The best educational conference I have ever attended.

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REGISTRANT INFORMATION Registration Fees A061.01 O Check if you require special facilities or assistance and attach a note with specific details and requirements. Payment Method DEGREE: O MD O PhD O PharmD O RN O Other SPECIALTY: O Psychiatry O Psychology O Family or General Medicine CARDHOLDER S NAME SIGNATURE O Nursing O Other FIRST NAME MI LAST NAME EMAIL ADDRESS TELEPHONE FAX INSTITUTE DEPARTMENT ADDRESS CITY STATE/PROVINCE ZIP/POSTAL CODE COUNTRY O American Express O Discover O MasterCard O Visa O Check in the amount of $ CARD NUMBER EXP. DATE 4325 Alexander Dr. Alpharetta, GA 30022-3740 Important Dates Regular Registration Deadline February 26, 2009 Conference Dates March 6-7, 2009 Quotes The best educational conference I have ever attended. The speakers were all outstanding as to their knowledge and clarity of their presentations. Loved the debates and audience participation. 3 ways To Learn: PRINT materials are produced by Imedex for your reference needs ONLINE products are produced by Imedex in 6 user-friendly formats LIVE meetings are produced by Imedex in 15 countries Visit www.imedex.com to learn more. Regular (If payment received by February 26, 2009)...O $125 Full/Onsite (If payment received after February 26, 2009...O $150 To pre-register, registration and payment must be received no later than February 26, 2009. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure that the meeting is being held as scheduled and to confirm that the meeting is not full. For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex. com no later than February 26, 2009. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after February 26, 2009. Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this activity should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda content is subject to change without notice. Imedex is a brand and assumed name used by Imedex, LLC (hereby referred to as Imedex). Imedex is solely responsible for this agenda s content. Although Imedex attempts to ensure that the information in our program is accurate and timely, matters and opinions discussed and/or presented with respect to clinical matters are those of the discussion participants only, and not necessarily those of Imedex. Moreover, although Imedex attempts to identify and integrate the most qualified medical professionals in our program, TO THE FULLEST EXTENT PERMITTED BY LAW, IMEDEX EXPRESSLY DISCLAIM ALL WARRANTIES, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT OF THIRD PARTIES RIGHTS, AND FITNESS FOR A PARTICULAR PURPOSE, WITH RESPECT TO THE CONTENT PRESENTED. IMEDEX FURTHER MAKES NO REPRESENTATIONS OR WARRANTIES ABOUT THE ACCURACY, RELIABILITY, COMPLETENESS OR TIMELINESS OF THE CONTENT OR ANY MATERIAL PRESENTED. In addition, the material presented and related discussions are not intended to be medical advice, and the presentation or discussion of such material is not intended to create and does not establish a physician-patient relationship. Medical advice of any nature should be sought from an individual s own physician. Neither Imedex nor any of its subsidiaries or affiliates is affiliated with or formally endorsed by a medical society. 2008 Imedex, LLC. All rights reserved. Reproduction in whole or part is prohibited without prior written consent from Imedex and contributing faculty.

2009 Clinical dialogue: update on PSYCHOPHARMACOLOGY NEW YORK, NEW YORK MARCH 6-7, 2009 CHAIRS: Columbia University Yale Depression Research Program New Haven, Connecticut University of North Carolina School of Medicine at Chapel Hill Chapel Hill, North Carolina University of Texas Southwestern Medical School Dallas, Texas First Announcement W W W. I M E D E X. C O M

