Supplemental Table 1. Characteristics of patients with multiple unenhanced CT scans number Contrastenhanced procedure Pre-CE exam egfr present at first NCCT type Days between first and second NCCT present at second NCCT Negative patient outcome 1 Cath 52 Yes Cortical 4.4 No None 2 Cath 83 Yes Global/Focal 1.2 No None 3 Cath 36 Yes Global 12.6 No None 4 Cath 41 Yes Cortical 8.4 No AKI 5 Cath 18 Yes Global 5.5 No AKI, dialysis 6 Cath 43 No - 8.2 No AKI, dialysis 7 Cath 28 No - 2.5 No None 8 Cath 37 No - 25.5 No None 9 Cath 72 No - 29.5 No None 10 CECT 68 Yes Cortical 4.6 No AKI, dialysis, died 11 CECT 65 No - 1.1 No None 12 CECT 57 No - 2.4 No None 13 CECT 61 No - 18.5 No None 14 CECT 102 No - 3.5 No None 15 CECT 73 No - 8.3 No AKI, dialysis
Supplemental Table 2. Characteristics of patients and procedures with and without faint to moderate bilateral global nephrograms (HU>55) * No Number 28 (25%) 82 Age (median, IQR) 75 (62-80) 70 (56-77) 1.03 (0.99-1.06).07 Female (%) 16 (57%) 38 (46%) 1.54 (0.65-3.67).38 Diabetes mellitus 4 (14%) 4 (4.9%) 3.25 (0.76-14.0).20 Chronic kidney disease 13 (46%) 23 (28%) 2.22 (0.92-5.39).10 Nephrectomy or atrophic kidney 2 (7.1%) 3 (3.7%) 2.03 (0.32-12.8).44 Kidney transplant 1 (3.6%) 4 (4.9%) 0.72 (0.08-6.74).99 Acute kidney injury (history of) 0 4 (4.9%) -.57 Acute kidney injury 2 (7.1%) 5 (6.1%) 1.18 (0.22-6.48).99 Acute hypotension/shock 8 (29%) 9 (11%) 3.24 (1.11-9.49).0357 Pre- egfr 51 (33-68) 70 (56-91) 0.97 (0.94-0.99) <.001 Pre- egfr subgroups -.003 > 60 ml/min/1.73 m 2 9 (32%) 56 (68%) 30-59 ml/min/1.73 m 2 16 (57%) 23 (28%) < 30 ml/min/1.73 m 2 3 (11%) 3 (3.7%) CT 12 (22%) 43 (78%) 0.68 (0.29-1.62).51** Cardiac catheterization 16 (29%) 39 (71%) Diagnostic catheterization 5 (17%) 25 (83%) 3.93 (1.13-13.6).04*** Interventional catheterization 11 (44%) 14 (56%) Contrast dose (g I/kg) 0.43 (0.31-0.49) 0.43 (0.28-0.53) 0.70 (0.05-10.4).75 **Comparing nephrogram proportions between CT versus catheterization recipients. ***Comparing nephrogram proportions between interventional versus diagnostic catheterization recipients.
