DUAL CHAMBER SYSTEMS

HEALTH is the inestimable value to which Pharmaceutical Industry is committed. BORMIOLI PHARMA contributes to this mission by following the same values that guide this industry: quality, precision, safety, innovation. Our packaging solutions are developed to guarantee absolute integrity of the contained drugs, to allow them expressing their full healing potential and ensure patients a secure treatment. Our products are innovatively designed to satisfy patients functional needs and improve the quality of their life. We are conscious and proud to carry HEALTH INSIDE.

SUMMARY INTRODUCTION 04 DUAL CHAMBER SYSTEMS 07 POWERREC 10 EASYREC 16 Caps 18 Plastic bottles 21 Accessories 22 Caps 12 Glass bottles 14 Plastic bottles 15 The information contained in this catalogue may be subject to change. For confirmation concerning the relevant information, please contact the sales team. ACCUREC 24 Caps 26 Plastic bottles 27 DUAL CHAMBER SYSTEMS 3

DEVELOPED TO DUAL CHAMBER SYSTEMS Technology Bormioli Pharma is a primary packaging supplier to the world s leading Pharma companies. Long-term expertise, research and innovation allow us to be a partner of choice in the supplying of complex packaging systems. Dedicated manufacturing technologies: - for plastic: injection, injection-blowmolding, injection-stretch-blow-molding, printing - for glass: blow-and-blow High specialisation on barrier technologies to offer even greater drugs protection Continuous technological improvement to enhance the usability of packaging systems while minimising the changes on filling lines Full in-process controls and functionality checks to ensure the highest possible quality 4

REVOLUTIONISE ORAL DRUGS RECONSTITUTION Quality Our manufacturing processes and quality standards are aligned with pharmaceutical requirements and contribute to the integrity of the world`s leading drugs. Manufacturing practices - Production in GMP environment - Full product traceability and inspection - Continuous improvement programme Quality management system - GMP training of personnel - ISO 9001 and ISO 15378 certifications Regulatory support - Compliance with European, United States and Japanese Pharmacopeia and international product guidelines - DMF type III available upon request for US and Canada - International product registrations Product Accuracy, efficacy and ease of use are the distinctive features of our Dual Chamber Systems, designed for both single-dose and multi-dose drug products. All the components are designed to perfectly match each other, allowing fully customization. Dual Chamber System components: - Cap, Plug and Plunger - Glass or Plastic Bottle Three products available to meet different needs: - AccuRec, for drugs that demand accuracy and safety - EasyRec, for products that need easy and effective administration (3Phase Technology available to offer a Total Moisture Barrier) - PowerRec, for energy products that benefit from manual activation DUAL CHAMBER SYSTEMS 5

DUAL CHAMBER SYSTEMS 6

DUAL CHAMBER SYSTEMS 7

The most reliable solutions to reconstitute drugs just before the administration Thanks to a long-standing expertise in the Dual Chamber Systems segment, we fine-tuned an highly precise dosing mechanism. It enables the instant mixture of active principles, while ensuring the perfect drugs integrity. DUAL CHAMBER SYSTEMS PowerRec Single-dose Glass or plastic bottle available from 7ml to 50ml Dual chamber cap size: from 0,5 cc to 1 cc In-sight mechanism 8

PowerRec EasyRec AccuRec AccuRec Single-dose or Multi-dose Plastic bottle available from 25ml to 1000ml Dual chamber cap size: from 4 cc to 30 cc Safe and accurate mechanism EasyRec Single-dose Plastic bottle available from 7ml to 60ml Dual chamber cap size: from 0,5 cc to 1 cc Simple and intuitive activation DUAL CHAMBER SYSTEMS 9

POWERREC The powerful gesture to activate energy blends PowerRec is a single-dose packaging for instant and right-dosed energy recharge. Its fully manual activation enhances the powerful properties of the mixture. DUAL CHAMBER SYSTEMS Key advantages: To keep the properties of your product unchanged In-sight mechanism Pocket size Ideal for food supplements, especially energy products 10

