Comparative table of insulin pumps

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Comparative table of insulin pumps Pumps reviewed: insight (Roche Veo 640G Mylife OmniPod Mylife S () The first stop for professional medicines advice www.sps.nhs.uk Authored May 2018

Insight OmniPod S () Image Description Dimensions (mm) Weight (g) Water Proofing (IPX8 = fully waterproof) Reservoir/ cartridge and capacity (units) System combines insulin pump with smart handset that is both a blood test meter and a bolus calculator linked via Bluetooth. Insulin Pump for users of large daily volume of insulin Insulin pump for patients with very low basal insulin requirements. It offers option of using a prefilled insulin cartridge; Handset acts as a blood glucose monitor, bolus advisor, data manager and remote control for the pump, linked via Bluetooth 82.5 x 56 x 21 72 x 52 x 16 mm without adapter 84 x 52 x 19 mm with adapter 80 (no cartridge or battery)/ 110 incl battery, full cartridge and infusion set IPX 8 (waterproof up to a depth of 2.5m for 60mins) Accu-Chek Easyfill cartridge (315 units) 115 (including battery, full cartridge, infusion set) IPX8 (1.3m for 60 minutes) Pre-filled NovoRapid PumpCart (160 units) Insulin Pump with low glucose suspend feature when used with compatible CGM sensors Insulin Pump with SmartGuard algorithm that uses CGM data to predict and prevent hypos. Provided as standard, however, some patients may still be offered Veo, the previous model* 51 x 94 x 20cm 86 or 96 x53x25 (1.8 or 3.0mL pump) 102 (including battery) IPX 7 (splash proof) Reservoirs: 180 or 300 units 102 (3.0mL) including battery- IPX 8 (3.6 m for up to 60 minutes) Reservoirs: 180 or 300 units Tubeless insulin pump comprising insulin filled pod with automatic insertion mechanism. Personal diabetes monitor (PDM) has built-in FreeStyle blood glucose meter Intuitive insulin pump focused on ease-ofuse and data connectivity. Links to App for bolus calculations and data sharing / review Insulin Pump and handset (Bluetooth connection) with built-in blood test meter. Bluetooth connection to Android smartphone for full remote control. (fully featured***) Insulin pump that communicates with smartphone app via two-way Bluetooth low Energy 4.0 connectivity, to remotely operate pump (fully featured***) Tubeless Insulin pump (reusable pump base and disposable resevoir patch) and CGM System 52 x 39 x 14.5 78 x48 x16 79 x 45 x 19 79 x 45 x 19 Patch pump: 56.5 x 33.3 x 13.3 Transmitter: 36.1 x 19.4 25 83g (incl battery and full cartridge) IPX 8 (7.6m for 60 mins) IPX 8 (1m for 60 mins) Pod itself 200 units Replace Pod at least once every 72 hours or up to 200 units of insulin (3 days). Novo Nordisk Pump Cart (Pre-filled) or Reservoir (selffilled) cartridges 160 units 63 (incl battery 62 (incl battery) Patch pump: 21.5 Transmitter: 4.8 (incl battery_ IPX 8 IPX 8 IPX 8 (2.5m for up to 60 mins) Diabecare R 3ml cartridges 300 units Diabecare R 3ml cartridges 300 units Self-contained reservoir patch (changed every 2-3 days) 200 units Insulin pump and handset with touch screen controls and built in blood glucose monitor Pump:52.8 x 35.34 x 14.3 (including insulin cartridge) Pump: 32 (incl cartridge) IPX8 (1.1m for 60mins) Insulin cartridge (changed every 3 days) 150 units