2009 Clinical dialogue: update on PSYCHOPHARMACOLOGY NEW YORK, NEW YORK MARCH 6-7, 2009 Faculty Cheryl Corcoran, MD Columbia University Medical Center Letter from the Chairs Dear Colleague: It is with great pleasure that we invite you to participate in the 2009 Clinical Dialogue: Update on Psychopharmacology. This educational conference will focus on a variety of topics ranging from prodrome and firstepisode psychosis to new treatments for mood disorders and schizophrenia. This conference will provide you with the opportunity to enhance your knowledge on new and upcoming management techniques and treatments. We received great feedback on the level of audience participation at last year s meeting, so we will continue to offer expert panel and clinical case discussions. We look forward to sharing this essential clinical information with you at this important educational forum. We encourage you to register early to guarantee your seat! Sincerely, Robert Drake, MD Dartmouth Medical School Lebanon, New Hampshire Donald C. Goff, MD Massachusetts General Hospital Harvard Medical School Boston, Massachusetts Eric Hollander, MD Mount Sinai School of Medicine L. Fredrik Jarskog, MD Lieber Center for Schizophrenia Research & Treatment, New York State Psychiatric Institute Columbia University Thomas Mellman, MD Howard University Hospital Washington, D.C. Andrew Nierenberg, MD Massachusetts General Hospital Harvard Medical School Boston, Massachusetts Yale Depression Research Program New Haven, Connecticut University of North Carolina School of Medicine at Chapel Hill Chapel Hill, North Carolina University of Texas Southwestern Medical School Dallas, Texas Kimberly Yonkers, MD Yale University School of Medicine New Haven, Connecticut

Clinical dialogue: update on 2009 PSYCHOPHARMACOLOGY NEW YORK, NEW YORK MARCH 6-7, 2009 Continuing Medical Education Objectives Imedex, LLC is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. After successful completion of this educational activity, attendees should be able to: Review the molecular interaction through which antipsychotic agents elicit their pharmacological effects Imedex, LLC designates this educational activity for a maximum 12.25 of AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity. Comment on the role of polypharmacy in schizophrenia Outline a therapeutic strategy to overcome refractory psychosis Describe treatment approaches that circumvent and/or manage challenging clinical problems associated with psychosis such as substance abuse, violence, and suicide Discuss early detection and treatment strategies for first-episode psychosis Summarize available and emerging treatment options for schizophrenia Discuss the development of novel therapies targeting new molecular pathways in mood disorders Summarize available therapeutic options for unipolar and bipolar depression Incorporate into clinical practice most favorable treatment modality specific for women that are pregnant or wanting to become pregnant Adapt a measurement-based care approach to facilitate individualized patient management based upon dose optimization, disease progression, therapeutic tolerability and sequencing algorithms Expand the therapeutic armamentarium for treatment-resistant mood and anxiety disorders including obsessive compulsive disorder and post traumatic stress disorder Who Should Attend This educational activity is specifically designed for psychiatrists, psychologists, and other health care practitioners involved or interested in the psychopharmacologic and psychosocial care of patients with psychotic Dark C100, M55,and Y0, K55 andblue mood disorders as well as their co-morbidities. Light Blue C29, M12, Y0, K0 Orange C0, M66, Y100, K0 Corporate Support Several options are available to companies interested in supporting this conference. For more information, please contact Imedex at +1 (770) 751 7332, or by email at cme@imedex.com. Conference Organizer 4325 Alexander Drive Alpharetta, Georgia 30022-3740 USA Tel.: +1 (770) 751 7332 Fax: +1 (770) 751 7334 meetings@imedex.com www.imedex.com 4 EASY WAYS TO REGISTER: O nline... FA X US... www.imedex.com C ALL US... MAIL US... You can fax your registration 24 hours a day. +1 (678) 242 0920 The Registrar will take your registration over the phone. +1 (678) 242 0906 Imedex 4325 Alexander Drive Alpharetta, GA 30022-3740, USA

Scientific Agenda Friday, March 6, 2009 Saturday, March 7, 2009 Psychosis Mood Disorders 8:30 am Opening remarks 8:30 am Opening remarks Session I 8:35 am Mechanism of action of antipsychotic drugs L. Fredrik Jarskog, MD 9:20 am Antipsychotic polypharmacy for schizophrenia: What is the rationale and state of evidence? Donald C. Goff, MD 10:05 am Coffee break 10:30 am Approaches to refractory symptoms and difficult clinical problems: Suicide, violence, substance abuse Speaker Invited 11:15 am Update on psychosocial treatments for schizophrenia Robert Drake, MD 12:00 pm Lunch break Session II 1:00 pm Roundtable discussion: Management of antipsychotic drug side effects Donald C. Goff, MD Speaker Invited Session III 8:35 am New targets/new treatments for mood disorders 9:20 am Evidence-based treatment for unipolar and bipolar depression: What are the options? Andrew Nierenberg, MD 10:05 am Coffee break 10:30 am Managing mood disorders in and following pregnancy Kimberly Yonkers, MD 11:15 am Roundtable discussion: Case-based discussions of treatment-resistant mood and anxiety disorders Moderated by: Andrew Nierenberg, MD Kimberly Yonkers, MD 12:00 pm Lunch break Session IV 1:00 pm Treatment options for post traumatic stress disorder Thomas Mellman, MD 1:45 pm What s new regarding the prodrome and first-episode psychosis? Cheryl Corcoran, MD 1:45 pm Measurement-based care: Why? How? To what effect? 2:30 pm Coffee break 2:30 pm Coffee break 2:55 pm Update on emerging treatments for schizophrenia 2:55 pm Treatment options for obsessive compulsive disorder Eric Hollander, MD 3:40 pm Ask the expert: Panel discussion Moderators: and 4:30 pm Adjourn 3:40 pm Ask the expert: Panel discussion Moderated by: A. John Rush, MD Eric Hollander, MD Thomas Mellman, MD 4:30 pm Adjourn

