FRIDAY, MAY 11, TH ANNUAL WOMEN AND ISCHEMIC HEART DISEASE SYMPOSIUM

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SMIDT HEART INSTITUTE 12 TH ANNUAL WOMEN AND ISCHEMIC HEART DISEASE SYMPOSIUM FRIDAY, MAY 11, 2018 Offered in cooperation with the California Chapter of the American College of Cardiology and WomenHeart: The National Coalition for Women with Heart Disease COURSE DIRECTOR C. Noel Bairey Merz, MD, FACC, FAHA CONFERENCE LOCATION Harvey Morse Conference Center Plaza Level, South Tower 8701 Gracie Allen Drive Los Angeles, CA 90048 For the latest course information and to register, visit cedars-sinai.edu/womenheartcme

ACTIVITY INFORMATION COURSE DESCRIPTION AND STATEMENT OF NEED Cardiovascular disease (CVD) was once thought of as primarily affecting men, but today CVD is the number-one killer of women in the U.S., claiming almost 400,000 American women every year. Furthermore, as the average age of the American woman increases, the morbidity and mortality rates of CVD are likely to increase dramatically. Yet, many women at risk for coronary heart disease are often not referred for appropriate diagnostic testing, perhaps because until recently it was thought that the clinical manifestations of women with cardiovascular disease were essentially similar to those of men and warranted similar management. This means the disease process resulting in a heart attack or stroke may not be detected in women until later, with more serious consequences. Despite significant advances in our knowledge about preventive interventions, cardiovascular disease remains the leading killer of women in the United States. In an effort to further educate in this area, our planning committee has assembled a distinguished faculty of national speakers, each with a unique expertise in the field of cardiovascular health and heart disease. This in-depth educational symposium will explore gender-specific issues in coronary microvascular dysfunction, hormone therapy, cardiac resynchronization therapy, and updates in research and health policy. The purpose of this conference is to close the knowledge gap of physicians and allied healthcare professionals regarding sex-specific differences in cardiovascular disease and the impact these differences have on treatment options, and to highlight the importance of identifying women at risk for cardiovascular disease by utilizing the most current evidence-based treatment strategies for improved patient outcomes. TARGET AUDIENCE This activity is designed to meet the educational needs of physicians, surgeons and other healthcare professionals. EDUCATIONAL OBJECTIVES Examine the improvement of medical product development, product safety and efficacy in women from a regulatory perspective Discuss how to advise women on reproductive hormone therapy and cardiac risk Relate the benefits of referring women with heart disease to a cardiac rehabilitation program Review and understand the impact of supplements and fish oil on cholesterol Analyze the benefits of using cardiac resynchronization therapy in women with heart failure with preserved ejection fraction Describe anatomical valve disease that is amenable to percutaneous therapies Assess the risks and benefits of percutaneous therapies ACCREDITATION STATEMENT is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT DESIGNATION STATEMENT designates this live activity for a maximum of 7.0 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. NURSES The California State Board of Registered Nursing accepts courses approved by the ACCME for Category 1 credit as meeting the educational requirements for license renewal. POLICY ON DISCLOSURE It is the policy of to ensure balance, independence, objectivity and scientific rigor in all its educational activities. assesses conflicts of interest with its faculty, planners and managers of CME activities. Conflicts of interest that are identified are resolved by reviewing that presenter s content for fair balance and absence of bias, scientific objectivity of studies utilized in this activity, and patient care recommendations. While endeavors to review faculty content, it remains the obligation of each physician or other healthcare practitioner to determine the applicability or relevance of the information provided from this course in his or her own practice. ACKNOWLEDGMENT OF COMMERCIAL SUPPORT gratefully acknowledges the educational grants from: Abbott, Gilead, Medtronic, and St. Jude. The companies names will be displayed at the meeting and in the course materials. PARKING Self-parking is available in visitor parking lots P1, P2 (George Burns Road) or P4 (Sherbourne Drive).