ADMINISTRATION PowerRec allows to get a ready-to-drink product in a few simple steps. POWERREC Dual chamber cap Compatible with standard glass and plastic bottles 1 2 3 4 5 6 DUAL CHAMBER SYSTEMS 11

CAPS PowerRec SINGLE-PHASE Cap Neck Glass bottles bottles PE bottles AM 1007 20 mm AM 1520 20 mm AM 1007 AM 1520 12

PowerRec CAPS BI-PHASE Dual chamber cap Neck Glass bottles bottles PE bottles Capacity cc Cap Plug Plunger 0,5 cc AM 890 AMN 732 AM 1108 20 mm 0,5 0,8 cc AM 890 AM 1109 AM 1110 20 mm 0,8 0,5 CC 0,8 CC AM 890 AMN 732 AM 1108 AM 890 AM 1109 AM 1110 13

BOTTLES PowerRec 20 mm Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Glass type clear Glass type amber Single-phase Bi-phase AM 1007 0,5 cc 0,8 cc H 6/5 8,0 10,5 16,5 20 mm 46,8 23,0 H 309/8 Quarter 10,0 13,0 19,0 20 mm 49,0 24,5 H 410/8 10,0 13,1 19,0 20 mm 49,0 24,5 H 1/10 10,0 15,0 23,0 20 mm 53,5 25,4 H 389/12 Bis 12,0 13,0 16,5 20 mm 42,3 26,0 H 473/15 15,0 18,3 23,0 20 mm 62,5 24,8 GLASS 14 H 6/5 8 ml H 309/8 Quarter 10 ml H 410/8 10 ml H 1/10 10 ml H 389/12 Bis 12 ml H 473/15 15 ml

PowerRec BOTTLES 20 mm Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Single-phase Bi-phase AM 1007 AM 1520 0,5 cc 0,8 cc FI 8071 7,0 13,0 4,4 20 mm 49,8 21,5 FI 8040 10,0 17,0 4,4 20 mm 49,0 24,5 FI 8070 15,0 20,0 4,4 20 mm 52,9 25,5 FI 9215 15,0 18,5 4,1 20 mm 53,4 25,0 FI 8071 7 ml FI 8040 10 ml FI 8070 15 ml FI 9215 15 ml 15

EASYREC The intuitive way to mix active ingredients EasyRec is a single-dose system that preserves the freshness and integrity of active ingredients. Thanks to its internal mechanism it ensures a simple and intuitive activation. DUAL CHAMBER SYSTEMS Key advantages: One shot solution Interactive and effective Tamper evident closure Ideal for food supplements 16

ADMINISTRATION EasyRec facilitates product reconstitution thanks to its user-friendly mechanism. EASYREC Dual chamber cap Compatible with standard plastic bottles Accessories 1 2 3 4 5 DUAL CHAMBER SYSTEMS 17

CAPS EasyRec SINGLE-PHASE Cap Neck bottles AM 1422 AM 1556 13,5 mm 17,8 mm AM 1422 AM 1556 18

EasyRec CAPS BI-PHASE Dual chamber cap Neck bottles Capacity cc Cap Plug Plunger 0,5 cc AM 1299 AM 1301 AM 1108 17,8 mm 0,5 0,8 cc AM 1299 AM 1376 AM 1110 17,8 mm 0,8 1 cc AM 1299 AM 1491 AM 1490 17,8 mm 1,0 0,5 CC 0,8 CC 1 CC AM 1299 AM 1301 AM 1108 AM 1299 AM 1376 AM 1110 AM 1299 AM 1491 AM 1490 19

CAPS EasyRec 3PHASE TECHNOLOGY The newest and most advanced technology to guarantee an extra protection against moisture. Moisture-proof certified: laboratory tests show a significant reduction of the moisture percentage in the ed products Ideal to maximize the product shelf life: the active ingredients effectiveness is better preserved Unchanged pack processing: it takes place on existing single-dose filling lines Dual chamber cap Neck bottles Capacity cc Cap Plug Plunger 3Phase 0,5 cc AM 1299 AM 1376 AM 1547 17,8 mm 0,5 3Phase 0,5 CC AM 1299 AM 1376 AM 1547 20

