Notification of Product Changes (NOPC) forms, Containered Trade Product Pack (CTPP) codes and Pharmacodes

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29 February 2016 TENDER RESULTS PHARMAC has resolved to award tenders for Sole Subsidised Supply Status and Status for some products included in the 2014/15 Invitation to Tender, d 6 November 2014, and the 2015/16 Invitation to Tender, d 6 November 2015. Some of the pharmaceuticals that will be delisted when the period of Sole Subsidised Supply/ Status commences may be subject to existing listing contracts with PHARMAC. Suppliers of pharmaceuticals that are subject to such contracts should continue to supply their pharmaceuticals under those contracts. PHARMAC will continue to subsidise those pharmaceuticals accordingly until such time as those pharmaceuticals are delisted. Notification of Product Changes (NOPC) forms, Containered Trade Product Pack (CTPP) codes and Pharmacodes Please note that for any changes (price change, size change, new listing etc) to be effective in the Pharmaceutical Schedule (including Section H), suppliers are required to notify any changes to PHARMAC and the Pharmacy Guild of New Zealand by 4pm on the 12 th of the month prior to the of subsidy change. More information and NOPC forms can be found on our website http://www.pharmac.health.nz/medicines/how-medicines-arefunded/new-funding-applications/pharmaceutical-product- specifications-the-change-process Suppliers are required to ensure that a Pharmacode has been obtained from the Pharmacy Guild of New Zealand (http://www.pgnz.org.nz/pharmacode) and that a CTPP code has been obtained from the New Zealand Universal List of Medicines (http://www.nzulm.org.nz/sponsors). Pharmacodes and CTPP codes must be provided to PHARMAC by the 5 th of the month prior to the of listing, or 10 business days following the market notification (whichever is earliest). PHARMAC cannot list a product (and pharmacies cannot claim) without the correct Pharmacode. A868991 Page 1 of 10

2014/15 Tender Sole Subsidised Supply Status or Status applies until 30 June 2018 Hospital pharmaceutical tenders Section H of the Pharmaceutical Schedule 1. Tenders awarded to pharmaceuticals where no brand is listed. The decisions were as follows: Chemical name Pack Price Listing Status Milrinone Inj 1 mg per ml, 10 ml ampoule; 10 ampoules $300.30 Milrinone Generic Health (Max Health) 1 May 2016 1 July 2016 2015/16 Tender Sole Subsidised Supply Status or Status applies until 30 June 2019 Community pharmaceutical tenders Section B of the Pharmaceutical Schedule 2. Tenders awarded to currently listed pharmaceuticals where no other brand is listed. The decisions were as follows: Chemical name subsidy (and price) New subsidy (and price) Aciclovir Tab dispersible 200 mg; 25 tablets $1.78 $1.60 Aciclovir Tab dispersible 400 mg; 56 tablets $5.98 $5.38 Aciclovir Tab dispersible 800 mg; 35 tablets $6.64 $5.98 Amoxicillin Amoxicillin Cap 250 mg; 500 tablets, bottle Cap 500 mg; 500 tablets, bottle $16.18 $14.97 $20.94 $16.75 Sole supply brand (Supplier) Apo-Amoxi Apo-Amoxi Date of subsidy change Sole Subsidised Supply A868991 Page 2 of 10

Chemical name Cefaclor monohydrate Cefaclor monohydrate Cetomacrogol with glycerol Cetomacrogol with glycerol Cilazapril with hydrochlorothiazide Clindamycin Clindamycin Desmopressin Desmopressin Digoxin Digoxin Dihydrocodeine tartrate Cap 250 mg; 100 capsules, bottle Grans for oral liq 125 mg per 5 ml; Crm 90% with glycerol 10%; 1,000 ml OP Crm 90% with glycerol 10%; 500 ml OP Tab 5 mg with hydrochlorothiazide 12.5 mg; 100 tablets, bottle Cap 150 mg; 16 capsule, blister Inj phosphate 150 mg per ml, 4 ml ampoule; 10 ampoules Tab 100 mcg; 30 tablets, bottle Tab 200 mcg; 30 tablets, bottle Tab 250 mcg; 240 tablets, blister Tab 62.5 mcg; 240 tablets, blister Tab long-acting 60 mg; 60 tablets, bottle subsidy (and price) New subsidy (and price) $26.00 $24.70 $3.53 $3.53 $6.50 $3.87 $4.50 $2.82 $10.72 $10.18 $5.80 $4.10 $100.00 $65.00 $36.40 $25.00 $93.60 $54.45 Sole supply brand (Supplier) Ranbaxy- Cefaclor Ranbaxy-Cefaclor Pharmacy Health Sorbolene with Glycerin Pharmacy Health Sorbolene with Glycerin Apo- Cilazapril/Hydrochlorothia zide Clindamycin ABM (ABM) Dalacin C (Pfizer) Minirin (Pharmaco) Minirin (Pharmaco) Date of subsidy change A868991 Page 3 of 10 Sole Subsidised Supply 1 June 2016 1 September 2016 1 June 2016 1 September 2016 $14.52 $14.52 Lanoxin (Aspen) $6.67 $6.67 Lanoxin PG (Aspen) $13.64 $9.55 Dimethicone Crm 5%; pump bottle, 500 ml OP $4.73 $4.59 DHC Continus (MundiPharma) healthe Dimethicone 5%