AGENDA 12 TH ANNUAL WOMEN AND ISCHEMIC HEART DISEASE SYMPOSIUM FRIDAY, MAY 11, 2018 HARVEY MORSE CONFERENCE CENTER, CEDARS-SINAI MEDICAL CENTER, LOS ANGELES 7:15 7:45 A.M. Registration, Breakfast and Exhibits 7:45 7:50 Introduction C. Noel Bairey Merz, MD, FACC, FAHA 7:50 8:00 Fifth Annual Linda Joy Pollin Women s Heart Health Leadership Award 8:00 9:00 KEYNOTE Women & Cardiovascular Disease: The Intersection of Research Health Policy & Clinical Care SPEAKER: Marjorie Jenkins, MD, FACP 9:00 9:15 Break and Exhibits 9:15 9:40 Hormone Therapy and Cardiac Risk: How to Advise Women CHAIR: Sarah Kilpatrick, MD, PhD SPEAKER: Chrisandra L. Shufelt, MD, MS, FACP, NCMP 9:40 9:50 Hormone Case Presentation SPEAKER: Erica T. Wang, MD, MAS 9:50 10:00 Question & Answer 10:00 10:25 Heart Healthy or Heart-Hoax? Fish Oil & Vitamin Supplements - Impact on Cholesterol CHAIR: Timothy D. Henry, MD, FACC SPEAKER: Janet Wei, MD, FACC 10:25 10:35 Question & Answer 10:35 11:00 Exercise, Cardiac Rehab and High Intensity Interval Training for Women CHAIR: Deborah Clegg, PhD SPEAKER: C. Noel Bairey Merz, MD, FACC, FAHA 11:00 11:10 Question & Answer 11:10 11:35 Morning Faculty Panel Discussion C. Noel Bairey Merz, MD, FACC, FAHA; Deborah Clegg, PhD; Timothy D. Henry, MD, FACC; Marjorie Jenkins, MD, FACP; Sarah Kilpatrick, MD, PhD; Chrisandra L. Shufelt, MD, MS, FACP, NCMP; Erica T. Wang, MD, MAS; Janet Wei, MD, FACC 11:35 11:45 Overview of WomenHeart: The National Coalition for Women with Heart Disease SPEAKER: Evan McCabe, RN, MN 11:45 12:00 P.M. Women s Heart Alliance (Advocacy Update) SPEAKER: C. Noel Bairey Merz, MD, FACC, FAHA 12:00 12:45 Lunch 12:45 1:10 HFpEF and Cardiac Resynchronization Therapy CHAIR: Balaji Tamarappoo, MD, PhD SPEAKER: Michelle Kittleson, MD, PhD 1:10-1:20 Question & Answer 1:20 1:50 Case Studies Stress Management Techniques (4-min. case; 6-min. discussion and/or stress management technique demonstration) Eynav Accortt, PhD The Complicated Cholesterol Patient (4-min. case; 6-min. discussion) Margo B. Minissian, PhD, ACNP, CLS, AACC, FAHA SPRINTing to Hypertension Targets (4-min. case; 6-min. discussion) Florian Rader, MD, FACC 1:50 2:15 Minimally Invasive Valve Surgery: Transcatheter Aortic Valve and MitraClip CHAIR: Bruce Samuels, MD SPEAKERS: Rajendra Makkar, MD, FACC (TAVR) and Saibal Kar, MD (MitraClip) 2:15 2:25 Question & Answer 2:25 2:50 Coronary Microvascular Dysfunction - Update 2018 CHAIR: Louise Thomson, MD SPEAKER: Eileen M. Handberg, PhD, ARNP 2:50 3:00 CMD Case Christine Pacheco, MD 3:00 3:10 Question & Answer 3:10 3:35 Afternoon Faculty Panel Discussion Eynav Accortt, PhD; Eileen M. Handberg, PhD, ARNP; Saibal Kar, MD; Michelle Kittleson, MD, PhD; Rajendra Makkar, MD, FACC; Margo B. Minissian, PhD, ACNP, CLS, AACC, FAHA; Christine Pacheco, MD; Florian Rader, MD, FACC; Bruce Samuels, MD; Balaji Tamarappoo, MD, PhD; Louise Thomson, MD 3:35 3:40 Post-test 3:40 P.M. Adjourn

REGISTRATION 12 TH ANNUAL WOMEN AND ISCHEMIC HEART DISEASE SYMPOSIUM FRIDAY, MAY 11, 2018 HARVEY MORSE CONFERENCE CENTER, CEDARS-SINAI MEDICAL CENTER, LOS ANGELES REGISTER ONLINE TODAY! Visit cedars-sinai.edu/womenheartcme to register. All registrations must be completed online. For additional course or registration information, please call 310-423-5548. REGISTRATION FEES PHYSICIAN NON-PHYSICIAN RESIDENT/FELLOW Received by 4/28/18 $185 $145 $25 Received after 4/28/18 $235 $185 $25 REGISTRATION METHODS TO PAY BY CHECK Complete the online registration, continue to the payment section and select I will mail a separate check for my registration. MAIL PAYMENT (with checks made payable to ) to: Office of Continuing Medical Education Attn: Registration 8797 Beverly Blvd., Suite 250 Los Angeles, CA 90048 REFUND POLICY All cancellations must be submitted in writing, and refunds will be subject to a $50 administrative charge. No refunds will be given after April 27, 2018. Please email cancellation requests to cme@cshs.org. If you do not receive confirmation of your cancellation via email, please call 310-423-5548. We encourage participation by all individuals. If you have a disability, advance notification of any special needs will help us better serve you.

