Material Safety Data Sheet NFPA HMIS Personal Protective Equipment 0 Health Hazard Fire Hazard 0 See Section 5. Section. Chemical Product and Company Identification Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Vitamin A acetate SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 Myvak, Myvax, Crystalets Catalog Number(s). CAS# RTECS TSCA V257, VI9 27-47-9 VH6825000 Retinyl acetate; all-trans-retinyl acetate; Trans-Vitamin A Acetate; Vitamin A alcohol acetate; Retinol, acetate IN CASE OF EMERGENCY CHEMTREC (24hr) 800-424-9300 all-trans-3,7-dimethyl-9-(2,6,6-trimethyl--cyclohexene--yl)-2,4,6,8-n CI# Page Number: TSCA 8(b) inventory: Vitamin A acetate Chemical Family Chemical Formula Supplier C22-H32-O2 SPECTRUM LABORATORY PRODUCTS INC. 4422 S. SAN PEDRO STREET GARDENA, CA 90248 CALL (30) 56-8000 Section 2.Composition and Information on Ingredients Name CAS # Exposure Limits TWA (mg/m 3 ) STEL (mg/m 3 ) CEIL (mg/m 3 ) % by Weight ) Vitamin A acetate 27-47-9 5-20 2) Starch 9005-25-8 0 0-30 3) Sucrose 57-50- 0 0-30 4) 2,6-di-tert-butyl-p-cresol 28-37-0 0-2.5 Toxicological Data on Ingredients Vitamin A acetate: ORAL (LD50): Sucrose: ORAL (LD50): Acute: 400 mg/kg [Mouse]. 2740 mg/kg [Rat]. Acute: 29700 mg/kg [Rat]. Section 3. Hazards Identification Potential Acute Health Effects Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation. Potential Chronic Health Effects CARCINOGENIC EFFECTS: MUTAGENIC EFFECTS: TERATOGENIC EFFECTS: DEVELOPMENTAL TOXICITY: The substance may be toxic to blood, liver. Repeated or prolonged exposure to the substance can produce target organs damage.
Vitamin A acetate Page Number: 2 Section 4. First Aid Measures Eye Contact Skin Contact Serious Skin Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 5 minutes. Get medical attention if irritation occurs. Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Inhalation Serious Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion Serious Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention if symptoms appear. Section 5. Fire and Explosion Data Flammability of the Product Auto-Ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances May be combustible at high temperature. These products are carbon oxides (CO, CO2). Slightly flammable to flammable in presence of heat. Non-flammable in presence of shocks. Explosion Hazards in Presence of Various Substances Slightly explosive in presence of open flames and sparks. Non-explosive in presence of shocks. Fire Fighting Media and Instructions Fire Hazards Explosion Hazards SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. As with most organic solids, fire is possible at elevated temperatures Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Section 6. Accidental Release Measures Small Spill Large Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Precautions Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not ingest. Do not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents, acids, alkalis. Keep container tightly closed. Keep container in a cool, well-ventilated area. Air Sensitive Sensitive to light. Store in light-resistant containers. Keep under inert atmosphere.
Vitamin A acetate Page Number: 3 Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection Personal Protection in Case of a Large Spill Exposure Limits Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Section 9. Physical and Chemical Properties Physical state and appearance Solid (crystals, granules, fine granular powder) Odor Amine like. (Slight.) Molecular Weight ph (% soln/water) 328.5 Taste Color Yellowish. (Light.) Off-white. Boiling Point Melting Point Not available Critical Temperature Specific Gravity Not available Vapor Pressure Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties Solubility Insoluble in cold water, hot water. Soluble in ethanol, chloroform. Section 0. Stability and Data Stability Instability Temperature Conditions of Instability Incompatibility with various substances Corrosivity The product is stable. Excess heat, dust generation, incompatible materials, light, air, humidity Reactive with oxidizing agents, acids, alkalis. Non-corrosive in presence of glass. Corrosivity Polymerization Air and light sensitive. Incompatible with copper, copper alloys, iron, iron salts, strong oxidizing agents, peroxides, strong inorganic acids, strong bases. Will not occur.
Vitamin A acetate Page Number: 4 Section. Toxicological Information Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Toxicity to Animals Chronic Effects on Humans other Toxic Effects on Humans Inhalation. Ingestion. For Vitamin A Acetate: Acute oral toxicity (LD50): 2740 mg/kg [Rat]. May cause damage to the following organs: blood, liver. Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. For Vitamin A Acetate: May affect genetic material (mutagenic). May cause adverse developmental effects and birth defects(teratogenic) based on animal test data according to the Registry of Toxic Effects of Chemicals Substances (RTECS). There was no other supporting information. May cause cancer based on animal test data according to RTECS criteria. No other supporting information was found. Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Ingestion of large amounts may cause gastrointestinal disturbances (nausea, vomiting), sedation, irritability, headache, fatigue, stupor, anorexia/loss of appetite, yellow pigmentation of skin. Generalized peeling of the skin may occur. Chronic Potential Health Effects: Ingestion: Prolonged or repeated ingestion of large amounts can have similar effects to that of acute ingestion. It may also affect the liver and blood. Chronic overdosages may also cause chapped lips, dry and itching skin, erythematous dermatits, desquamation, disturbed hair growth, loss of hair, bone decalcification. Section 2. Ecological Information Ecotoxicity BOD5 and COD Products of Biodegradation Toxicity of the Products of Biodegradation the Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The product itself and its products of degradation are not toxic. Section 3. Disposal Considerations Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control regulations. Section 4. Transport Information DOT Classification Identification Not a DOT controlled material (United States). Special Provisions for Transport DOT
Vitamin A acetate Page Number: 5 Section 5. Other Regulatory Information and Pictograms Federal and State Regulations California Proposition 65 Warnings Other Regulations California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the statute: Vitamin A acetate California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Vitamin A acetate (listed as Retinol/retinyl esters, when in daily dosages in excess of 0,000 IU, or 3,000 retinol equivalents.) TSCA 8(b) inventory: Vitamin A acetate California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: No products were found. California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: Vitamin A acetate (listed as Retinol/retinyl esters, when in daily dosages in excess of 0,000 IU, or 3,000 retinol equivalents.) Not Available Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC) Not Applicable HMIS (U.S.A.) Health Hazard Fire Hazard Personal Protection 0 E National Fire Protection Association (U.S.A.) Health 0 Flammability Specific hazard WHMIS (Canada) DSCL (Europe) TDG (Canada) ADR (Europe) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Vitamin A acetate Page Number: 6 Safety glasses. Section 6. Other Information MSDS Code References Other Special Considerations V330 Validated by Sonia Owen on /28/204. Verified by Sonia Owen. Printed /28/204. CALL (30) 56-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, Inc. assumes no responsibility for the completeness or accuracy of the information contained herein.