Supplementary Online Content

Supplementary Online Content Drury KE, Schaeffer M, Silverberg JI. Association between atopic disease and anemia in US children. JAMA Pediatr. Published online vember 30, 2015. doi:10.1001/jamapediatrics.2015.3065. etable 1. Survey Characteristics etable 2. Questions Used in This Study etable 3. uency of Missing Values for Variables Used in the Study etable 4. Comparison of Demographics in Entire Cohort vs Complete Case Analysis Cohort etable 5. Associations of Pediatric Allergic Disease and Anemia in, 1997-2013 etable 6. Association Between Pediatric Eczema and Anemia in Individual Years of etable 7. Association Between Pediatric Asthma and Anemia in Individual Years of 1997-2013 etable 8. Association Between Pediatric Hay Fever and Anemia in Individual Years of 1997-2013 etable 9. Association Between Pediatric Food Allergy and Anemia in Individual Years of 1997-2013 This supplementary material has been provided by the authors to give readers additional information about their work

etable 1. Survey Characteristics Study Size Age (yr) Type Languages Assessments 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 NHANES 1999-2000 NHANES 2001-2002 NHANES 2003-2004 NHANES 2005-2006 NHANES 2007-2008 NHANES 2009-2010 14,290 36,116 0 17 18 85 Household 13,645 0 17 Household 32,440 18 85 12,910 0 17 Household 30,801 18 85 13,376 0 17 Household 32,374 18 85 13,579 0 17 Household 33,326 18 85 12,524 0 17 Household 31,044 18 85 12,229 0 17 Household 30,852 18 85 12,424 0 17 Household 31,326 18 85 12,523 0 17 Household 31,428 18 85 9,837 0 17 Household 24,275 18 85 9,417 0 17 Household 23,393 18 85 8,815 0 17 Household 21,781 18 85 11,156 0 17 Household 27,731 18 85 11,277 0 17 Household 27,157 18 85 12,850 0 17 Household 33,014 18 85 13,275 0 17 Household 34,525 18 85 12,860 0 17 Household 34,557 18 85 4,517 0 17 Household Mobile Center 5,046 0 17 Household Mobile Center 4,502 0 17 Household Mobile Center 4,785 0 17 Household Mobile Center 3,921 0 17 Household Mobile Center 4,010 0 17 Household Mobile Center Laboratory assessment Laboratory assessment Laboratory assessment Laboratory assessment Laboratory assessment Laboratory assessment

NHANES 2011-2012 3,892 0 17 Household Mobile Center Laboratory assessment

etable 2. Questions Used in This Study Variable Question Surveys asked Eczema Has a doctor or other health professional ever told you NHANES 2005-2006 Eczema During the past 12 months, has (child) had or 1997-2013 Ever Has a doctor or other health professional ever told you 1997-2013 asthma that (child) had asthma? NHANES 1999-2012 Current Does (child) still have? NHANES 1999-2012 Hay During the past 12 months, has (child) had an episode of NHANES 1999-2012 Hay During the past 12 months, has (child) had hay? 1997-2013 Food Does (child) have any food allergies? NHANES 2007-2010 Food During the past 12 months, has (child) had any kind of 1997-2013 Eczema Has a doctor or other health professional ever told you NHANES 2005-2006 that (child) had? Anemia During the past 12 months, has (child) had anemia? 1997-2013

etable 3. uency of Missing Values for Variables Used in the Study Study Variable (%) NHANES 1999 2012 Eczema (2005-2006) 10 (0.30) Asthma (1999-2012) 28 (0.13) Hay (1999-2012) 70 (0.38) Food (2007-2010) 14 (0.26) Household income (1999-2012) 129 (0.15) Age (1999-2012) 0 (0.00) Race/ethnicity (1999-2012) 0 (0.00) Sex (1999-2012) 0 (0.00) 1997 2013 Anemia 957 (0.02) Eczema 1029 (0.50) Asthma 348 (0.17) Hay 1484 (0.72) Food 1140 (0.55) Age 0 (0.00) Race/ethnicity 301 (0.1) Sex 0 (0.0) Household income 0 (0.0) Highest level of education in the 1409 (0.68) household US birthplace 830 (0.40) Insurance coverage 1444 (0.7)