Hotel Accommodations 111 East 48th Street 10017 Tel.: + 1 (212) 755 5900 Fax: +1 (212) 644 0079 new-york-barclay.intercontinental.com Restored to its 1926 neo-federal style, welcomes guests with residential warmth and luxury. Few hotels provide such easy access to must-see attractions including Rockefeller Center, Carnegie Hall, The Metropolitan Museum of Art, Times Square and Central Park. The Statue of Liberty is a short taxi ride away. For the convenience of attendees, a limited number of rooms have been reserved until February 12, 2009 at a discounted rate of $309 single/double occupancy, plus tax, currently at 13.375%. This rate is not guaranteed outside the conference dates or after February 12, 2009. To reserve your room please contact the reservations department at + 1 (212) 755 5900 or visit the hotel s website at new-yorkbarclay.intercontinental.com. To receive the group rate, callers must identify themselves as being with the Clinical Dialogue: Update on Psychopharmacology group. Internet users must enter the meeting promotional code: IMEDEX08. Reservation requests received after February 12, 2009 may not be guaranteed the group rate. Discounted Airfares Contact Congress travel agent, Williamsburg Travel, for assistance with your travel needs. Williamsburg Travel can also accommodate pre- and post-congress extensions. Tel.: +1 (888) 232-9394 or +1 (770) 261-8613 Email: judit@willtrav.com Conference Location and Registration 111 East 48th Street 10017 Tel.: + 1 (212) 755 5900 Fax: +1 (212) 644 0079 new-york-barclay.intercontinental.com The Registration and Information Desk will be staffed: Friday, March 6, 2009 8:00 am 4:30 pm Saturday, March 7, 2009 8:00 am 4:30 pm Registration Fees Regular $125 If payment received by February 26, 2009 Full/Onsite $150 If payment received after February 26, 2009 Registration Procedures To Register: You may register online by February 26, 2009 at www.imedex.com, by calling Imedex at +1 (678) 242 0906 or by returning the registration form in this announcement by mail or fax. If you mail the form, please keep a copy for your records. Registration confirmations will be issued before the meeting. To qualify for special registration fees, registration and full payment must be received by Imedex by the dates specified. Payment: To pre-register, registration and payment must be received no later than February 26, 2009. Please register onsite after this date. Contact Imedex at +1 (678) 242 0906 or visit our website at www.imedex.com to ensure the course is being held as scheduled and to confirm that the meeting is not full. Registration fees must be remitted by credit card or check. Checks should be payable to Imedex. Attendee is not registered until full payment is received. Registration Fee Inclusions: Registration fees include admittance to all scientific sessions, conference materials, processing of certificates of attendance or continuing medical education, and all event functions as specified in the announcement. Cancellation: For registration fees to be refunded, written notice of cancellation must be received at meetings@imedex.com no later than February 26, 2009. The amount of registration fees remitted, minus a $75 administrative charge, will be refunded after the conference. Substitutions are accepted with written notification. No refunds will be made if notice is received after February 26, 2009. Imedex does not accept responsibility for covering travel, accommodation or any other costs incurred by registrants in the rare event that this meeting should be canceled for any reason. Every effort will be made to give reasonable notice in the event of cancellation. The event agenda is subject to change without notice.