UCLA Radiation Oncology Workshop: Integration of State-of-the-Art Innovations into Clinical Radiation Oncology Practice June 9-10, 2017

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UCLA Workshop: Integration of State-of-the-Art Innovations into Clinical Radiation Practice June 9-10, 2017 Neuroscience Research Building Auditorium (NRB) UCLA Campus Los Angeles, California

UCLA Workshop: Integration of State-of-the-Art Innovations into Clinical Radiation Practice Course Description: Radiation therapy is one of the mainstay treatments for cancer. Recent advances have increased the repertoire of tools for radiation oncologists to maximize tumor control and minimize toxicity. These advances include stereotactic body radiation therapy/stereotactic ablative radiation therapy, stereotactic radiosurgery, high-dose-rate brachytherapy, as well as advances in radiation planning and better understanding of biological modifiers that may enhance the effectiveness of radiation therapy when optimally applied. Given the rapid advances in the last 5-10 years for these radiation specific modalities in larger academic centers, adoption of these treatment approaches has disseminated into other radiation oncology clinics. This course will review state-of-the-art radiation treatment strategies and provide a how-to approach to integrate these new treatment modalities into a community radiation oncology practice. Issues regarding treatment volume, treatment dose, fractionation, biological and technological rationale based on evidence will be discussed in order to enhance the confidence of practitioners in their ability to translate these advances into improved patient outcomes in their practices. Target Audience: Radiation oncologists, medical physicists, medical oncologists, surgical oncologists, and biologists interested in implementing recent advances related to radiation treatment delivery, integrations of biological and technological advances in cancer care into daily radiation oncology practice, and having exposure to novel approaches in cancer detection, radiation treatment planning, and treatment delivery. Course Objectives At the conclusion of the course, participants should be better able to: List the indications for thoracic SBRT and techniques that offer the best outcome using this technique in early stage lung cancer and thoracic oligometastases Discuss the limitation of current motion management strategies and the advantages brought by model based breathing motion management List the indications of SBRT and high-dose-rate brachytherapy for prostate cancer and how best to integrate radiation therapy in the management of high-risk prostate cancer Deliver the various newer breast irradiation techniques such as accelerated partial breast irradiation, prone breast irradiation, and deep inhale breath-hold technique, and understand their roles in the multi-disciplinary management for breast cancer Describe the roles of various radiation modalities for primary and metastatic brain tumors and understand how best to incorporate these techniques for treatment of malignant brain tumors Discuss practical considerations in implementing a novel planning and treatment delivery approach using ultra-compact radiation dose distribution Recognize the current and future role of MRI in radiation therapy and how to best integrate this newer imaging modality into the current radiation oncology work-flow

Course Directors Percy Lee, MD Associate Professor and Vice Chair of Education, UCLA Department of Radiation Minsong Cao, PhD, DABR Associate Professor, UCLA Department of Radiation Course Faculty Michael Steinberg, MD Professor and Chair, UCLA Department of Daniel Low, PhD, DABMP Professor and Vice Chair of Physics, UCLA Department of Joanne Weidhaas, MD, PhD, MSM Professor and Vice Chair, Division of Molecular and Cellular, UCLA Department of Robert Chin, MD, PhD D. Jeffrey Demanes, MD Professor Emeritus, UCLA Department of Anusha Kalbasi, MD Clinical Instructor, UCLA Department of Christopher King, MD, PhD Professor, UCLA Department of Radiation KEYNOTE SPEAKER: Brian Kavanagh, MD, MPH Professor and Chair, Department of Radiation, University of Colorado School of Medicine James Lamb, PhD, DABR William McBride, DSc Professor, UCLA Department of Radiation Susan McCloskey, MD Nicholas Nickols, MD, PhD Ann Raldow, MD, MPH Dorthe Schaue, MRes, PhD Ke Sheng, PhD, DABR Professor, UCLA Department of Radiation Erina Vlashi, PhD

Program Schedule FRIDAY, JUNE 9, 2017 7:30 Breakfast 8:00 Welcome Percy Lee, MD and Michael Steinberg, MD Morning Session I THORACIC 8:15 SBRT/SABR for Early Stage NSCLC: Indications and Emerging Trends Percy Lee, MD 8:45 Model Based Breathing Motion Management for Lung Cancer: Replacing 4D-CT Daniel Low, PhD, DABMP 9:15 Immunotherapeutic Advances in Thoracic Tumors Anusha Kalbasi, MD 9:45 Discussion 10:00 Coffee Break 10:15 Keynote: New Lenses, New Visions for Radiotherapy in the Molecular-Genetic- Immunomodulator Era of Brian Kavanagh, MD, MPH Morning Session II BIOLOGY 11:15 Danger-Signaling Interfaces: Immunotherapy with Radiation Therapy William McBride, DSc 11:45 Lessons Learned from Immune Monitoring During Clinical Trials Dorthe Schaue, MRes, PhD 12:15 Lunch Afternoon Session I GU 1:15 SBRT for Prostate Cancer: Techniques, Toxicities and Outcomes for Low to High- Risk Patients Christopher King, MD, PhD 1:45 High Dose Rate Prostate Brachytherapy: A Versatile Tool for Mono, Combination, Focal, and Salvage Therapy D. Jeffrey Demanes, MD 2:15 Radiation as Part of Multi-Modal Approach to Aggressive Prostate Cancer Nicholas Nickols, MD, PhD 2:45 Discussion 3:00 Coffee Break

