Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Spironolactone SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 Aldactazide; Aldactone; Spiresis; Spiridon; Uractone; Verospiron; Verospirone 7-alpha-Pregn-4-ene-2-carboxylic acid, 7-hydroxy-7-alpha-mercapto-3-oxo-, gamma-lactone acetate Catalog Number(s). CAS# RTECS TSCA CI# SP320 52-0-7 TU4725000 Page Number: TSCA 8(b) inventory: Spironolactone 7-(Acetylthio)-7-hydroxy-3-oxopregn-4-ene-2-carboxylic acid gamma-lactone; 3'-(3-Oxo-7-alpha-acetylthio-7-beta-hydroxyandrost-4-en-7-beta-yl)p IN CASE OF EMERGENCY CHEMTREC (24hr) 800-424-9300 a c i d l a c t o n e ; 3-(3-Keto-7-alpha-acetylthio-7-beta-hydroxy-4-androsten-7-alpha-yl) a c i d l a c t o n e ; 7-alpha-Acetylthio-3-oxo-7-alpha-pregn-4-ene-2,7-beta-carbolacton Chemical Family Chemical Formula Supplier C24H32O4S SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 CALL (30) 56-8000 Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Spironolactone 52-0-7 00 Toxicological Data on Ingredients Spironolactone: ORAL (LD50): Acute: >000 mg/kg [Rat]. >000 mg/kg [Rabbit]. >000 mg/kg [Mouse].
Spironolactone Page Number: 2 Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (sensitizer), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects Slightly hazardous in case of skin contact (sensitizer). CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Get medical attention if irritation occurs. In case of contact, immediately flush skin with plenty of water for at least 5 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. These products are carbon oxides (CO, CO2). Slightly flammable to flammable in presence of heat. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures When heated to decomposition it emits toxic fumes of sulfoxides.
Spironolactone Page Number: 3 Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant containers. Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves (impervious). Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystals solid. Crystalline powder.) Odor Mercaptan-like (Slight.) Molecular Weight ph (% soln/water) 46.59 g/mole Taste Color Tan. Cream-colored (Light.) Boiling Point Melting Point 34.5 C (274. F) Critical Temperature Specific Gravity Vapor Pressure Not applicable. Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility The product is more soluble in oil; log(oil/water) = 2.8 Soluble in most organic solvents.
Spironolactone Page Number: 4 Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Non-corrosive in presence of glass. Corrosivity Polymerization Sensitive to light. Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): >000 mg/kg [Mouse]. CARCINOGENIC EFFECTS: 3 (Not classifiable for human.) by IARC. Hazardous in case of inhalation. Slightly hazardous in case of skin contact (irritant, sensitizer), of ingestion. May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data Acute Potential Health Effects: Skin: May cause skin irritation with redness rash and itching. May cause increased hairiness. Eyes: May cause eye irritation. Inhalation: Dust may cause respiratory tract irritaiton. Ingestion: May be harmful if ingested. May affect gastrointestinal tract, metabolism (change in body's fluid and salt balances), blood (changes in bone marrow, agranulocytosis, urinary system, respiration (fibrosis, pneumoconiosis). Symptoms may include thirst, dryness of mouth, gastrointestinal tract irritation with possible stomach bleeding, ulcers, abdominal cramping, nausea, vomiting, diarrhea, low blood pressure, respiratory difficulties. May also affect behavior/central nervous system (headache, fatigue, drowsiness, confusion, dizziness, tremors, convulsions). Chronic Potential Health Effects: Skin: May cause allergic skin reaction (contact dermatitis) which may cause itching, skin rash. Ingestion: May affect thyroid, blood (changes in serum composition). Inhalation and ingestion: May cause allergic reaction (anaphylaxis) resulting in breathing problems. Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation the Products of Biodegradation The products of degradation are more toxic.
Spironolactone Page Number: 5 Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Not applicable. Special Provisions for Transport Not applicable. DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Spironolactone California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Spironolactone California Director's List of Hazardous Sustances: Spironolactone TSCA 8(b) inventory: Spironolactone California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Spironolactone EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. Other Classifications WHMIS (Canada) Not available under WHMIS (Canada). DSCL (EEC) R22- Harmful if swallowed. R43- May cause sensitization by skin contact. S36/37- Wear suitable protective clothing and gloves. S46- If swallowed, seek medical advice immediately and show this container or label. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 0 E National Fire Protection Association (U.S.A.) Health 0 Flammability Specific hazard WHMIS (Canada) DSCL (Europe)
Spironolactone Page Number: 6 TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations S470 Validated by Sonia Owen on 8//2006. Verified by Sonia Owen. Printed 9/4/2006. CALL (30) 56-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.