Insight OmniPod S () CGM capability Eversense XL CGM system. Sensor does not need to be changed for up to 180 days (claimed to be longer than other CGM systems which require weekly or more frequent sensor change) Standalone CGM only MiniLink Transmitter and CG Sensor Guardian 2 Link transmitter and Enlite sensor X X AAPS compatible (opensource system that can connect CGM technologies to pumps via smartphone app; system independent of Advanced UK Ltd ) Fully intergrated system with low glucose suspend (LGS) and predictive LGS mechanism. CGM can be used as a standalone sytem known as TouchCare CGM System. X Basal settings Min: 0.05U/h Max:50U/h -24 hourly basal rates, adjustable in unit of 0.01 (up to 1.00 U/h), 0.05 (up to 10.0 U/h) and 0.1 (up to 50.0 U/h). -Option to set 5 basal profiles. -Temporary basal rate(tbr) can be set Min: 0.02 U/h; Max: 25 U/h -1 to 24 hr basal rates, duraton adjustable in units of 15 min, and in of 0.01 (up to 1.00 U/h), 0.05 (up to 10.0 U/h) and 0.1 (up to 50.0 U/h). -Option to set up to 5 different basal rates, and to personalise names of basal rates and TBRs Basal rates from 0.025 U/hr; max: 35 U/h in of 0.025 U/h Potential for 48 Basal rates Standard and 2 additional basal patterns available Minimum: 0.025 U/hr Maximum: 35 U/h -potential for 48 Basal rates -Option for up to 8 pre-set temporary basal patterns e.g. high, moderate and low activity, work day, day off and sick Minimum: 0.05U/h Maximum: 30U/h PDM can store up to 7 basal programmes; of which each contains 24 rates programmed in half hour Minimum 0.02U/h in of 0.01U/h Maximum: 40U/hr; Up to 24 segments per programme 2 basal rate profiles. Temp basal available 15 minute for up 24hr Min: 0.04u/h Max: 16U/h Minimum increment 0.01U/hr 4 individual adjustable basal profiles with 24 basal rates Minimal: 0.04 U/h Increments: 0.1 U/hr or 0.01 U/h Number of Rates Per Profile: 24/day, hourly 4 Profiles Minimum:: 0.05U/h Maximum: 10 U/h 48 segments basal rate setting Basal rate 0.05 U/hr Option to set 5 basal profiles Basal flow rate from 0.05U/h to 5.0 U/hr adjustable in 0.05u, programmed in hour by hour time blocks over 24hr period. Potential for 24 different basal rates in 24 hours Potential for up to 20 different basal profiles Bolus settings Delivers up to 50U 4 bolus options: quick/standard/extended bolus/multiwave Quick bolus: 0.1/0.2/0.5/1.0/2.0U ; for other modes, 0.1U Maximum bolus amount/delivery: 50 U Standard, Extended and Multiwave Boluses, adjustable in of:0.05 U (up to 2.0 U), 0.1 U (2-5 U), 0.2 U (5-10 U, 0.5 U (10-20 U), 1.0 U (20-25 U) Minimum: 0.025 Maximum: 75U 3 settings: standard/ Square wave/ Dual wave 0.025 to 0.05 U -Maximum: 75U -3 personalised bolus settings: standard, dual, and square wave -Discrete remote bolus from Bayer Contour Next Link Meter (provided with pump). -Pre-set bolus options. 0.05, 0.1, 0.5 or 1.0U bolus Max 30 U Max flow rate 1.5U/min 0.1U, 0.5U, 1.0U and 2.0U bolus 30U maximum Dosage in 0.05, 0.1, 0.5 or 1.0 units up to 80U Extended bolus (30 mins to 8 hrs) Dual pattern bolus Bolus Increments in 0.05, 0.1, 0.5, 1.0 units Up to 80 units Extended bolus (30mins to 12hrs) Dual pattern Bolus Bolus : 0.05 U (maximum 25 U) Normal, extended and combo boluses Delivers up to 30U bolus in of 0.05U -4 different methods of delivery: immediate/extended/d ual phase/multi phase

