Cardiac Bone Marrow Cell Injection for Chronic Ischemic Heart Disease Monique R.M. Jongbloed 070303 Beeres Boek.indb 1 06-09-2007 17:13:27
The studies described in this thesis were performed at the Department of Cardiology of the Leiden University Medical Center, Leiden, the Netherlands. Copyright 2007 Saskia L.M.A. Beeres, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author. Layout: Buijten & Schipperheijn, Amsterdam, The Netherlands. Printed by: Buijten & Schipperheijn, Amsterdam, The Netherlands. ISBN: 978-90-9022211-0 Financial support to the costs associated with the publication of this thesis from Astellas Pharma BV, Biologics Delivery Systems Group, Biotronik NL, Boston Scientific Benelux BV, Bristol-Myers Squibb BV, Boehringer Ingelheim BV, Datascope BV, Eli Lilly Nederland BV, GE Healthcare Medical Diagnostics, GE Medical Systems Ultrasound, J.E. Jurriaanse Stichting, Medtronic Trading NL BV, Merck Sharp & Dohme BV, Novartis Pharma BV, OrbusNeich Medical BV, Pfizer BV, Sanofi-Aventis Netherlands BV, Schering-Plough BV, Servier Farma BV, Siemens Nederland NV, St. Jude Medical Nederland BV, Stichting EMEX and Toshiba Medical Systems Nederland is gratefully acknowledged. 070303 Beeres Boek.indb 2 06-09-2007 17:13:28
Cardiac Bone Marrow Cell Injection for Chronic Ischemic Heart Disease Proefschrift ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op woensdag 17 oktober 2007 klokke 16.15 uur door Saskia Lambertha Maria Anna Beeres geboren te Leidschendam in 1979 070303 Beeres Boek.indb 3 06-09-2007 17:13:28
Promotiecommissie Promotores: Co-promotor: Referent: Overige leden: prof. dr. M.J. Schalij prof. dr. J.J. Bax dr. D.E. Atsma prof. dr. P.A.F.M. Doevendans (Universitair Medisch Centrum, Utrecht) prof. dr. R.N.W. Hauer (Universitair Medisch Centrum, Utrecht) prof. dr. E. E. van der Wall prof. dr. W.E. Fibbe prof. dr. A.C. Gittenberger-de Groot dr. K. Zeppenfeld Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. 070303 Beeres Boek.indb 4 06-09-2007 17:13:29
Voor mijn ouders Aan Paul 070303 Beeres Boek.indb 5 06-09-2007 17:13:29
Table of Contents Chapter 1 General introduction 8 Chapter 2 Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocytes cultures Journal of the American College of Cardiology 2005;46:1943-1952 38 Chapter 3 Feasibility of trans-endocardial cell transplantation in chronic ischemia Heart 2007;93:113-114 56 Chapter 4 Electrophysiological and arrhythmogenic effects of intramyocardial bone marrow cell injection in patients with chronic ischemic heart disease Heart Rhythm 2007;4:257-265 64 Chapter 5 Intramyocardial bone marrow cell transplantation and the progression of coronary atherosclerosis in patients with chronic myocardial ischemia Acute Cardiac Care 2007 in press 84 Chapter 6 Usefulness of intramyocardial injection of autologous bone marrowderived mononuclear cells in patients with severe angina pectoris and stress-induced angina pectoris American Journal of Cardiology 2006;97:1326-1331 102 Chapter 7 Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia Journal of Magnetic Resonance Imaging 2007 in press 116 Chapter 8 Chapter 9 Effect of intramyocardial injection of autologous bone marrowderived mononuclear cells on perfusion, function and viability in patients with drug-refractory chronic ischemia Journal of Nuclear Medicine 2006;47:574-580 Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: twelve-month follow-up results American Heart Journal 2006;152:684.e11-684.e16 130 146 070303 Beeres Boek.indb 6 06-09-2007 17:13:29
Chapter 10 Intramyocardial injection of autologous bone marrow mononuclear cells in patients with chronic myocardial infarction and severe left ventricular dysfunction American Journal of Cardiology 2007 in press Chapter 11 Role of Imaging in Cardiac Stem Cell Therapy Journal of the American College of Cardiology 2007;49:1137-1148 Summary, conclusions and future perspectives Samenvatting, conclusies en toekomstperspectieven List of publications Acknowledgements Curriculum vitae 160 174 196 206 216 220 224 070303 Beeres Boek.indb 7 06-09-2007 17:13:30