Web appendix 2: SEARCH STRATEGIES Interventions for non-metastatic squamous cell carcinoma of the skin: a systematic review and pooled analysis of observational studies MEDLINE 1. exp epidemiologic studies/ 2. exp case-control studies/ 3. exp cohort studies/ 4. case control.tw. 5. (cohort adj (study or studies)).tw. 6. Cohort anal$.tw. 7. (Follow up adj (study or studies)).tw. 8. (observational adj (study or studies)).tw. 9. Longitudinal.tw. 10. Retrospective.tw. 11. Cross sectional.tw. 12. Cross-sectional studies/ 13. or/1-12 14. (squamous cell carcinoma or skin cancer$ or skin neoplasm$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 15. (skin tumour$ or skin tumor$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 16. (non-metastatic squamous cell carcinoma or NMSC or non-melanoma skin cancer).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 17. exp Carcinoma,Squamous Cell/ 18. exp Skin neoplasms/ 19. 14 or 15 or 16 or 17 or 18 20. (cryotherapy or cryosurgery or (moh$ and surgery) or (excision$ and surgery)).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 21. (curettage or cauter$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 22. (electrosurgery or electrodesiccation).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 23. (photodynamic therapy or photochemotherapy).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 24. (laser surgery or laser therapy or radiotherapy or interferon$).mp. [mp=title, original title, abstract, name of substance word, subject heading word]
25. (intralesional chemotherapy or bleomycin or fluorouracil or solasodine glycoside$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 26. (retinoi$ or cisplatin).mp. [mp=title, original title, abstract, name of substance word, subject heading word] 27. exp Cryotherapy/ 28. exp Cryosurgery/ 29. exp Mohs Surgery/ 30. excision$ surgery.mp. 31. exp Curettage/ 32. exp Cautery/ 33. exp Electrosurgery/ 34. exp Photochemotherapy/ 35. exp Laser Therapy/ 36. exp Radiotherapy/ 37. Interferons/ 38. exp Interferons/ 39. Drug Therapy/ 40. 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 41. 13 and 19 and 40 42. Epidural Neoplasms/ or Salivary Gland Neoplasms/ or Nasopharyngeal Neoplasms/ or Perivascular Epithelioid Cell Neoplasms/ or Nervous System Neoplasms/ or Cerebral Ventricle Neoplasms/ or Retinal Neoplasms/ or Central Nervous System Neoplasms/ or Gingival Neoplasms/ or Jejunal Neoplasms/ or Neoplasms, Fibrous Tissue/ or Digestive System Neoplasms/ or Laryngeal Neoplasms/ or Choroid Plexus Neoplasms/ or Palatal Neoplasms/ or Neoplasms, Mesothelial/ or Urethral Neoplasms/ or Tracheal Neoplasms/ or Endometrial Neoplasms/ or Brain Stem Neoplasms/ or Neoplasms, Neuroepithelial/ or Oropharyngeal Neoplasms/ or Uveal Neoplasms/ or Maxillary Neoplasms/ or Sublingual Gland Neoplasms/ or Pelvic Neoplasms/ or Cecal Neoplasms/ or Urogenital Neoplasms/ or "Neoplasms, Ductal, Lobular, and Medullary"/ or Stomach Neoplasms/ or Liver Neoplasms, Experimental/ or Neoplasms, Adipose Tissue/ or Nerve Sheath Neoplasms/ or Neoplasms, Bone Tissue/ or Mammary Neoplasms, Animal/ or Mediastinal Neoplasms/ or Submandibular Gland Neoplasms/ or Sigmoid Neoplasms/ or Adrenal Gland Neoplasms/ or Cerebellar Neoplasms/ or Pancreatic Neoplasms/ or Neoplasms, Experimental/ or Tonsillar Neoplasms/ or Spinal Neoplasms/ or Bronchial Neoplasms/ or Parathyroid Neoplasms/ or Mouth Neoplasms/ or Thyroid Neoplasms/ or Hypothalamic Neoplasms/ or Common Bile Duct Neoplasms/ or Supratentorial Neoplasms/ or Respiratory Tract Neoplasms/ or Optic Nerve Neoplasms/ or Skull Base Neoplasms/ or Pleural Neoplasms/ or Neoplasms, Connective Tissue/ or Urologic Neoplasms/ or Abdominal Neoplasms/ or Colorectal Neoplasms, Hereditary Nonpolyposis/ or Neoplasms, Radiation-Induced/ or Retroperitoneal Neoplasms/ or Vascular Neoplasms/ or Vulvar Neoplasms/ or Hematologic Neoplasms/ or Bone Marrow Neoplasms/ or Fallopian Tube Neoplasms/ or
Gestational Trophoblastic Neoplasms/ or Peritoneal Neoplasms/ or Appendiceal Neoplasms/ or Esophageal Neoplasms/ or Colonic Neoplasms/ or Mammary Neoplasms, Experimental/ or Biliary Tract Neoplasms/ or Cranial Nerve Neoplasms/ or "Neoplasms, Cystic, Mucinous, and Serous"/ or Pharyngeal Neoplasms/ or Neoplasms, Unknown Primary/ or Lung Neoplasms/ or Ovarian Neoplasms/ or Penile Neoplasms/ or Neoplasms, Nerve Tissue/ or Brain Neoplasms/ or Parotid Neoplasms/ or Urinary Bladder Neoplasms/ or Testicular Neoplasms/ or Neoplasms, Muscle Tissue/ or Hypopharyngeal Neoplasms/ or Otorhinolaryngologic Neoplasms/ or Neoplasms, Gonadal Tissue/ or "Neoplasms, Complex and Mixed"/ or Soft Tissue Neoplasms/ or Trophoblastic Neoplasms/ or Rectal Neoplasms/ or Ileal Neoplasms/ or Gallbladder Neoplasms/ or Mandibular Neoplasms/ or Neoplasms, Second Primary/ or Breast Neoplasms/ or Genital Neoplasms, Female/ or Intestinal Neoplasms/ or Kidney Neoplasms/ or "Head and Neck Neoplasms"/ or Maxillary Sinus Neoplasms/ or Choroid Neoplasms/ or Muscle Neoplasms/ or Meningeal Neoplasms/ or Adrenal Cortex Neoplasms/ or Splenic Neoplasms/ or Neoplasms, Hormone-Dependent/ or Peripheral Nervous System Neoplasms/ or Thymus Neoplasms/ or Sweat Gland Neoplasms/ or Endocrine Gland Neoplasms/ or Neoplasms, Vascular Tissue/ or Conjunctival Neoplasms/ or Sebaceous Gland Neoplasms/ or Duodenal Neoplasms/ or Pituitary Neoplasms/ or Spinal Cord Neoplasms/ or Neoplasms, Fibroepithelial/ or Uterine Neoplasms/ or Gastrointestinal Neoplasms/ or Neoplasms, Basal Cell/ or Liver Neoplasms/ or Ureteral Neoplasms/ or Uterine Cervical Neoplasms/ or Iris Neoplasms/ or Prostatic Neoplasms/ or Thoracic Neoplasms/ or Colorectal Neoplasms/ or Genital Neoplasms, Male/ or Vaginal Neoplasms/ or Heart Neoplasms/ or Breast Neoplasms, Male/ or Orbital Neoplasms/ or Bile Duct Neoplasms/ or "Neoplasms, Germ Cell and Embryonal"/ or Anal Gland Neoplasms/ or Neoplasms, Plasma Cell/ or Paranasal Sinus Neoplasms/ or Bone Neoplasms/ or Infratentorial Neoplasms/ or Tongue Neoplasms/ or Femoral Neoplasms/ or Anus Neoplasms/ or Eye Neoplasms/ or Skull Neoplasms/ 43. 41 not 42 44. limit 43 to humans EMBASE 1. Clinical study/ 2. case control study/ 3. Family study/ 4. Longitudinal study/ 5. Retrospective study/ 6. Prospective study/ 7. Randomized controlled trials/ 8. 6 not 7 9. Cohort analysis/ 10. (Cohort adj (study or studies)).mp. 11. (Case control adj (study or studies)).tw. 12. (follow up adj (study or studies)).tw. 13. (observational adj (study or studies)).tw.
