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CD2 (EP222) CD2 is one of the earliest T-cell lineage restricted antigens to appear during T-cell differentiation and only rare CD2+ cells can be found in the bone marrow. Anti-CD2 is a pan-t-cell antigen marker. Anti-CD2 is therefore useful for the identification of virtually all normal T-lymphocytes. It is also very useful in the assessment of lymphoid malignancies as it is expressed in the majority of precursor and mature T-cell lymphomas and leukemias. As with other pan-t-cell antigens, CD2 may be aberrantly deleted in some neoplastic T-cell populations, especially peripheral T-cell lymphomas. When combined with anti-cd25, anti-cd2 may assist in the identification of systemic mastocytosis and mastocytic leukemia. Above: Anti-CD2 stains angioimmunoblastic T-cell lymphoma cells in cytoplasmic and perinuclear Golgi pattern. 0.1 ml, concentrate...102r-14 0.5 ml, concentrate...102r-15 1 ml, concentrate...102r-16 1 ml, prediluted...102r-17 7 ml, prediluted...102r-18 Positive control slides...102s, membranous Control Tonsil Desmin (EP15) Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. This antibody is used to demonstrate the myogenic components/derivation of tumors. Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis. Above: Anti-desmin highlights rhabdomyosarcoma cells in a cytoplasmic pattern. 0.1 ml, concentrate...243r-14 0.5 ml, concentrate...243r-15 1 ml, concentrate...243r-16 1 ml, prediluted...243r-17 7 ml, prediluted...243r-18 Positive control slides...243s Control Skeletal muscle 2

ERG (EP111) ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes FLI-1 and ETS-1. ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms. ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN). ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG. ERG has also been observed to be positive in a minority of Ewing sarcomas. This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG). ERG has also been observed to stain some meningiomas due to cross reactivity with FLI-1. Above: Anti-ERG decorates nuclei of prostatic carcinoma. 0.1 ml, concentrate...434r-14 0.5 ml, concentrate...434r-15 1 ml, concentrate...434r-16 1 ml, prediluted...434r-17 7 ml, prediluted...434r-18 Positive control slides...434s Visualization Nuclear Control Tonsil, hemangioma FSH (EP257) Follicle-stimulating hormone (FSH) is a member of the pituitary glycoprotein hormone family which includes luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. Follicle-stimulating hormone enables ovarian folliculogenesis to the antral follicle stage and is essential for Sertoli cell proliferation and maintenance of sperm quality in the testis. Members of the pituitary glycoprotein hormone family consist of a shared alpha chain and a beta chain encoded by a separate gene. The FSHB gene encodes the beta subunit of follicle stimulating hormone. Anti-FSH is a useful marker in classification of pituitary tumors and the study of pituitary disease, as it reacts with FSH-producing cells (gonadotrophs). Above: Rabbit monoclonal anti-fsh displays pituitary adenoma cells. 0.1 ml, concentrate...207r-14 0.5 ml, concentrate...207r-15 1 ml, concentrate...207r-16 1 ml, prediluted...207r-17 7 ml, prediluted...207r-18 Positive control slides...207s Control Pituitary 3

Granzyme B (EP230) Granzymes are serine proteases, which are stored in specialized lytic granules of cytotoxic T-lymphocytes and in natural killer cells. Anti-granzyme B has been useful in the identification of natural killer/t-cell lymphoma, as well as anaplastic large cell lymphoma. Above: Anti-granzyme B shows cytotoxic granules in the cytoplasm of angioimmunoblastic T-cell lymphoma cells. 0.1 ml, concentrate...262r-14 0.5 ml, concentrate...262r-15 1 ml, concentrate...262r-16 1 ml, prediluted...262r-17 7 ml, prediluted...262r-18 Positive control slides...262s Control Spleen, anaplastic large cell lymphoma Kappa (EP171) Anti-kappa detects surface immunoglobulin on normal and neoplastic B-cells. In paraffin-embedded tissue, anti-kappa exhibits strong staining of kappa-positive plasma cells and cells that have absorbed exogenous immunoglobulins. When dealing with B-cell neoplasms, the determination of light chain ratios remains the centerpiece. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder exists. Above: Anti-kappa light chain demonstrates kappa producing plasma cells in the tonsilar tissue. 0.1 ml, concentrate...274r-14 0.5 ml, concentrate...274r-15 1 ml, concentrate...274r-16 1 ml, prediluted...274r-17 7 ml, prediluted...274r-18 Positive control slides...274s Control Tonsil 4