Chemical name Dipyridamole Furosemide [frusemide] Isosorbide mononitrate Itraconazole Tab long-acting 150 mg; 60 tablets, bottle Inj 10 mg per ml, 2 ml ampoule; 5 ampoules Tab long-acting 40 mg; 30 tablets, blister Cap 100 mg; 15 capsules, blister subsidy (and price) New subsidy (and price) Sole supply brand (Supplier) Date of subsidy change A868991 Page 4 of 10 Sole Subsidised Supply $11.52 $11.52 Pytazen SR $1.30 $1.20 Frusemide-Claris $7.50 $7.50 Ismo 40 Retard (Riemser) $2.99 $2.79 Lactulose Oral liq 10 g per 15 ml; 500 ml $3.84 $3.18 Misoprostol Nortriptyline Nortriptyline Perhexiline maleate Phenoxymethylpenicillin (Penicillin V) Phenoxymethylpenicillin (Penicillin V) Polyvinyl alcohol Polyvinyl alcohol Pramipexole Tab 200 mcg; 120 tablets, blister $56.92 $41.50 Tab 10 mg; 100 tablets, blister $4.00 $3.22 Tab 25mg; 180 tablets, blister $9.00 $7.08 Tab 100 mg; 100 tablets, bottle Grans for oral liq 125 mg per 5 ml; Grans for oral liq 250 mg per 5 ml; Itrazole Laevolac Cytotec (Pfizer) Norpress Norpress $62.90 $62.90 Pexsig (Aspen) $1.64 $1.48 $1.74 $1.58 Eye drops 1.4%; 15 ml OP $2.68 $2.62 Eye drops 3%; 15 ml OP $3.75 $3.68 Tab 0.25 mg; 100 tablets, blister AFT AFT Vistil Vistil Forte $7.20 $7.20 Ramipex (Deva)

Chemical name Pramipexole subsidy (and price) New subsidy (and price) Sole supply brand (Supplier) Date of subsidy change Sole Subsidised Supply Tab 1 mg; 100 tablets, blister $24.39 $24.39 Ramipex (Deva) Tetrabenazine Tab 25 mg; 112 tablets, bottle $118.00 $91.10 Thymol glycerin Compound, BPC; 500 ml $9.15 $9.15 Timolol Timolol Eye drops 0.25%, gel forming; 2.5 ml OP Eye drops 0.5%, gel forming; 2.5 ml OP $3.30 $3.30 $3.78 $3.78 Urea Crm 10%; 100 g OP $1.65 $1.37 Zidovudine [AZT] Cap 100 mg; 100 capsules, blister Motetis PSM Timoptol XE (MSD) Timoptol XE (MSD) healthe Urea Cream 1 June 2016 1 September 2016 $152.25 $152.25 Retrovir (GSK) Zidovudine [AZT] Oral liq 10 mg per ml; 200 ml OP $30.45 $30.45 Retrovir (GSK) Hospital pharmaceutical tenders Section H of the Pharmaceutical Schedule 3. Tenders awarded to currently listed pharmaceuticals where no other brand is listed. The decisions were as follows: Chemical Name price New price Aciclovir Tab dispersible 200 mg; 25 tablets $1.78 $1.60 Aciclovir Tab dispersible 400 mg; 56 tablets $5.98 $5.38 Aciclovir Tab dispersible 800 mg; 35 tablets $6.64 $5.98 Listing Status Amoxicillin Cap 250 mg; 500 tablets, bottle $16.18 $14.97 Apo-Amoxi A868991 Page 5 of 10