14. (epidemiologic$ adj (study or studies)).tw. 15. (cross sectional adj (study or studies)).tw. 16. or/1-5,8-15 17. (squamous cell carcinoma or skin cancer$ or skin neoplasm$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 18. (skin tumour$ or skin tumor$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 19. (non-metastatic squamous cell carcinoma or NMSC or non-melanoma skin cancer).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 20. exp Carcinoma, Squamous Cell/ 21. exp Skin Neoplasms/ 22. 17 or 18 or 19 or 20 or 21 23. (cryotherapy or cryosurgery or (moh$ and surgery) or (excision$ and surgery)).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 24. (curettage or cauter$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 25. (electrosurgery or electrodesiccation).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 26. (photodynamic therapy or photochemotherapy).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 27. (laser surgery or laser therapy or radiotherapy or interferon$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 28. (intralesional chemotherapy or bleomycin or fluorouracil or solasodine glycoside$).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 29. (retinoi$ or cisplatin).mp. [mp=title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer, device trade name, keyword] 30. exp Cryotherapy/ 31. exp Cryosurgery/ 32. exp Mohs Surgery/ 33. excision$ surgery.mp. 34. exp Curettage/ 35. exp Cautery/ 36. exp Electrosurgery/
37. exp Photochemotherapy/ 38. exp Laser Therapy/ 39. exp Radiotherapy/ 40. Interferons/ 41. exp Interferons/ 42. Drug Therapy/ 43. 23 or 24 or 25 or 26 or 27 or 28 or 29 or 30 or 31 or 32 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 44. 16 and 22 and 43 45. Epidural Neoplasms/ or Salivary Gland Neoplasms/ or Nasopharyngeal Neoplasms/ or Perivascular Epithelioid Cell Neoplasms/ or Nervous System Neoplasms/ or Cerebral Ventricle Neoplasms/ or Retinal Neoplasms/ or Central Nervous System Neoplasms/ or Gingival Neoplasms/ or Jejunal Neoplasms/ or Neoplasms, Fibrous Tissue/ or Digestive System Neoplasms/ or Laryngeal Neoplasms/ or Choroid Plexus Neoplasms/ or Palatal Neoplasms/ or Neoplasms, Mesothelial/ or Urethral Neoplasms/ or Tracheal Neoplasms/ or Endometrial Neoplasms/ or Brain Stem Neoplasms/ or Neoplasms, Neuroepithelial/ or Oropharyngeal Neoplasms/ or Uveal Neoplasms/ or Maxillary Neoplasms/ or Sublingual Gland Neoplasms/ or Pelvic Neoplasms/ or Cecal Neoplasms/ or Urogenital Neoplasms/ or "Neoplasms, Ductal, Lobular, and Medullary"/ or Stomach Neoplasms/ or Liver Neoplasms, Experimental/ or Neoplasms, Adipose Tissue/ or Nerve Sheath Neoplasms/ or Neoplasms, Bone Tissue/ or Mammary Neoplasms, Animal/ or Mediastinal Neoplasms/ or Submandibular Gland Neoplasms/ or Sigmoid Neoplasms/ or Adrenal Gland Neoplasms/ or Cerebellar Neoplasms/ or