etable 4. Comparison of Demographics in Entire Cohort vs Complete Case Analysis Cohort Variables Entire cohort Complete case analysis cohort Sex Male 51.1% 51.1% Female 48.9% 48.9% Race/ethnicity White 58.9% 58.9% Black/African-American 14.4% 14.4% Hispanic 19.7% 19.7% Multiracial/other 7.1% 7.0% Household income (% FPL) 0-99 19.5% 19.5% 100-199 23.0% 22.9% 200-399 31.4% 31.9% 400 26.2% 26.2% Family size 2 4.5% 4.5% 3-4 54.1% 54.1% 5-21 41.4% 41.4% Highest level of education in the h < High h ld school 4.7% 4.7% High school or graduate equivalence 8.1% 8.0% d > High school 86.8% 87.3% US birthplace 4.5% 4.5% Yes 95.4% 95.5% Insurance coverage 9.3% 9.3% Yes 90.4% 90.7%

etable 5. Associations of pediatric allergic disease and anemia in 1997-2013 (n=207,007). Variable no. (%) Eczema Asthma Hay Food Anemia (95%CI) Sex Male 9.2 (9.1 9.4) Female 9.9 (9.7 10.1) Age (yr) 0-5 11.1 (10.8 11.4) 6-10 10.1 (9.7 10.4) 11-17 8.7 (8.4 8.9) Race Caucasian 9.4 (9.3 9.6) Black 12.9 (12.6 13.3) Hispanic 7.3 (7.1 7.5) Multiracial / 11.6 other (11.1 12.1). of people in household 1.04 (1.01 1.08) 0.76 (0.73 0.79) 0.90 (0.86 0.94) 1.40 (1.34 1.47) 0.80 (0.77 0.84) 1.24 (1.16 1.32) 14.9 (14.7 15.1) 10.9 (10.7 11.1) 8.5 (8.3 8.8) 13.5 (13.1 13.9) 15.9 (15.6 16.2) 12.1 (11.8 12.3) 18.3 (17.8 18.7) 11.6 (11.3 11.9) 13.0 (12.5 13.6) 0.69 (0.67 0.71) 1.68 (1.60 1.75) 2.03 (1.95 2.12) 1.63 (1.56 1.70) 0.99 (0.95 1.03) 1.16 (1.08 1.23) 18.1 (17.9 18.4) 15.7 (15.5 16.0) 11.3 (11.0 11.6) 18.2 (17.8 18.6) 21.2 (20.8 21.5) 19.7 (19.4 19.9) 16.4 (16.0 16.8) 12.9 (12.6 13.2) 16.3 (15.8 16.9) 0.82 (0.80 0.85) 1.75 (1.69 1.83) 2.11 (2.04 2.19) 0.76 (0.73 0.80) 0.61 (0.59 0.63) 0.83 (0.79 0.88) 4.3 (4.2 4.4) 4.2 (4.1 4.3) 4.5 (4.3 4.7) 4.1 (3.9 4.3) 4.1 (3.9 4.2) 4.6 (4.5 4.7) 4.3 (4.1 4.6) 3.2 (3.1 3.3) 5.6 (5.2 5.9) 0.97 (0.92 1.03) 0.90 (0.84 0.97) 0.89 (0.84 0.95) 0.97 (0.90 1.05) 0.76 (0.66 0.76) 1.22 (1.12 1.34) 1.0 (0.9 1.0) 1.5 (1.4 1.5) 1.5 (1.4 1.6) 0.8 (0.7 0.9) 1.1 (1.0 1.2) 0.8 (0.8 0.9) 1.9 (1.8 2.1) 1.5 (1.4 1.6) 1.1 (0.9 1.2) 1.43 (1.29 1.58) 0.72 (0.64 0.80) 0.52 (0.45 0.60) 2.42 (2.13 2.76) 1.80 (1.61 2.03) 1.14 (0.92 1.41) 1-2 11.5 (11.0 12.0) 3-4 9.7 (9.5 9.9) 5 8.6 (8.4 8.9) 0.87 (0.82 0.92) 0.78 (0.73 0.83) 18.3 (17.7 18.9) 12.7 (11.8 12.9) 12.0 (11.8 12.3) 0.67 (0.64 0.70) 0.64 (0.61 0.68) 20.8 (20.2 21.4) 17.6 (17.4 17.8) 14.5 (14.2 14.8) 0.83 (0.79 0.87) 0.66 (0.63 0.70) 5.1 (4.7 5.4) 4.4 (4.3 4.5) 3.6 (3.4 3.7) 0.88 (0.81 0.95) 0.72 (0.66 0.79) 1.4 (1.3 1.6) 1.0 (1.0 1.1) 1.3 (1.2 1.4) 0.70 (0.61 0.81) 0.88 (0.75 1.03)

