FACULTY. James Daubert, MD, FACC Chief, Cardiac Electrophysiology Professor of Medicine Duke University

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FACULTY William Abraham, MD, FACC, FHFSA, Physiology, and Cell Biology Director and Chair, Division of Cardiovascular Medicine Associate Dean for Clinical Research Director, Clinical Trials Management Office Deputy Director, Davis Heart and Lung Research Institute The Ohio State University Tariq Ahmad, MD, FACC Advanced Heart Failure and Transplant Assistant Yale New Haven Health System Ana Barac, MD, PhD, FACC Director, Cardio-Oncology program Medical Director, Cardiac Rehabilitation program MedStar Heart and Vascular Institute Assistant, Georgetown University Linda Bogar MD, FACC Surgical Director of the Heart and Lung Transplant Programs Eugene Braunwald, MD, MACC, FAHA, FESC Distinguished Hershey Harvard Medical School Founding Chairman of the TIMI Study Group Brigham and Women's Hospital Michael Bristow, MD, PhD, FACC, FHFSA (Cardiology) Director of Pharmacogenomics University of Colorado Division of Cardiology President and CEO, ARCA biopharma Javed Butler, MD, MPH, MBA, FACC, FHFSA Patrick Lehan Chair, Cardiovascular Research Chair, Department of Medicine University of Mississippi Robert Califf, MD, MACC, FAHA, FESC Vice-Chancellor for Health Data Science Senior Management Team, Verily Life Sciences Former FDA Commissioner Peter Carson, MD, FACC Clinical Georgetown University Director, Heart Failure Program Washington DC VA Medical Center Lauren Cooper, MD, MHS, FACC Director of Heart Failure Disease Management Clinic Associate Director of Heart Failure Research Inova Heart & Vascular Institute James Daubert, MD, FACC Chief, Cardiac Electrophysiology Shashank Desai, MD, FACC Medical Director Advanced Heart Failure and Transplant Program G. Michael Felker, MD, FACC, FHFSA Chief of the Heart Failure Section Mona Fiuzat, PharmD, FACC, FHFSA, FHFA Former Sr. Scientific Advisor to FDA Commissioner Associate James Januzzi, MD, FACC Hutter Family Senior Cardiometabolic Faculty Baim Institute for Clinical Research Harvard Medical School Marvin A. Konstam, MD, FACC, FHFSA Chief Physician Executive The CardioVascular Center Tufts University School of Medicine Harlan Krumholz, MD, SM, FACC, FAHA Harold H. Hines, Jr. Professor in the Institute for Social and Policy Studies Director, Center for Outcomes Research and Evaluation Yale University JoAnn Lindenfeld, MD, FACC, FAHA, FHFSA Director, Heart Failure and Transplant Program Vanderbilt University Doug Mann, MD, FACC, FAHA, FHFSA Lewin Chair and Chief, Cardiovascular Division, Cell Biology and Physiology Washington University School of Medicine

