Advances in Cardiovascular Risk Reduction

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NYU School of Medicine Continuing Medical Education Advances in Cardiovascular Risk Reduction IMPROVING TREATMENT FOR PATIENTS WITH DIABETES Thursday, May 3, 2018 nyulmc.org/cvriskcme Dietary and Lifestyle Strategies for Cardiovascular Risk Reduction Friday, May 4, 2018 nyulmc.org/dietcvcme

Advances in Cardiovascular Risk Reduction IMPROVING TREATMENT FOR PATIENTS WITH DIABETES COURSE DESCRIPTION This one-day course will cover state-of-the-art management of patients with cardiovascular risk factors, focusing on prevention. The course will feature presentations on diabetes, obesity, hypertension, familial hypercholesterolemia and will also explore the role of liproprotein(a), platelets and PCSK9 in cardiovascular disease risk. The morning session will review the latest scientific and clinical advances in the management of diabetes, including topics such as the role of the RAGE receptor in diabetes-related complications, new glucose control treatments and their effects on cardiovascular disease risk. New insulin therapies and their potential for improving diabetic care and updated guidelines in diabetes management will be reviewed. The afternoon session includes a presentation on obesity as a cardiovascular risk factor, an update on hypertension and the latest research pertaining to cardiovascular markers including lipoprotein(a), PCSK9 and platelets. A presentation on familial hypercholesterolemia will highlight risk assessment strategies and treatment paradigms. Attendees will participate in a lunch case conference reviewing challenging cases in cardiovascular disease risk reduction. EDUCATIONAL OBJECTIVES After participating in this activity, clinicians should be able to: Describe the role of the RAGE receptor in diabetic complications and how inhibition of this receptor may be a novel avenue of treatment for diabetesrelated complications Describe the types of familial hypercholesterolemia (FH), how FH increases CVD risk and current testing and treatment strategies for FH patients Describe the safety and efficacy data for new insulins and how novel insulins may improve diabetic care Outline the results of recent trials assessing the cardiovascular safety of glucose-lowering treatments Describe the mechanisms for the development of obesity related complications and outline treatment options that focus on the weight-centric management of diabetes Describe the optimal treatment goals in cardiovascular and diabetic patients Describe rationale behind the ISCHEMIA trial and how this trial may affect standard of care in patients with stable ischemic heart disease Co-Organized by the Division of Cardiology and the Division of Endocrinology, Diabetes, and Metabolism Summarize the role of anti-thrombotic therapies in preventing cardiovascular events and their efficacy and safety in light of recent clinical trials Describe the role of Lp(a) in cardiovascular disease risk Describe how PCSK9 modulates LDL levels and reduces risk for cardiovascular events TARGET AUDIENCE Cardiologists, endocrinologists, internists, general practice, family practitioners, advanced practice providers, nurses and physician trainees LOCATION NYU Langone Health Alumni Hall 550 First Avenue 10016 COURSE FEES Full: $175 Reduced*: $95 Residents and Fellows: $60 NYU Langone Health Residents and Fellows: Waived * Reduced fee applies to all nursing and allied healthcare professionals, as well as NYU Langone Health Faculty and Staff REGISTRATION nyulmc.org/cvriskcme After 12 pm on May, 1, 2018, only onsite registration is available, provided the course has not reached capacity. Onsite registrants will incur an additional $20 charge. We cannot accept telephone or email registration. Registration is non-transferable. ELECTRONIC SYLLABUS Course syllabus will only be distributed electronically. A link will be sent the week of the