Final Program. 9 th Georg Rajka ISAD Program - Thursday, May 19, 2016 at the Renaissance São Paulo Hotel Theater

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Final Program Program - Thursday, May 19, 2016 at the Renaissance São Paulo Hotel Theater Theme / Lecture Speaker / Country Time schedule Prologue: "My Adorable Son" Verônica SARNO (Brazil) 14:00-14:05 Introduction Roberto TAKAOKA (Brazil) 14:05-14:10 Rajka Symposium Susanne RAJKA (Norway) 14:10-14:20 AD Timeline - The History of Atopic Dermatitis Johannes RING (Germany) 14:20-14:40 The Hanifin & Rajka Criteria Revisited Jon HANIFIN (USA) 14:40-15:00 AD Around the World Chairs: Valeria AOKI (Brazil) & Alain TAÏEB (France) DENMARK Christian VESTERGAARD 15:00-15:10 FRANCE Alain TAÏEB 15:10-15:20 AFRICA Gail TODD 15:20-15:30 INDIA Murlidhar RAJAGOPALAN 15:30-15:40 Discussion 15:40-16:00 Coffee-Break 16:00-16:30 Music Performance Taiko + Samba WADAIKO SHO (Brazil) 16:30-16:40 JAPAN Norito KATOH 16:40-16:50 CHINA Jianzhong ZHANG 16:50-17:00 CANADA Danielle MARCOUX 17:00-17:10 BRAZIL Valeria AOKI 17:10-17:20

Patient Satisfaction in AD Julie BLOCK (USA) 17:20-17:35 Discussion 17:35-17:55 Concluding remarks Roberto TAKAOKA (Brazil) 17:55-18:00 Opening Cocktail (Renaissance Hotel) 18:00-19:00 Program - Friday, May 20, 2016 at the Renaissance São Paulo Hotel America's Room Theme / Lecture Speaker / Country Time schedule Valeria AOKI (Brazil) Opening Raquel ORFALI (Brazil) Eric SIMPSON (USA) 8:30-8:40 How can AD research translate into better treatments and outcomes? Hywel WILLIAMS (UK) 8:45-9:05 Immunology and Microbiome Chairs: Christian VESTERGAARD (Denmark), Maria SATO (Brazil), Heidi KONG (USA) State of Art: Immunology and AD Christian VESTERGAARD (Denmark) 9:05-9:25 OC01 - A Novel Human Immune System Mouse Model for Human Atopic Dermatitis Yan LI (France) 9:30-9:40 OC02 - Modulatory Effect of Vitamin D on Dendritic Cell Phenotype in Children with Atopic Dermatitis Arturo BORZUTSKY (Chile) 9:40-9:50 OC03 - Evidence of regulatory myeloid dendritic cells and circulating inflammatory epidermal dendritic cells-like modulated by Toll-like receptor (TLR)-2 and TLR7/TLR8 in adults with atopic dermatitis Raquel ORFALI (Brazil) 9:50-10:00 Microbiome and AD Heidi KONG (USA) 10:00-10:20 Discussion 10:20-10:30 Coffee-Break 10:30-11:00

Skin Barrier Chairs: Alain TAÏEB (France), Kyu Han KIM (S. Korea) and Michael CORK (UK) Barrier Defects in AD Michael CORK (UK) 11:00-11:20 OC04 - Effect of water hardness and season of birth on the prevalence of atopic dermatitis in young children: a study within the danish national birth cohort Kristiane ENGEBRETSEN (Denmark) 11:20-11:30 OC05 - High mobility group box 1 (hmgb1) protein downregulates filaggrin gene translation and protein expression, impair stratum corneum formation, and reduce epidermal growth Uffe NYGAARD (Denmark) 11:30-11:40 OC06 - An organotypic model for assessing skin barrier function gives evidence of functional effect for the eczema candidate gene C11ORF30 Sara BROWN (UK) 11:40-11:50 OC07 - Advances in understanding atopic dermatitis - A morphological and functional comparison with healthy skin Simon G. DANBY (UK) 11:50-12:00 Discussion 12:00-12:15 Lunch (Renaissance Hotel) 12:15-13:30 Program - Friday, May 20, 2016 at the Renaissance São Paulo Hotel America's Room Theme / Lecture Speaker / Country Time schedule Poster View (with authors on site) 13:30-14:30 The Therapeutic Effects of Origami Mari KANEGAE (Brazil) 14:30-14:45 Itch Chairs: Norito KATOH (Japan), Jianzhong ZHANG (China) and Martin STEINHOFF (Ireland) Novel therapeutic approaches in pruritus Martin STEINHOFF (Ireland) 14:50-15:10 OC08 - The Disease Cycle in Patients with Chronic Severe and Very Severe Itch Reported by Community Dermatologists in Martin STEINHOFF (Ireland) 15:10-15:20