Christopher W. May, MD, FACP, FACC, FHFSA Heart Failure/Transplant Program Medical Director CTUN Roxanna Mehran, MD, FACC, FESC, FAHA Director, Interventional Cardiovascular Research and Clinical Trials Zena and Michael A. Weiner Cardiovascular Institute Mount Sinai School of Medicine Alan B Miller MD, FACC, FHFSA University of Florida/Jacksonville Christopher O Connor, MD, FACC, FESC, FHFSA CEO and Executive Director Inova Heart & Vascular Institute, Mitchell Psotka, MD, PhD Advanced Heart Failure, Transplant, and Pulmonary Hypertension Associate Director Heart Failure Site Based Research and Heart Failure Outreach Programs Joseph G. Rogers, MD, FACC, FHFSA, Division of Cardiology Interim Chair, Department of Medicine Palak Shah, MD, MS, FACC, FHFSA Director, Cardiovascular Genomics Center Director, Heart Failure Research Assistant, GW University Ramesh Singh MD, FACS, FACC Surgical Director of Mechanical Circulatory Support Professor, Department of Surgery Division of Cardiothoracic Surgery Virginia Commonwealth University John Teerlink, MD, FACC, FHFSA Director, Heart Failure Program and Clinical Echocardiography Lab, San Francisco VA Medical Center, UCSF Behnam Tehrani, MD, FACC, FSCAI Medical Director, Cardiac Catheterization Laboratory Orly Vardeny, PharmD, MS, FHFSA Associate Professor of Pharmacy and Medicine University of Minnesota Hector O. Ventura, MD, FACC, FACP Section Head Cardiomyopathy and Heart Transplantation Ochsner Medical Center Mary N. Walsh, MD, FACC, FHFSA Medical Director, Heart Failure and Transplantation Director, Nuclear Cardiology St. Vincent Heart Center David Whellan, MD, FACC, FHFSA James C. Wilson Associate Provost for Clinical Research Associate Dean for Clinical Research Executive Director, Jefferson Clinical Research Institute Thomas Jefferson University, MACC, FAHA, FHFSA Vice Dean for Diversity and Inclusion Chief of Cardiology, Department of Medicine Northwestern Feinberg School of Medicine Alan Speir, MD, FACC Director, Cardiothoracic Surgery

PROGRAM 7:30 8:20 AM Registration, Coffee, Exhibits 7:55 8:25 AM Opening Breakout Session: Sponsored by Medtronic 8:25 8:30 AM Opening Remarks Christopher M. O Connor, MD Shashank Desai, MD 8:30 9:10 am OPENING KEYNOTE ADVANCES IN HEART FAILURE: Cardiac and Renal Effects of SGLT2 Inhibitors in Diabetes Eugene Braunwald, MD SESSION 1: DRUG THERAPY PHARMACOLOGY: NOVEL APPROACHES TO DRUG THERAPY FOR HEART FAILURE Session Moderator: Michael Bristow, MD, PhD Panel Moderator: Mona Fiuzat, PharmD 9:15 9:25 AM: Current Management Strategies in HFpEF: The New Worldwide Epidemic Orly Vardeny, PharmD 9:25 9:35 AM: Should Race and Gender Affect Drug Therapy Decisions? 9:35 9:45 AM: Beyond Diuretics Anything Else for Symptom Relief? G. Michael Felker, MD 9:45 9:55 AM: Antiplatelets and Anticoagulation in HF Good for All? John Teerlink, MD 9:55 10:05 AM: Novel Therapies for Diabetes and HF Javed Butler, MD 10:05 10:15 AM: Treating Pulmonary Hypertension and RV Failure Mitchell Psotka, MD, PhD 10:15 10:35 AM: Clinical Cases and Panel Discussion (Moderator: Mona Fiuzat, PharmD) Orly Vardeny, PharmD Clinical Case #1 Mitchell Psotka, MD, PhD Clinical Case #2 G. Michael Felker, MD John Teerlink, MD Javed Butler, MD Patient Representative 10:35-11:15 AM: Exhibit and Networking Break, Posters 10:45 11:15 AM: Breakout Session: Sponsored by Abbott