course where you can view, download or print course information and presentations in advance. This link will also allow you to view the course syllabus on your smartphone, tablet, or laptop during the course. Course presentations remain available for one year after the course. REFUND POLICY In order to request a refund, you must email cme@nyumc.org no later than 7 days prior to the first day of the course. Cancellations or no-shows after this date are not eligible for a refund. Fax and email cancellations are not accepted. PROVIDED BY Jointly provided by NYU School of Medicine and the New York State Chapter American College of Physicians (NYACP)

AGENDA Thursday, May 3, 2018 7:45 am Registration and Continental Breakfast 8:20 Course Director s Introduction Arthur Z. Schwartzbard, MD 8:30 Diabetes Causes RAGEing Complications Ann Marie Schmidt, MD 9:00 New Insulins: Will Therapy be Easier? Daniel S. Donovan, Jr., MD, MS, CDE 9:30 Beyond ACCORD: New Treatments of Glucose and Cardiovascular Risk Arthur Z. Schwartzbard, MD 10:00 Coffee Break 10:15 With Fat it Begins and with Fat it Ends: Obesity, Its Complications, and Treatments Jose O. Aleman, MD, PhD 10:45 Are All FH Patients the Same? Risk Assessment and Treatment Paradigms in Familial Hypercholesterolemia James A. Underberg, MD 11:15 Morning Panel Discussion 12:00 pm Lunch and Case Conference: Navigating Diabetes Treatment Ira J. Goldberg, MD 1:00 7th Annual Leon H. Charney Lecture Hypertension: Reconsiderations After the New Guidelines Howard Weintraub, MD Dr. Howard Weintraub s presentation has been designated as the 7th Annual Leon H. Charney Lecture. This lecture series features outstanding basic, translational or clinical research by a NYU Langone faculty member in an area related to the prevention of cardiovascular disease. 1:30 The Role of Revascularization in Stable Ischemic Heart Disease Harmony R. Reynolds, MD 2:00 Antithrombotic Therapy in CAD: Which One and For How Long? Jeffrey S. Berger, MD 2:30 Coffee Break 2:45 When Bad Cholesterol Gets Worse: An Update on Lp(a) Sergio Fazio, MD, PhD 3:15 PCSK9 Inhibition: Proof, Promises, and Practicalities Marc Sabatine, MD 3:45 Afternoon Panel Discussion 4:30 pm Adjourn COURSE CANCELLATION POLICY If a course is cancelled due to inclement weather, insufficient enrollment, or any other reason, NYU SOM will refund registration fees in full. NYU SOM will provide at least two weeks advance notice if cancelling due to insufficient enrollment and as soon as possible in all other circumstances. NYU SOM is not responsible for any airfare, hotel, or other noncancellable costs incurred by the registrant. CREDIT DESIGNATION STATEMENT The NYU School of Medicine designates this live activity for a maximum of 7.50 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. CONTINUING NURSING EDUCATION CONTACT HOURS This program has been approved for 7.00 continuing nursing education contact hours. The NYU Meyers College of Nursing Center for Continuing Education in Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. CME ACCREDITATION STATEMENT This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the NYU School of Medicine and the New York State Chapter American College of Physicians (NYACP). The NYU School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Dietary and Lifestyle Strategies for Cardiovascular COURSE DESCRIPTION Diet and lifestyle are crucial components in the development and progression of cardiovascular disease (CVD) and related comorbidities such as hypertension, diabetes and dyslipidemias, but are underemphasized in the educational training of most health care providers. This course will review the evidence for diet and cardiovascular disease including recent guidelines, analyses, and controversies while providing practical counseling advice for assessing and implementing change to a patient s diet. The course will review the evidence for exercise, how to appropriately