the United States OC09 - TLR 3 and its role in the itch scratch cycle of nodular prurigo- new insights into innate immune pathways of peripheral itch sensitization Ian MCDONALD (Ireland) 15:20-15:30 Discussion 15:30-15:40 Coffee-Break 15:40-16:00 Evidence Based & Outcome Measures Chairs: Hywel WILLIAMS (UK), Jean-François STALDER (France) and Eric SIMPSON (USA) AD Outcomes Eric SIMPSON (USA) 16:00-16:20 OC10 - Harmonising Outcome Measures for Eczema (HOME) STATEMENT TO ASSESS ATOPIC ECZEMA SYMPTOMS IN CLINICAL TRIALS Phyllis SPULS (Netherlands) 16:20-16:30 OC11 - Evaluation of the measurement properties of symptom measurement instruments for atopic eczema: a systematic review Louise GERBENS (Netherlands) 16:30-16:40 OC12 - How patient-reported outcomes can be useful in routine practice in children with atopic dermatitis? Sebastian BARBAROT (France) 16:40-16:50 OC13 - Atopic dermatitis scores for dark skinned patients John SU (Australia) 16:50-17:00 OC14 - Serum levels of thymus and activation-regulated chemokine as a biomarker for atopic dermatitis Koji MASUDA (Japan) 17:00-17:10 Discussion 17:10-17:30 Gala Dinner (Renaissance Hotel) Brazilian Night Georg Rajka Medal Ceremony 20:00-22:00 Program - Saturday, May 21, 2016 at the University of São Paulo Medical School

Theme / Lecture Speaker / Country Time schedule AD Grand Rounds (AD cases) University of São Paulo Medical School Hospital Medical Doctors only 8:30-9:30 100th Year Celebration Department of Dermatology University of São Paulo Medical School Theater All participants Evandro RIVITTI (Brazil) Jose Antonio SANCHES Jr. (Brazil) 9:30-9:45 Discussion Panel Jon HANIFIN (USA), Johannes RING (Germany), Norito KATOH (Japan), Carlo GELMETTI (Italy) Valeria AOKI (Brasil) 9:45-10:30 Coffee-Break 10:30-10:50 New Perspectives in the Treatment of Atopic Dermatitis Andreas WOLLENBERG (Germany) 10:50-11:10 Treatment & Education Chairs: Andreas WOLLENBERG (Germany) and Peter SCHIMID-GRENDELMEIER (Switzerland) OC15 - Efficacy and safety of crisaborole, a novel, topical, nonsteroidal, antiinflammatory, phosphodiesterase 4 inhibitor in 2 phase 3 studies in children and adults with mild-to-moderate atopic dermatitis Eric SIMPSON (USA) 11:10-11:20 OC16 - Topical corticosteroid phobia in atopic dermatitis: an international validation study of the TOPICOP SCORE Jean-François STALDER (France) 11:20-11:30 OC17 - Preliminary results of the clothes trial: a randomised controlled trial of silk clothing for the management of eczema in children Kim THOMAS (UK) 11:30-11:40 OC18 - Efficacy and safety of Dupilumab for moderate-to-severe atopic dermatitis in adults: a pooled analysis of two phase 2 clinical trials Eric SIMPSON (USA) 11:40-11:50

OC19 - Effects of oral and topical antibiotics in children with infected eczema in the community: The CREAM Study Nick FRANCIS (UK) 11:50-12:00 Discussion 12:00-12:10 Innovations in Patient Care in AD Jean-François STALDER (France) 12:10-12:25 Education and AD Uwe GIELLER (Germany) 12:25-12:40 Annoucements: Abstract awards Final remarks ISAD 2018 12:40-13:00 Roberto TAKAOKA (Brazil) Johannes RING (Germany) Farewell Lunch (Melia Paulista Hotel) 13:00-15:00 Wednesday, May 18, 2016 09h00 ~ 18h00 Preliminary Meeting For AD Non Profit organizations and health professionals who work in the field of education. To apply for the Preliminary Meeting, please, send email to info@isad2016.org 09h00 ~ 12h00 Organization of Care in Atopic Dermatitis - The Role of AD Non Profit Organizations 14h00 ~ 18h00 Design Thinking Workshop - Creating New Solutions for the Patient with Atopic Dermatitis Hotel Renaissance São Paulo - Yukon Room