NEUROLOGY th Annual Update OCTOBER 8 12, 2018 CAMBRIDGE, MA. Register at Neurology.HMSCME.com. Diagnosis. Neurological Examination

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26th Annual Update NEUROLOGY 2018 OCTOBER 8 12, 2018 CAMBRIDGE, MA UPDATES and STATE-of-the-ART PRACTICES for INPATIENT and OUTPATIENT NEUROLOGY Diagnosis Neurological Examination Neuroimaging Treatment Options Challenging Cases Optimized Outcomes How to improve outcomes for common conditions Guidance for challenging cases New options for diagnosis Comprehensive treatment strategies Updates for pharmacologic treatment How to optimize your use of imaging Instruction to improve clinical reasoning Can t-miss diagnoses The newest guidelines Updates in sleep medicine Expert opinions on errors and risk management State-of-the-art treatments of neurologic pain Earn up to 32.50 AMA PRA Category 1 Credits 32.50 AAFP Prescribed credits Course Directors This course sold out last year. Early registration advised.

Dear Colleague, Every year, there are a staggering number of critically important updates that need to be understood and incorporated into the practice of neurology to ensure optimal patient care. This special update synthesizes this vast amount of information and presents it with efficiency and effectiveness to ensure that you are current with these updates and the best ways to incorporate them into practice. Over the course of a week, you will be immersed in an impactful and inspiring neurology learning experience. The faculty, the leading clinical educators at Harvard Medical School, provide a learning experience that delivers: Guidance for clinical reasoning and approaches to enable you to practice state-of-the-art neurology Case studies and dedicated time for you to pose your specific questions to leaders in their respective fields of neurology and delve into how information presented in this course can be used in your specific clinical setting Practical knowledge that you can take home and immediately apply to patient care Year after year, attendees report they are inspired by the knowledge transfer and find the experience to be invaluable to their clinical practice, understanding of neurologic diseases, diagnostic skills and treatment outcomes. I hope you will join us in October for this important and rewarding educational experience. Sincerely, Course Director Miriam Sydney Joseph Professor of Neurology Harvard Medical School Chair, Department of Neurology Brigham and Women s Hospital

Course Overview Epilepsy Stroke Multiple Sclerosis Concussions N-M Junction Disorders Alzheimer s Disease Parkinson s Disease Neuro-oncology Headache Spinal Cord Neurology Sleep Disorders Pain Dementia Neuropathy Movement Disorders Coma Neuropsychiatry Visual Disturbances Autoimmune Neurology Dizziness Women s Neurology Neuro-ophthalmological Disorders Reasons to Attend The new guidelines for epilepsy, stroke, neuromuscular disorders Comprehensive updates for treatment of neurologic pain Expert instruction for neuro-ophthalmology Expanded options to diagnose and treat dementia Improved management of headache Best practices for treatment of neurologic autoimmune disorders Steps to ensure delivery of high-quality care in the emergency room and in outpatient settings Techniques to effectively manage epilepsy and psychogenic non-epileptic seizures Best practices in neuro-oncology New insights and best practices for myelopathy and other spinal cord disorders Expanded options to treat movement disorders Updates in sleep medicine State-of-the-art approaches to concussion and coma Expanded options to diagnose and treat the causes of dizziness Alcohol and the nervous system: what we now know Use of genetic tests Optimal use of imaging Harvard Medical School Faculty Course Co-Director Assistant Professor of Neurology, Harvard Medical School Vice Chair for Education, Department of Neurology Clinical Competency Director, Partners Neurology Residency Brigham and Women s Hospital Anthony A. Amato, MD Aaron L. Berkowitz, MD, PhD Shamik Bhattacharyya, MD Ellen J. Bubrick, MD Rebecca Burch, MD Michael E. Charness, MD Kirk R. Daffner, MD Amar Dhand, MD, DPhil Christopher T. Doughty, MD Barbara A. Dworetzky, MD Steven K. Feske, MD Christopher Gilligan, MD Michael T. Hayes, MD Galen V. Henderson, MD Saef Izzy, MD Tamara B. Kaplan, MD Joshua P. Klein, MD, PhD Eudocia Quant Lee, MD, MPH Jong Woo Lee, MD, PhD Robert M. Mallery, MD Joseph B. Martin, MD, PhD Scott M. McGinnis, MD Edison K. Miyawaki, MD William J. Mullally, MD Lakshmi Nayak, MD Peter Novak, MD, PhD Mary Angela O Neal, MD Milena Pavlova, MD Page B. Pennell, MD David M. Pilgrim, MD Sashank Prasad, MD Paul B. Rizzoli, MD Laura Safar, MD Christopher Severson, MD Reisa A. Sperling, MD Chizoba Umeh, MD Henrikas Vaitkevicius, MD Victor Wang, MD