and safely prescribe an exercise regimen for the prevention and treatment of cardiovascular disease, and review the role and evidence for cardiac rehabilitation programs. The goal is for attendees to have a better understanding of the evidence for CVD reductions with a specific focus on the Mediterranean, DASH and plant-based whole food diets including discussions on how these diets effect CVD comorbidities such as hyperlipidemia, diabetes and hypertension. A specific focus will be placed on methods to navigate budget friendly grocery shopping for heart healthy eating and community programs available to help patients with lifestyle change. EDUCATIONAL OBJECTIVES After participating in this activity, clinicians should be able to: Describe how the Mediterranean, DASH and plant based/whole food diets can be used in the primary and secondary prevention of cardiovascular disease as well as what the current guidelines recommend Prescribe exercise and at what intensity and frequency to patients with established CVD or at risk for CVD and discuss the benefits of a cardiac rehabilitation program and the evidence to support it Describe the factors influencing the American diet and steps to mitigate disparities in access to healthy food and exercise Accurately assess a patient s diet within their clinical setting, describe the importance of motivating their patients to achieve positive clinical outcomes Describe how to develop a shopping plan to avoid the pitfalls of grocery store shopping and to maximize the purchase and consumption of heart healthy food Describe how to incorporate lifestyle interventions into a clinical practice including the areas of diet, exercise, smoking cessation and how community programs can help patients improve lifestyle and reduce disparities Outline the ideal eating patterns for diabetes, hypertension and dyslipidemias and describe how those diets optimize patient outcomes Describe how the microbiome has recently emerged as an important factor in human physiology and disease Describe how medically supervised diets, pharmaceutical therapies and surgical interventions effect risk for cardiovascular disease and co-morbidities Describe how the duration and quality of sleep effects cardiovascular disease risk and means to assess for and treat sleep apnea TARGET AUDIENCE Physicians, physician assistants, medical trainees, nurse practitioners, nurses, students, dietitians, pharmacists, and allied health professionals LOCATION NYU Langone Health Alumni Hall 550 First Avenue 10016 REGISTRATION nyulmc.org/dietcvcme After 12 pm on May, 1, 2018, only onsite registration is available, provided the course has not reached capacity. Onsite registrants will incur an additional $20 charge. We cannot accept telephone or email registration. Registration is non-transferable. PROVIDED BY Jointly provided by NYU School of Medicine and the New York State Chapter American College of Physicians (NYACP) COURSE FEES Regular Fee for registrants also enrolled for Advances in Cardiovascular Risk Reduction on May 3, 2018 Full $130 $110 Reduced* $75 $65 Residents, Fellows, and Students $40 NYU Langone Faculty and Staff $40 * Reduced fee applies to physicians employed by the Department of Veterans Affairs Medical Center; full-time active military personnel; retired physicians; and all other non-physician healthcare professionals.

