NUTR 43800: Micronutrient Metabolism in Human Health and Disease Course Objectives: This course will integrate previous knowledge in physiology, chemistry, biochemistry, biology, and nutrition courses to understand the pathways and regulation of cellular and physiological vitamin, mineral, and phytochemical metabolism. The overall objective is to apply these concepts to human nutrition in health and disease. The specific goals of this course include: To understand the processes of digestion, absorption, utilization and function of vitamins, minerals, and phytochemicals in humans. To have knowledge on the relationship of vitamins, minerals, and phytochemicals to the regulation and processes of biochemical physiology. To have knowledge of cellular and molecular mechanisms related to vitamin, mineral, and phytochemical metabolism. To understand the role of vitamin, mineral, and phytochemical metabolism in the etiology and pathophysiology of disease. To demonstrate the ability to interpret current research in vitamin, mineral, and phytochemical metabolism. For Dietetics students (DPD or CPD), this course provides the following required components for ACEND accreditation: Organic chemistry, Biochemistry, Anatomy, Physiology, Genetics, Microbiology, Pharmacology, Statistics, Logic, Nutrient metabolism, Integrative and functional nutrition, and Nutrition across the lifespan Credit Hours: 3 Prerequisites: NUTR315, BCHM 307 or CHM 333, BCHM 309, NUTR437 Instructors: Dr. Qing Jiang Dr. Nana Gletsu-Miller Phone: 494-2483 496-9462 Email: qjiang@purdue.edu ngletsum@purdue.edu Office: Stone Hall, Room G1-A Stone Hall, Room 208 Office hours: By appointment By appointment Teaching Assistant: Alyssa Zembroski; azembros@purdue.edu, Office hour: Wed, 1-2pm, Stone Hall G32. Scheduled Meeting Times: MWF 8:30am 9:20 pm Lilly Hall of Life Sciences 3118
Textbook and learning resources: Gropper, S.S., Smith, J.L., and Carr, T.P. 2018. Advanced Nutrition and Human Metabolism. 7 th edition, Cengage Learning, Boston, MA, USA www.cengage.com/global. 6 th edition of this book can also be used as reference. A copy has been reserved in the Life Science library. The 5 th edition of this textbook also has some online resources available that are free and good. These include tutorial quizzes and a study guide for each chapter. The website is: http://www.cengagebrain.com/cgiwadsworth/course_products_wp.pl?fid=m20b&pr oduct_isbn_issn=9780495116578&token= Evaluation Possible Points Exam 1 80 Exam 2 60 Exam 3 70 Exam 4 70 Exam 5 70 Quizzes (6 total) 60 Video lecture Assignments (8 total) 40 Concept Maps (5 total) 100 Final 150 TOTAL 700 Percentages Points Grade Lower Upper Lower Upper A+ 97 100 679 700 A 93 97 651 678 A- 90 93 630 650 B+ 87 90 609 629 B 83 87 581 608 B- 80 83 560 580 C+ 77 80 539 559 C 73 77 511 538 C- 70 73 490 510 D+ 67 70 469 489 D 63 67 441 468 D- 60 63 420 440 Examinations: Examinations will be given at indicated times ONLY. If there is an extreme situation when you must miss an examination, then please contact the TA and instructor(s) AHEAD OF TIME (if possible). Based on individual cases, an alternative examination and time may be granted at the discretion of the instructor(s). 2
s: The assignments will be posted 24-48 hours prior to the due time. The assignments are due at the beginning of the following class meeting (as indicated in the schedule table). Late submission will NOT be accepted. Quizzes: Total 6 quizzes will be given at indicated times. There will be NO make-up quizzes. Each quiz will be worth 10 points. Please note: No cell phones, computers and other web devices will be allowed during quizzes and exams. Please bring your Purdue ID for the exams. Concept Maps: Due days of concept maps are indicated in the schedule. It is the most convenient to submit them in the class of that day. The key of concept maps will be posted the day after submission deadline. Late submission (for one day) but prior to key being posted will result in 3 pt deduction. No concept map will be accepted (0 credit) after the key is posted. Course Policies: This course will be taught in compliance with Purdue University Policies stated in University Regulations (http://www.purdue.edu/univregs/). Students with disabilities: If you are eligible for academic accommodations due to documented disability that will impact your work in this class, then please schedule an appointment with your instructor as soon as possible to discuss your needs. It is also the student's responsibility to notify the Disability Resource Center (http://www.purdue.edu/drc) of an impairment/condition that may require accommodations and/or classroom modifications. Academic Honesty: The instructors of this course expect, and will enforce, a strict policy of