Agenda Course Description Neurologists, primary care providers and specialists who diagnose and treat neurological conditions can rely on this program for a comprehensive, evidence-based review of state-of-the-art practices for outpatient and inpatient neurology. Education covers the latest guidelines, clinical strategies, and recent advances, including the use of genetic tests, optimal use of imaging, new approaches for diagnosis, and expanded options for treatment for a wide array of neurological diseases. Education is practical and focused on patient outcomes. Led by the foremost authorities in neurology subspecialties, the program provides tools to improve your care of patients with common, complex, and rare neurological conditions. As updates are presented, they are paired with specific practice recommendations to help you optimize patient care and outcomes. Lectures are designed to be engaging and to quickly and effectively transfer knowledge. Learning Objectives Upon completion of this activity, participants will be able to: Develop strategies to apply updated research and guidelines for common neurological conditions in their care of patients Explain the principles of delivering neurological care in resource-constrained environments Recognize immune-mediated neurological diseases and initiate appropriate therapy Identify the most common causes of cognitive error in the diagnosis and treatment of neurological diseases Identify types of seizures and mimickers of seizures Develop strategies to recognize and treat common and uncommon headache disorders Review strategies to effectively prevent and manage stroke Develop strategies for diagnosing and treating complicated neurologic problems in the outpatient and inpatient settings Recognize and treat causes of dizziness Monday, October 8 7:00-8:00 Registration and Continental Breakfast 8:00-8:05 Introduction and 8:05-9:00 Dementia Cases Kirk R. Daffner, MD 9:00-9:45 Challenging Cases in Neuropsychiatry Laura Safar, MD 9:45-10:15 Morning Break (Refreshments provided) 10:15-11:00 Imaging in Neurologic Diseases Joshua P. Klein, MD, PhD 11:00-12:00 CNS Lymphoma Lakshmi Nayak, MD 12:00-1:00 Break for lunch* 1:00-1:45 Video Cases in Parkinsonism and Hypokinetic Movement Disorders Chizoba Umeh, MD 1:45-2:45 Hyperkinetic Movements Edison K. Miyawaki, MD 2:45-3:15 Afternoon Break (Refreshments provided) 3:15-4:00 Challenging Cases in Global Neurology Aaron L. Berkowitz, MD, PhD 4:00-4:45 Sleep Neurology Milena Pavlova, MD *There are many convenient and varied lunch options within a short walking distance of the course. A Comprehensive Clinical Update of State-of-the-Art Practices for Inpatient and Outpatient Neurology Education for: NEUROLOGISTS PSYCHIATRISTS INTERNISTS FAMILY PHYSICIANS NPs PAs

