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1. Programme Sunday, 4 th November 2018 Time Topic Speaker Abbreviation 08:00 Welcome, distribution materials 08:30 Overview of the Medical Eligibility Criteria (2015), and the Selected Practices Recommendations for contraceptive use (2016), and the Family Planning Training Resource Package Mario Festin WHO Guides 09:20 Combined hormonal contraceptives Gabriele Merki CHC I 09:45 Combined hormonal contraceptives Gabriele Merki CHC II 10:35 Combined hormonal contraceptives Gabriele Merki CHC III 10:55 Coffee break 11:15 MEC WHO questions Mario Festin WHO Guides Part 2 11:35 Combined vaginal ring, combined transdermal patch Frans Roumen CHC IV: CVR,CTP 12:10 Workshop 1 Case 1: CHC history risks Case 2 : CHC history All teachers WS 1 12:50 Medical condition: Mental disabilities Eating disorders 13:10 Lunch Teresa Bombas MC Mental disorders 14:00 Progestin only contraceptives overview Iñaki Lete Lasa POC Overview 14:30 Progestin only pill with desogestrel and Depot medroxyprogesterone acetate (DMPA) Teresa Bombas POP and DMPA 15:10 Etonogestrel-releasing implant Iñaki Lete Lasa POC Implant 15:30 Coffee break 16:00 Medical condition: Obesity and family history for VTE Iñaki Lete Lasa MC Obesity, family history and VTE 16:25 Workshop 2 Case 1 : breastfeeding and obesity Case 2 : POC and bleeding 17:00 Medical condition: 1.Contraception in women with HIV infection 2.Hormonal contraceptives and drug interactions All teachers WS 2 Katarina Sedlecky MC Women with HIV CHC and Drug interactions 17:35 18:00 Complete evaluation form day 1; Discussion All teachers 1

Monday, 5 th November 2018 Time Topic Speaker Abbreviation 08:30 Intrauterine devices overview Iñaki Lete Lasa IUD Overview 09:00 Copper-IUDs Iñaki Lete Lasa Copper-IUDs 09:20 Levonorgestrel releasing intrauterine system Katarina Sedlecky LNG-IUS 09:45 Coffee break 10:10 Medical condition: Migraine and depression Gabriele Merki MC Migraine and depression 10:35 Female and male sterilisation Frans Roumen Female and male sterilisation 11:10 Workshop 3 Case 1: Permanent methods Case 2 : LNG-IUS abortion-dysmenorrhoea All teachers WS 3 11:50 IUDs in special situations Katarina Sedlecky IUDs in special situations 12:20 Medical Condition: Hormonal contraception and Breast and ovarian Cancer BRCA1/BRCA2 carriers 12:45 Lunch 13:35 Workshop 4 Case 1: Non-oral CHCs (15 min) Case 2: POC-Breastfeeding-EC (15 min) Case 3: STD and IUD (30 min) Implanon insertion Gabriele Merki 14:35 Counselling role play Mario Festin All teachers WS 4 15:15 Country training plans Gabriele Merki Frans Roumen 15:45 Short coffee break 16:00 Kahoot quiz / discussion of responses Katarina Sedlecky 16:40 17:00 Course evaluation Open discussion MC CHC breast and ovarian cancer 2

2. Content CHC I Clinical relevant metabolic effects of ethinylestradiol (EE) The variations in individual steroid plasma levels and potential clinical consequences The difference between the mostly used progestins in CHCs Typical properties of progestins Types and dosages of CHCs Clinical effects of a lower EE dosage Difference between pills with estradiol /estradiolvalerate and EE CHC II How to take a history before contraceptive counseling Special risk screening for use of CHCs (higher risks/ lower risks and WHO MEC category 4 criteria criteria) There are two types of risks one affecting the arterial system and one the venous system VTE risk in healthy young women without contraception and in pregnancy o EMAS recommendation: VTE risk according to progestin type and method of application o VTE risk according to estrogen dose and type of estrogen o Understand what is meant by a positive family history and what it means for risk counselling o VTE risk in women with thrombophilia o Overview risk for VTE in numbers and multiplication of risks o VTE risk with age, obesity and duration of CHC use Arterial risk: stroke and myocardial infarction in numbers, in relation to age and obesity Balancing risks against other contraceptive options and benefits during counselling 3