etable 5 continued. Variable no. Eczema Asthma Hay Food Anemia (%) (95%CI) Household income (% FPL) 0 99 10.1 (9.8 10.5) 0.98 (0.92 1.04) 100 199 9.7.93 (9.4 10.0) (0.88 0.98) 200 399 10.0 0.95 (9.8 10.3) (0.91 ) 400 10.8 (10.5 11.1) Highest level of household education <High school 5.4 (4.9 5.8) High school 6.3 or GED (5.9 6.8) >High school 10.5 (10.3 10.6) Birthplace in the US 5.7 (5.2 6.3) Yes 10.1 (9.9 10.2) Insurance coverage 7.1 (6.6 7.5) Yes 10.2 (10.0 10.3) 0.58 (0.54 0.62) 0.49 (0.44 0.53) 0.55 (0.49 0.61) 0.67 (0.63 0.72) 15.6 (15.2 16.0) 13.2 (12.9 13.6) 12.9 (12.6 13.2) 12.2 (11.9 12.5) 11.6 (10.9 12.3) 11.9 (11.3 12.5) 13.0 (12.8 13.2) 8.2 (7.6 8.9) 13.0 (12.8 13.2) 9.7 (9.2 10.2) 13.1 (12.9 13.3) 1.41 (1.33 1.48) 1.15 (1.09 1.21) 1.04 (0.99 1.09) 0.88 (0.82 0.95) 0.91 (0.86 0.96) ( ) 0.60 (0.55 0.65) 0.71 (0.67 0.76) 14.8 (14.4 15.2) 15.6 (15.3 16.0) 18.5 (18.2 18.9) 20.9 (20.5 21.3) 11.4 (10.7 12.1) 14.4 (13.8 15.0) 17.7 (17.5 17.9) 10.8 (10.0 11.5) 17.4 (17.2 17.6) 13.6 (13.0 14.1) 17.5 (17.3 17.7) 0.66 (0.63 0.69) 0.71 (0.68 0.74) 0.86 (0.82 0.89) 0.60 (0.56 0.64) 0.78 (0.75 0.83) ( ) 0.57 (0.53 0.62) 0.74 (0.70 0.78) 4.2 (4.0 4.5) 4.2 (4.0 4.4) 4.4 (4.2 4.5) 5.0 (4.8 5.2) 2.3 (1.9 2.6) 2.8 (2.5 3.0) 4.5 (4.4 4.6) 3.0 (2.6 3.4) 4.3 (4.2 4.4) 3.2 (2.9 3.5) 4.3 (4.2 4.5) 0.88 (0.80 0.95) 0.88 (0.81 0.95) 0.89 (0.83 0.96) 0.49 (0.42 0.57) 0.60 (0.54 0.67) 0.69 (0.60 0.78) 0.74 (0.66 0.82) 2.0 (1.9 2.2) 1.4 (1.3 1.6) 0.9 (0.8 1.1) 0.6 (0.6 0.7) 1.7 (1.4 2.0) 1.2 (1.0 1.4) 1.1 (1.1 1.2) 1.0 (0.8 1.2) 1.1 (1.1 1.2) 1.2 (1.0 1.4) 1.1 (1.1 1.2) 3.22 (2.74 3.79) 2.25 (1.90 2.66) 1.48 (1.24 1.76) 1.07 (0.90 1.27) 1.54 (1.30 1.83) 0.87 (0.69 1.10) 1.08 (0.92 1.26)

