institute Duration: April 1 30, 2008 Locations: TT3 (Cleveland Clinic), A81 Gynecology ART Teaching and Training Schedule Week 1: 4/1 4/4 Lectures 4/1: Orientation CCF International Department: Sajal Working hours: 9am 5pm Lunch break: 12:30 1:30pm ART Training: from 2 nd April, Surveen Ghumman Sindhu, (Times: 9-11 and 2-4:30) ICSI: Intracytoplasmic sperm injection Classical IVF Oocyte handling Embryo handling Embryo scoring Embryo loading Assisted hatching (chemical) Embryo biopsy ICSI with HOS test Cell spreading Fixation techniques Embryo cryopreservation Date/ Time April 1 st April 1st 11.30am April 1 st 2pm 10:30 am April 3 rd 10:30am April 3 rd 3.00pm April 4 th 8:00am April 4 th Speaker Title Location Manjula Gupta, Kelly Athayde, MT, MS / Reda Mahfouz, Gita Gidwani, Edmund Sabanegh, Appointment for Orientation Endocrine Investigation of Gonadal Function How to Set up an IVF Laboratory: Equipments and Design Medical Management of Male Infertility: Evidence Based Medicine Lab Demonstration: Sperm Selection Techniques for ART Selection Methods for Gametes and Embryos in ART: Latest Results Mullerian Congenital Anomalies; Diagnosis and Management Understanding Spermatogenesis Implications of Ageing on Male and Female Reproduction

(mouse embryos) Vitrification April 4 th Setting up IVF lab: Air quality Management April 7 th 10:30 am April 7th 4:00 pm Reda Mahfouz, / Abdelrazik, Lab Demonstration: Semen Analysis and WBC Detection Sajal Gupta, Intrauterine Insemination April 8th 8:00am April 8th Adi Mehta, Manjula Gupta, Practice Patterns among Reproductive Endocrinologists: the Male Infertility Evaluation Lab Cases: Curves and Sinkers 7.00am- Amy Cronister, MS Associate Director, Genetic Services, Genzyme Genetics GYN Grand Rounds: Broadening Our Perspective on Fragile X: Premature Ovarian Failure and Other Reproductive Issues 8.00 am Surgical Techniques for Sperm Retrieval: Latest update Controlled Ovarian Stimulation for Poor Responders: New Options April 10 th 7.00 am - 8.30am April 10th Linda Bradley, Diagnostic Hysteroscopy April 10 th Kelly Athayde, MT, MS Benchmarks for Quality Management in an ART Laboratory 3.30pm Ashok Agarwal,./ Rakesh Sharma, / Sajal Gupta, Sajal Gupta, Welcome and Introduction to Reproductive Research at Cleveland Clinic: Ph.D. and Sajal Gupta, Superovulation Strategies in Poor Responders: Latest Options Female Infertility Incidence, Etiology and Guidelines for

Management Week 3: 4/14 4/18 Clinical rotation in Human IVF Lab (Times 8-4): Amit Gupta, / Surveen Ghuman, ART Training: Madhuma Shilahar, Kiran Bijlani, April 14 th April 15 th 8.30am April 15 th 3:30pm Amr Kader, Nisarg Desai, Current and Future Perspectives on ICSI: a Critical Commentary Oocyte/Embryo Vitrification: The Latest Results Cell Phone Radiation and Impact on Male Fertility: Evidence Based Medicine ICSI: Intracytoplasmic sperm injection Classical IVF Oocyte handling Embryo handling Embryo scoring Embryo loading Assisted hatching (chemical) Embryo biopsy ICSI with HOS test Cell spreading Fixation techniques Embryo cryopreservation (mouse embryos) Vitrification 7.00-4:00 pm Mark Phippen, Senior Clinical Educator, Covidien Energy-based Devices GYN Grand Rounds: The Art and Science of Electrosurgery: Principles, Applications and Risks Superovulation Strategies for Assisted Reproduction Cryopreservation of Oocytes and Embryos: Latest Review Amr Kader, Women with Cancer-Ovarian tissue Freezing, Embryo Freezing and Oocyte Donation Role of Ultrasound in ART April 18 th 8:30 am Abdelrazik, Sperm DNA Damage and male infertility: evidence based medicine April 18 th 4.30pm Sajal Gupta, Role of Oxidative Stress in Female Infertility and ART Week 4: 4/21-4/25 Clinical rotation in Human IVF Lab (Time 8-4): Madhuma Shilahar, / Kiran Bijlani, 8:30 am 5:00 pm Dan French, Abdelrazik, Diagnosis and Management of Varicocoele: Evidence Based Medicine Optimization of Embryo Culture Media: An Update Sajal Gupta, Ovarian Reserve Tests

