Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Octreotide Acetate SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 Sandostatinel L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threon cyclic (2,7)-disulfide, (R-(R*, R*))-, acetate (salt) Catalog Number(s). CAS# RTECS TSCA CI# O3003 7957-0-4 HA000000 IN CASE OF EMERGENCY CHEMTREC (24hr) 800-424-9300 Page Number: TSCA 8(b) inventory: No products were found. Not listed on TSCA 8(b) inventory Chemical Family Chemical Formula Supplier C49-H66-N0-O0-S2 x C2-H4-O2 SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 CALL (30) 56-8000 Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Octreotide Acetate 7957-0-4 00 Toxicological Data on Ingredients Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: The substance may be toxic to gastrointestinal tract, endocrine. Repeated or prolonged exposure to the substance can produce target organs damage.
Octreotide Acetate Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Cold water may be used. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...). Slightly flammable to flammable in presence of heat. Explosion Hazards in Presence of Various Substances Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system.
Octreotide Acetate Page Number: 3 Section 7. Handling and Storage Precautions Storage Keep away from heat. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill Exposure Limits Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.) Odor Acetic acid. (Slight.) Molecular Weight ph (% soln/water) 079.29 g/mole Taste Color White. Boiling Point Melting Point Critical Temperature Specific Gravity Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water, methanol. Solubility Soluble in cold water, methanol. Solubility in Water: >9 g/l Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat
Octreotide Acetate Page Number: 4 Protect from light. Corrosivity Polymerization Will not occur. Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. Acute oral toxicity (LD50): >2000 mg/kg [Rat]. May cause damage to the following organs: gastrointestinal tract, endocrine. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Acute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Abdominal disconfort, nausea, vomiting, flatulence, diarrhea or constipation, anorexia, dizziness, headache Chronic Potential Health Effects: Ingestion: Repeated or prolonged ingestion may cause abdominal discomfort, nausea, vomiting, flatulence, diarrhea or constipation, headache, anorexia, diffuse loss of scalp hair. It may affect the pancreas (hyperglycemia or hypoglycemia), thyroid (hypothyroidism), endocrine system, gall bladder (inibit gallbladder contractility, decrease bile secretion, gall stones, biliary sludge), cardiovascular system (sinus bradycardia, conduction abnormalities, arrhythmias), liver (hepatitis). Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Octreotide Acetate Page Number: 5 Section 4. Transport Information DOT Classification Not a DOT controlled material (United States). Identification Special Provisions for Transport DOT Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non-Domestic Substance List (NDSL) China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) This product is not classified according to the EU regulations. HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 0 E National Fire Protection Association (U.S.A.) Health 0 Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada)
Octreotide Acetate Page Number: 6 ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations O0300 Use: Medication (drug) to treat acomegaly, to control symptoms of diarrhea or flushing in patients with carcinoid syndrome (tumors), pancreatic islet cell tumors, gastrinoma, or vasoactive intestinal peptide-secreting tumors. It inhibits secretion of many hormones such as gastrin, cholecystokinin, glucagon, growth hormone, insulin, secretin, pancreatic polypeptide, TSH, and vasoacitve intestinal peptide. Validated by Sonia Owen on 6/29/2007. Verified by Sonia Owen. Printed 9/3/2007. CALL (30) 56-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.