Infusion sets Accu-Chek FlexLink Plus range: Manual or automatic insertion using Accu-Chek LinkAssist Plus insertion device, in a 90 angle with a soft cannula. Three cannula lengths (6 / 8 / 10mm) and three (40 / 70 / 100cm) tubing lengths for maximum comfort, convenience and wear ability Snap out snap in mechanism exposes introducer needle only when needed Accu-Chek FlexLink Flexible teflon 90 cannula (Cannula lengths 6mm, 8mm, 10mm 22 gauge) (Tubing 30cm, 60cm, 80cm). Accu-Chek Tender Link is Flexible 45 cannula (Cannula Lengths 13mm, 17mm) (Tubing Lengths 30cm, 60cm, 80cm, 110cm). Accu-Chek Rapid D Link 90 steel cannula available in lengths of 6mm, 8mm, 10mm, and tubing in 20/ 50/ 70/ 110cm lengths Insight Accu-Chek Insight Flex range: -automatic or manual insertion in a 90 angle with a soft cannula. --three cannula lengths 6 / 8 / 10 mm and three tubing lengths 40 / 70 / 100 cm for maximum comfort and convenience. -unique snap out snap in mechanism exposes introducer needle only when needed. Accu-Chek Insight Tender infusion set -soft cannula with a variable 20 45 degree insertion angle -needle guard safety mechanism only exposes needle for use -two cannula lengths (13 and 17mm) and three tubing lengths (40/70/100 cm) Minimed Mio / Quick Set/ Silhouette/ SureT -cannula lengths 6mm, 9mm 90degree & 13mm and 17mm 30 degree angle -cannula tubing length 45cm, 60cm, 80cm and 110 cm OmniPod None required (tubeless) Self-inserting soft (teflon) 9mm cannula in pod inserted at 45 angle to depth of 6.5mm All infusion sets rotate 360 to reduce kinks and snagging. All cannulas are inserted at 90 Soft Teflon cannulas available in 6mm and 9mm lengths tubing available 45cm, 60cm, 80cm and 110cm. Steel cannulas available in 5.5mm and 8.5mm tubing available in 45cm, 60cm, 80cm and 110cm. S Reverse Luer Lock system-manufacturers own infusion sets Soft Release O, 6mm or 9mm cannula lengths, 60cm, 80cm or 100cm tubing lengths, 360 degree spinning cannula connection Easy Release (4.5mm, 7.5mm stainless steel needle) 70cm tubing None required (tubeless) () Cannulas manufactured and supplied by Ypsomed and include: 90 degree insertion in Teflon (6mm and 9mm) and Steel (5.5mm). All Cannulas come with an Insertion device provided in patient starter kit. Battery for pump (life expectancy where stated) Warranty 1x 1.5V AA lithium battery lasts up to 8 weeks for Pump/ 3xAAA Lithium batteries last up to 4 weeks for handset (part of service pack) 1x 1.5 V AAA Alkaline or lithium battery (based on typical usage pattern [50 U/day using U-100 insulin]; battery life ~: 5 days alkaline and 14-28 days lithium (with Bluetooth 1 AAA alkaline (~14 days based on 50 U/ day)) 1 AA (1.5 V) battery, preferably lithium (7-14 days) 3 xenergizer A76INS inside pod which are discarded with pod. 2 AAA in PDM (3 weeks) 4 years 1.5 V alkaline AAA. (~ 30 days based on 50 U/day) Company s own 3.6v lithium (6-8 weeks) Patch pump: powered by 2 button batteries (1.5V); lasts ~3 weeks PDM: 1 X AAA Alkaline battery (1.5V) Transmitter: built-in 3.7V polymer lithium ion battery (lasts over 7 days and then recharged for 15-20 minutes) Both pumps and handset contain internal rechargeable 3.7v lithium polymer batteries (starter kit includes charger) Pump battery life: 3 days based on 50U per day.

Insight OmniPod S () Availability 24 hour Support 24-hour insulin pump helpline (Tel 0800 731 22 91) 24-hour technical Support (Tel 01923 205 167; office hours 09.00-17.00, US call centre out of hours) 24-hour Customer support (Tel 03448567820 UK based personal) 24-hour Customer support (Tel 07775 642 239 UK based personal) 24-hour helpline (Tel 01923 883623) and email customer support service at: customerservice.uk @medtrum.com 24hr support helpline (Tel 0800 025 8009- UK based personal) Online support available: www.cellnovo.com Real time chat, appointments and email * Veo does not have following capabilities of 640G system: SmartGuard (predictive suspend before low) capability, favourite' temporary basal rates and boluses cannot be saved, remote bolus from blood glucose meter, LCD coloured screen, quick view icons, water resistant but not waterproof, transmitter is MiniLink Transmitter (and not Guardian 2 Link Transmitter). A seperate CareLink USB dongle is required to download pump data into the CareLink software. ** Manufacturer of Omnipod System, Insulet Corporation, will take over marketing, sales, and distribution of Omnipod System, including all associated customer service activities, from Ypsomed as of 1 July 2018. *** Handset and the companion smartphone apps are complete remote controls; once remote control is set up there is no part of pump functionality that is not available via remote control.

Appendix Features Insight Veo ** 640G OmniPod (Ypsomed Ltd) Diabecare R UK Ltd) Diabecare RS UK Ltd) Syst em () Bolus calculator/wizard Carbohydrate calculator x x x x Reference food library x x x x x x x x x Missed meal bolus alert x x x x Button lock mode to prevent unintended operation Alarm: low battery/low reservoir/occlusion Bolus frequency restriction x x x x x x x x Programmable reminders x (for low insulin reservoir) Pump data download Accu-Chek 360⁰ Diabetes Management System Accu-Chek Smart Pix Carelink Therapy Management System or Diasend software Monitor or Diasend Web based: easyview.medtrum. eu Online System Diasend