ACG S HEPATOLOGY SCHOOL & SOUTHERN REGIONAL

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2018 ACG'S HEPATOLOGY SCHOOL & SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 - DECEMBER 2, 2018 JW MARRIOTT HOTEL NASHVILLE, TN ACG S HEPATOLOGY SCHOOL EARN CME EARN UP TO 8. 2 5 CREDITS UP TO 8. 2 5 SOUTHERN REGIONAL COURSE MOC EARN CME EARN POINTS UP TO 12. 2 5 CREDITS UP TO 12. 2 5 MOC POINTS REGISTER ONLINE: MEETINGS.GI.ORG

2018 ACG'S HEPATOLOGY SCHOOL & SOUTHERN REGIONAL POSTGRADUATE COURSE MARK YOUR CALENDAR FOR ACG S HEPATOLOGY SCHOOL AND SOUTHERN REGIONAL POSTGRADUATE COURSE, NOVEMBER 30 DECEMBER 2, AT THE JW MARRIOTT HOTEL IN NASHVILLE, TN. ACG s Hepatology School, to be held on Friday, November 30, is a day-long interactive program that provides comprehensive education for GI clinicians in the diagnosis and treatment of a variety of liver disease states. This program is designed to better enable clinical gastroenterologists and their advanced practice provider colleagues to triage, treat, and refer patients more efficiently. The Southern Regional Postgraduate Course, offered on Saturday and Sunday, December 1 and 2, will focus on topics such as: IBD, pancreatobiliary, liver, the future of MIPS, maximizing the use of advanced practice providers, upper GI, and lower GI. Hands-on sessions will also be offered on Saturday afternoon. Both programs will take place at the new JW Marriott Hotel, located in the heart of downtown Nashville. Also known as Music City, U.S.A., Nashville is the premier destination for country music lovers. The Country Music Hall of Fame, as well as dozens of cafes and honky-tonks that showcase live music, are within walking distance. 2 For more of what there is to see and do in Nashville, go to visitmusiccity.com.

November 30-December 2, 2018 JW MARRIOTT HOTEL NASHVILLE, TENNESSEE PROGRAM DESCRIPTION ACG's Hepatology School Building on the success of ACG s prior Hepatitis School, the program has been expanded to provide comprehensive education for GI clinicians in the diagnosis and treatment of many other frequently diagnosed liver disease states. ACG s Hepatology School is designed to better enable clinical gastroenterologists and their advanced practice providers to triage, treat, and refer patients more efficiently. The program content is tailored to reflect the rapid changes in treatment options and national trends meeting the standard of care. After completing ACG s Hepatology School, attendees will be able to summarize the current management options for HCV and HBV infections and understand the timeline of new drug development for the treatment of these infections. Participating in this educational activity will also enable learners to analyze the challenges of treating patients with NAFLD, end-stage organ disease, cirrhosis, hepatic encephalopathy, hepatocellular carcinoma, alcoholic liver disease and alcoholic hepatitis, metabolic liver disorders, primary biliary cholangitis, autoimmune hepatitis, and drug-induced liver injury. The structure of the program includes a mix of didactic presentations and case-based presentations delivered by expert faculty. This program is designed for gastroenterologists, primary care physicians, nurses, physician assistants, and nurse practitioners interested in the latest information on liver diseases and state-of-the-art treatment of these illnesses. Southern Regional Postgraduate Course The introduction and advances of innovative diagnostic techniques and novel therapeutics has created an exciting range of approaches to many important areas of GI disease and patient care. This program is designed to address those compelling and controversial areas in the care of patients with gastrointestinal disease. During this course, multiple topics will be covered including inflammatory bowel disease, chronic pancreatitis, biliary strictures, transition of the pediatric liver patient to adult care, SIBO, the future of MIPS, maximizing the use of advanced practice providers, esophageal motility disorders, advanced polypectomy techniques, and FMT. A special Saturday lunchtime presentation on the female patient with IBD is also planned. The structure of the program includes a mix of didactic presentations delivered by expert faculty, question and answer periods, smaller afternoon general sessions, and non-cme hands-on workshop sessions. This program is designed for gastroenterologists, primary care physicians, nurses, physician assistants, and nurse practitioners interested in the latest information on diagnostic GI and liver diseases and state-of-the-art treatment of these illnesses. Learn and earn your end-of-year CME and MOC 3