Agenda Tuesday, October 9 8:00-8:45 Meet the Professor: Approach to Myopathy Cases Anthony A. Amato, MD 8:45-9:30 Neuropathy and Neuromuscular Junction Cases Christopher T. Doughty, MD 10:00-10:45 Visual Disturbances Sashank Prasad, MD 10:45-11:30 Keynote - The Convergence of Research in Neurology and Psychiatry: Should It Affect How We Train Our Students and Residents? Joseph B. Martin, MD, PhD 11:30-1:00 Break for lunch* 1:00-1:45 Current Approaches in Stroke Prevention and Treatment Galen V. Henderson, MD 1:45-2:30 Updates in Hemorrhagic Stroke Steven K. Feske, MD 2:30-3:00 Afternoon Break (Refreshments provided) 3:00-3:45 Neurologic Emergencies Saef Izzy, MD 3:45-4:30 Challenging Stroke Cases Amar Dhand, MD, DPhil Wednesday, October 10 8:00-8:45 State-of-the-Art Differential Diagnosis of Epilepsy: Video Cases 8:45-9:30 Best Practices for Psychogenic Non-Epileptic Seizures Barbara A. Dworetzky, MD 10:00-10:45 Updates in Pharmacological Treatment of Epilepsy Jong Woo Lee, MD, PhD 10:45-11:30 New Concepts in Non- Pharmacologic Rx for Epilepsy Ellen J. Bubrick, MD 11:30-1:00 Break for lunch* 1:00-1:45 Meet the Professor: Problematic Epilepsy Cases Page B. Pennell, MD 1:45-2:30 Keynote - Current Approaches in the Treatment of Dementia Reisa A. Sperling, MD 2:30-3:00 Afternoon Break (Refreshments provided) 3:00-3:45 Current Approaches in the Diagnosis of Dementia Scott M. McGinnis, MD 3:45-4:30 Neurology of Alcohol Michael E. Charness, MD Accreditation ACCREDITATION COUNCIL FOR CONTINUING MEDICAL EDUCATION: The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The Harvard Medical School designates this live activity for a maximum of 32.50 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Main Course, Neurology 2018: 29.00 AMA PRA Category 1 Credits Neurologic Pain Workshop: 3.50 AMA PRA Category 1 Credits AMERICAN ACADEMY OF FAMILY PHYSICIANS: This Live activity, 26th Annual Update Neurology 2018, with a beginning date of 10/08/2018, has been reviewed and is acceptable for up to 32.50 Prescribed credit(s) by the American Academy of Family Physicians. Physicians should claim only the credit commensurate with the extent of their participation in the activity. RISK MANAGEMENT: This activity meets the criteria of the Massachusetts Board of Registration in Medicine for 1.25 credits of Risk Management Study. Please check your individual state licensing board requirements before claiming these credits. NURSE PRACTITIONERS and REGISTERED NURSES: For the purpose of recertification, the American Academy of Nurse Practitioners Certification Board and American Nurses Credentialing Center accept AMA PRA Category 1 Credit issued by organizations accredited by the ACCME (Accreditation Council for Continuing Medical Education). We would also suggest that learners check with their state licensing board to ensure they accept reciprocity with AMA PRA Category 1 Credit for re-licensure.

Agenda Thursday, October 11 8:00-8:45 New Concepts in Autoimmune Neurology Henrikas Vaitkevicius, MD 8:45-9:30 Best Practices for Diagnosis and Treatment of Multiple Sclerosis Christopher Severson, MD 10:00-10:45 Below-the-Belt Neurology Tamara B. Kaplan, MD 10:45-11:45 Cases in Geriatric Neurology David M. Pilgrim, MD 11:45-1:00 Break for lunch* 1:00-1:45 Eye Movement Disorders Robert M. Mallery, MD 1:45-2:45 Cancer Neurology Eudocia Quant Lee, MD, MPH 2:45-3:15 Afternoon Break (Refreshments provided) 3:15-4:00 Non-Pharmacologic Rx for Movement Disorders Michael T. Hayes, MD 4:00-5:00 Dizziness Program changes/substitutions may be made without notice. To view the most up-to-date version of the course program, please visit the course website. PHYSICIAN ASSISTANTS: The National Commission on Certification of Physician Assistants (NCCPA) states that AMA PRA Category 1 Credits are acceptable for continuing medical education requirements for recertification. We would also suggest that learners check with their state licensing board to ensure they accept reciprocity with AMA PRA Category 1 Credit for re-licensure. CANADIAN ACCREDITATION: The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities. EUROPEAN ACCREDITATION: Through an agreement between the American Medical Association and the European Union of Medical Specialists, physicians may convert AMA PRA Category 1 Credit to an equivalent number of European CME Credits (ECMECs ). Information on the process of converting AMA PRA Category 1 Credits to ECMECs can be found at: www.eaccme.eu. Friday, October 12 8:00-8:45 Concussion William J. Mullally, MD 8:45-9:30 Headache Paul B. Rizzoli, MD 10:00-10:45 Issues in Women s Neurology Mary Angela O Neal, MD 10:45-12:00 Keynote - How Neurologists Think: What My Errors Taught Me 12:00-1:00 Break for lunch* Optional Friday Afternoon Workshop State-of-the-Art Treatments of Neurologic Pain 1:00-1:45 The New Options for Treating Chronic Migraine Rebecca Burch, MD 1:45-2:30 How to Deliver the Best Care for Neck and Back Pain Shamik Bhattacharyya, MD 2:30-3:00 Afternoon Break (Refreshments provided) 3:00-3:30 Updates for Evaluation and Treatment of Autonomically Maintained Pain Peter Novak, MD, PhD 3:30-4:15 Local Nerve Blocks in the Office: When, Why and How Victor Wang, MD 4:15-5:00 Updates in What Anesthesiologists Can Now Provide for Pain Management Christopher Gilligan, MD