Chemical Name Amoxicillin Cefaclor Cefaclor Cetomacrogol with glycerol Cilazapril with hydrochlorothiazide Clindamycin Clindamycin Desmopressin Desmopressin Dihydrocodeine tartrate Cap 500 mg; 500 tablets, bottle Cap 250 mg; 100 capsules, bottle Grans for oral liq 25 mg per ml; Crm 90% with glycerol 10%; 1,000 ml Tab 5 mg with hydrochlorothiazide 12.5 mg; 100 tablets, bottle Cap 150 mg; 16 capsule, blister Inj 150 mg per ml, 4 ml ampoule; 10 ampoules Tab 100 mcg; 30 tablets, bottle Tab 200 mcg; 30 tablets, bottle Tab long-acting 60 mg; 60 tablets, bottle price New price $20.94 $16.75 $26.00 $24.70 $3.53 $3.53 $6.50 $3.87 $10.72 $10.18 $5.80 $4.10 $100.00 $65.00 $36.40 $25.00 $93.60 $54.45 $13.64 $9.55 Dimethicone Crm 5% pump bottle; 500 ml $4.73 $4.59 Dimethicone Crm 5% tube; 100 g $1.65 $1.59 Apo-Amoxi Ranbaxy- Cefaclor Ranbaxy-Cefaclor Pharmacy Health Sorbolene with Glycerin Apo- Cilazapril/Hydrochlo rothiazide Clindamycin ABM (ABM) Dalacin C (Pfizer) Minirin (Pharmaco) Minirin (Pharmaco) DHC Continus (MundiPharma) healthe Dimethicone 5% healthe Dimethicone 5% A868991 Page 6 of 10 Listing Status 1 June 2016 1 August 2016

Chemical Name Dipyridamole Tab long-acting 150 mg; 60 tablets, bottle price New price $11.52 $11.52 Fluconazole Inj 2 mg per ml,, bottle $6.47 $6.47 Fluconazole Inj 2 mg per ml, 50 ml, bottle $4.95 $4.95 Furosemide [frusemide] Isosorbide mononitrate Itraconazole Inj 10 mg per ml, 2 ml ampoule; 5 ampoules Tab long-acting 40 mg; 30 tablets, blister Cap 100 mg; 15 capsules, blister $1.30 $1.20 $7.50 $7.50 $2.99 $2.79 Lactulose Oral liq 10 g per 15 ml; 500 ml $3.84 $3.18 Nortriptyline Nortriptyline Perhexiline maleate Phenoxymethylpenicillin (Penicillin V) Phenoxymethylpenicillin (Penicillin V) Pramipexole Pramipexole Tab 10 mg; 100 tablets, blister $4.00 $3.22 Tab 25mg; 180 tablets, blister $9.00 $7.08 Tab 100 mg; 100 tablets, bottle Grans for oral liq 125 mg per 5 ml; Grans for oral liq 250 mg per 5 ml; Tab 0.25 mg; 100 tablets, blister Pytazen SR Fluconazole-Claris Fluconazole-Claris Frusemide-Claris Ismo 40 Retard (Riemser) Itrazole Laevolac Norpress Norpress $62.90 $62.90 Pexsig (Aspen) $1.64 $1.48 $1.74 $1.58 AFT AFT $7.20 $7.20 Ramipex (Deva) Tab 1 mg; 100 tablets, blister $24.39 $24.39 Ramipex (Deva) Listing Status A868991 Page 7 of 10

Chemical Name price New price Tetrabenazine Tab 25 mg; 112 tablets, bottle $118.00 $91.10 Timolol Eye drops 0.25%, gel forming; 2.5 ml $3.30 $3.30 Timolol Eye drops 0.5%, gel forming; 2.5 ml $3.78 $3.78 Zidovudine [AZT] Cap 100 mg; 100 capsules, blister Motetis Timoptol XE (MSD) Timoptol XE (MSD) $152.25 $152.25 Retrovir (GSK) Listing Status Zidovudine [AZT] Oral liq 10 mg per ml; 200 ml $30.45 $30.45 Retrovir (GSK) 4. Tenders awarded to pharmaceuticals where at least one other brand is listed. The decisions were as follows: Chemical Name price New price Listing Status affected by delisting Cetomacrogol with glycerol Crm 90% with glycerol 10%; 500 ml $4.50 $2.82 Pharmacy Health Sorbolene with Glycerin 1 June 2016 1 August 2016 healthe Polyvinyl alcohol Eye drops 1.4%; 15 ml $2.68 $2.62 Vistil Liquifilm Tears (Allergan) Polyvinyl alcohol Eye drops 3%; 15 ml $3.80 $3.68 Vistil Forte Liquifilm Forte (Allergan) 5. Tenders awarded to pharmaceuticals where no brand is listed. The decisions were as follows: Chemical name Pack Price Listing Status Digoxin Tab 250 mcg; 240 tablets, blister $14.52 Lanoxin (Aspen) Digoxin Tab 62.5 mcg; 240 tablets, blister $6.67 Lanoxin PG (Aspen) A868991 Page 8 of 10

