STEP THERAPY CRITERIA

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STEP THERAPY This is a complete list of drugs that have written coverage determination policies. Drugs on this list do not indicate that this particular drug will be covered under your medical or prescription drug benefit. Please verify drug coverage by checking your formulary and member handbook. Additional restrictions and exclusions may apply. If you have questions, please contact Providence Health Plan Customer Service at 503-574-7500 or 1-800-878-4445 (TTY: 711). Service is available five days a week, Monday through Friday, between 8 a.m. and 6 p.m.

BYSTOLIC, BYVALSON BYSTOLIC For Bystolic : Documented trial or intolerance of two of the following formulary cardio selective betablockers: atenolol, metoprolol succinate, metoprolol tartrate or bisoprolol. For Byvalson : Documented trial or intolerance of two of the following formulary cardio selective betablockers: atenolol, metoprolol succinate, metoprolol tartrate or bisoprolol. AND One of the following formulary ARBs: losartan, irbesartan, telmisartan valsartan, eprosartan or candesartan.

ELIDEL ELIDEL Documented trial or contraindication to tacrolimus 0.1% ointment or tacrolimus 0.3% ointment.

FINACEA FINACEA Documented trial or contraindication to a generic topical metronidazole product.

FLECTOR FLECTOR 1. Trial and failure of one of the following oral NSAIDs: celecoxib, etodolac, nabumetone, meloxicam, or sulindac. AND 2. Trial and failure of diclofenac sodium 1% topical gel (Voltaren 1% topical gel) or diclofenac 1.5% topical solution (Pennsaid 1.5% topical solution).

GLP-1 RECEPTOR AGONISTS BYDUREON, BYDUREON BCISE, BYDUREON PEN, BYETTA, OZEMPIC, TRULICITY, VICTOZA 2- PAK, VICTOZA 3-PAK COVERED USES: All medically accepted indications not otherwise excluded from the benefit. : 1.Documentation of trial, contraindication or intolerance to metformin AND 2.For albiglutide (Tanzeum ) and lixisenatide (Adlyxin ): documentation of trial, contraindication or intolerance to at least TWO of the preferred glucagon-like peptide-1 (GLP-1) receptor agonists: [exenatide (Byetta ), exenatide ER (Bydureon ), liraglutide (Victoza ), semaglutide (Ozempic )] EXCLUSION : N/A REQUIRED MEDICAL INFORMATION: For initiation of treatment, a prior authorization form and relevant chart notes documenting medical rationale are required and for continuation of therapy, ongoing documentation of successful response to the medication may be necessary. AGE RESTRICTIONS: N/A PRESCRIBER RESTRICTIONS: N/A COVERAGE DURATION: Authorization may be reviewed annually to assess continued medical necessity and effectiveness of medication. QUANTITY LIMITATIONS: Byetta = 2.4 ml per 30 days Bydureon = 3.4 ml per 28 days BCise = 3.4 ml per 28 days Victoza = 9 ml per 30 days Trulicity = 2 ml per 28 days Adlyxin = 6 ml per 28 days Tanzeum = 2.25 ml per 30 days Ozempic 0.25 or 0.5 mg pen = 1.5 ml per 28 days

Ozempic 1 mg pen = 3 ml per 28 days

HECTORAL/ZEMPLAR DOXERCALCIFEROL 0.5 MCG CAP, DOXERCALCIFEROL 1 MCG CAPSULE, DOXERCALCIFEROL 2.5 MCG CAP, HECTOROL 0.5 MCG CAPSULE, HECTOROL 1 MCG CAPSULE, HECTOROL 2.5 MCG CAPSULE, PARICALCITOL 1 MCG CAPSULE, PARICALCITOL 2 MCG CAPSULE, PARICALCITOL 4 MCG CAPSULE, ZEMPLAR 1 MCG CAPSULE, ZEMPLAR 2 MCG CAPSULE Documentation of trial, intolerance, or contraindication to calcitriol.

LUMIGAN STEP THERAPY BIMATOPROST 0.03% EYE DROPS, LUMIGAN An adequate trial and failure, contraindication or intolerance to the use of latanoprost ophthalmic solution. QUANTITY LIMIT: 2.5 ml per 25 days

NON-PREFERRED ARBS EDARBI, EDARBYCLOR Documentation of trial or contraindication to two (2) generic, formulary angiotensin-receptor antagonists (ARBs) (e.g. losartan, valsartan, telmisartan, irbesartan, eprosartan, candesartan).

OVERACTIVE BLADDER MEDICATIONS DARIFENACIN ER, ENABLEX, MYRBETRIQ, TOVIAZ, VESICARE COVERED USES: All Food and Drug Administration (FDA) approved indications not otherwise excluded from the benefit. : Trial of or contraindication to: 1.Oxybutynin AND 2.tolterodine Note: Contraindication to anticholinergics can include delirium, dementia/cognitive impairment, preexisting issue with chronic constipation, urinary retention, gastric retention, or uncontrolled narrowangle glaucoma. EXCLUSION : NA REQUIRED MEDICAL INFORMATION: For initiation of treatment, a prior authorization form and relevant chart notes documenting medical rationale are required and for continuation of therapy, ongoing documentation of successful response to the medication may be necessary. AGE RESTRICTIONS: NA PRESCRIBER RESTRICTIONS: NA COVERAGE DURATION: Initial authorization and reauthorization will be approved for up to one year.

PHOSPHATE BINDERS AURYXIA, FOSRENOL, LANTHANUM CARBONATE, PHOSLYRA, RENAGEL, VELPHORO Documentation of trial, contraindication, or intolerance to calcium acetate tablets/capsules (Phos-Lo ) AND sevelamer carbonate tablets (Renvela ) Or for Auryxia to control iron deficiency anemia: Documentation of trial and failure, contraindication, or intolerance to iron supplementation. Failure defined as failure of hemoglobin to return to normal by eight weeks of iron supplementation. Intolerance will include constipation that is not controlled by increasing fiber in diet, docusate, bulk forming laxatives (Metamucil, Citrucel, Benefiber ), or polyethylene glycol (Miralax ).

RANEXA STEP THERAPY RANEXA Documented trial of or contraindication to a long-acting nitrate (ie isosorbide dinitrate, isosorbide mononitrate, or nitroglycerin patch products).

SEROTONIN ANTAGONISTS ANZEMET, SANCUSO Documented trial, failure, intolerance or contraindication to ondansetron AND granisetron tablets.

SOOLANTRA STEP THERAPY SOOLANTRA Documented trial, failure, intolerance or contraindication to metronidazole 0.75% topical gel, cream, or lotion. COVERAGE DURATION: Authorization may be reviewed annually to assess continued medical necessity and effectiveness of medication.

TRIPTAN STEP THERAPY ALMOTRIPTAN MALATE, AXERT, ELETRIPTAN HBR, RELPAX, ZOLMITRIPTAN 2.5 MG TABLET, ZOLMITRIPTAN 5 MG TABLET, ZOLMITRIPTAN ODT, ZOMIG 2.5 MG TABLET, ZOMIG 5 MG TABLET, ZOMIG ZMT Documented trial or intolerance to both of the following medications: sumatriptan, rizatriptan.

VYZULTA STEP THERAPY VYZULTA Documented trial or contraindication to latanaprost eye drops.