FACULTY COURSE DIRECTOR C. Noel Bairey Merz, MD, FACC, FAHA Director, Barbra Streisand Women s Heart Center Director, Linda Joy Pollin Women s Heart Center Director, Preventive Cardiac Center Professor of Medicine GUEST FACULTY Eileen Handberg, PhD, ANP-BC, FAHA, FACC, FPCNA Professor of Medicine Division of Cardiovascular Medicine University of Florida Marjorie Jenkins, MD, MEdHP Professor of Medicine Associate Dean for Women Faculty Chief Scientific Officer, Laura W. Bush Institute for Women s Health Silver Spring, MD Evan McCabe, RN, MN Chair, Board of Directors WomenHeart: The National Coalition for Women with Heart Disease Washington, DC CEDARS-SINAI MEDICAL CENTER FACULTY Eynav E. Accortt, PhD Assistant Professor, Clinical Psychologist Department of Obstetrics and Gynecology Deborah J. Clegg, PhD Professor Sports Spectacular Diabetes and Obesity Research Insitute Timothy D. Henry, MD Lee and Harold Kapelovitz Chair in Research Cardiology Director, Cardiology Saibal Kar, MD Director, Interventional Cardiac Research Associate Professor, Medicine Sarah J. Kilpatrick, MD, PhD Professor, Helping Hand of Los Angeles Chair Chair, Department of Obstetrics and Gynecology Associate Dean for Faculty Development Michelle Kittleson, MD, PhD Director, Education in Heart Failure and Transplantation Director, Heart Failure Research Associate Professor of Medicine Raj R. Makkar, MD Director, Interventional Cardiology and Cardiac Catheterization Lab Associate Director Margo B. Minissian, PhD, ACNP, FAHA Nurse Scientist Clinical Lipid Specialist Cardiology Nurse Practitioner Barbra Streisand Women s Heart Center Christine Pacheco, MD Clinical and Research Fellow, Women s Heart Disease and Health Barbra Streisand Women s Heart Center Florian Rader, MD, MSC Co-Director, Clinic for Hypertrophic Cardiomyopathy and Aortopathies Bruce Samuels, MD Interventional Cardiologist Chrisandra Shufelt, MD, MS, FACP, NCMP Associate Director, Barbra Streisand Women s Heart Center Associate Director, Preventive and Rehabilitative Cardiac Center Director, Women s Hormone and Menopause Program Associate Professor Balaji Tamarappoo, MD, PhD Cardiologist Louise Thomson, MBChB Co-Director, Nuclear Medicine S. Mark Taper Foundation Imaging Center Erica T. Wang, MD, MAS Assistant Professor Associate Director, REI Fellowship Division of Reproductive Endocrinology & Infertility Department of Obstetrics & Gynecology Janet Wei, MD, FACC Cardiologist, Barbra Streisand Women s Heart Center Assistant Medical Director, Biomedical Imaging Research Institute Co-Director, Stress Echocardiography Lab

8797 Beverly Blvd., Suite 250 Los Angeles, CA 90048 REGISTER TODAY! 12 TH ANNUAL WOMEN AND ISCHEMIC HEART DISEASE SYMPOSIUM MAY 11, 2018 IN-DEPTH SYMPOSIUM EXPLORING SEX-SPECIFIC DIFFERENCES IN CARDIOVASCULAR DISEASE, INCLUDING: Women s Health Policy Updates and FDA Initiatives Fish Oil & Vitamin Supplements Impact on Cholesterol Cardiovascular Disease in Women: Coronary Microvascular Dysfunction Exercise, Cardiac Rehab and High-Intensity Interval Training for Women Heart Failure with Preserved Ejection Fraction in Women, Including Cardiac Resynchronization Therapy Minimally Invasive Valve Surgery: Transcatheter Aortic Valve and MitraClip For the latest course information and to register, visit cedars-sinai.edu/womenheartcme. Earn up to 7.0 AMA PRA Category 1 Credit(s)! Non-Profit Org. U.S. Postage PAID Los Angeles, CA Permit #22328