Risk Reduction CME ACCREDITATION STATEMENT This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education through the joint providership of the NYU School of Medicine and the New York State Chapter American College of Physicians (NYACP). The NYU School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. CREDIT DESIGNATION STATEMENT The NYU School of Medicine designates this live activity for a maximum of 5.50 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. DIETICIAN CREDITS This activity has been approved by the Commission on Dietetic Registration for 5.5 CPEUs. CONTINUING NURSING EDUCATION CONTACT HOURS This program has been approved for 5.25 continuing nursing education contact hours. The NYU Meyers College of Nursing Center for Continuing Education in Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. ELECTRONIC SYLLABUS Course syllabus will only be distributed electronically. A link will be sent the week of the course where you can view, download or print course information and presentations in advance. This link will also allow you to view the course syllabus on your smartphone, tablet, or laptop during the course. Course presentations remain available for one year after the course. REFUND POLICY In order to request a refund, you must email cme@nyumc.org no later than 7 days prior to the first day of the course. Cancellations or no-shows after this date are not eligible for a refund. Fax and email cancellations are not accepted. COURSE CANCELLATION POLICY If a course is cancelled due to inclement weather, insufficient enrollment, or any other reason, NYU SOM will refund registration fees in full. NYU SOM will provide at least two weeks advance notice if cancelling due to insufficient enrollment and as soon as possible in all other circumstances. NYU SOM is not responsible for any airfare, hotel, or other noncancellable costs incurred by the registrant. CONTACT INFORMATION NYU School of Medicine Phone: 212-263-5295 Fax: 212-263-5293 Email: cme@nyumc.org

AGENDA Friday, May 4, 2018 7:30 am Registration and Continental Breakfast 8:00 Course Director s Introduction Eugenia Gianos, MD Dietary Research 8:05 Conclusions from Dietary Research: Clear as Mud! Eugenia Gianos, MD 8:30 The Gut Microbiome and its Role in Cardiovascular Disease Stanley L. Hazen, MD, PhD 9:00 Animal- versus Plant-Based Protein in Coronary Artery Disease: Insights from the EVADE-CAD Trial Binita Shah, MD, MS 9:25 Cardiovascular Mortality and Nutrition: Taking the DIE out of DIET Kim A. Williams, Sr., MD, MACC, FAHA, MASNC, FESC 9:50 Question and Answer 10:00 Coffee Break Dietary Assessment and Counseling 10:20 Assessing a Patient s Diet and Motivation in Clinical and Research Settings Lisa Ganguzza, MS, RD, CDN Keep the Change: Patient Education Tips for Healthy Eating on a Budget Emily Johnston, MPH, RD, CDE Weight Loss: When to Take Next Steps 11:05 Moving Beyond Calories: Nutrition for Weight Loss and Disease Prevention Holly F. Lofton, MD Update on Pharmacotherapy for Weight Management Holly F. Lofton, MD Surgical Solutions to Severe Obesity Sean P. Heffron, MD, MSc Lifestyle: Exercise and Sleep 11:45 Exercise as Medicine to Prevent and Treat Cardiovascular Disease Jonathan H. Whiteson, MD, FAAPMR Sleep and Cardiovascular Disease: Strange Yet Likely Bedfellows Azizi A. Seixas, PhD, MA, MPsyc 12:20 pm Coffee Break Food Politics 12:40 Food Politics: Overcoming the Barriers to Healthy Diets Marion Nestle, PhD, MPH 1:15 Panel Discussion/Question and Answer Session Panel Discussion 2:00 pm Adjourn Key Ingredients to a Successful CV Prevention Team: Too Many Cooks in the Kitchen or Recipe for Success? Barbara J. George, EdD, RCEP, MSN, AGNP-C

SPEAKERS ADVANCES IN CARDIOVASCULAR RISK REDUCTION: IMPROVING TREATMENT FOR PATIENTS WITH DIABETES COURSE DIRECTOR Arthur Z. Schwartzbard, MD Associate Professor of Medicine Director, Clinical Lipid Research, Center for the Prevention of Cardiovascular Disease NYU School of Medicine COURSE PLANNERS Edward A. Fisher, MD, PhD, MPH Mattia Gilmartin, RN, PhD Ira J. Goldberg, MD Ana M. Mola, RN, PhD, ANP-BC, MAACVPR Lawrence Phillips, MD NY Chapter American College of Physicians James A. Underberg, MD NYU LANGONE HEALTH Jose O. Aleman, MD, PhD Assistant Professor of Medicine Ricardo J. Benenstein, MD Assistant Professor of Medicine Jeffrey S. Berger, MD Associate Professor of Medicine and Surgery Director, Cardiothoracic Thrombosis Program Edward A. Fisher, MD, PhD, MPH Leon H. Charney Professor of Cardiovascular Medicine