etable 6. Association Between Pediatric Eczema and Anemia in Individual Years of year anemia Anemia 1997 12966 98.6 (98.4 98.8) Eczema 1046 96.8 (95.5 98.0) 1998 12457 98.8 (98.6 99.1) Eczema 973 96.4 (95.0 97.7) 1999 11256 99.2 (98.9 99.4) Eczema 788 97.5 (96.1 98.8) 2000 12279 99.0 (98.8 99.2) Eczema 913 97.3 (96.2 98.5) 2001 12326 99.0 (98.8 99.2) Eczema 1071 96.4 (94.6 98.3) 2002 11329 99.2 (99.0 99.4) Eczema 1033 97.8 (96.9 98.6) 2003 11053 99.2 (99.0 99.4) Eczema 1045 98.5 (97.7 99.3) 2004 11116 99.1 (98.9 99.3) Eczema 1148 98.4 (97.5 99.3) 2005 11163 99.0 (98.7 99.2) Eczema 1183 97.1 (96.0 98.2) 2006 8749 98.9 (98.7 99.2) Eczema 950 98.9 (98.2 99.5) 188 1.4 (1.2 1.6) 37 3.2 (2.0 4.5) 153 1.2 (0.9 1.4) 34 3.6 (2.3 5.0) 101 0.8 (0.6 1.1) 20 2.5 (1.2 3.9) 138 1.0 (0.8 1.2) 27 2.7 (1.5 3.8) 125 1.0 (0.8 1.2) 33 3.6 (1.7 5.4) 97 0.8 (0.6 1.0) 35 2.2 (1.4 3.1) 107 0.8 (0.6 1.0) 19 1.5 (0.7 2.3) 115 0.9 (0.7 1.1) 20 1.6 (0.7 2.5) 118 1.0 (0.8 1.3) 36 2.9 (1.8 4.0) 95 1.1 (0.8 1.3) 17 1.1 (0.5 1.8) Crude OR Adjusted OR 2.36 (1.49 3.74) 0.0003 2.50 (1.54 4.06) 0.0002 3.20 (2.00 5.12) 3.28 (1.96 5.48) 3.04 (1.69 5.46) 0.0002 2.35 (1.20 4.60) 0.01 2.74 (1.65 4.53) 2.75 (1.62 4.69) 0.0002 3.70 (2.06 6.66) 3.88 (2.08 7.22) 2.95 (1.93 4.50) 3.43 (2.14 5.49) 1.80 (1.05 3.07) 0.03 1.54 (0.81 2.92) 0.19 1.77 (0.97 3.24) 0.06 0.95 (0.47 1.95) 0.90 2.84 (1.76 4.57) 3.16 (1.86 5.39) 1.06 (0.57 2.00) 0.85 0.81 (0.40 1.63) 0.55