26th Annual Update Neurology 2018 Course #732205-1901 Tuition Register on or before September 15, 2018 Physicians $1,295 Allied Health Professionals $1,095 $1,195 (SAVE $100) $995 (SAVE $100) Residents, Fellows and Trainees $895 Optional Workshop Your course tuition includes continental breakfast each day, and morning and afternoon refreshment breaks. All course State-of-the-Art participants Treatments receive a flash of Neurologic drive that contains Pain all of the course materials. You can purchase a printed copy of these materials at the time of online registration for $50, or on site at the course $145 Friday, October 12, 1:00-5:00 pm for $65. Your course tuition includes continental breakfast each day, and morning and afternoon refreshment breaks. All course participants receive a flash drive that contains all of the course materials. If you would like a printed copy of these materials, you can purchase them in advance for $50 with your online course registration. A very limited supply will be available on site at the course for $65. Registration, Payment, Confirmation and Refund Policy Registrations for Harvard Medical School CME programs are made via our secure online registration system. To register for this course, please visit the course website at Neurology.HMSCME.com. At the end of the registration process, a $5 non-refundable processing fee will be added to your registration, and you will have the choice of paying by check or credit card (Visa, MasterCard, or American Express). If you are paying by check (draft on a United States bank), the online registration system will provide you with instructions and a printable form for remitting your course fees by check. Postal, telephone, fax, and cash-payment registrations are not accepted. All fees shown in USD. Upon receipt of your paid registration, an email confirmation from the HMS GCE office will be sent to you. Be sure to include an email address that you check frequently. Your email address is used for critical information, including registration confirmation, evaluation, and certificate. Refunds, less an administrative fee of $75, will be issued for all cancellations received two weeks prior to the start of the course. Refund requests must be received by email. No refund will be issued should cancellation occur less than two weeks prior. No shows are subject to the full course fee and no refunds will be issued once the conference has started. Venue Royal Sonesta Boston 40 Edwin H. Land Boulevard Cambridge, Massachusetts 02142 617-806-4200 This course sold out last year. Early registration advised. Accommodations A limited number of discounted rooms* have been reserved at the Royal Sonesta Boston until September 14, 2018. Reservations must be received by the hotel on or before 5:00 p.m. on September 14, 2018. You can call the hotel reservation line to make a room reservation: 617-806-4200. Please specify that you are enrolled in the Harvard HMS/Annual Update in Neurology 2018 Course in order to request the reduced room rate. To make your discounted hotel reservation online, please visit the Venue page of the course website before 5:00 p.m. on September 14, 2018 at https://neurology.hmscme.com/venue and click on the dedicated reservation link. *Please note that the discounted rooms may sell out before the deadline. Please do not make non-refundable travel arrangements until you have received an email from the HMS GCE office confirming your paid registration. Questions? Call 617-384-8600 Monday-Friday 9am 5pm (ET) or send an email to CEPrograms@hms.harvard.edu