Chemical name Misoprostol Tab 200 mcg; 120 tablets, blister Pack Price $41.50 Thymol glycerin Compound, BPC; 500 ml $9.15 Urea Crm 10%; 100 g $1.37 Cytotec (Pfizer) PSM healthe Urea Cream Listing Status 1 June 2016 1 August 2016 Tender declines - Products where no tender is to be awarded for Sole Subsidised Supply Status or Status PHARMAC has resolved not to award tenders for Sole Subsidised Supply Status or Status for the following products listed in the 2014/15 Invitation to Tender, d 6 November 2014, and the 2015/16 Invitation to Tender, d 6 November 2015: 2014/15 Invitation to Tender Chemical Name Bortezomib Line Item Inj 3.5 mg 2015/16 Invitation to Tender Chemical Name Line Item Chemical Name Line Item Adenosine Inj 3 mg per ml, 2 ml Mycophenolate mofetil Inj 500 mg Adenosine Inj 3 mg per ml, 10 ml Mycophenolate mofetil Powder for oral liq 1 g per 5 ml Benzoyl peroxide Gel 2.5% Noradrenaline Inj 0.06 mg per ml, bag Benzoyl peroxide Gel 5% Noradrenaline Inj 0.06 mg per ml, 50 ml syringe Disopyramide phosphate Cap 100 mg Noradrenaline Inj 0.1 mg per ml, bag Disopyramide Phosphate Cap 150 mg Noradrenaline Inj 0.12 mg per ml, 50 ml syringe A868991 Page 9 of 10

Chemical Name Line Item Chemical Name Line Item Fusidic acid Tab 250 mg Noradrenaline Inj 0.12 mg per ml, bag Fusidic acid Eye drops Noradrenaline Inj 0.16 mg per ml, 50 ml syringe Glyceryl trinitrate Inj 1 mg per ml, 50 ml Noradrenaline Inj 1 mg per ml, bag Glyceryl trinitrate Inj 1 mg per ml, 5 ml Risperidone [current access] Orally-disintegrating tablets 0.5 mg Glyceryl trinitrate Inj 5 mg per ml, 10 ml Risperidone [current access] Orally-disintegrating tablets 1 mg Glyceryl trinitrate Tab 500 mcg - 600 mcg Risperidone [current access] Orally-disintegrating tablets 2 mg Indomethacin Cap long-acting 75 mg Risperidone [widened access] Orally-disintegrating tablets 0.5 mg Indomethacin Suppos 100 mg Risperidone [widened access] Orally-disintegrating tablets 1 mg Indomethacin Cap 25 mg Risperidone [widened access] Orally-disintegrating tablets 2 mg Indomethacin Cap 50 mg Sumatriptan Inj 12 mg per ml, 0.5 ml Indomethacin Inj 1 mg Sumatriptan Nasal spray Methadone Inj 10 mg per ml, 1 ml Topotecan Inj 1 mg Methadone Tab 10 mg - 20 mg Topotecan Inj 4 mg Minoxidil Tab 10 mg Trimipramine maleate Cap 25 mg Minoxidil Tab 2.5 mg Trimipramine maleate Cap 50 mg Minoxidil Tab 5 mg For products included in the 2014/15 and 2015/16 Invitation to Tender where no announcement has yet been made, either a decision is still pending or is provisional, subject to the product gaining market approval and being available to supply, and subject to PHARMAC Board (or its delegate) approval. We will keep you informed of any ups regarding such tender products as decisions are made. If you have any queries regarding this notification please contact PHARMAC on 0800 66 00 50. A868991 Page 10 of 10