ACG'S HEPATOLOGY SCHOOL AGENDA COURSE DIRECTORS: David E. Bernstein, MD, FACG, Paul Y. Kwo, MD, FACG, and Mitchell L. Shiffman, MD, FACG FRIDAY, NOVEMBER 30, 2018 7:00 am Registration and Continental Breakfast 8:00 am Welcome and Introduction David E. Bernstein, MD, FACG SESSION 1: VIRAL HEPATITIS 8:10 am HCV Treatment and Post-Treatment Follow-Up David E. Bernstein, MD, FACG Summarize the current management options for chronic HCV infection and describe post-treatment follow-up. 8:30 am Treatment of HCV in Patients With End-Stage Organ Disease and Other Populations Paul Y. Kwo, MD, FACG Describe the current available treatments for patients with HCV and end-stage liver disease. 8:50 am Natural History and Diagnosis of HBV Mitchell L. Shiffman, MD, FACG Discuss the natural history of HBV, serologies, the different immune stages of the disease, and screening recommendations for HCC in patients with HBV. 9:10 am HBV Treatment Mark W. Russo, MD, MPH, FACG Explain current recommendations for the treatment of HBV including for pregnant patients, and strategies to prevent reactivation. 4 9:30 am Q & A 9:45 am Break SESSION 2: DIAGNOSING AND TREATING LIVER DISEASE 10:00 am Assessing Fibrosis in the Management of Chronic Liver Disease Joseph K. Lim, MD, FACG Discuss the strengths and weaknesses of the currently available modalities used to assess hepatic fibrosis. 10:25 am Routine Care of the Patient With Cirrhosis Catherine T. Frenette, MD Define the liver-specific care of patients with cirrhosis including the evaluation of complications of portal hypertension. 10:50 am Hepatic Encephalopathy Mitchell L. Shiffman, MD, FACG Identify the classification, diagnostic testing, and treatment of hepatic encephalopathy. 11:15 am Hepatocellular Carcinoma Paul Y. Kwo, MD, FACG List risk factors, screening, evaluation methods, and treatments for patients with HCC. 11:40 am Q & A 11:55 am Break 12:15 pm Lunch With Faculty and Case Presentations / Q & A Mitchell L. Shiffman, MD, FACG 1:15 pm The Role of the Advanced Health Care Provider in the GI Hepatology Practice April G. Morris, FNP Outline the role of AHCPs in working with chronic liver disease patients.

2018 ACG'S HEPATOLOGY SCHOOL AND SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 DECEMBER 2, 2018 JW MARRIOTT HOTEL, NASHVILLE, TN SESSION 3: CAUSES OF LIVER DISEASE 1:40 pm Management of NAFLD Catherine T. Frenette, MD Describe the causes, epidemiology, natural history, and treatment of NAFLD. 2:05 pm Diagnosis and Management of Alcoholic Liver Disease and Alcoholic Hepatitis Mark W. Russo, MD, MPH, FACG Discuss liver diseases secondary to alcohol use and their treatments. 2:30 pm Metabolic Liver Disorders Joseph K. Lim, MD, FACG Explain the causes, epidemiology, natural history, and treatments of hereditary hemochromatosis, Wilson s disease, and alpha-1 antitrypsin deficiency. 2:55 pm Q & A 3:10 pm Break SESSION 4: PBC AND OTHER IMMUNE DISORDERS 3:25 pm Primary Biliary Cholangitis David E. Bernstein, MD, FACG Identify the epidemiology, natural history, and treatments of PBC. 3:45 pm Autoimmune Hepatitis and Its Variants Paul Y. Kwo, MD, FACG Explain the epidemiology, natural history, and treatments of autoimmune hepatitis and primary sclerosing cholangitis. 4:05 pm Drug-Induced Liver Injury Mark W. Russo, MD, MPH, FACG Describe the typical patterns of drug-induced liver injury and commonly used medications that may cause it. 4:25 pm Q & A 4:40 pm Course Wrap-Up and Take-Away Points Mitchell L. Shiffman, MD, FACG 5:00 pm Course Adjourns MOBILE APP INFORMATION Included with your registration is complimentary access to the course presentations via the ACG Mobile App. The app can be used to view faculty presentations on tablets, mobile devices, and laptops. Attendees will be able to take notes and highlight key points on the presentation slides at the event, and can continue reviewing them after the course. PDFs of the presentations can be downloaded directly from the app or can be printed from the website version of the app. Pre-registrants will receive access to the app prior to the course to view, download, or print the presentation slides. (NOTE: A printed syllabus will not be provided.) 5