etable 6 continued. year anemia Anemia 2007 8455 98.9 (98.6 99.1) Eczema 832 97.7 (96.6 98.8) 2008 7779 99.0 (98.7 99.2) Eczema 914 97.5 (96.2 98.9) 2009 9724 99.0 (98.7 99.3) Eczema 1275 98.1 (97.3 98.9) 2010 9787 99.1 (98.9 99.3) Eczema 1329 97.0 (96.0 98.1) 2011 11109 98.9 (98.7 99.1) Eczema 1548 97.5 (96.6 98.3) 2012 11529 99.1 (98.9 99.3) Eczema 1557 97.7 (96.9 98.6) 2013 11183 99.1 (98.8 99.3) Eczema 1501 98.0 (97.0 99.0) 98 1.1 (0.9 1.4) 23 2.3 (1.2 3.4) 85 1.0 (0.8 1.3) 25 2.5 (1.1 3.8) 100 1.0 (0.7 1.3) 32 1.9 (1.1 2.7) 100 0.9 (0.7 1.1) 39 3.0 (1.9 4.0) 125 1.1 (0.9 1.3) 44 2.5 (1.7 3.4) 125 0.9 (0.7 1.1) 43 2.3 (1.4 3.1) 123 0.9 (0.7 1.2) 37 2.0 (1.1 3.0) Crude OR Adjusted OR 2.06 (1.17 3.62) 0.01 2.33 (1.24 4.39) 0.009 2.44 (1.32 4.49) 0.004 2.28 (1.14 4.57) 0.02 1.87 (1.11 3.17) 0.02 1.74 (1.01 3.00) 0.047 3.29 (2.14 5.06) 3.23 (2.04 5.10) 2.34 (1.49 3.66) 0.0002 1.98 (1.23 3.18) 0.005 2.49 (1.57 3.96) 0.0001 2.37 (1.44 3.89) 0.0006 2.18 (1.34 3.56) 0.002 2.03 (1.19 3.45) 0.009 Binary survey logistic regression models were constructed with anemia as the binary dependent variable and history of as the binary independent variable. Multivariable models were constructed that included age, sex, race/ethnicity, household income, highest level of education in the family, insurance coverage, number of persons in the household and birthplace in the US. Crude and adjusted OR and 95% CI were estimated.

etable 7. Association Between Pediatric Asthma and Anemia in Individual Years of, 1997-2013 year anemia Anemia 1997 asthma 12439 98.6 (98.4 98.8) Asthma 1563 97.0 (96.2 97.9) 1998 asthma 11826 98.8 (98.6 99.0) Asthma 1583 97.4 (96.6 98.1) 1999 asthma 10687 99.1 (98.9 99.2) Asthma 1348 98.6 (98.0 99.2) 2000 asthma 11588 98.9 Asthma 1593 97.7 (97.0 98.5) 2001 asthma 11722 98.9 (98.8 99.1) Asthma 1674 98.1 (97.5 98.8) 2002 asthma 10816 99.1 (98.9 99.2) Asthma 1532 98.0 (97.3 98.7) 2003 asthma 10587 99.1 (98.9 99.2) Asthma 1508 98.3 (97.7 99.0) 2004 asthma 10727 99.0 (98.9 99.2) Asthma 1530 98.0 (97.3 98.7) 2005 asthma 10718 98.8 (98.6 99.0) Asthma 1624 98.2 (97.6 98.9) 2006 asthma 8390 99.0 Asthma 1304 98.0 (97.3 98.8) 178 1.4 (1.2 1.6) 48 3.0 (2.1 3.8) 144 1.2 (1.0 1.4) 43 2.6 (1.9 3.4) 102 0.9 (0.8 1.1) 19 1.4 (0.8 2.0) 128 1.1 37 2.3 (1.5 3.0) 126 1.1 (0.9 1.2) 32 1.9 (1.2 2.5) 102 0.9 (0.8 1.1) 31 2.0 (1.3 2.7) 101 0.9 (0.8 1.1) 26 1.7 (1.0 2.3) 104 1.0 (0.8 1.1) 31 2.0 (1.3 2.7) 125 1.2 (1.0 1.4) 29 1.8 (1.1 2.4) 86 1.0 26 2.0 (1.2 2.7) Crude OR Adjusted OR 1.93 (1.33 2.80) 0.0006 1.92 (1.24 2.98) 0.004 2.43 (1.59 3.69) 2.49 (1.52 4.08) 0.0003 1.67 (0.91 3.06) 0.10 1.96 (1.01 3.78) 0.046 2.25 (1.41 3.58) 0.0007 2.14 (1.23 3.72) 0.007 1.52 (0.98 2.38) 0.06 1.38 (0.81 2.36) 0.24 2.36 (1.39 4.02) 0.002 2.33 (1.19 4.54) 0.01 1.73 (1.07 2.81) 0.03 1.85 (1.06 3.22) 0.03 2.23 (1.34 3.70) 0.002 1.80 (1.03 3.13) 0.04 2.37 (1.44 3.90) 0.0007 2.13 (1.24 3.65) 0.006 1.15 (0.67 1.98) 0.62 1.06 (0.55 2.04) 0.85