DEVICES: CUTTING EDGE DEVICE THERAPY FOR HEART FAILURE Session Moderator: Alan Miller, MD Panel Moderator: Peter Carson, MD 11:20 11:30 AM: Sensor Strategies for Heart Failure Apple, Oranges and Bananas David Whellan, MD SESSION 2: DEVICES 11:30 11:40 AM: Ablation, ICD s and CRT for Heart Failure James Daubert, MD 11:40 11:50 AM: Sleep Apnea To Treat or Not to Treat? Christopher O Connor, MD 11:50 12:00 PM: Novel Device Therapies for HF William Abraham, MD 12:00 12:10 PM: Treating Mitral Regurgitation in HF JoAnn Lindenfeld, MD 12:10 12:20 PM: The Intersection of A. Fib and HF Michael Bristow, MD, PhD 12:20 12:30 PM: Patient Decisions about Device Therapy Mary Walsh, MD 12:30 pm-12:50 PM: Clinical Cases and Panel Discussion (Moderator: Peter Carson, MD) Mary Walsh, MD Clinical Case #1 Alan Miller, MD Clinical Case #2 David Whellan, MD Michael Bristow, MD, PhD JoAnn Lindenfeld, MD Christopher O Connor, MD William Abraham, MD James Daubert, MD 12:50 1:30 PM: Lunch, Exhibits and Networking 1:05 1:20 PM: Poster Session Moderators / Judges: Lauren Cooper, MD; Mitch Psotka, MD; Palak Shah, MD, Chris defilippi, MD 1:00 1:30 PM: Breakout Session 1:35 2:15 PM LUNCH KEYNOTE SESSION 1:35 1:55 PM: THE FUTURE OF HEALTHCARE AND CV MEDICINE IN AMERICA Robert Califf, MD 1:55 2:15 PM: PANEL Moderator: Christopher M. O Connor Panelists: Robert Califf, MD; Alan Speir; MD, Harlan Krumholz, MD

Debates and Health Policy Session Moderator: Marvin Konstam, MD Panel Moderator: G. Michael Felker, MD SESSION 3: DEBATES DEBATE 1: CARDIO-ONCOLOGY: DOES LVEF MATTER? 2:20 2:30 PM: LVEF Changes Should be Managed Ana Barac, MD 2:30 2:40 PM: No Clear Evidence Marvin Konstam, MD DEBATE 2: SHOULD WE USE BIOMARKERS TO GUIDE THERAPY? 2:40 2:50 PM: Use Biomarkers to Guide Therapy James Januzzi, MD 2:50 3:00 PM: Guideline Directed, not Biomarker Guided DEBATE 3: HOW TO TREAT WOMEN: FROM THE EXPERTS 3:00 3:10 PM: Expert #1 Roxanna Mehran, MD 3:10 3:20 PM: Expert #2 Hector Ventura, MD 3:20 3:40 PM: Panel Discussion (Moderator: G. Michael Felker, MD) Roxanna Mehran, MD Hector Ventura, MD Ana Barac, MD Marvin Konstam, MD James Januzzi, MD 3:40 3:55 PM: Exhibits and Networking Coffee Break

SESSION 4: ADVANCED HF CUTTING EDGE CONCEPTS IN ADVANCED HEART FAILURE Session Moderator: JoAnn Lindenfeld, MD Panel Moderator: Shashank Desai, MD 3:55 4:05 PM: Transitions of Care: Hospital to Home Harlan Krumholz, MD 4:05 4:15 PM: The New Allocation System: Who is Appropriate for Heart Transplant or Mechanical Support? Shashank Desai, MD 4:15 4:25 PM: Novel Mechanical Support Devices in 2018 Ramesh Singh, MD 4:25 4:35 PM: Palliative Care in End Stage Heart Failure: Symptom Management Joseph Rogers, MD 4:35 4:45 PM: Medical Management of LVAD patients for the Non-LVAD Specialist Tariq Ahmad, MD 4:45 4:55 PM: LVAD Explantation Can it Be Done? Doug Mann, MD 4:55 5:05 PM: Cutting Edge Concepts in Surgical Options Linda Bogar, MD 5:05 5:15 PM: Improving Outcomes in Cardiogenic Shock Behnam Tehrani, MD 5:15 5:35 PM Clinical Cases and Panel Discussion (Moderator: Shashank Desai, MD) Palak Shah, MD Clinical Case #1 IHVI Nurse, TBD Clinical Case #2 Christopher May, MD Linda Bogar, MD Ramesh Singh, MD Joseph Rogers, MD Doug Mann, MD Tariq Ahmad, MD Behnam Tehrani, MD 5:35 5:45 PM: Poster Awards, Raffle Winners, Closing Remarks Christopher M. O Connor