Cover Page The handle http://hdl.handle.net/1887/38506 holds various files of this Leiden University dissertation. Author: Nies, Jessica Annemarie Bernadette van Title: Early identification of rheumatoid arthritis Issue Date: 2016-03-03
Early identification of rheumatoid arthritis Jessica van Nies
The research presented in this thesis was performed at the department of Rheumatology at the Leiden University Medical Center, Leiden. The research was financially supported by the Centre for Medical Systems Biology (CMSB), The European Community Seventh Framework Programme FP7 Health-F2-2008-223404 (Masterswitch), the IMI JU funded project BeTheCure, contract no 115142-2, the Dutch Arthritis Foundation (Reumafonds) and EuroTEAM. The printing of this thesis was financially supported by Lamepro B.V., Abbvie B.V., Pfizer B.V., Sanofi B.V., UCB Pharma B.V. and Chipsoft B.V., which is gratefully acknowledged. Cover design by Jessica Arana Thesis layout: Alex Wesselink, Persoonlijkproefschrift.nl Printing: Ipskamp Drukkers, Amsterdam, The Netherlands ISBN/EAN: 978-94-028-0040-1
Early identification of rheumatoid arthritis Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker, volgens besluit van het College voor Promoties te verdedigen op donderdag 3 maart 2016 klokke 16.15 uur door Jessica Annemarie Bernadette van Nies Geboren te Leidschendam in 1986
Promotores: Prof. dr. A.H.M. van der Helm-van Mil Prof. dr. T.W.J. Huizinga Leden promotiecommissie: Prof. dr. D.M.F.M. van der Heijde Prof. dr. R.E.M. Toes Prof. dr. A.E.R.C.H. Boonen Dr. E. Brouwer MUMC, Universiteit Maastricht UMCG, Universiteit Groningen
TABLE OF CONTENTS Chapter 1 Introduction 9 Part I Chapter 2 Chapter 3 Early recognition of arthritis Improved early identification of arthritis: evaluating the efficacy of Early Arthritis Recognition Clinics. Ann Rheum Dis. 2013 Aug;72(8):1295-301 Reasons for medical help-seeking behaviour of patients with recent-onset arthralgia. Ann Rheum Dis. 2013 Aug;72(8):1302-7 27 45 Part II Chapter 4 Chapter 5 A therapeutic window of opportunity in rheumatoid arthritis What is the evidence for the presence of a therapeutic window of opportunity in rheumatoid arthritis? A systematic literature review. Ann Rheum Dis. 2014 May;73(5):861-70 Evaluating relationships between symptom duration and persistence of rheumatoid arthritis: does a window of opportunity exist? Results on the Leiden Early Arthritis Clinic and ESPOIR cohorts Ann Rheum Dis. 2015 May;74(5):806-12. 67 95 Part III Chapter 6 Chapter 7 Diagnostic and prognostic value of disease symptoms, characteristics and classification criteria in arthralgia, early arthritis and RA patients Reappraisal of the diagnostic and prognostic value of morning stiffness in arthralgia and early arthritis. Results from the Groningen EARC, Leiden EARC, ESPOIR, Leiden EAC and REACH. Arthritis Res Ther. 2015 Apr;17(1):108. The PTPN22 susceptibility risk variant is not associated with the rate of joint destruction in anti-citrullinated protein antibodypositive rheumatoid arthritis Ann Rheum Dis. 2010 Sep;69(9):1730-1 117 139
Chapter 8 Chapter 9 Evaluating processes underlying the predictive value of baseline erosions for future radiological damage in early rheumatoid arthritis. Ann Rheum Dis. 2015 May;74(5):883-9. Long-term outcome of Rheumatoid Arthritis defined according to the 2010-classification criteria. Ann Rheum Dis. 2014 Feb;73(2):428-32. 145 163 Part IV Chapter 10 Chapter 11 Chapter 12 Mortality in RA TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis; two large longitudinal studies. Arthritis Res Ther. 2010;12(2):R38 Rheumatoid Factor and Anti-Citrullinated Protein Antibody positivity, but not their concentration, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts. Arthritis Res Ther. 2014 Dec;16(6):483. Improved treatment strategies reduce the increased mortality risk in early RA patients. Rheumatology (Oxford). 2010 Nov;49(11):2210-16. 181 195 219 Chapter 13 Summary and Discussion 233 Chapter 14 Nederlandse samenvatting Curriculum Vitae Publications Dankwoord 250 266 268 272