UvA-DARE (Digital Academic Repository) Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Hoekman, D.R. Link to publication Citation for published version (APA): Hoekman, D. R. (2016). Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. UvA-DARE is a service provided by the library of the University of Amsterdam (http://dare.uva.nl) Download date: 03 Oct 2018
Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Daniël R. Hoekman Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults Daniël R. Hoekman
Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults
Layout and printing: Print Service Ede 2016 Daniël Robin Hoekman. All rights are reserved. No part of this thesis may be reproduced, distributed, or transmitted in any form or by any means without the prior written permission of the author.
Studies on inflammatory bowel disease and functional gastrointestinal disorders in children and adults ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel op dinsdag 20 december 2016, te 12:00 uur door Daniël Robin Hoekman geboren te Amsterdam
Promotiecommissie Promotores: Prof. dr. M.A. Benninga Universiteit van Amsterdam Prof. dr. G.R.A.M. D Haens Universiteit van Amsterdam Copromotores: Dr. M. Löwenberg Universiteit van Amsterdam dr. A.M. Vlieger St. Antonius Ziekenhuis Overige leden: Prof. dr. J.C. Escher Erasmus Universiteit Rotterdam Prof. dr. H.S.A. Heymans Universiteit van Amsterdam Prof. dr. A.J.P.M. Smout Universiteit van Amsterdam dr. P.C.F. Stokkers St. Lucas Andreas Ziekenhuis Prof. dr. F.A. Wijburg Universiteit van Amsterdam Prof. dr. N.J. de Wit Universiteit Utrecht Faculteit der Geneeskunde
Table of contents Chapter 1 Introduction and outline 9 Part I Functional gastrointestinal disorders Chapter 2 Annual costs of care for pediatric irritable bowel syndrome, 23 functional abdominal pain, and functional abdominal pain syndrome Chapter 3 The placebo response in pediatric abdominal pain-related functional 39 gastrointestinal disorders; a systematic review and meta-analysis Chapter 4 Functional constipation in childhood: current pharmacotherapy 61 and future perspectives Chapter 5 Polyethylene glycol 3350 with electrolytes versus polyethylene 77 glycol 4000 without electrolytes for childhood constipation: A randomized controlled trial Part II Inflammatory bowel diseases Chapter 6 The association of infliximab trough levels with disease activity in 95 pediatric inflammatory bowel disease Chapter 7 Prediction of infliximab trough levels based on measurements of 109 intermediate serum concentrations Chapter 8 Long-term outcome of early combined immunosuppression versus 119 conventional management in newly diagnosed Crohn s disease Chapter 9 Patterns of anti-tnf use and associated treatment outcomes in 135 inflammatory bowel disease patients: results from an analysis of Dutch health insurance claims data Chapter 10 A survey of patient reported outcome measures in Crohn s disease 153 Chapter 11 Relationship of clinical symptoms with biomarkers of inflammation 169 in pediatric inflammatory bowel disease Chapter 12 Fecal calprotectin accurately predicts symptomatic relapse in 185 children and adolescents with inflammatory bowel disease in clinical remission Chapter 13 Case report of cheilitis granulomatosa and joint complaints as 201 presentation of Crohn s disease
6 Part III Inflammatory bowel diseases and functional gastrointestinal disorders Chapter 14 The prevalence of irritable bowel syndrome-type symptoms in 215 pediatric inflammatory bowel disease and the relationship with biochemical markers of disease activity Chapter 15 Prevalence of irritable bowel syndrome-type symptoms in 229 inflammatory bowel disease in remission Chapter 16 Hypnotherapy for irritable bowel syndrome-like symptoms in 243 patients with quiescent inflammatory bowel disease: a randomized, controlled trial Appendices Summary, discussion and future perspectives 261 Samenvatting (Nederlands) 271 References 277 contributing authors 299 list of publications 302 PhD portfolio 303 Dankwoord 308 curriculum vitae 310