Director, Marc and Ruti Bell Vascular Biology Program and the Center for the Professor of Cell Biology, Medicine, Microbiology, and Pediatrics Eugenia Gianos, MD Associate Professor of Medicine Co-Clinical Director, Center for Ira J. Goldberg, MD Clarissa and Edgar Bronfman, Jr. Professor of Endocrinology Director, Division of Endocrinology, Diabetes and Metabolism Dennis A. Goodman, MD Clinical Professor of Medicine Director, Integrative Medicine Sean P. Heffron, MD, MSc Instructor of Medicine Ana M. Mola, RN, PhD, ANP-BC, MAACVPR Clinical Assistant Professor of Rehabilitation Director, Care Transitions and Population Health Management Jonathan Newman, MD, MPH Eugene Braunwald, MD Assistant Professor of Cardiology Harmony R. Reynolds, MD Associate Professor of Medicine Co-Director, Sarah Ross Center for Women s Cardiovascular Research Associate Director, Cardiovascular Clinical Research Center Ann Marie Schmidt, MD Dr. Iven Young Professor of Endocrinology Professor of Biochemistry and Molecular Pharmacology and Pathology James A. Underberg, MD Clinical Assistant Professor of Medicine Howard Weintraub, MD Clinical Professor of Medicine Clinical Director, Center for the GUEST SPEAKERS Daniel S. Donovan, Jr., MD, MS, CDE Professor of Medicine Icahn School of Medicine at Mount Sinai Sergio Fazio, MD, PhD Professor of Medicine Director, Center for Preventive Cardiology Oregon Health and Science University School of Medicine Portland, OR Marc Sabatine, MD Professor of Medicine Lewis Dexter, MD Distinguished Chair in Cardiovascular Medicine Harvard University Boston, MA DIETARY AND LIFESTYLE STRATEGIES FOR CARDIOVASCULAR RISK REDUCTION COURSE DIRECTOR Eugenia Gianos, MD Associate Professor of Medicine Co-Clinical Director, Center for NYU School of Medicine COURSE PLANNERS Edward A. Fisher, MD, PhD, MPH Lisa Ganguzza, MS Mattia Gilmartin, RN, PhD Dennis A. Goodman, MD Ana M. Mola, RN, PhD, ANP-BC, MAACVPR Lawrence Phillips, MD NY Chapter American College of Physicians Howard Weintraub, MD NYU LANGONE HEALTH Edward A. Fisher, MD, PhD, MPH Leon H. Charney Professor of Cardiovascular Medicine Director, Marc and Ruti Bell Vascular Biology Programand the Center for the Professor of Cell Biology, Medicine, Microbiology, and Pediatrics Lisa Ganguzza, MS, RD, CDN Clinical Nutritionist Dennis A. Goodman, MD Clinical Professor of Medicine Director, Integrative Medicine Barbara J. George, EdD, RCEP, MSN, AGNP-C Director, Center for Cardiovascular Lifestyle Medicine at NYU Winthrop Hospital Sean P. Heffron, MD, MSc Instructor of Medicine Holly F. Lofton, MD Assistant Professor of Medicine and Surgery Ana M. Mola, RN, PhD, ANP-BC, MAACVPR Clinical Assistant Professor of Rehabilitation Director of Care Transitions and Population Health Management Azizi A. Seixas, PhD, MA, MPsyc Assistant Professor of Population Health Binita Shah, MD, MS Assistant Professor of Medicine Howard Weintraub, MD Clinical Professor of Medicine Clinical Director, Center for the Jonathan H. Whiteson, MD, FAAPMR Assistant Professor Rehabilitation Medicine and Medicine Vice Chair, Rusk Rehabilitation Clinical Operations Medical Director, Cardiac Rehabilitation GUEST SPEAKERS Stanley L. Hazen, MD, PhD The Jan Bleeksma Chair in Vascular Cell Biology and Atherosclerosis Cleveland Clinic Cleveland, OH Emily Johnston, MPH, RD, CDE The Pennsylvania State University University Park, PA Marion Nestle, PhD, MPH Paulette Goddard Professor, Emerita NYU School of Medicine Kim A. Williams, Sr., MD, MACC, FAHA, MASNC, FESC James B. Herrick Professor Chief, Division of Cardiology Rush University School of Medicine Chicago, IL

Advances in Cardiovascular Risk Reduction IMPROVING TREATMENT FOR PATIENTS WITH DIABETES May 3, 2018 nyulmc.org/cvriskcme Dietary and Lifestyle Strategies for Cardiovascular Risk Reduction May 4, 2018 nyulmc.org/dietcvcme School of Medicine 550 First Avenue, MS1 195 10016 Non-Profit Org. U.S. Postage PAID Permit #8167