Pancreatic Neoplasms/ or Neoplasms, Experimental/ or Tonsillar Neoplasms/ or Spinal Neoplasms/ or Bronchial Neoplasms/ or Parathyroid Neoplasms/ or Mouth Neoplasms/ or Thyroid Neoplasms/ or Hypothalamic Neoplasms/ or Common Bile Duct Neoplasms/ or Supratentorial Neoplasms/ or Respiratory Tract Neoplasms/ or Optic Nerve Neoplasms/ or Skull Base Neoplasms/ or Pleural Neoplasms/ or Neoplasms, Connective Tissue/ or Urologic Neoplasms/ or Abdominal Neoplasms/ or Colorectal Neoplasms, Hereditary Nonpolyposis/ or Retroperitoneal Neoplasms/ or Vascular Neoplasms/ or Vulvar Neoplasms/ or Hematologic Neoplasms/ or Bone Marrow Neoplasms/ or Fallopian Tube Neoplasms/ or Gestational Trophoblastic Neoplasms/ or Peritoneal Neoplasms/ or Appendiceal Neoplasms/ or Esophageal Neoplasms/ or Colonic Neoplasms/ or Mammary Neoplasms, Experimental/ or Biliary Tract Neoplasms/ or Cranial Nerve Neoplasms/ or "Neoplasms, Cystic, Mucinous, and Serous"/ or Pharyngeal Neoplasms/ or Neoplasms, Unknown Primary/ or Lung Neoplasms/ or Ovarian Neoplasms/ or Penile Neoplasms/ or Neoplasms, Nerve Tissue/ or Brain Neoplasms/ or Parotid Neoplasms/ or Urinary Bladder Neoplasms/ or Testicular Neoplasms/ or Neoplasms, Muscle Tissue/ or Hypopharyngeal Neoplasms/ or Otorhinolaryngologic Neoplasms/ or Neoplasms, Gonadal Tissue/ or "Neoplasms, Complex and Mixed"/ or Soft Tissue Neoplasms/ or Trophoblastic Neoplasms/ or Rectal Neoplasms/ or Ileal Neoplasms/ or Gallbladder Neoplasms/ or Mandibular Neoplasms/ or Neoplasms, Second Primary/ or Breast Neoplasms/ or Genital Neoplasms, Female/ or Intestinal Neoplasms/ or Kidney Neoplasms/ or "Head and Neck Neoplasms"/ or Maxillary Sinus Neoplasms/ or Choroid Neoplasms/ or Muscle Neoplasms/ or Meningeal Neoplasms/ or Adrenal Cortex Neoplasms/ or Splenic Neoplasms/ or Neoplasms, Hormone-
Dependent/ or Peripheral Nervous System Neoplasms/ or Thymus Neoplasms/ or Sweat Gland Neoplasms/ or Endocrine Gland Neoplasms/ or Neoplasms, Vascular Tissue/ or Conjunctival Neoplasms/ or Sebaceous Gland Neoplasms/ or Duodenal Neoplasms/ or Pituitary Neoplasms/ or Spinal Cord Neoplasms/ or Neoplasms, Fibroepithelial/ or Uterine Neoplasms/ or Gastrointestinal Neoplasms/ or Neoplasms, Basal Cell/ or Liver Neoplasms/ or Ureteral Neoplasms/ or Uterine Cervical Neoplasms/ or Iris Neoplasms/ or Prostatic Neoplasms/ or Thoracic Neoplasms/ or Colorectal Neoplasms/ or Genital Neoplasms, Male/ or Vaginal Neoplasms/ or Heart Neoplasms/ or Breast Neoplasms, Male/ or Orbital Neoplasms/ or Bile Duct Neoplasms/ or "Neoplasms, Germ Cell and Embryonal"/ or Anal Gland Neoplasms/ or Neoplasms, Plasma Cell/ or Paranasal Sinus Neoplasms/ or Bone Neoplasms/ or Infratentorial Neoplasms/ or Tongue Neoplasms/ or Femoral Neoplasms/ or Anus Neoplasms/ or Eye Neoplasms/ or Skull Neoplasms/ 46. 44 not 45 47. exp Lymphoma/ 48. 46 not 47 49. limit 48 to humans