CHC III Contraceptive health benefits of CHCs Minor harmless side effects Treatment of side effects Major side effects / reasons to stop pill immediately VTE risk in newstarters and counselling for symptoms associated with DVT and PE Pill return visit Measurement of blood pressure CHC IV: CVR,CTP Description and formulation; Application Pharmacokinetics; Regimen of use Similarities ring, patch and pill; Advantages ring and patch > pill Contraceptive failure rates Dosing errors; Extended use Concurrent use Cycle control; Acceptability; Compliance; Side effects compared with pill Device-related problems; Acceptability ring vs patch Venous and arterial thromboembolism Counselling MC Mental disorders General considerations Feeding and eating disorders Psychotic disorders Some aspects of contraception in disabled women POC Overview Progestin types Working mechanism Contraceptive efficacy and safety of POC Use in women with medical conditions Health benefits Adverse events: bleeding, breast tenderness, weight, acne, BMD 4

POP and DMPA POP General characteristics of the desogestrel 75 µg POP Contraceptive efficacy Health benefits, migraine Side effects, bleeding Emergency contraception Breastfeeding Summary DMPA General characteristics of DMPA Contraceptive efficacy and duration of use Contraindications Health benefits Safety Side effects and treatment Reasons for discontinuation Summary POC Implant General characteristics of the ENG-releasing implant Contraceptive efficacy Health benefits Contraindications Side effects and treatment, continuation Summary MC Obesity, family history and VTE Obesity Definition of obesity Obesity and VTE risk Which contraceptives are efficient in obese women Contraception after bariatric surgery Family history and VTE Contraception after VTE Definition of positive family history for VTE Efficient and safe contraception if FH is positive VTE risk in women with positive FH 5

MC Women with HIV CHC and Drug interactions HIV Main characteristics of HIV infection, classification and clinical stages of HIV infection Concerns regarding contraception: o Drug interaction o Possible impact on progression of HIV infection o Impact on HIV transmission and acquisition o Potential risks related to HIV infection/aids Hormonal contraceptives and drug interactions Overview of the metabolism of the contraceptive steroids Pharmacokinetic drug interaction Interactions of CHC and POC with: o anti-epileptic drugs o psychotropic drugs o herbal remedies o antimicrobial therapy IUD Overview Types of IUD Efficacy of IUDs and duration of use IUDs and PID risk, screening for STIs prior to insertion Need for antibiotic prophylaxis during insertion Pain management during IUD insertion When to insert (include after abortion and pregnancy), switching from another method Risk factors, frequency of expulsion and dislocation, reinsertion after expulsion Post-insertion visit Copper-IUDs Efficacy, duration of use Side effects: harmless, harmful, frequency Treatment of side effect Contraindications Misconceptions Counseling Risk of ectopic pregnancy Copper ball and expulsion 6

LNG-IUS What is the hormone-releasing intrauterine system (IUS) and why was it developed General characteristics of the LNG-IUS Contraceptive efficacy and duration of use Side effects: harmless and harmful, treatment Reasons for discontinuation Medical indications for LNG-IUS use MC Migraine and depression Migraine Sex differences in epidemiology of migraine Prevalence of migraine Background of hormonal triggers for migraine Basics on diagnostic criteria for migraine WHO recommendation for CHC use in migraineurs The strength of the association between migraine and stroke When to stop CHCs in migraineurs Benefits and risks of non-hormonal contraceptive options for migraineurs Depression Definition of depression Prevalence in Europe How not to miss depression in taking a history Potential effects of contraceptive methods on the course of depression in women with depression as a pre-existing condition Which contraceptives may cause depressed mood Female and male sterilisation Female sterilisation Introduction Surgical planning Postpartum sterilisation Interval sterilisation Laparoscopic sterilisation Hysteroscopic sterilisation Essure Preoperative counselling Contraceptive failure rates Causes of failed sterilisation Potential post-sterilisation effects Risk of regret Opportunistic bilateral salpingectomy 7

Male sterilisation Introduction Procedures and techniques Postoperative care Confirmation of sterility Contraceptive failure rates Contraindications Complications Associated morbidity concerns Counselling Vasectomy reversal IUDs in special situations Adolescents Risk of cervical cancer risk (LSIL and HSIL) Women after STI or at increased risk of STI IUDs and cardiovascular disease Women with HIV Women with immunosuppression MC CHC breast and ovarian cancer Effect of CHC on breast cancer risk Effect of CHC on ovarian cancer risk CHC and breast cancer risk in women with hereditary breast cancer CHC and ovarian cancer risk in carriers of BRCA1/BRCA2 mutations CHC and breast cancer risk in carriers of BRCA1/BRCA2 mutations Contraceptive options for women after breast cancer Counselling role play A short lecture on the role of counselling in FP Two scenarios will be presented There will be volunteers to enact the role play There will be two reactors Country training plans Discussion on how countries will be able to use and incorporate the WHO FP TRP and the ESC training modules in their country training. A commitment to give feedback to WHO and the ESC regarding the modules, for continuing improvement and for monitoring 8