EasyRec BOTTLES 13,5 mm - 17,8 mm Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Single-phase Bi-phase AM 1422 AM 1556 0,5 cc 0,8 cc 1,0 cc 3Phase 0,5 cc FI 8127 10,0 11,0 3,1 13,5 mm 74,0 16,0 FI 8098 25,0 28,5 9,3 17,8 mm 110,3 20,8 FI 8159 7,0 10,7 4,75 17,8 mm 44,2 22,1 FI 8093 7,0 13,7 4,9 17,8 mm 53,1 21,5 FI 8056 10,0 17,2 4,9 17,8 mm 52,3 24,5 FI 8083 15,0 20,3 4,8 17,8 mm 56,2 25,5 FI 8183 30,0 35,5 8,8 17,8 mm 72,1 30,0 FI 8230 60,0 65,9 10,1 17,8 mm 88,6 36,0 FI 8127 10 ml FI 8098 25 ml FI 8159 7 ml FI 8093 7 ml FI 8056 10 ml FI 8083 15 ml FI 8183 30 ml FI 8230 60 ml 21

ACCESSORIES EasyRec 17,8 mm Screw cap Screw cap Bulb capacity PVC Bulb capacity Natural rubber Bulb capacity Butyl rubber Bulb capacity Nitrile rubber Pipette cover Single-dose 0,60-1,0 0,60-0,75 0,75 0,40-0,75 70 Glass pipette Glass pipette Length Plastic pipette Plastic pipette Length Nasal 45 120 Nasal 51,7-61 - 63* Pencil 45 120 Pencil 59-76 Bulb 45 120 * Graduated pipettes 0,5-1 ml 22

EasyRec ACCESSORIES 17,8 mm Reference Weight Diameter Material bottles AM 1446 AM 1446 1,2 20 LDPE The single-dose dispenser can be used either as applicator or dropper, according to the needs, and has been conceived for both vials and samples. Reference Weight Diameter Material Dual chamber cap AM 1494 AM 1494 1 20 The single-dose key is an effective senior friendly solution for the opening of single-doses: the consumer has just to fit in and turn the key without effort to unscrew the cap. PP 23

ACCUREC The evolution of drug reconstitution AccuRec is high-tech solution that offers precise reconstitution for oral products. Its mechanism guarantees safety during administration. DUAL CHAMBER SYSTEMS Key advantages: To keep the properties of your product unchanged Perfect dosing and recostitution Mistake proof system Safety features Ideal for food supplements, OTC and prescription oral drugs 24

ADMINISTRATION AccuRec provides a unique functional experience in taking drugs and food supplements ACCUREC Dual chamber cap Compatible with standard plastic bottles 1 2 3 4 5 6 DUAL CHAMBER SYSTEMS 25

CAPS AccuRec BI-PHASE Dual chamber cap Neck bottles PE bottles Capacity cc Cap Plug Plunger 4 cc* AM 1586 AM 1583 AM 1587 4 10 cc AM 1582 AM 1583 AM 1584 10 30 cc AM 1579 AM 1580 AM 1581 PFP 35 30 *Availability subject to minimum order quantities, please contact our commercial team 4 CC 10 CC 30 CC 26

AccuRec BOTTLES Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8252 30,0 38,8 12,5 63,3 35,0 FI 8016 50,0 70,0 12,5 87,8 38,0 FI 8085 90,0 97,5 15,1 92,9 44,0 FI 8086 90,0 97,0 15,0 102,0 40,8 FI 8252 30 ml FI 8016 50 ml FI 8085 90 ml FI 8086 90 ml 27

BOTTLES AccuRec Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8035 100,0 112,0 15,0 96,8 46,1 FI 8006 120,0 130,0 16,5 113,0 46,0 FI 8189 125,0 149,5 18,5 104,5 50,0 28 FI 8035 100 ml FI 8006 120 ml FI 8189 125 ml