SOUTHERN REGIONAL POSTGRADUATE COURSE AGENDA COURSE DIRECTORS: Timothy Denton, MD, FACG, and Sara N. Horst, MD, MPH SATURDAY, DECEMBER 1, 2018 6:30 am Registration and Continental Breakfast in the Exhibit Hall 7:40 am Welcome Remarks and Announcements Timothy Denton, MD, FACG, and Sara N. Horst, MD, MPH SESSION 1: IBD Moderator: Edward V. Loftus, Jr., MD, FACG 7:45 am Update on Ulcerative Colitis Millie D. Long, MD, MPH, FACG Discuss care for the mild-to-moderate and the severe ulcerative colitis patient populations. 8:05 am Biologic Drug Monitoring in Inflammatory Bowel Disease David A. Schwartz, MD, FACG Discuss how biologic drug monitoring can be utilized in patients with inflammatory bowel disease. 8:25 am Positioning Biologics for Patients With Crohn s Disease in 2018 Edward V. Loftus, Jr., MD, FACG Explain the options for new biologic therapy in patients with inflammatory bowel disease, including anti-tnf therapy, anti-integrin therapy, and IL 12-23 receptor antagonists. 6 8:45 am Care Beyond the Gut: Health Maintenance in IBD Sara N. Horst, MD, MPH 9:05 am Q & A Describe practical health maintenance objectives for patients with inflammatory bowel disease that focus on vaccines, bone health, and psychosocial outcomes.

2018 ACG'S HEPATOLOGY SCHOOL AND SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 DECEMBER 2, 2018 JW MARRIOTT HOTEL, NASHVILLE, TN SESSION 2: PANCREATOBILIARY Moderator: Douglas G. Adler, MD, FACG 9:25 am Chronic Pancreatitis Update Timothy B. Gardner, MD, MS, FACG List the causes of chronic pancreatitis, the most recent diagnostic strategies, and new management strategies available for these patients. 9:45 am Endoscopic Management of Complex Pancreatic Fluid Collections Patrick S. Yachimski, MD, MPH Identify endoscopic therapy options for patients with complex pancreatic cysts. 10:05 am Biliary Strictures: Why Do They Happen, and When and How Do We Treat Them Endoscopically? Douglas G. Adler, MD, FACG 10:25 am Q & A Discuss causes of biliary stricturing disease and how best to manage diagnosis and treatment endoscopically. 10:45 am Refreshment Break / Visit the Exhibit Hall SESSION 3: LIVER Moderator: Mitchell L. Shiffman, MD, FACG 11:15 am Alcoholic Liver Disease Management Nancy S. Reau, MD, FACG Discuss new guidelines for alcoholic liver disease management. 11:35 am Portal Hypertension Treatment: What Is New? Paul Y. Kwo, MD, FACG Discuss the current literature and new options for treating patients with esophageal and gastric varices. 11:55 am Vascular Lesions and Solid Tumors of the Liver Mitchell L. Shiffman, MD, FACG Explain the diagnosis and management of vascular and solid lesions of the liver. 12:15 pm Transition of the Pediatric Liver Patient to Adult Care Girish S. Rao, MD Recognize the best ways to transition a pediatric liver patient to adult care. 12:35 pm Q & A 12:55 pm Break REGISTER ONLINE: MEETINGS.GI.ORG 1:10 pm Working Luncheon Session "Ask the Experts" Edward V. Loftus, Jr., MD, FACG, and Mitchell L. Shiffman, MD, FACG 1:55 pm Break Dessert in the Exhibit Hall 7