Afternoon Session II BREAST 3:15 Personalized Planning for Breast Radiation Therapy: Tools in the Toolbox Susan McCloskey, MD 3:45 New Genomics and Radiosensitivity in Breast Cancer Therapy Joanne Weidhaas, MD, PhD, MSM 4:15 Discussion 4:30 Chair s Lecture: Valuing Value: Health Policy in the Era of Affordable Care Act Michael Steinberg, MD and Ann Raldow, MD, MPH 5:30 Adjourn 5:45 Reception Luskin Conference Center SATURDAY, JUNE 10, 2017 7:30 Breakfast Morning Session I CNS 8:00 Brain Metastases: Too Much Versus Too Little Robert Chin, MD, PhD 8:30 New Era of Ultra-Compact Radiation Dose Delivery Using 4pi Radiotherapy for Recurrent High-Grade Gliomas Ke Sheng, PhD, DABR 9:00 Radiotherapy and Glioma Stem Cells Erina Vlashi, PhD 9:30 Discussion 9:45 Coffee Break Morning Session II MRI IN RADIATION THERAPY 10:00 MRI-Driven Radiation Treatment Planning Minsong Cao, PhD, DABR 10:30 Challenges for MRI-Guided Real-Time Adaptive Radiotherapy: Physics Perspective James Lamb, PhD, DABR 11:00 MRI-Guided Real-Time Adaptive SBRT: Clinical Perspective Percy Lee, MD 11:30 Discussion 11:45 Concluding Remarks Percy Lee, MD and Michael Steinberg, MD 12:00 Adjourn

General Information Registration Fees: Physicians: $395 Physicists/Trainees: $195 Refunds: Cancellations must be received in writing by May 24, 2017 and will be subject to a $75 processing fee. No refunds will be given after May 24, 2017. A full refund will be provided if for any reason the course must be cancelled or rescheduled. Enrollment: Online: Go to www.cme.ucla.edu/ courses and click on UCLA Workshop. You may use your MasterCard, Visa, American Express or Discover card to register. By Mail: Use the form attached. Mail to the UCLA Office of Continuing Medical Education David Geffen School of Medicine at UCLA Workshop 10920 Wilshire Blvd., Suite 1060 Los Angeles, CA 90024-6512 By Fax: Send the completed enrollment form with credit card information and authorizing signature. Fax to: (310) 794-2624 By Phone: Use your MasterCard, VISA, American Express, or Discover Card. Call (310) 794-2620 Please visit our website for other UCLA CME offerings. www.cme.ucla.edu Conference Location Neuroscience Research Building Auditorium (NRB) UCLA Campus 635 Charles E Young Drive South Los Angeles, CA 90095 Parking and Directions From the 405 freeway, exit on Wilshire Blvd. East. Proceed on Wilshire Blvd. to Westwood Blvd. and make a left. Proceed north on Westwood Blvd., turn right on Charles E. Young Drive South and continue 1/2 a block. At the stoplight, turn left into Lot 9. There will be a parking attendant selling permits from 6:30-8:30 AM. If you arrive outside of this time frame, please visit the parking kiosk on Westwood Plaza to pay for your parking permit. Participants are responsible to pay for their own parking charges at a rate of $12 per vehicle, cash only. Suggested Hotel Accommodations: Luskin Conference Center 425 Westwood Plaza Los Angeles, CA 90049 Within walking distance Reservations: (855) 522-8252 Hilgard House 927 Hilgard Avenue Los Angeles, CA 90024 Within walking distance Reservations: (310) 208-3945 W Los Angeles Westwood Hotel 930 Hilgard Avenue Los Angeles, CA 90024 Within walking distance Reservations: (310) 208-8765 UCLA Tiverton House 900 Tiverton Avenue Los Angeles, CA 90024 Within walking distance Reservations: (310) 794-0151 Accreditation Statement The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Office of Continuing Medical Education, David Geffen School of Medicine at UCLA, designates this live activity for a maximum of 11.75 AMA PRA Category 1 Credits TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. This meeting has applied to CAMPEP for approval of 9 Medical Physics Continuing Education Credit (MPCEC) hours. Disclosure Statement The FDA has issued a concept paper that classifies commercial support of scientific and educational programs as promotional unless it can be affirmed that the program is truly independent and free of commercial influence. In addition to independence, the FDA requires that non-promotional, commercially supported education be objective, balanced, and scientifically rigorous. The policy further states that all potential conflicts of interest of the CME staff and faculty be fully disclosed to the program s participants. In addition, Accreditation Council for Continuing Medical Education policy now mandates that the sponsor adequately manage all identified potential conflicts of interest prior to the program. We at UCLA fully endorse the letter and spirit of these concepts.

Registration (Please Print) Course Title and Number Registration Fee UCLA Workshop 2017 M167-34 Registration Fees: Physicians: $395 Physicists/Trainees: $195 *Breakfast, Refreshments and Lunch will be provided with registration. All attendees are invited to a reception at the Luskin Conference Center immediately following the course on Friday (6/9) evening. TOTAL Last four digits of your Social Security Number Name (First/Middle/Last) l Male l Female Degree Specialty Preferred Mailing Address City/State/ZIP ( ) ( ) Area Code Phone Fax: Area Code E-Mail Address l Check enclosed payable to: The Regents of the University of California l Charge: l MasterCard l Visa l Discover l American Express Card Number Expiration Mo/Yr Authorizing Signature Mail to: UCLA Office of Continuing Medical Education David Geffen School of Medicine at UCLA Workshop 10920 Wilshire Blvd., Suite 1060 Los Angeles, CA 90024

UCLA Office of Continuing Medical Education David Geffen School of Medicine at UCLA 405 Hilgard Avenue MC 29 Los Angeles, California 90095-6938 UCLA Workshop: Integration of State-of-the-Art Innovations into Clinical Practice June 9-10, 2017 Neuroscience Research Building Auditorium (NRB) UCLA Campus Los Angeles, California Register today! Enroll now by mail, fax, phone or online. www.cme.ucla.edu/courses nonprofit organization u.s. postage PAID u c l a