AccuRec BOTTLES Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8036 150,0 162,0 18,5 111,5 51,6 FI 8017 180,0 190,0 21,0 116,9 54,7 FI 8060 200,0 215,0 22,0 121,4 57,0 FI 8036 150 ml FI 8017 180 ml FI 8060 200 ml 29

BOTTLES AccuRec Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8032 250,0 262,0 23,0 125,7 61,7 FI 8061 300,0 330,0 28,5 142,8 65,6 FI 8048 500,0 525,0 37,0 166,4 74,0 30 FI 8032 250 ml FI 8061 300 ml FI 8048 500 ml

AccuRec BOTTLES Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8197 150,0 175,3 17,7 125,0 49,0 FI 8139 200,0 216,0 22,0 136,0 52,0 FI 8140 250,0 284,0 25,5 148,3 58,0 FI 8145 500,0 522,0 38,5 180,4 69,9 FI 8197 150 ml FI 8139 200 ml FI 8140 250 ml FI 8145 500 ml 31

BOTTLES AccuRec Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 9190 60,0 72,0 10,2 72,8 42,5 FI 9152 100,0 113,0 15,0 101,0 44,0 FI 9147 50,0 61,0 11,5 79,8 38,5 FI 9167 70,0 85,5 12,8 98,2 39,0 32 FI 9190 60 ml FI 9152 100 ml FI 9147 50 ml FI 9167 70 ml

AccuRec BOTTLES Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 9150 100,0 112,0 15,8 104,0 45,0 FI 9216 150,0 175,0 21,8 109,5 55,0 FI 9187 200,0 235,0 22,5 136,0 54,0 FI 9150 100 ml FI 9216 150 ml FI 9187 200 ml 33

BOTTLES AccuRec Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8118 60,0 94,0 12,4 78,5 49,2 FI 9131 100,0 115,0 14,2 91,0 49,2 FI 9166 120,0 134,5 16,9 104,7 48,0 34 FI 8118 60 ml FI 9131 100 ml FI 9166 120 ml

AccuRec BOTTLES Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 8051 130,0 155,0 18,8 115,7 49,2 FI 9176 170,0 190,0 22,7 136,0 49,2 FI 9206 240,0 280,0 27,0 136,0 60,0 FI 8051 130 ml FI 9176 170 ml FI 9206 240 ml 35

BOTTLES AccuRec Reference Nominal Brimful Weight Neck Height Diameter capacity capacity Material Bi-phase 4 cc 10 cc FI 9129 25,0 35,0 6,0 51,4 35,9 FI 9140 40,0 49,0 7,0 66,4 35,5 36 FI 9129 25 ml FI 9140 40 ml

AccuRec BOTTLES PFP 35 Reference Nominal capacity Brimful capacity Weight Neck Height Diameter Material Bi-phase 30 cc FI 8072 60,0 81,0 15,3 PFP 35 75,9 42,9 FI 8095 100,0 120,0 18,5 PFP 35 82,5 50,0 FI 8072 60 ml FI 8095 100 ml 37

BOTTLES AccuRec PFP 35 Reference Nominal capacity Brimful capacity Weight Neck Height Diameter Material Bi-phase 30 cc FI 9191 60,0 78,0 11,5 PFP 35 61,0 50,0 FI 9192 100,0 112,0 13,8 PFP 35 79,8 50,0 FI 9193 170,0 188,0 22,0 PFP 35 122,8 50,0 38 FI 9191 60 ml FI 9192 100 ml FI 9193 170 ml

AccuRec BOTTLES PFP 35 Reference Nominal capacity Brimful capacity Weight Neck Height Diameter Material Bi-phase 30 cc FI 9201 40,0 60,0 10,0 PFP 35 56,0 44,8 FI 9217 60,0 84,0 11,7 PFP 35 72,0 44,8 FI 9199 100,0 114,0 14,0 PFP 35 79,8 50,0 FI 9195 150,0 165,0 19,0 PFP 35 96,5 54,5 FI 9201 40 ml FI 9217 60 ml FI 9199 100 ml FI 9195 150 ml 39