academic honesty. Students who engage in cheating, plagiarism (from books, articles, the Internet, etc.), representing another student's work as one's own, knowingly furnishing false information to the instructor or university, or other forms of academic dishonesty, will receive appropriate disciplinary action and/or a failing grade in this course. For more information about Academic Integrity please read Academic Integrity: A Guide for Students. (https://www.purdue.edu/odos/osrr/academic-integrity-brochure/) Use of Lecture Presentations and Copyrighted Materials The lecture materials (presentations, videos, lecture notes, exams and quizzes) were created by the instructors and contain some information that is copyrighted. For this reason, students may not sell or purchase such materials. University regulations are as follows: Students are expected, within the context of the Regulations Governing Student Conduct and other applicable University policies, to act responsibly and ethically by applying the appropriate exception under the Copyright Act to the use of copyrighted works in their activities and studies. The University does not assume legal responsibility for violations of copyright law by students who are not employees of the University. 3
On-Campus Emergency In the event of a major campus emergency, course requirements, deadlines and grading percentages are subject to changes that may be necessitated by a revised semester calendar or other circumstances beyond the instructor s control. Please contact instructors to get information about changes in this course. 4
TENTATIVE COURSE SCHEDULE FALL 2016 NUTR 43800 Dates Lecture Topics Quizzes, Assignments, and Exams The instructor reserves the right to make changes to the course schedule if necessary. Required reading will be assigned for each lecture. INSTRUCTOR: Dr. Qing Jiang Week 1 Aug 21 Introduction: Definition of Vitamins and Minerals; General Functions of Vitamins and Minerals. Aug 23 Nutritional Genomics Reading: pp. 29-31, 366-369 Aug 25 Video lecture: Overview of Water Soluble Vitamins; Niacin (Vitamin B3) Chapter 9 No class but LEARN FROM Week 2 Aug 28 Video Discussion; Riboflavin (Vitamin B2) Aug 30 Riboflavin (Vitamin B2), Thiamin (Vitamin B1) Sept 1 Thiamin (Vitamin B1) QUIZ 1 (10 Week 3 Sept 4 Labor day NO CLASS Sept 6 Video lecture: Pantothenic acid (Vitamin B5)+biotin No class but LEARN FROM Sept 8 Video Discussion, Folate Concept Map 1 due (20pts) Chapter 9 Week 4 Sept 11 Exam 1 (80 Sept 13 Folate Sept 15 Vitamin B12 Week 5 Sept 18 Video lecture: Vitamin B6 No class but LEARN FROM Sept20 Sept 22 Video discussion, Clinical Correlate: Pathophysiology and Etiology of Anemia as Related to Vitamin; Folate and Cancer Clinical Correlate As Related to Cardiovascular Disease and B- vitamins; Neural tube defect, and review for EXAM 1 ; QUIZ 2 (10 Concept Map 2 due (20pts) 5
Dates Lecture Topics Quizzes, Assignments, and Exams Week 6 Sept 25 EXAM 2 (60 Sept 27 Vitamin C and oxidative stress Reading: pp. 416-424 Sept 29 Vitamin C and vitamin E oxidative stress Chapter 10 Week 7 Oct 2 Vitamin E and Disease Chapter 10 Oct 4 Video lecture: Vitamin A No class but LEARN FROM Chapter 10 Oct 6 Video Discussion: Vitamin A and - carotene Week 8 Oct 9 OCTOBER BREAK NO CLASS No Class Oct 11 Exam 3 (70 QUIZ 3 (10 pts) Chapter 10 INSTRUCTOR: Dr. Nana GletsuMiller Oct 13 Iron Reading: Chapter 13 Week 9 Oct 16 Iron Oct 18 Video Lecture: Copper No class but LEARN FROM Reading: Chapter 13 Oct 20 Video discussion, Clinical Correlate: Pathophysiology and Etiology of Anemia as Related to Minerals QUIZ 4 (10 Week 10 Oct 23 Zinc and Selenium Chapter 13; Concept Map 3 due (20 Oct 25 Iodine Reading: Chapter 13 Oct 27 Fluoride; Chromium Reading: Chapter 13; Week 11 Oct 30 Review Nov 1 EXAM4 (70 Nov 3 Video Lecture: Calcium No class but LEARN FROM Reading: Chapter 11 Week 12 Nov 6 Video discussion Vitamin D Reading: Chapters 10 6
Dates Lecture Topics Quizzes, Assignments, and Exams Nov 8 Phosphorus Reading: Chapter 11; Nov 10 Magnesium Reading: Chapters 11 QUIZ 5 (10 Week 13 Nov 13 Video Lecture: Vitamin K No class but LEARN FROM Nov 15 Video Discussion, Clinical Correlates: Pathophysiology and Etiology of Bone Diseases as Related to Vitamins and Minerals Reading: Chapter 10 Nov 17 Review Concept Map 4 due (20 Week 14 Nov 20 EXAM 5 (70 Nov 22 THANKSGIVING VACATION No Class Nov 24 THANKSGIVING VACATION No Class Week 15 Nov 27 Fluid, Electrolyte, and Fluid Balance Chapter 12 Nov 29 Sodium Chapter 12 Dec 1 Potassium Chapter 12; QUIZ 6 (10 Week 16 Dec 4 Video Lecture: Chloride No class but LEARN FROM Chapter 12 Dec 6 Clinical Correlates: Nutrients and Hypertension Concept Map 5 due (20 Chapter 12 Dec 8 Review Chapter 14 Finals Exams: FINAL EXAM (150 FINAL EXAM Dec 11-16 7