April 22 nd Embryo Culture Systems: an Update April 22 nd 12:00pm Tommaso Falcone, Book Chapter in Female Infertility: Seminar A8-800 April 22 nd Clinical Reproductive Medicine and Surgery Editors: Hurd & Falcone, 2007 Superovulation Strategies for Assisted Reproduction April 23 rd April 23 rd Amr Kader, Patient Selection for ART Dan French, Management of Unexplained Male Infertility: Evidence Based Medicine 7.00am 8.00 am 11.00am 3:30pm Linda Bradley, Operative Hysteroscopy Adi Mehta, Clinical and Metabolic Features of Polycystic Ovarian Syndrome Lab Demonstration: Sperm Cryopreservation April 25 th 7.00am April 25 th 12:00pm April 26 th 2.00pm Marjan Attaran, Courtenay Moore, Mohammad Bedaiwy, Ovarian Hyperstimulation Syndrome Female Sexual Dysfunction Patient Selection for ART/ Ovulation Induction Protocols for ART April 28 th 1.00pm Abdelrazik, Tommaso Falcone, Lab Demonstration: TUNEL test for Sperm DNA Damage Laparoscopic Management of Endometriosis A8-800 April 28 th 6.30pm Dinner for Trainees and RRC Faculty Restaurant: Bravo Cucina Eton Collection 28889 Chagrin Blvd. Woodmere, OH 44122 Phone: 216-360-0099 Obstructive Azoospermia

10.00am 11.00 am 2.00pm Amr Kader, Jeffrey Goldberg, Ashok Agarwal, Oocyte/Embryo Vitrification Lab Demonstration Recurrent Pregnancy Loss Update on Routine and Advanced Andrology Lab Techniques 7.00am- Elliot Philipson, Nutrition in Pregnancy (Grand Rounds) Trainee and Course Evaluation Farewell Luncheon and Award of Certificates Sajal Gupta, Female Fertility Preservation Options in Women with Cancer Course Director: Dr. Ashok Agarwal Kelly Athayde, MT, MS, ART Training Supervisor, Main campus Ph.D., ART Training Faculty Course Faculty (Cleveland Clinic): Tommaso Falcone, M.D, Chairman, Ob/Gyn and Women s Health Institute Jeffrey Goldberg, Staff,, Ob/Gyn and Women s Health Institute Marjan Attaran,, Staff, Ob/Gyn and Women s Health Institute Linda Bradley,, Staff, Ob/Gyn and Women s Health Institute Gita Gidwani,, Staff, Ob/Gyn and Women s Health Institute Edmund Sabanegh,, Head, Center for Male Infertility, Glickman Urological and Kidney Institute Adi Mehta,, Staff, Department of Endocrinology Manjula Gupta, Ph.D, Staff, Department of Clinical Pathology Mohamed Bedaiwy,, Resident in Ob/Gyn, University Hospital, CWRU Dan French,, Glickman Urological Institute, Glickman Urological Institute Ph.D., Reproductive Research Center Sajal Gupta,, Reproductive Research Center Reda Mahfouz,, Reproductive Research Center Abdelrazik,, Reproductive Research Center Amr Kader,, Reproductive Research Center Nisarg Desai,, Reproductive Research Center Ph.D., Reproductive Research Center Kelly Athayde, MT, MS, Andrology Laboratory Anitra Patrick, MT, Andrology Laboratory Debbie Garlak, MT, Andrology Laboratory Deb Smith, Andrology Laboratory Indian Speakers: Madhuma Shilahar, Amit Gupta, Surveen Ghuman, Kiran Bijlani,