Lambda (EP172) Anti-lambda detects surface immunoglobulin on normal and neoplastic B-cells. Anti-lambda staining is seen in B-cell follicles of human lymphoid tissue. When dealing with B-cell neoplasms, the determination of light chain ratios remains helpful. Most B-cell lymphomas express either kappa or lambda light chains, whereas reactive proliferations display a mixture of kappa and lambda positive cells. If only a single light chain type is detected, a lymphoproliferative disorder is very likely. Above: Plasma cells in the tonsil are highlighted by the anti-lambda light chain. 0.1 ml, concentrate...277r-14 0.5 ml, concentrate...277r-15 1 ml, concentrate...277r-16 1 ml, prediluted...277r-17 7 ml, prediluted...277r-18 Positive control slides...277s Control Tonsil Mammaglobin (EP249) Mammaglobin (10 kd) is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. Mammaglobin mrna is present in high levels in human breast cancer cell lines, which has been shown to be a sensitive marker of breast cancer. When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity for breast carcinoma of 84% has been achieved. Anti-mammaglobin can also be used to determine breast origin in the setting of metastatic carcinoma. Above: Anti-mammaglobin illustrates the protein expression in the cells of invasive ductal carcinoma of the breast. 0.1 ml, concentrate...280r-24 0.5 ml, concentrate...280r-25 1 ml, concentrate...280r-26 1 ml, prediluted...280r-27 7 ml, prediluted...280r-28 Positive control slides...280s Control Breast carcinoma 5

Napsin A (EP205) Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kda. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs. Above: Lung adenocarcinoma is strongly and diffusely positive for anti-napsin A. 0.1 ml, concentrate...352r-14 0.5 ml, concentrate...352r-15 1 ml, concentrate...352r-16 1 ml, prediluted...352r-17 7 ml, prediluted...352r-18 Positive control slides...352s Control Lung adenocarcinoma, kidney, renal cell carcinoma SOX-10 (EP268) Sry-related HMG-BOX gene 10 (SOX-10) is a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage. It has been recently shown to be a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. SOX-10 was expressed by metastatic melanomas in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Anti-SOX-10 has been shown to be superior to all other immunostains in detecting residual invasive and in situ melanoma. Anti-SOX-10 is also a useful marker in detecting both the in situ and invasive components of desmoplastic melanoma. It is known that the commonly used melanoma markers, anti-hmb-45 and anti-melan A, are poorly expressed in desmoplastic melanomas while it has been reported that anti-sox-10 was moderately to strongly expressed in almost all desmoplastic melanomas. SOX-10 is diffusely expressed in schwannomas and neurofibromas. SOX-10 presence was not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas. Above: SOX-10 rabbit monoclonal antibody highlights tumor cells of desmoplastic melanoma. 0.1 ml, concentrate...383r-14 0.5 ml, concentrate...383r-15 1 ml, concentrate...383r-16 1 ml, prediluted...383r-17 7 ml, prediluted...383r-18 Positive control slides...383s Visualization Nuclear Control Melanoma, skin melanocytes 6

TTF-1 (EP229) Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid, germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. TTF-1 labeling is also seen in thyroid and thyroid-derived tumors. TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions. TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large cell carcinomas. Above: Lung adenocarcinoma strongly and diffusely express TTF-1 protein in the nuclei of the tumor cells. 0.1 ml, concentrate...343r-14 0.5 ml, concentrate...343r-15 1 ml, concentrate...343r-16 1 ml, prediluted...343r-17 7 ml, prediluted...343r-18 Positive control slides...343s Visualization Nuclear Control Lung adenocarcinoma Cell Marque + RabMAb Portfolio Rabbit Monoclonal Primary Antibodies Coming Soon! BCL6 (EP278) CD19 (EP169) GLUT1 (EP141) Glycophorin A (EP213) IMP3 (EP286) MCM3 (EP202) Myogenin (EP162) Olig2 (EP112) SATB2 (EP281) WT1 (EP122) Also Available BCL2 (E17) c-myc (EP121) Caldesmon (E89) Calponin-1 (EP798Y) CD1a (EP3622) CD4 (EP204) CD5 (EP77) CD14 (EPR3653) CD21 (EP3093) CD99 (EPR3097Y) CD117, c-kit (YR145) CDX-2 (EPR2764Y) Cyclin D1 (EP12) Cytokeratin 5 (EP1601Y) Cytokeratin 10 (EP97) E-cadherin (EP700Y) Estrogen Receptor (EP1) Factor XIIIa (EP3372) GCDFP-15 (EP1582Y) GFAP (EP672Y) Hemoglobin A (EPR3608) Her2/Neu (EP3) MyoD1 (EP212) PAX-5 (EP156) PMS2 (EPR3947) Progesterone Receptor (Y85) PU.1 (EPR3158Y) S100A1 (EP184) Thyroid Peroxidase (EP159) 7