SOUTHERN REGIONAL POSTGRADUATE COURSE AGENDA SATURDAY AFTERNOON GENERAL SESSIONS / HANDS-ON WORKSHOP SESSIONS: *Hands-on workshops do not offer CME. 2:15 pm Update on SIBO Mark Pimentel, MD, FACG Outline the new ACG guidelines regarding the diagnosis and treatment of small bowel bacterial overgrowth. OR Hands-on Workshop Session* 3:05 pm The Future of MIPS Caroll Koscheski, MD, FACG Analyze the new landscape of the Merit-based Incentive Payment System (MIPS) and the effect it may have on gastroenterology practice in the coming years. OR Hands-on Workshop Session* 3:55 pm What Else Is Your Patient Taking? Alternative Therapies in IBD Dawn M. Beaulieu, MD Discuss alternative therapies including herbal supplements and dietary management for patients with inflammatory bowel disease. OR Hands-on Workshop Session* 4:45 pm Maximizing the Use of Advanced Practice Providers in the GI Practice Panel: Timothy Denton, MD, FACG, and Sara N. Horst, MD, MPH Describe how to best position advanced practice providers in a gastroenterology practice to allow for a thriving environment for all involved. OR Hands-on Workshop Session* 5:30 pm Adjourn for the Day 8 HANDS-ON WORKSHOPS Attendees have the opportunity to participate in the hands-on workshops at no additional charge. These sessions focus on specific endoscopic procedures, and offer participants a chance to gain tactile experience using a variety of tools and techniques. Faculty will demonstrate a device and/or technique, and attendees will be able to practice. While the handson workshop sessions do not offer CME, they are a valuable learning experience, and provide an opportunity for attendees to interact with the experts. Hands-on workshops will be concurrent with the general sessions Saturday afternoon. There are limited spaces available. Registrants are able to select their top two stations when they register for the course. The College will assign stations based on availability. HANDS-ON WORKSHOP SESSIONS REGIONAL COURSE WORKSHOP DIRECTORS: Shivangi T. Kothari, MD, FACG, and Kevin E. Woods, MD, MPH 6 hands-on stations will be offered. The stations are: EMR / ESD Mucosal Ablation: RFA Hemostasis Hemorrhoid Banding Foreign Body Removal ERCP

2018 ACG'S HEPATOLOGY SCHOOL AND SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 DECEMBER 2, 2018 JW MARRIOTT HOTEL, NASHVILLE, TN SUNDAY, DECEMBER 2, 2018 7:00 am Registration and Continental Breakfast in the Exhibit Hall 7:55 am Welcome and Announcements Timothy Denton, MD, FACG, and Sara N. Horst, MD, MPH SESSION 4: UPPER GI Moderator: Michael F. Vaezi, MD, PhD, MSc(Epi), FACG 8:00 am Achalasia and Other Esophageal Dysmotility Rena H. Yadlapati, MD Outline the diagnostic and treatment strategies for achalasia. 8:20 am Eosinophilic Esophagitis: New Options in Dietary and Medical Management Evan S. Dellon, MD, MPH, FACG Describe new treatment options, including dietary management, for eosinophilic esophagitis. 8:40 am PPIs: What Are the Data Regarding Long-Term Use? Colin W. Howden, MD, FACG Understand the new data regarding side effects of protonpump inhibitors. 9:00 am Refractory GERD: What to Consider if PPIs Don t Help Michael F. Vaezi, MD, PhD, MSc(Epi), FACG 9:20 am Q & A Discuss diagnostic and treatment strategies for dyspepsia symptoms that are nonresponsive to PPIs. 9:40 am Refreshment Break / Visit the Exhibit Hall SESSION 5: LOWER GI Moderator: Timothy Denton, MD, FACG 10:00 am Colorectal Cancer Screening Robert D. Marks, MD Assess colorectal cancer screening options. 10:20 am Advanced Polypectomy Techniques Amit Rastogi, MD Analyze advanced polypectomy techniques for large polyps, and their potential as an alternative to major abdominal surgery. 10:40 am Chronic Constipation and Pelvic Floor Dysfunction Lin Chang, MD, FACG Describe new therapies available for patients with chronic constipation and how pelvic floor dysfunction may play a role in certain patient populations. 11:00 am FMT: How to Best Deliver Therapy Colleen R. Kelly, MD, FACG 11:20 am Q & A Discuss new modalities for delivery of fecal microbiota transplant. 11:40 am Course Wrap-Up and Take-Away Points Timothy Denton, MD, FACG, and Sara N. Horst, MD, MPH 12:00 pm Course Adjourns 9