etable 7 continued. year anemia Anemia 2007 asthma 8088 98.8 (98.6 99.1) Asthma 1191 97.9 (97.1 98.7) 2008 asthma 7484 98.9 (98.6 99.1) Asthma 1202 98.2 (97.5 98.9) 2009 asthma 9442 98.9 Asthma 1555 98.3 (97.7 98.9) 2010 asthma 9572 98.9 Asthma 1537 98.1 (97.4 98.8) 2011 asthma 10868 98.8 (98.6 99.0) Asthma 1797 97.7 (97.0 98.4) 2012 asthma 11206 98.9 Asthma 1879 97.8 (97.2 98.5) 2013 asthma 10937 98.8 (98.6 99.0) Asthma 1746 98.3 (97.7 98.9) 96 1.2 (0.9 1.4) 25 2.1 (1.3 2.9) 87 1.1 (0.9 1.4) 22 1.8 (1.1 2.5) 105 1.1 27 1.7 (1.1 2,3) 109 1.1 30 1.9 (1.2 2.6) 127 1.2 (1.0 1.4) 42 2.3 (1.6 3.0) 127 1.1 42 2.2 (1.5 2.8) 131 1.2 (1.0 1.4) 30 1.7 (1.1 2.3) Crude OR Adjusted OR 1.90 (1.06 3.41) 0.03 2.00 (1.06 3.79) 0.03 1.52 (0.85 2.71) 0.16 1.31 (0.70 2.47) 0.40 1.97 (1.16 3.36) 0.01 1.78 (0.99 3.16) 0.05 1.44 (0.87 2.38) 0.16 1.22 (0.73 2.03) 0.45 2.01 (1.32 3.06) 0.001 1.82 (1.20 2.74) 0.005 1.71 (1.13 2.59) 0.01 1.81 (1.16 2.84) 0.01 1.59 (0.99 2.53) 0.05 1.54 (0.95 2.50) 0.08 Binary survey logistic regression models were constructed with anemia as the binary dependent variable and history of asthma as the binary independent variable. Multivariable models were constructed that included age, sex, race/ethnicity, household income, highest level of education in the family, insurance coverage, number of persons in the household and birthplace in the US. Crude and adjusted OR and 95% CI were estimated.

etable 8. Association Between Pediatric Hay Fever and Anemia in Individual Years of 1997-2013 year anemia Anemia 1997 hay 11536 98.6 (98.4 98.8) Hay 2438 97.5 (96.9 98.1) 1998 hay 11081 98.8 (98.6 99.0) Hay 2310 97.7 (97.1 98.3) 1999 hay 10001 99.1 (98.9 99.3) Hay 2000 98.4 (97.8-98.9) 2000 hay 10986 99.0 Hay 2164 97.6 (96.9 98.2) 2001 hay 11019 99.0 Hay 2343 98.0 (97.5 98.6) 2002 hay 10150 99.2 (99.0 99.3) Hay 2193 98.0 (97.5 98.6) 2003 hay 10042 99.1 (99.0 99.3) Hay 2025 98.2 (97.6 98.7) 2004 hay 10169 99.0 Hay 2064 98.3 (97.8 98.9) 2005 hay 10111 99.0 Hay 2208 97.8 (97.2 98.4) 2006 hay 8069 99.0 (98.8 99.3) Hay 1602 98.0 (97.3 98.7) 161 1.4 (1.2 1.6) 63 2.5 (1.9 3.1) 130 1.2 (1.0 1.4) 55 2.3 (1.7 2.9) 88 0.9 (0.7 1.1) 33 1.6 (1.1 2.2) 111 1.0 54 2.4 (1.8 3.1) 111 1.0 47 2.0 (1.4 2.5) 87 0.8 (0.7 1.0) 44 2.0 (1.4 2.5) 88 0.9 (0.7 1.0) 38 1.8 (1.3 2.4) 99 1.0 35 1.7 (1.1 2.2) 105 1.0 49 2.2 (1.6 2.8) 78 1.0 (0.7 1.2) 33 2.0 (1.3 1.7) Crude OR Adjusted OR 1.94 (1.39 2.70) 2.29 (1.58 3.32) 2.03 (1.38 2.99) 0.0003 2.26 (1.46 3.49) 0.0002 1.89 (1.12 3.18) 0.02 1.90 (0.99 3.65) 0.06 2.28 (1.55 3.34) 2.88 (1.91 4.35) 2.49 (1.54 4.02) 0.0002 3.42 (2.14 5.47) 2.22 (1.37 3.59) 0.001 2.80 (1.57 4.97) 0.0005 1.83 (1.17 2.86) 0.008 2.04 (1.20 3.48) 0.009 1.90 (1.19 3.03) 0.007 1.82 (1.10 3.03) 0.02 2.56 (1.67 3.94) 2.57 (1.59 4.14) 0.0001 1.87 (1.10 3.20) 0.02 1.67 (0.91 3.05) 0.10