Supplemental Table 3. Characteristics of patients and procedures with and without moderate to marked bilateral global nephrograms (HU>100) * No Number 6 (5.5%) 104 Age (median, IQR) 77 (70-80) 71 (57-78) 1.04 (0.97-1.12).23 Female (%) 2 (33%) 52 (50%) 0.50 (0.09-2.85).68 Diabetes mellitus 0 8 (7.7%) -.99 Chronic kidney disease 2 (33%) 34 (33%) 1.03 (0.18-5.90).99 Nephrectomy or atrophic kidney 1 (17%) 4 (3.9%) 5.00 (0.47-53.4).25 Kidney transplant 0 5 (4.8%) -.99 Acute kidney injury (history of) 0 4 (3.9%) -.99 Acute kidney injury 0 7 (6.7%) -.99 Acute hypotension/shock 3 (50%) 14 (13%) 6.43 (1.18-35.1).05 Pre- egfr 60 (30-75) 65 (50-86) 0.98 (0.95-1.01).30 Pre- egfr subgroups -.46 > 60 ml/min/1.73 m 2 3 (50%) 62 (60%) 30-59 ml/min/1.73 m 2 2 (33%) 37 (36%) < 30 ml/min/1.73 m 2 1 (17%) 5 (4.8%) CT 2 (3.6%) 53 (96%) 0.48 (0.08-2.74).68** Cardiac catheterization 4 (7.3%) 51 (93%) Diagnostic catheterization 1 (3.3%) 29 (97%) 3.95 (0.38-40.6).32*** Interventional catheterization 3 (12%) 22 (88%) Contrast dose (g I/kg) 0.49 (0.29-0.71) 0.43 (0.29-0.51) 9.18 (0.10-818).30 **Comparing nephrogram proportions between CT versus catheterization recipients. ***Comparing nephrogram proportions between interventional versus diagnostic catheterization recipients.
Supplemental Table 4. Characteristics of patients and procedures with and without bilateral global nephrograms following CECT * No Number 19 (32%) 41 Odds Ratio (95% CI) Age (median, IQR) 68 (54-75) 68 (54-75) 1.03 (0.99-1.07).18 Female (%) 10 (53%) 20 (49%) 1.17 (0.39-3.47).99 Diabetes mellitus 3 (16%) 2 (4.9%) 3.65 (0.56-24.0).31 Chronic kidney disease 10 (53%) 9 (22%) 3.95 (1.23-12.7).03 Nephrectomy or atrophic kidney 0 1 (2.4%) -.99 Kidney transplant 0 2 (4.9%) -.99 Acute kidney injury (history of) 0 2 (4.9%) -.99 Acute kidney injury 2 (11%) 2 (4.9%) 2.29 (0.30-17.7).58 Acute hypotension/shock 5 (26%) 4 (9.8%) 3.30 (0.77-14.1).13 Pre- egfr 65 (49-85) 78 (64-100) 0.98 (0.96-1.01).04 Contrast dose (g I/kg) 0.44 (0.39-0.50) 0.45 (0.41-0.54) 0.10 (0-34.4).40
Supplemental Table 5. Characteristics of patients and procedures with and without bilateral global nephrograms following cardiac catheterization * No Number 27 (43%) 36 Age (median, IQR) 79 (69-82) 70 (59-77) 1.06 (1.01-1.12).01 Female (%) 17 (63%) 16 (44%) 2.13 (0.77-5.90).20 Diabetes mellitus 2 (7.4%) 2 (5.6%) 1.36 (0.18-10.3).99 Chronic kidney disease 10 (37%) 11 (31%) 1.34 (0.47-3.84).60 Nephrectomy or atrophic kidney 1 (3.7%) 3 (8.3%) 0.42 (0.04-4.31).63 Kidney transplant 0 3 (8.3%) -.25 Acute kidney injury (history of) 1 (3.7%) 2 (5.6%) 0.65 (0.06-7.61).99 Acute kidney injury 2 (7.4%) 3 (8.3%) 0.88 (0.14-5.67).99 Acute hypotension/shock 7 (26%) 3 (8.3%) 3.85 (0.89-16.6).08 Pre- egfr 52 (35-67) 61 (50-79) 0.99 (0.97-1.01).11 Diagnostic (vs. PCI) 9 (33%) 24 (67%) 0.25 (0.09-0.72).01 Femoral (vs. radial) 23 (85%) 33 (92%) 0.52 (0.11-2.56).42 LVEF (%) 50 (36-60) 60 (51-65) 0.97 (0.94-1.00).04 Total fluoroscopy time 18 (8-29) 9 (5-23) 1.04 (1.00-1.08).02 Contrast dose (g I/kg) 0.43 (0.20-0.81) 0.22 (0.15-0.45) 16.0 (1.38-187).07