PROGRAM DESCRIPTION / REGISTRATION INFORMATION REGISTRATION INFORMATION There are separate registration fees for ACG s Hepatology School and the ACG Southern Regional Postgraduate Course. The registration fee for each program includes admission to all sessions, continental breakfasts, lunch on Friday for ACG s Hepatology School attendees, lunch on Saturday for Regional Postgraduate Course attendees, and refreshment breaks. All registrants must pay the full registration fee; partial registration is not available. Full refund of registration fees will be given, less a $25 administrative fee, if written notice of cancellation is received by ACG by October 26, 2018. No refunds will be given after this date. ACG'S HEPATOLOGY SCHOOL REGISTRATION SOUTHERN REGIONAL COURSE REGISTRATION ACG MEMBER TYPE EARLY BIRD (by 11/1) FEE (AFTER 11/1) ACG MEMBER TYPE EARLY BIRD (by 11/1) FEE (AFTER 11/1) Physician $125 $200 Physician $449 $499 Resident / Trainee / Candidate $125 $200 Resident / Trainee / Candidate $179 $254 Associate / Advanced Practice Provider $125 $200 Associate / Advanced Practice Provider $289 $364 NON-MEMBER TYPE NON-MEMBER TYPE Physician / PharmD / PhD / Guest $175 $250 Physician / PharmD / PhD / Guest $549 $599 Resident / Trainee $175 $250 Resident / Trainee $229 $304 NP / PA / Allied Health (RN, LPN) $175 $250 NP / PA / Allied Health (RN, LPN) $349 $424 10

2018 ACG'S HEPATOLOGY SCHOOL AND SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 DECEMBER 2, 2018 JW MARRIOTT HOTEL, NASHVILLE, TN ACCREDITATION / CME / MOC The American College of Gastroenterology is accredited by the American Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. ACG s Hepatology School The American College of Gastroenterology designates this live activity for a maximum of 8.25 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 8.25 MOC points in the ABIM s MOC program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. Southern Regional Postgraduate Course The American College of Gastroenterology designates this live activity for a maximum of 12.25 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 12.25 MOC points in the ABIM s MOC program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. ACCOMMODATIONS The programs will be held at the new JW Marriott Hotel in downtown Nashville. The hotel is adjacent to the Music City Center and blocks away from Bridgestone Arena, home of the NHL s Nashville Predators. Opening in July 2018, the hotel will feature a full-service spa, fitness center, rooftop terrace and pool, complimentary WiFi in all guest rooms and meeting rooms, an impressive collection of contemporary art, as well as world-class dining in three restaurants. To make your hotel reservation, please contact the JW Marriott directly at 615-291- 8600 or 1-888-236-2427. Special meeting room rates per night are $239 for single/ double, plus state and local taxes. Valet parking is available for an additional fee of $39 per day. All major credit cards are accepted. Reservations must be made before October 15, 2018 to receive the special meeting rate. Only a certain number of rooms are available at this rate and are available on a first-come, first-served basis. Once ACG s room block is sold out, the hotel may charge a higher rate for any additional rooms made available. Requests for reservations received after this date will be on a space-available basis only. All reservations require a deposit of one night s room and tax upon reservation. Cancellations made within 24 hours of check-in will be charged one night s room and tax. Check-in time is 4:00 p.m. Check-out time is 11:00 a.m. The JW Marriott is located at 201 8th Avenue South, Nashville, TN 37203. MORE INFORMATION For more information about these programs, contact ACG at education@gi.org. Americans with Disabilities Act (ADA): Attendees of these programs who have special needs, including dietary needs, should contact the ACG office at registration@gi.org no later than October 26, 2018. 11

AMERICAN COLLEGE OF GASTROENTEROLOGY 6400 Goldsboro Road, Suite 200 2018 Bethesda, MD 20817 ACG'S HEPATOLOGY SCHOOL & SOUTHERN REGIONAL POSTGRADUATE COURSE NOVEMBER 30 - DECEMBER 2, 2018 JW MARRIOTT HOTEL, NASHVILLE, TN REGISTER BY NOVEMBER 1 AND SAVE! meetings.gi.org