etable 8 continued. year anemia Anemia Crude OR P Value 2007 hay 7826 98.7 102 1.3 (98.5 99.0) Hay 1438 98.7 (98.1 99.3) 2008 hay 7222 98.9 Hay 1455 98.0 (97.3 98.7) 2009 hay 9175 99.0 Hay 1808 98.0 (97.4 98.6) 2010 hay 9219 98.9 Hay 1881 98.3 (97.7 98.9) 2011 hay 10543 98.8 (98.6 99.0) Hay 2102 97.9 (97.2 98.5) 2012 hay 10954 98.9 Hay 2118 98.1 (97.5 98.6) 2013 hay 10650 98.9 Hay 2015 98.1 (97.5 98.7) (1.0 1.5) 19 1.3 (0.7 1.9) 80 1.1 30 2.0 (1.3 2.7) 94 1.0 37 2.0 (1.4 2.6) 105 1.1 33 1.7 (1.1 2.3) 123 1.2 (1.0 1.4) 46 2.1 (1.5 2.8) 127 1.1 42 1.9 (1.4 2.5) 121 1.1 39 1.9 (1.3 2.5) Adjusted OR (0.56 1.80) 0.99 0.96 (0.47 1.98) 0.91 1.94 (1.12 3.39) 0.02 1.68 (0.94 3.00) 0.08 1.72 (1.04 2.85) 0.03 1.97 (1.19 3.25) 0.008 1.40 (0.87 2.25) 0.17 1.71 (1.02 2.85) 0.04 1.83 (1.19 2.81) 0.006 1.88 (1.20 2.95) 0.006 1.51 (0.99 2.29) 0.05 1.85 (1.20 2.86) 0.005 1.45 (0.93 2.26) 0.10 1.43 (0.91 2.27) 0.12 Binary survey logistic regression models were constructed with anemia as the binary dependent variable and history of hay as the binary independent variable. Multivariable models were constructed that included age, sex, race/ethnicity, household income, highest level of education in the family, insurance coverage, number of persons in the household and birthplace in the US. Crude and adjusted OR and 95% CI were estimated.

