NCCN TRENDS DEMOGRAPHICS. Results: November 2013 BASAL CELL CARCINOMA. Distribution of Respondent Types (n = 835) Page 1

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NCCN TRENDS Results: November 2013 NCCN Trends is an analytics tool from the National Comprehensive Cancer Network (NCCN ) that surveys how clinicians across the U.S. and around the globe are delivering cancer care. This summary includes the results of the November 2013 NCCN Trends Survey, which focused on Basal Cell Carcinoma. This survey was sent to U.S. and International users of NCCN.org. DEMOGRAPHICS Distribution of Respondent Types (n = 835) 11% Physician/Surgeon/Oncologist Nurse/Oncology Nurse or Clinical Nurse Specialist 7 3% Pharmacist 6% Physician Assistant or Nurse Practitioner Other Clinician Note: Percentages may not total 100 because of rounding. Page 1

Q1. Do you treat patients with locally advanced basal cell carcinoma (BCC)? (n = 688) 54% Yes No 47% Q2. Have you used a hedgehog pathway inhibitor to treat locally advanced BCC? (n = 301) Yes 23% No 77% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% Page 2

Q3. What is your primary specialty? (n = 270) Mohs surgery Otolaryngology-head and neck surgery Surgical oncology General surgery Dermatology Medical oncology Plastic surgery 3% 6% 14% 7% 8% 56% 0% 10% 20% 30% 40% 50% 60% Q4. What percent of your patients would you consider treating with a hedgehog pathway inhibitor before surgery for locally advanced BCC (neoadjuvant setting)? (n = 269) 0-2 74% >25-50% 18% >50-7 >75-100% 2% 0% 10% 20% 30% 40% 50% 60% 70% 80% Page 3

Q5. What percent of your patients would you consider treating with a hedgehog pathway inhibitor after surgery for locally advanced BCC (e.g. if surgical margins were not clear, perineural invasion, invades orbit, invades bone) (adjuvant setting)? (n = 269) 0-2 50% >25-50% 23% >50-7 >75-100% 13% 14% 0% 10% 20% 30% 40% 50% 60% Page 4

NCCN TRENDS Results: November 2013 NCCN Trends is an analytics tool from the National Comprehensive Cancer Network (NCCN ) that surveys how clinicians across the U.S. and around the globe are delivering cancer care. NCCN Trends surveys are designed to reach targeted populations that can include several thousand clinicians as a potential sample size. NCCN can also provide analytics on existing NCCN Trends and clinician demographic data sets, allowing for greater insight into oncology practice patterns. To commission an NCCN Trends survey, to discuss analytic and data services, or to request information on other NCCN programs and resources, please contact: Christine MacCracken, MSHEd, BSN Senior Director, Business Insights 215.690.0557 maccracken@nccn.org National Comprehensive Cancer Network (NCCN ) The National Comprehensive Cancer Network (NCCN ), a not-for-profit alliance of 23 of the worldês leading cancer centers, is dedicated to improving the quality, effectiveness, and efficiency of care provided to patients with cancer. Through the leadership and expertise of clinical professionals at NCCN Member Institutions, NCCN develops resources that present valuable information to the numerous stakeholders in the health care delivery system. As the arbiter of high-quality cancer care, NCCN promotes the importance of continuous quality improvement and recognizes the significance of creating clinical practice guidelines appropriate for use by patients, clinicians, and other health care decision-makers. The primary goal of all NCCN initiatives is to improve the quality, effectiveness, and efficiency of oncology practice so patients can live better lives. 275 Commerce Drive Suite 300 Fort Washington, PA, 19034 Telephone: 215.690.0300 Fax: 215.690.0280 NCCN.org - For Clinicians NCCN.org/patients - For Patients * All NCCN Trends survey content and resulting data are owned by NCCN. Survey responses are made anonymous to protect the privacy of survey respondents. NCCN may license survey content, data, and analytic results to third parties, but retains the rights to use this data for other purposes, including the support of educational and research efforts or for other strategic or business purposes. Summary C-N-1411-1113 Page 5