etable 9. Association Between Pediatric Food Allergy and Anemia in Individual Years of 1997-2013 year anemia Anemia 1997 13541 98.5 (98.3 98.7) Food 469 95.9 (95.2 97.7) 1998 12950 98.7 (98.6 98.9) Food 470 95.7 (93.9 97.5) 1999 11678 99.1 (98.9 99.2) Food 370 96.9 (95.1 98.6) 2000 12738 98.9 Food 448 95.3 (93.4 97.2) 2001 12934 98.9 Food 457 96.6 (95.0 98.2) 2002 11902 99.0 Food 451 97.4 (96.0 98.9) 2003 11659 99.0 (98.9 99.2) Food 431 97.1 (95.5 98.6) 2004 11758 99.0 Food 492 96.7 (95.1 98.2) 2005 11836 98.9 Food 496 96.5 (94.9 98.1) 2006 9275 99.0 Food 416 96.7 (95.1 98.4) 206 1.5 (1.3 1.7) 20 4.1 (3.3 4.8) 165 1.3 (1.1 1.4) 21 4.3 (2.5 6.1) 109 0.9 (0.8 1.1) 12 3.1 (1.4 4.9) 143 1.1 22 4.7 (2.8 6.6) 142 1.1 16 3.4 (1.8 5.0) 120 1.0 12 2.6 (1.1 4.0) 113 1.0 (0.8 1.1) 13 2.9 (1.4 4.5) 116 1.0 17 3.3 (1.8 3.9) 135 1.1 18 3.5 (1.9 5.1) 96 1.0 14 3.3 (1.6 4.9) Crude OR Adjusted OR 2.83 (1.68 4.79) 2.91 (1.67 5.09) 0.0002 4.41 (2.56 7.60) 4.93 (2.79 8.70) 2.47 (1.22 5.02) 0.01 2.96 (1.30 6.73) 0.01 5.02 (2.83 8.88) 5.01 (2.54 9.86) 5.26 (2.31 12.02) 6.90 (2.87 16.57) 2.56 (1.27 5.16) 0.009 1.77 (0.83 3.80) 0.14 4.03 (1.94 8.40) 0.0002 4.17 (1.87 9.34) 0.0005 3.94 (2.16 7.18) 2.99 (1.54 5.82) 0.001 3.26 (1.87 5.67) 3.19 (1.70 5.99) 0.0003 2.94 (1.76 4.92) 2.17 (1.02 4.64) 0.046

etable 9 continued. year anemia Anemia Crude OR 2007 8920 98.8 (98.6 99.0) Food 366 96.8 (95.1 98.6) 2008 8277 98.8 (98.6 99.1) Food 411 97.2 (95.6 98.7) 2009 10430 98.9 Food 563 97.4 (96.1 98.7) 2010 10609 98.9 Food 507 96.8 (95.2 98.3) 2011 11984 98.9 (98.7 99.0) Food 670 95.9 (94.4 97.3) 2012 12380 98.8 (98.6 99.0) Food 697 97.9 (96.8 98.9) 2013 11977 98.9 (98.7 99.0) Food 700 97.1 (95.9 98.3) 109 1.2 (1.0 1.4) 12 3.2 (1.4 4.9) 98 1.2 (0.9 1.4) 12 2.8 (1.3 4.4) 117 1.1 15 2.6 (1.3 3.9) 121 1.1 17 3.2 (1.7 4.8) 139 1.1 (1.0 1.3) 29 4.1 (2.7 5.6) 152 1.2 (1.0 1.4) 15 2.1 (1.1 3.2) 139 1.1 (1.0 1.3) 21 2.9 (1.7 4.1) Adjusted OR 2.18 ( 4.74) 0.049 2.17 (0.83 5.66) 0.11 1.85 (0.91 3.74) 0.09 2.19 (1.04 4.61) 0.04 1.83 (0.91 3.68) 0.09 1.92 (0.96 3.84) 0.07 3.21 (1.87 5. 51) 3.36 (1.81 6.23) 0.0001 3.83 (2.33 6.29) 3.72 (2.21 6.26) 1.63 (0.82 3.23) 0.16 1.69 (0.84 3.42) 0.14 1.87 (1.08 3.23) 0.03 1.56 (0.84 2.89) 0.16 Binary survey logistic regression models were constructed with anemia as the binary dependent variable and history of food as the binary independent variable. Multivariable models were constructed that included age, sex, race/ethnicity, household income, highest level of education in the family, insurance coverage, number of persons in the household and birthplace in the US. Crude and adjusted OR and 95% CI were estimated.